Advanced search
Publication Cover
Gynecological Endocrinology Volume 36, 2020 - Issue 5
Submit an article Journal homepage
371
Views
19
CrossRef citations to date
0
Altmetric
DIABETES AND OSTEOPOROSIS RISK

Metformin use is associated with a lower risk of osteoporosis in adult women independent of type 2 diabetes mellitus and obesity. REDLINC IX study

Juan E. BlümelDepartamento de Medicina Interna Sur, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-2867-1549View further author information
ORCID Icon,
Eugenio ArteagaDepartamento de Endocrinología and CETREN, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile; ORCID Iconhttp://orcid.org/0000-0002-8090-539XView further author information
ORCID Icon,
Sócrates AedoEscuela de Medicina, Facultad de Medicina, Universidad Finis Terrae, Santiago de Chile, Chile; View further author information
,
José Arriola-MontenegroSociedad Nacional de Capacitación (SONACAP), Lima, Perú; ORCID Iconhttp://orcid.org/0000-0001-6921-7230View further author information
ORCID Icon,
Marcela LópezDepartamento de Endocrinología, Hospital Militar, Santiago de Chile, Chile; View further author information
,
Mabel MartinoRed Latinoamericana de Investigación en Climaterio, Rosario, Argentina; View further author information
,
Carlos MirandaHospital Central FAP, Lima, Perú; View further author information
,
Octavio MirandaFacultad de Medicina, Universidad Uniandes, Ambato, Ecuador; View further author information
,
Desireé MostajoRed Latinoamericana de Investigación en Climaterio, Santa Cruz, Bolivia; View further author information
,
Mónica ÑañezUniversidad Nacional de Córdoba, Córdoba, Argentina; View further author information
,
Eliana OjedaDepartamento de Obstetricia y Ginecología, Universidad Andina del Cusco, Cusco, Perú; ORCID Iconhttp://orcid.org/0000-0001-6606-3029View further author information
ORCID Icon,
Susana PilnikHospital Italiano, Buenos Aires, Argentina; View further author information
,
José RojasUniversidad Peruana Cayetano Heredia, Lima, Perú; View further author information
,
Carlos SalinasHospital Ángeles Puebla, Puebla, México; ORCID Iconhttp://orcid.org/0000-0001-5106-8724View further author information
ORCID Icon,
Lida SosaHospital Central del Instituto de Previsión Social, Asunción, Paraguay; View further author information
,
Poli M. SpritzerGynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas, Porto Alegre, Brazil; ORCID Iconhttp://orcid.org/0000-0002-6734-7688View further author information
ORCID Icon,
Konstantinos TserotasDepartamento de Gineco-Obstetricia, Complejo Hospitalario Dr. Arnulfo Arias Madrid de la Caja del Seguro Social de Panamá, Ciudad de Panamá, Panamá; ORCID Iconhttp://orcid.org/0000-0002-9004-0078View further author information
ORCID Icon,
María S. VallejoClínica Quilín, Universidad de Chile, Santiago de Chile, Chile; ORCID Iconhttp://orcid.org/0000-0003-0007-2592View further author information
ORCID Icon,
Alejandra. BelardoInstituto Universitario del Hospital Italiano, Buenos Aires, Argentina; View further author information
,
Tayane M. FigheraGynecological Endocrinology Unit, Division of Endocrinology, Hospital de Clínicas, Porto Alegre, Brazil; View further author information
&
Peter ChedrauiFacultad de Ciencias Médicas, Instituto de Investigación e Innovación en Salud Integral, Universidad Católica de Santiago de Guayaquil, Guayaquil, Ecuador; ;Facultad de Ciencias de la Salud, Universidad Católica ‘Nuestra Señora de la Asunción’, Asunción, ParaguayView further author information
 show all
Pages 421-425 | Received 05 Dec 2019, Accepted 15 Jan 2020, Published online: 29 Jan 2020

Citations (19)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Jerilynn C. Prior, Sonia Shirin & Azita Goshtasebi. (2023) Bone health and prevalent fractures in women with polycystic ovary syndrome: a meta-analysis and endocrine-context pathophysiology review. Expert Review of Endocrinology & Metabolism 18:4, pages 283-293.
Read now
Jing Liu, Zhihong Liu, Ming Lu & Yanrong Zhang. (2023) The combination of linagliptin and metformin rescues bone loss in type 2 diabetic osteoporosis. Journal of Drug Targeting 31:6, pages 646-654.
Read now
Kathrin Kahnert, Rudolf A Jörres, Tanja Lucke, Franziska C Trudzinski, Pontus Mertsch, Christiane Bickert, Joachim H Ficker, Jürgen Behr, Robert Bals, Henrik Watz, Tobias Welte, Claus F Vogelmeier & Peter Alter. (2021) Lower Prevalence of Osteoporosis in Patients with COPD Taking Anti-Inflammatory Compounds for the Treatment of Diabetes: Results from COSYCONET. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 3189-3199.
Read now

Articles from other publishers (16)

Anastasia Marchenko. (2023) Sclerostin-dependent mechanisms of osteoporosis in patients with type 2 diabetes and obesity. Ukrainian Scientific Medical Youth Journal 142:4, pages 87-93.
Crossref
Rui Lin, Bilian Xu, Zhiqiang Ye, Yin Gao, Haiping Fang, Jintong Song, Dahong Liang, Lingna Liu, Zilong Hu, Min Zhang, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui & Yanzhi Liu. (2023) Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis. Journal of Orthopaedic Translation 40, pages 37-48.
Crossref
Yining Wang, Liming Yu, Zhiqiang Ye, Rui Lin, Antonia RuJia Sun, Lingna Liu, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Li Li & Yanzhi Liu. (2023) Association of metformin use with fracture risk in type 2 diabetes: A systematic review and meta-analysis of observational studies. Frontiers in Endocrinology 13.
Crossref
Faisal E. Aljofi, Aminah Alesawy, Bader Alzaben, Marwa Alshaikh, Norah Alotaibi, Hajer A. Aldulaijan, Sami Alshehri, Eman Aljoghaiman, Yousif A. Al-Dulaijan & Mishali AlSharief. (2023) Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue. International Journal of Environmental Research and Public Health 20:2, pages 1095.
Crossref
Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou & Guohui Liu. (2022) Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1. Cell Communication and Signaling 20:1.
Crossref
JunWei Sun, Qi Liu, Huan He, Lanlan Jiang, Kok Onn Lee, Dongmei Li & Jianhua Ma. (2022) Metformin treatment is associated with an increase in bone mineral density in type 2 diabetes mellitus patients in China: A retrospective single center study. Diabetes & Metabolism 48:5, pages 101350.
Crossref
Amin Hasanvand. (2022) The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases. Inflammopharmacology 30:3, pages 775-788.
Crossref
Yanhong Song, Ziyi Wu & Ping Zhao. (2022) The Function of Metformin in Aging-Related Musculoskeletal Disorders. Frontiers in Pharmacology 13.
Crossref
Qiyun Zhou, Zhiqiang Guan, Shengfu Liu, Yanjiao Xuan, Gang Han, Hua Chen, Xiao Jin, Kun Tao & Zhiyuan Guan. (2022) The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice. Aging 14:1, pages 272-285.
Crossref
Moein Ala & Mahan Ala. (2021) Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next?. ACS Pharmacology & Translational Science 4:6, pages 1747-1770.
Crossref
Simone Antonini & Gherardo Mazziotti. (2021) Ruolo della metformina nella prevenzione dell’osteoporosi. L'Endocrinologo 22:6, pages 578-578.
Crossref
Jaana van Gastel, Hanne Leysen, Jan Boddaert, Laura vangenechten, Louis M. Luttrell, Bronwen Martin & Stuart Maudsley. (2021) Aging-related modifications to G protein-coupled receptor signaling diversity. Pharmacology & Therapeutics 223, pages 107793.
Crossref
Iacopo Chiodini, Agostino Gaudio, Andrea Palermo, Nicola Napoli, Fabio Vescini, Alberto Falchetti, Daniela Merlotti, Cristina Eller-Vainicher, Vincenzo Carnevale, Alfredo Scillitani, Giuseppe Pugliese, Domenico Rendina, Antonio Salcuni, Francesco Bertoldo, Stefano Gonnelli, Ranuccio Nuti, Vincenzo Toscano, Vincenzo Triggiani, Simone Cenci & Luigi Gennari. (2021) Management of bone fragility in type 2 diabetes: Perspective from an interdisciplinary expert panel. Nutrition, Metabolism and Cardiovascular Diseases 31:8, pages 2210-2233.
Crossref
Desye Gebrie, Desalegn Getnet & Tsegahun Manyazewal. (2021) Cardiovascular safety and efficacy of metformin-SGLT2i versus metformin-sulfonylureas in type 2 diabetes: systematic review and meta-analysis of randomized controlled trials. Scientific Reports 11:1.
Crossref
Samir Morsli & Ilaria Bellantuono. (2021) The use of geroprotectors to prevent multimorbidity: Opportunities and challenges. Mechanisms of Ageing and Development 193, pages 111391.
Crossref
Myat Aung, Saba Amin, Azouba Gulraiz, Fenil R Gandhi, Julio A Pena Escobar & Bilal Haider Malik. (2020) The Future of Metformin in the Prevention of Diabetes-Related Osteoporosis. Cureus.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.