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Platelets Volume 15, 2004 - Issue 7
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Original Article

Pharmacodynamic enhancement of the anti-platelet antibody Fab abciximab by site-specific pegylation

David M. Knight Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
,
Robert E. Jordan Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
,
Marian Kruszynski Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
,
Susan H. Tam Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
,
Jill Giles-Komar Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
,
George Treacy Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USA
&
George A. Heavner Pharmaceutical Research, Centocor, Inc., 200 Great Valley Parkway, Malvern, PA 19355, USACorrespondence[email protected]
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Pages 409-418 | Published online: 07 Jul 2009

Citations (18)

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Germaine Fuh. (2007) Synthetic antibodies as therapeutics. Expert Opinion on Biological Therapy 7:1, pages 73-87.
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Articles from other publishers (17)

Moeka Yoshikawa, Hitomi Nakamura, Naoko Oda-Ueda & Takatoshi Ohkuri. (2023) Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. The Journal of Biochemistry.
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Jong Shin, Paul J. Phelan, Ole Gjoerup, William Bachovchin & Peter A. Bullock. (2021) Characterization of a single chain variable fragment of nivolumab that targets PD-1 and blocks PD-L1 binding. Protein Expression and Purification 177, pages 105766.
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Hitomi Nakamura, Makoto Anraku, Naoko Oda-Ueda, Tadashi Ueda & Takatoshi Ohkuri. (2020) C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond. Biological and Pharmaceutical Bulletin 43:3, pages 418-423.
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Hitomi Nakamura, Naoko Oda-Ueda, Tadashi Ueda & Takatoshi Ohkuri. (2018) A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. Biochemical and Biophysical Research Communications 495:1, pages 7-11.
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Maria Vamvakaki. 2014. Chemistry of Bioconjugates. Chemistry of Bioconjugates 203 238 .
Yasuto AKIYAMA, Haruo MIYATA, Masaru KOMIYAMA, Masahiro NOGAMI, Kazumichi OZAWA, Chie OSHITA, Akiko KUME, Tadashi ASHIZAWA, Naoki SAKURA, Tohru MOCHIZUKI & Ken YAMAGUCHI. (2014) The identification of affinity peptide ligands specific to the variable region ofhuman antibodies. Biomedical Research 35:2, pages 105-116.
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Salome-Juliette Koussoroplis, Sam Heywood, Catherine Uyttenhove, Céline Barilly, Jacques Van Snick & Rita Vanbever. (2013) Production, purification and biological characterization of mono-PEGylated anti-IL-17A antibody fragments. International Journal of Pharmaceutics 454:1, pages 107-115.
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Annabelle Patricia Herrington-Symes, Monika Farys, Hanieh Khalili & Steve Brocchini. (2013) Antibody fragments: Prolonging circulation half-life special issue-antibody research. Advances in Bioscience and Biotechnology 04:05, pages 689-698.
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R. Blake Pepinsky, Lee Walus, Zhaohui Shao, Benxiu Ji, Sheng Gu, Yaping Sun, Dingyi Wen, Xinhua Lee, Qin Wang, Ellen Garber & Sha Mi. (2011) Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination. Bioconjugate Chemistry 22:2, pages 200-210.
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Sam P. Heywood & David P. Humphreys. 2009. Recombinant Antibodies for Immunotherapy. Recombinant Antibodies for Immunotherapy 275 292 .
Aran F Labrijn, Rob C Aalberse & Janine Schuurman. (2008) When binding is enough: nonactivating antibody formats. Current Opinion in Immunology 20:4, pages 479-485.
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David Filpula. (2007) Antibody engineering and modification technologies. Biomolecular Engineering 24:2, pages 201-215.
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David P. Humphreys, Sam P. Heywood, Alistair Henry, Layla Ait-Lhadj, Pari Antoniw, Roger Palframan, Kevin J. Greenslade, Bruce Carrington, Dominc G. Reeks, Leigh C. Bowering, Shauna West & Helen A. Brand. (2007) Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering. Protein Engineering, Design and Selection 20:5, pages 227-234.
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Hisashi Koga, Motoki Kyo, Kazue Usui-Aoki & Kazuki Inamori. (2006) A chip-based miniaturized format for protein-expression profiling: The exploitation of comprehensively produced antibodies. ELECTROPHORESIS 27:18, pages 3676-3683.
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Robert Mabry, Mridula Rani, Robert Geiger, Gene B. Hubbard, Ricardo CarrionJrJr, Kathleen Brasky, Jean L. Patterson, George Georgiou & B. L. Iverson. (2005) Passive Protection against Anthrax by Using a High-Affinity Antitoxin Antibody Fragment Lacking an Fc Region. Infection and Immunity 73:12, pages 8362-8368.
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Rebecca L. Rich & David G. Myszka. (2005) Survey of the year 2004 commercial optical biosensor literature. Journal of Molecular Recognition 18:6, pages 431-478.
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Philipp Holliger & Peter J Hudson. (2005) Engineered antibody fragments and the rise of single domains. Nature Biotechnology 23:9, pages 1126-1136.
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