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Original Article

Assessment of the antiplatelet effects of low to medium dose aspirin in the early and late phases after ischaemic stroke and TIA

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Pages 269-280 | Received 19 Oct 2004, Accepted 29 Oct 2004, Published online: 07 Jul 2009

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Read on this site (4)

Soon Tjin Lim, Catherine A. Coughlan, Stephen J. X. Murphy, Israel Fernandez-Cadenas, Joan Montaner, Vincent Thijs, Lars Marquardt & Dominick J. H. McCabe. (2015) Platelet function testing in transient ischaemic attack and ischaemic stroke: A comprehensive systematic review of the literature. Platelets 26:5, pages 402-412.
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Matthew D. Linden & Huyen A. Tran. (2012) Overcoming aspirin treatment failure in diabetes. Critical Reviews in Clinical Laboratory Sciences 49:5-6, pages 183-198.
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Mehmet Akif Topçuoglu, Ethem Murat Arsava & Hakan Ay. (2011) Antiplatelet resistance in stroke. Expert Review of Neurotherapeutics 11:2, pages 251-263.
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Paul Harrison, Helen Segal, Louise Silver, Anila Syed, Fiona C. Cuthbertson & Peter M. Rothwell. (2008) Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests. Platelets 19:2, pages 119-124.
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Articles from other publishers (49)

S.T. Lim, S.J.X. Murphy, S.M. Murphy, T. Coughlan, D. O'Neill, S. Tierney, B. Egan, D.R. Collins, A.J. McCarthy, S.-Y. Lim, D.R. Smith, D. Cox & D.J.H. McCabe. (2022) Assessment of on-treatment platelet reactivity at high and low shear stress and platelet activation status after the addition of dipyridamole to aspirin in the early and late phases after TIA and ischaemic stroke. Journal of the Neurological Sciences 441, pages 120334.
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Arun Subramanian, Siobhan Delaney, Stephen J.X. Murphy, Deirdre R. Smith, Chika Offiah, Jean McMahon, Gert J. de Borst, A. Ross Naylor, George Hamilton, Justin A. Kinsella & Dominick J.H. McCabe. (2022) Platelet Biomarkers in Patients with Atherosclerotic Extracranial Carotid Artery Stenosis: A Systematic Review. European Journal of Vascular and Endovascular Surgery 63:3, pages 379-389.
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Stephen J Murphy, Soon T Lim, Justin A Kinsella, Sean Tierney, Bridget Egan, Tim M Feeley, Clare Dooley, James Kelly, Sinead M Murphy, Richard A Walsh, Ronan Collins, Tara Coughlan, Desmond O’Neill, Joseph A Harbison, Prakash Madhavan, Sean M O’Neill, Mary P Colgan, Jim F Meaney, George Hamilton & Dominick JH McCabe. (2019) Simultaneous assessment of plaque morphology, cerebral micro-embolic signal status and platelet biomarkers in patients with recently symptomatic and asymptomatic carotid stenosis. Journal of Cerebral Blood Flow & Metabolism 40:11, pages 2201-2214.
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Soon Tjin Lim, Vincent Thijs, Stephen J. X. Murphy, Israel Fernandez-Cadenas, Joan Montaner, Chika Offiah, Lars Marquardt, Peter J. Kelly, Philip M. Bath, Su-Yin Lim, Gary A. Ford, Bo Norrving, Dermot Cox, Calin I. Prodan, Philip A. Barber, David J. Werring, Richard Perry, Lina Zgaga, Jesse Dawson & Dominick J. H. McCabe. (2020) Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis. Journal of Neurology 267:10, pages 3021-3037.
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Vafa Alakbarzade, Xuya Huang, Irina Chis Ster, Meriel McEntagart & Anthony C. Pereira. (2020) High on-clopidogrel platelet reactivity in ischaemic stroke or transient ischaemic attack: Systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Diseases 29:7, pages 104877.
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A.R. Naylor & D.J.H. McCabe. (2020) New Data and the Covid-19 Pandemic Mandate a Rethink of Antiplatelet Strategies in Patients With TIA or Minor Stroke Associated With Atherosclerotic Carotid Stenosis. European Journal of Vascular and Endovascular Surgery 59:6, pages 861-865.
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Adam Wiśniewski, Joanna Sikora, Agata Sławińska, Karolina Filipska, Aleksandra Karczmarska-Wódzka, Zbigniew Serafin & Grzegorz Kozera. (2020) High On-Treatment Platelet Reactivity Affects the Extent of Ischemic Lesions in Stroke Patients Due to Large-Vessel Disease. Journal of Clinical Medicine 9:1, pages 251.
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S. J. X. Murphy, S. T. Lim, J. A. Kinsella, S. Tierney, B. Egan, T. M. Feeley, S. M. Murphy, R. A. Walsh, D. R. Collins, T. Coughlan, D. O’Neill, J. A. Harbison, P. Madhavan, S. M. O’Neill, M. P. Colgan, D. Cox, N. Moran, G. Hamilton, J. F. Meaney & D. J. H. McCabe. (2019) Relationship between ‘on-treatment platelet reactivity’, shear stress, and micro-embolic signals in asymptomatic and symptomatic carotid stenosis. Journal of Neurology 267:1, pages 168-184.
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Xiaolan Zheng, Wenchao Wu, Yi Zhang & Gang Wu. (2019) Changes in and significance of platelet function and parameters in Kawasaki disease. Scientific Reports 9:1.
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Kevin P. Bliden, Gabe Raviv, Udaya S. Tantry, Rahul Chaudhary, John W. Cochran, Eliano P. Navarese, Tricia Brannan, Ankit Vyas & Paul A. Gurbel. (2019) “Blueprinting” thrombogenicity and antithrombotic drug response at the bedside in patients presenting emergently with symptoms of acute stroke. Journal of Thrombosis and Thrombolysis 47:2, pages 192-199.
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Kate Navaratnam, Zarko Alfirevic, Munir Pirmohamed & Ana Alfirevic. (2017) How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. European Journal of Obstetrics & Gynecology and Reproductive Biology 219, pages 1-9.
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Xuan Cheng, Nan-Chang Xie, Hong-Liang Xu, Chen Chen & Ya-Jun Lian. (2017) Biochemical aspirin resistance is associated with increased stroke severity and infarct volumes in ischemic stroke patients. Oncotarget 8:44, pages 77086-77095.
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Justin A Kinsella, W Oliver Tobin, Sean Tierney, Timothy M Feeley, Bridget Egan, Tara Coughlan, D Ronan Collins, Desmond O'Neill, Joseph A Harbison, Colin P Doherty, Prakash Madhavan, Dermot J Moore, Sean M O'Neill, Mary-Paula Colgan, Maher Saqqur, Raymond P Murphy, Niamh Moran, George Hamilton & Dominick J H McCabe. (2017) Assessment of ‘on-treatment platelet reactivity’ and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis. Journal of the Neurological Sciences 376, pages 133-139.
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Claire Pearson, Karin Przyklenk, Valerie H. Mika, Syed Imran Ayaz, Morgan Ellis, Preet Varade, Rosa Tolomello & Robert D. Welch. (2017) Utility of point of care assessment of platelet reactivity (using the PFA-100®) to aid in diagnosis of stroke. The American Journal of Emergency Medicine 35:5, pages 802.e1-802.e5.
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WO Tobin, JA Kinsella, GF Kavanagh, JS O'Donnell, RT McGrath, S Tierney, B Egan, TM Feeley, T Coughlan, DR Collins, D O'Neill, SJX Murphy, SJ Lim, RP Murphy & DJH McCabe. (2017) Profile of von Willebrand factor antigen and von Willebrand factor propeptide in an overall TIA and ischaemic stroke population and amongst subtypes. Journal of the Neurological Sciences 375, pages 404-410.
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J.-S. Doly, E. Lorian, I. Desormais, J. Constans, A. Bura Rivière & P. Lacroix. (2016) Prévalence et valeur pronostique de la résistance à l’aspirine chez les patients en ischémie critique chronique des membres inférieurs. Journal des Maladies Vasculaires 41:6, pages 358-364.
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Joon-Tae KimSuk-Hee HeoKang-Ho ChoiTai-Seung NamSeong-Min ChoiSeung-Han LeeMan-Seok ParkByeong C. KimMyeong-Kyu KimJeffrey L. SaverKi-Hyun Cho. (2015) Clinical Implications of Changes in Individual Platelet Reactivity to Aspirin Over Time in Acute Ischemic Stroke. Stroke 46:9, pages 2534-2540.
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Janine Dretzke, Richard D Riley, Marie Lordkipanidzé, Susan Jowett, Jennifer O’Donnell, Joie Ensor, Eoin Moloney, Malcolm Price, Smriti Raichand, James Hodgkinson, Susan Bayliss, David Fitzmaurice & David Moore. (2015) The prognostic utility of tests of platelet function for the detection of ‘aspirin resistance’ in patients with established cardiovascular or cerebrovascular disease: a systematic review and economic evaluation. Health Technology Assessment 19:37, pages 1-366.
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Joon-Tae Kim, Suk-Hee Heo, Ji Sung Lee, Min-Ji Choi, Kang-Ho Choi, Tai-Seung Nam, Seung-Han Lee, Man-Seok Park, Byeong C. Kim, Myeong-Kyu Kim & Ki-Hyun Cho. (2015) Aspirin Resistance in the Acute Stages of Acute Ischemic Stroke Is Associated with the Development of New Ischemic Lesions. PLOS ONE 10:4, pages e0120743.
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Azza A. Eltayeb, Gamal A. Askar, Naglaa H. Abu Faddan & Taghreed M. Kamal. (2015) Prothrombotic risk factors and antithrombotic therapy in children with ischemic stroke. Therapeutic Advances in Neurological Disorders 8:2, pages 71-81.
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Dominick J.H. McCabe, Stephen J.X. Murphy, Richard Starke, Paul Harrison, Martin M. Brown, Paul S. Sidhu, Ian J. Mackie, Marie Scully & Samuel J. Machin. (2015) Relationship between ADAMTS13 activity, von Willebrand factor antigen levels and platelet function in the early and late phases after TIA or ischaemic stroke. Journal of the Neurological Sciences 348:1-2, pages 35-40.
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J. A. Kinsella, W. O. Tobin, G. F. Kavanagh, J. S. O'Donnell, R. T. McGrath, S. Tierney, T. M. Feeley, B. Egan, D. O'Neill, R. D. Collins, T. Coughlan, J. A. Harbison, C. P. Doherty, P. Madhavan, D. J. Moore, S. M. O'Neill, M.-P. Colgan, M. Saqqur, R. P. Murphy, N. Moran, G. Hamilton & D. J. H. McCabe. (2014) Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups. European Journal of Neurology 21:7, pages 969-e55.
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W. O. Tobin, J. A. Kinsella, G. F. Kavanagh, J. S. O’Donnell, R. T. McGrath, T. Coughlan, D. R. Collins, D. O’Neill, B. Egan, S. Tierney, T. M. Feeley, R. P. Murphy & D. J. H. McCabe. (2014) Longitudinal assessment of von Willebrand factor antigen and von Willebrand factor propeptide in response to alteration of antiplatelet therapy after TIA or ischaemic stroke. Journal of Neurology 261:7, pages 1405-1412.
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Matthew D. Linden. (2013) Using Platelet Function Testing to Guide Antiplatelet Therapy. Drug Development Research 74:8, pages 517-525.
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Nalyaka Sambu, Ashwin Radhakrishnan, Nicola Englyst, Nicolas Weir & Nick Curzen. (2013) “Aspirin Resistance” in Ischemic Stroke: Insights Using Short Thrombelastography. Journal of Stroke and Cerebrovascular Diseases 22:8, pages 1412-1419.
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Justin A. Kinsella, W. Oliver Tobin, Dermot Cox, Tara Coughlan, Ronan Collins, Desmond O’Neill, Raymond P. Murphy & Dominick J.H. McCabe. (2013) Prevalence of Ex Vivo High On-treatment Platelet Reactivity on Antiplatelet Therapy after Transient Ischemic Attack or Ischemic Stroke on the PFA-100® and VerifyNow®. Journal of Stroke and Cerebrovascular Diseases 22:7, pages e84-e92.
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J. A. Kinsella, W. O. Tobin, G. Hamilton & D. J. H. McCabe. (2012) Platelet Activation, Function, and Reactivity in Atherosclerotic Carotid Artery Stenosis: A Systematic Review of the Literature. International Journal of Stroke 8:6, pages 451-464.
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Pornpatr A. Dharmasaroja, Sombat Muengtaweepongsa & Suvaraporn Sae-Lim. (2013) Aspirin nonresponders in patients with ischaemic stroke. Blood Coagulation & Fibrinolysis 24:4, pages 361-364.
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W. O. Tobin, J. A. Kinsella, T. Coughlan, D. R. Collins, D. O'Neill, R. P. Murphy, B. Egan, S. Tierney, T. M. Feeley & D. J. H. McCabe. (2012) High on‐treatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the T rinity Antiplatelet Responsiveness ( TRAP ) study . European Journal of Neurology 20:2, pages 344-352.
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W. O. Tobin, J. A. Kinsella, G. F. Kavanagh, J. S. O’Donnell, R. A. McGrath, D. R. Collins, T. Coughlan, D. O’Neill, B. Egan, S. Tierney, T. M. Feeley, R. P. Murphy & Dominick J. H. McCabe. (2012) Longitudinal assessment of thrombin generation potential in response to alteration of antiplatelet therapy after TIA or ischaemic stroke. Journal of Neurology 260:2, pages 590-596.
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Robert C. Block, Lisa Kakinami, Matthew Jonovich, Illena Antonetti, Peter Lawrence, Nida Meednu, Pedro CalderonArtero, Shaker A. Mousa, J. Thomas Brenna & Steve Georas. (2012) The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. Prostaglandins, Leukotrienes and Essential Fatty Acids 87:4-5, pages 143-151.
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Ping-Tsun Lai, Shu-Yi Chen, Yu-Sun Lee, Yu-Ping Ho, Yi-Ying Chiang & Hung-Yi Hsu. (2012) Relationship between acute stroke outcome, aspirin resistance, and humoral factors. Journal of the Chinese Medical Association 75:10, pages 513-518.
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Saskia H. Meves, Ursula Overbeck, Heinz G. Endres, Christos Krogias & Horst Neubauer. (2017) Dose-dependent effect of early antiplatelet therapy in acute ischaemic stroke. Thrombosis and Haemostasis 107:01, pages 69-79.
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Serkan Ozben, Beste Ozben, Azra Meryem Tanrikulu, Feriha Ozer & Tomris Ozben. (2011) Aspirin resistance in patients with acute ischemic stroke. Journal of Neurology 258:11, pages 1979-1986.
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