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Platelets Volume 17, 2006 - Issue 3
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Original Article

Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA1/2 polymorphism

Roger Kranzhofer Division of Cardiology, University of Heidelberg, Heidelberg, Germany
&
Johannes Ruef MD Red Cross Cardiology Center, Frankfurt, GermanyCorrespondence[email protected]
Pages 163-169 | Received 01 Sep 2005, Accepted 27 Oct 2005, Published online: 07 Jul 2009

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Cormac T O’connor, Thomas J Kiernan & Bryan P Yan. (2017) The genetic basis of antiplatelet and anticoagulant therapy: A pharmacogenetic review of newer antiplatelets (clopidogrel, prasugrel and ticagrelor) and anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban). Expert Opinion on Drug Metabolism & Toxicology 13:7, pages 725-739.
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Articles from other publishers (27)

Nick M. A. Schubert, Marcel van Tuinen & Sonja J. Pyott. (2022) Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss. Biomolecules 12:4, pages 498.
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Dr. Matthieu Perier, Dr. Gabriel Seret, Dr. Florent Huang, Dr. Jean- Guillaume Dillinger, Pr. Patrick Henry, Pr. Ludovic Drouet & Dr. Hakim Benamer. (2021) Résistance à l'aspirine : l'ennemi de mon ami est mon ennemi. Annales de Cardiologie et d'Angéiologie 70:6, pages 401-409.
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Cristina Barale, Franco Cavalot, Chiara Frascaroli, Katia Bonomo, Alessandro Morotti, Angelo Guerrasio & Isabella Russo. (2020) Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia. International Journal of Molecular Sciences 21:14, pages 4983.
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Juan Guo, Jue Wang, Yanxia Guo & Juan Feng. (2020) Association of aspirin resistance with 4‐hydroxynonenal and its impact on recurrent cerebral infarction in patients with acute cerebral infarction. Brain and Behavior.
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Juan Guo, Jue Wang & Juan Feng. (2019) Aspirin resistance mediated by oxidative stress‐induced 8‐Isoprostaglandin F2. Journal of Clinical Pharmacy and Therapeutics 44:5, pages 823-828.
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Jing Wang, Jie Liu, Yaqing Zhou, Fei Wang, Ke Xu, Deyu Kong, Jianling Bai, Jun Chen, Xiaoxuan Gong, Haoyu Meng & Chunjian Li. (2019) Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis. Scientific Reports 9:1.
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Mei Xue, Xuesong Yang, Lin Yang, Na Kou, Yu Miao, Mingming Wang, Junhua Ren & Quanli Zhao. (2017) rs5911 and rs3842788 Genetic Polymorphism, Blood Stasis Syndrome, and Plasma TXB2 and hs-CRP Levels Are Associated with Aspirin Resistance in Chinese Chronic Stable Angina Patients. Evidence-Based Complementary and Alternative Medicine 2017, pages 1-8.
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Francesca Santilli, Damiano D'Ardes & Giovanni Davì. (2015) Oxidative stress in chronic vascular disease: From prediction to prevention. Vascular Pharmacology 74, pages 23-37.
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Adrian Doroszko, Ewa Szahidewicz-Krupska, Agnieszka Janus, Maciej Jakubowski, Aleksandra Turek, Paulina Ilnicka, Andrzej Szuba, Grzegorz Mazur & Arkadiusz Derkacz. (2015) Endothelial dysfunction in young healthy men is associated with aspirin resistance. Vascular Pharmacology 67-69, pages 30-37.
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Francesca Santilli, Domenico Lapenna, Sara La Barba & Giovanni Dav?. (2015) Oxidative stress-related mechanisms affecting response to aspirin in diabetes mellitus. Free Radical Biology and Medicine 80, pages 101-110.
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Christopher N. Floyd & Albert Ferro. (2014) The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis. British Journal of Clinical Pharmacology 77:3, pages 446-457.
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Zhiyuan Weng, Xiaobo Li, Yuqiong Li, Jinxiu Lin, Feng Peng & Wenquan Niu. (2013) The Association of Four Common Polymorphisms from Four Candidate Genes (COX-1, COX-2, ITGA2B, ITGA2) with Aspirin Insensitivity: A Meta-Analysis. PLoS ONE 8:11, pages e78093.
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Sayer I. Al-Azzam, Karem H. Alzoubi, Omar F. Khabour, Deniz Tawalbeh & Ola Al-Azzeh. (2013) The contribution of platelet glycoproteins (GPIa C807T and GPIba C-5T) and cyclooxygenase 2 (COX-2G-765C) polymorphisms to platelet response in patients treated with aspirin. Gene 526:2, pages 118-121.
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Tobias Geisler, Elke Schaeffeler, Elke Schaeffeler, Meinrad Gawaz & Matthias Schwab. (2017) Genetic variation of platelet function and pharmacology: An update of current knowledge. Thrombosis and Haemostasis 110:11, pages 876-887.
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Marie Lordkipanidz?Jean G. Diodati, Donald A. Palisaitis, Erick Schampaert, Jacques Turgeon & Chantal Pharand. (2011) Genetic determinants of response to aspirin: Appraisal of 4 candidate genes. Thrombosis Research 128:1, pages 47-53.
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Marie Lordkipanidzé, Chantal Pharand, Erick Schampaert, Donald A. Palisaitis & Jean G. Diodati. (2011) Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease. International Journal of Cardiology 150:1, pages 39-44.
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E. SCHWEDHELM, A. BIEREND, R. MAAS, R. TRINKS, G.D. KOM, D. TSIKAS & R.H. BÖGER. (2010) Redox‐generated isoprostanes are associated with residual platelet activity in aspirin‐treated patients with stable coronary heart disease. Journal of Thrombosis and Haemostasis 8:12, pages 2662-2670.
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Marie Lordkipanidzé, Jean G. Diodati, Jacques Turgeon, Erick Schampaert, Donald A. Palisaitis & Chantal Pharand. (2010) Platelet count, not oxidative stress, may contribute to inadequate platelet inhibition by aspirin. International Journal of Cardiology 143:1, pages 43-50.
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Srikanth Nagalla, Suzanne M. Leal & Paul F. Bray. 2009. New Therapeutic Agents in Thrombosis and Thrombolysis. New Therapeutic Agents in Thrombosis and Thrombolysis 49 66 .
S. Richard, M. Toussaint-Hacquard & T. Lecompte. (2009) Variabilité de réponse plaquettaire à l’aspirine et nouvelles cibles thérapeutiques. Journal des Maladies Vasculaires 34:1, pages 16-25.
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G Feher, A Feher, G Pusch, G Lupkovics, L Szapary & E Papp. (2009) The genetics of antiplatelet drug resistance. Clinical Genetics 75:1, pages 1-18.
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Timothy Goodman, Albert Ferro & Pankaj Sharma. (2008) Pharmacogenetics of aspirin resistance: a comprehensive systematic review. British Journal of Clinical Pharmacology 66:2, pages 222-232.
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Nicola A Englyst, Gill Horsfield, Joseph Kwan & Christopher D Byrne. (2008) Aspirin Resistance is More Common in Lacunar Strokes than Embolic Strokes and is Related to Stroke Severity. Journal of Cerebral Blood Flow & Metabolism 28:6, pages 1196-1203.
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S. Achterberg, L.J. Kappelle & A. Algra. (2008) Prognostic Modelling in Ischaemic Stroke Study, Additional Value of Genetic Characteristics. European Neurology 59:5, pages 243-252.
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Shinichi Takahashi, Miho Ushida, Risa Komine, Aya Shimodaira, Toshihiro Uchida, Hiroaki Ishihara, Toshiro Shibano, Gentaro Watanabe, Yasuo Ikeda & Mitsuru Murata. (2008) Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms. Thrombosis Research 121:4, pages 509-517.
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JOHANNES RUEF & ROGER KRANZHÖFER. (2006) Coronary Stent Thrombosis Related to Aspirin Resistance: What are the Underlying Mechanisms?. Journal of Interventional Cardiology 19:6, pages 507-509.
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Kaname NAKATANI. (2006) Personalized medicine for anticoagulation therapy. Japanese Journal of Thrombosis and Hemostasis 17:6, pages 706-710.
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