261
Views
44
CrossRef citations to date
0
Altmetric
Original

Allopregnanolone decrease with symptom improvement during placebo and gonadotropin-releasing hormone agonist treatment in women with severe premenstrual syndrome

, , , &
Pages 257-266 | Received 16 Aug 2006, Accepted 31 Jan 2007, Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Katherine McEvoy & Lauren M. Osborne. (2019) Allopregnanolone and reproductive psychiatry: an overview. International Review of Psychiatry 31:3, pages 237-244.
Read now

Articles from other publishers (43)

Torbjörn Bäckström, Sara K. S. Bengtsson, Jessica Sjöstedt, Evgenya Malinina, Maja Johansson, Gianna Ragagnin, Karin Ekberg & Per Lundgren. (2023) Isoallopregnanolone Inhibits Estrus Cycle-Dependent Aggressive Behavior. Biomolecules 13:6, pages 1017.
Crossref
Lisa F. UmmingerPhiline RojczykJohanna Seitz-HollandNico SollmannElisabeth KaufmannPhilipp KinzelFan ZhangJanna KochsiekMina LangheinCara L. KimTim L. T. WiegandJason D. KiltsJennifer C. NaylorGerald A. GrantYogesh RathiMichael J. ColemanSylvain BouixYorghos TripodisOfer PasternakMark S. GeorgeThomas W. McAllisterRoss ZafonteMurray B. SteinLauren J. O'DonnellChristine E. MarxMartha E. ShentonInga K. Koerte. (2023) White Matter Microstructure Is Associated with Serum Neuroactive Steroids and Psychological Functioning. Journal of Neurotrauma 40:7-8, pages 649-664.
Crossref
Qian Gao, Wei Sun, Yue-Rui Wang, Zi-Fa Li, Feng Zhao, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Ying Xing, Wei Liu & Sheng Wei. (2023) Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development. Frontiers in Psychiatry 14.
Crossref
Eleonora Gatta, Diletta Camussi, James Auta, Alessandro Guidotti & Subhash C. Pandey. (2022) Neurosteroids (allopregnanolone) and alcohol use disorder: From mechanisms to potential pharmacotherapy. Pharmacology & Therapeutics 240, pages 108299.
Crossref
Torbjörn Bäckström, Roshni Das & Marie Bixo. (2021) Positive GABA A receptor modulating steroids and their antagonists: Implications for clinical treatments . Journal of Neuroendocrinology 34:2.
Crossref
Afsane Bahrami, Asghar Zarban, Hadis Rezapour, Akram Agha Amini Fashami & Gordon A. Ferns. (2021) Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial. Phytotherapy Research 35:12, pages 6954-6962.
Crossref
Torbjörn Bäckström, Karin Ekberg, Angelica Lindén Hirschberg, Marie Bixo, C. Neill Epperson, Paula Briggs, Nick Panay & Shaughn O’Brien. (2021) A randomized, double-blind study on efficacy and safety of sepranolone in premenstrual dysphoric disorder. Psychoneuroendocrinology 133, pages 105426.
Crossref
MacKenzie R. Peltier, Terril L. Verplaetse, Yann S. Mineur, Ralitza Gueorguieva, Ismene Petrakis, Kelly P. Cosgrove, Marina R. Picciotto & Sherry A. McKee. (2021) Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 187, pages 108499.
Crossref
Lindsay R. Standeven, Katherine O. McEvoy & Lauren M. Osborne. (2020) Progesterone, reproduction, and psychiatric illness. Best Practice & Research Clinical Obstetrics & Gynaecology 69, pages 108-126.
Crossref
S.K.S. Bengtsson, T. Bäckström, R. Brinton, R.W. Irwin, M. Johansson, J. Sjöstedt & M.D. Wang. (2020) GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?. Neurobiology of Stress 12, pages 100206.
Crossref
Yen, Lin, Lin, Liu, Long & Ko. (2019) Early- and Late-Luteal-Phase Estrogen and Progesterone Levels of Women with Premenstrual Dysphoric Disorder. International Journal of Environmental Research and Public Health 16:22, pages 4352.
Crossref
Magnus Löfgren, Ellinor Holmberg, Torbjörn Bäckström, Emil Egecioglu & Suzanne L. Dickson. (2019) The additive effect of allopregnanolone on ghrelin's orexigenic effect in rats. Neuropeptides 76, pages 101937.
Crossref
Marcia H. Ratner, Vidhya Kumaresan & David H. Farb. (2019) Neurosteroid Actions in Memory and Neurologic/Neuropsychiatric Disorders. Frontiers in Endocrinology 10.
Crossref
Inger Sundström Poromaa, Erika Comasco, Torbjörn Bäckström, Marie Bixo, Peter Jensen & Vibe G. Frokjaer. (2019) Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age. Frontiers in Psychology 9.
Crossref
M. Bixo, M. Johansson, E. Timby, L. Michalski & T. Bäckström. (2018) Effects of GABA active steroids in the female brain with a focus on the premenstrual dysphoric disorder. Journal of Neuroendocrinology 30:2, pages e12553.
Crossref
E. Holmberg, J. Sjöstedt, E. Malinina, M. Johansson, S. Turkmen, G. Ragagnin, A. Lundqvist, M. Löfgren, L. Jaukkuri, M. Bixo & T. Bäckström. (2018) Allopregnanolone involvement in feeding regulation, overeating and obesity. Frontiers in Neuroendocrinology 48, pages 70-77.
Crossref
Marie Bixo, Karin Ekberg, Inger Sundström Poromaa, Angelica Lindén Hirschberg, Aino Fianu Jonasson, Lotta Andréen, Erika Timby, Marianne Wulff, Agneta Ehrenborg & Torbjörn Bäckström. (2017) Treatment of premenstrual dysphoric disorder with the GABA A receptor modulating steroid antagonist Sepranolone (UC1010)—A randomized controlled trial. Psychoneuroendocrinology 80, pages 46-55.
Crossref
Sahruh Turkmen, Marie Bixo, Helena Hedström, Ida Gideonsson, Sigrid Nyberg, Mingde Wang & Torbjörn Bäckström. (2016) The author's reply: Blood allopregnanolone levels in women with polycystic ovary syndrome. Clinical Endocrinology 85:1, pages 152-154.
Crossref
Anna Tiihonen Möller, Torbjörn Bäckström, Sigrid Nyberg, Hans Peter Söndergaard & Lotti Helström. (2014) Women with PTSD have a changed sensitivity to GABA-A receptor active substances. Psychopharmacology 233:11, pages 2025-2033.
Crossref
Torbjörn Bäckström, Marie Bixo & Jessica Strömberg. (2015) GABAA Receptor-Modulating Steroids in Relation to Women’s Behavioral Health. Current Psychiatry Reports 17:11.
Crossref
Sara K.S. Bengtsson, Sigrid Nyberg, Helena Hedström, Elisabeth Zingmark, Björn Jonsson, Torbjörn Bäckström & Marie Bixo. (2015) Isoallopregnanolone antagonize allopregnanolone-induced effects on saccadic eye velocity and self-reported sedation in humans. Psychoneuroendocrinology 52, pages 22-31.
Crossref
Timo De Bondt, Frank De Belder, Floris Vanhevel, Yves Jacquemyn & Paul M. Parizel. (2015) Prefrontal GABA concentration changes in women—Influence of menstrual cycle phase, hormonal contraceptive use, and correlation with premenstrual symptoms. Brain Research 1597, pages 129-138.
Crossref
Ellinor Holmberg, Maja Johansson, Torbjörn Bäckström & David Haage. (2014) Allopregnanolone preferentially induces energy-rich food intake in male Wistar rats. Physiological Reports 2:12, pages e12190.
Crossref
T. Bäckström, M. Bixo, M. Johansson, S. Nyberg, L. Ossewaarde, G. Ragagnin, I. Savic, J. Strömberg, E. Timby, F. van Broekhoven & G. van Wingen. (2014) Allopregnanolone and mood disorders. Progress in Neurobiology 113, pages 88-94.
Crossref
Charlotte Hellgren, Helena Åkerud, Alkistis Skalkidou, Torbjörn Bäckström & Inger Sundström-Poromaa. (2014) Low Serum Allopregnanolone Is Associated with Symptoms of Depression in Late Pregnancy. Neuropsychobiology 69:3, pages 147-153.
Crossref
Michael A. Rogawski, Carlos M. Loya, Kiran Reddy, Dorota Zolkowska & Christoph Lossin. (2013) Neuroactive steroids for the treatment of status epilepticus. Epilepsia 54, pages 93-98.
Crossref
E. Holmberg, T. Bäckström, M. Johansson, M. Löfgren & D. Haage. (2013) Allopregnanolone induces a diurnally dependent hyperphagic effect and alters feeding latency and duration in male Wistar rats. Acta Physiologica 208:4, pages 400-409.
Crossref
Torbjörn Bäckström, Marie Bixo, Sigrid Nyberg & Ivanka Savic. (2013) Increased neurosteroid sensitivity – An explanation to symptoms associated with chronic work related stress in women?. Psychoneuroendocrinology 38:7, pages 1078-1089.
Crossref
Sigrid Nyberg. (2013) Mood and physical symptoms improve in women with severe cyclical changes by taking an oral contraceptive containing 250-mcg norgestimate and 35-mcg ethinyl estradiol. Contraception 87:6, pages 773-781.
Crossref
EVA INNALA, TORBJÖRN BÄCKSTRÖM, INGER SUNDSTRÖM POROMAA, CHRISTER ANDERSSON & MARIE BIXO. (2012) Women with acute intermittent porphyria have a defect in 5α‐steroid production during the menstrual cycle. Acta Obstetricia et Gynecologica Scandinavica 91:12, pages 1445-1452.
Crossref
Olive Ford, Anne Lethaby, Helen Roberts & Ben Willem J Mol. (2012) Progesterone for premenstrual syndrome. Cochrane Database of Systematic Reviews.
Crossref
Sigrid Nyberg. (2011) How to determine symptom severity in premenstrual syndrome: A combination of daily symptom ratings and interviews. Sexual & Reproductive Healthcare 2:4, pages 161-168.
Crossref
Sahruh Turkmen, Torbjorn Backstrom, Goran Wahlstrom, Lotta Andreen & Inga‐Maj Johansson. (2010) Tolerance to allopregnanolone with focus on the GABA‐A receptor. British Journal of Pharmacology 162:2, pages 311-327.
Crossref
S. Lazzer, C. Lafortuna, C. Busti, R. Galli, F. Agosti & A. Sartorio. (2014) Effects of low- and high-intensity exercise training on body composition and substrate metabolism in obese adolescents. Journal of Endocrinological Investigation 34:1, pages 45-52.
Crossref
B. Predieri, S. Luisi, E. Casarosa, E. Farinelli, F. Antoniazzi, M. Wasniewska, S. Bernasconi, F. Petraglia & L. Iughetti. (2014) Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty. Journal of Endocrinological Investigation 34:1, pages 38-44.
Crossref
Simone N. Vigod, Benicio N. Frey, Claudio N. Soares & Meir Steiner. (2010) Approach to Premenstrual Dysphoria for the Mental Health Practitioner. Psychiatric Clinics of North America 33:2, pages 257-272.
Crossref
Simone N. Vigod, Lori E. Ross & Meir Steiner. (2009) Understanding and Treating Premenstrual Dysphoric Disorder: An Update for the Women's Health Practitioner. Obstetrics and Gynecology Clinics of North America 36:4, pages 907-924.
Crossref
Lotta Andréen, Sigrid Nyberg, Sharuh Turkmen, Guido van Wingen, Guillen Fernández & Torbjörn Bäckström. (2009) Sex steroid induced negative mood may be explained by the paradoxical effect mediated by GABAA modulators. Psychoneuroendocrinology 34:8, pages 1121-1132.
Crossref
Clarisa R. Gracia, Ellen W. Freeman, Mary D. Sammel, Hui Lin, Li Sheng & Cheryl Frye. (2009) Allopregnanolone Levels Before and After Selective Serotonin Reuptake Inhibitor Treatment of Premenstrual Symptoms. Journal of Clinical Psychopharmacology 29:4, pages 403-405.
Crossref
Olive Ford, Anne Lethaby, Helen Roberts & Ben Willem J Mol. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Helena Hedström, Marie Bixo, Sigrid Nyberg, Olav Spigset, Elisabeth Zingmark & Torbjörn Bäckström. (2008) Studies of pharmacokinetic and pharmacodynamic properties of isoallopregnanolone in healthy women. Psychopharmacology 203:1, pages 85-98.
Crossref
Rimma RosenfeldDana LivneOri NevoLior DayanVictor MilloulShahar LaviGiris Jacob. (2008) Hormonal and Volume Dysregulation in Women With Premenstrual Syndrome. Hypertension 51:4, pages 1225-1230.
Crossref
Akiko Dohi, Glenn H. Dillon & Meharvan Singh. 2008. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders. Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders 483 491 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.