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Original Article

Inhibition of human blood platelet aggregation and the stimulation of nitric oxide synthesis by aspirin

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Pages 421-427 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Gennadi Kobzar, Vilja Mardla & Nigulas Samel. (2014) Lactate is a possible mediator of the glucose effect on platelet inhibition. Platelets 25:4, pages 239-245.
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Gennadi Kobzar, Vilja Mardla & Nigulas Samel. (2011) Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors. Platelets 22:5, pages 338-344.
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G. V. Girish, Nehi Sinha, K. Chakraborty, G. Bhattacharya, Nighat N. Kahn & A. K. Sinha. (2006) Restoration by aspirin of impaired plasma maspin level in human breast cancer. Acta Oncologica 45:2, pages 184-187.
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Articles from other publishers (37)

Sergio Pandolfi, Salvatore Chirumbolo, Giovanni Ricevuti, Luigi Valdenassi, Geir Bjørklund, Roman Lysiuk, Monica Daniela Doşa, Larysa Lenchyk & Serafino Fazio. (2021) Home pharmacological therapy in early COVID‐19 to prevent hospitalization and reduce mortality: Time for a suitable proposal. Basic & Clinical Pharmacology & Toxicology 130:2, pages 225-239.
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Joana Campos & Alexander Brill. (2020) The role of bone marrow-derived cells in venous thromboembolism. The International Journal of Biochemistry & Cell Biology 128, pages 105850.
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Ben Driver, Denese C. Marks & Dianne E. van der Wal. (2020) Not all (N)SAID and done: Effects of nonsteroidal anti‐inflammatory drugs and paracetamol intake on platelets. Research and Practice in Thrombosis and Haemostasis 4:1, pages 36-45.
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Udayan Ray, Sarbashri Bank, Madawa W. Jayawardana, Jahar Bhowmik, Frank Redwig, Pradipta Jana, Suman BhattacharyaEmili Manna, Subrata Kumar De, Smarajit Maiti, Philip Roberts-Thomson, Venkat Parameswaran & Asru K. Sinha. (2019) Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease. Bioscience Reports 39:7.
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Nicholas K. Cheung, Michael W. Carr, Udayan Ray, Duncan McKenzie & Jens J. Froelich. (2019) Platelet Function Testing in Neurovascular Procedures: Tool or Gimmick?. Interventional Neurology 8:2-6, pages 123-134.
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Uttam Kumar Maji, Pradipta Jana, Mitali Chatterjee, Sanmay Karmakar, Arup Saha & Tamal Kanti Ghosh. (2018) Role of Acetyl Salicylic Acid in Controlling the DOCA-Salt Induced Hypertension in Rats by Stimulating the Synthesis of r-Cortexin in the Kidney. High Blood Pressure & Cardiovascular Prevention 25:1, pages 79-88.
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Xiao-Bing Huang, Xiao-Hui Mu, Qin-Li Wan, Xiao-Ming He, Gui-Sheng Wu & Huai-Rong Luo. (2017) Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLOS ONE 12:9, pages e0184027.
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Suman Bhattacharya, Md. Mobidullah Khan, Chandradipa Ghosh, Sarbashri Bank & Smarajit Maiti. (2017) The role of Dermcidin isoform-2 in the occurrence and severity of Diabetes. Scientific Reports 7:1.
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Gennadi Kobzar, Vilja Mardla & Nigulas Samel. (2017) Glucose impairs aspirin inhibition in platelets through a NAD(P)H oxidase signaling pathway. Prostaglandins & Other Lipid Mediators 131, pages 33-40.
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Sarbashri Bank, Suman Bhattacharya, Smarajit Maiti, Raja Bhattacharya, Debajyoti Chakraborty & Asru K Sinha. (2015) The impaired synthesis of insulin and its inability to inhibit platelet aggregation in cerebrovascular accident. Metabolic Brain Disease 30:5, pages 1309-1318.
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Pradipta Jana, Smarajit Maiti, Nighat N. Kahn & Asru K. Sinha. (2015) Estriol-induced fibrinolysis due to the activation of plasminogen to plasmin by nitric oxide synthesis in platelets. Blood Coagulation & Fibrinolysis 26:3, pages 316-323.
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D. Banerjee, S. Mazumder, S. Bhattacharya & A. K. Sinha. (2014) The sex specific effects of extraneous testosterone on ADP induced platelet aggregation in platelet-rich plasma from male and female subjects. International Journal of Laboratory Hematology 36:5, pages e74-e77.
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Debipriya Banerjee, Sahana Mazumder & Asru K. Sinha. (2014) The role of inhibition of nitric oxide synthesis in the aggregation of platelets due to the stimulated production of thromboxane A2. Blood Coagulation & Fibrinolysis 25:6, pages 585-591.
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Sarbashri Bank, Pradipta Jana, Smarajit Maiti, Santanu Guha & A. K. Sinha. (2014) Dermcidin isoform-2 induced nullification of the effect of acetyl salicylic acid in platelet aggregation in acute myocardial infarction. Scientific Reports 4:1.
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Rajeshwary Ghosh, Udayan Ray, Pradipta Jana, Rabindra Bhattacharya, Debipriya Banerjee & Asru Sinha. (2014) Reduction of Death Rate Due to Acute Myocardial Infarction in Subjects with Cancers through Systemic Restoration of Impaired Nitric Oxide. PLoS ONE 9:2, pages e88639.
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Bandana Singh, Indranil Biswas, Iti Garg, Ragumani Sugadev, Abhay K. Singh, Sharmistha Dey & Gausal A. Khan. (2013) von Willebrand Factor Antagonizes Nitric Oxide Synthase To Promote Insulin Resistance during Hypoxia. Biochemistry 53:1, pages 115-126.
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Rajeshwary Ghosh, Sarbashri Bank, Rabindra Bhattacharya, Nighat N. Khan & A. Kumar Sinha. (2014) Neutralization by Insulin of the Hypertensive Effect of Dermcidin Isoform 2: An Environmentally Induced Diabetogenic and Hypertensive Protein. Cardiology Research and Practice 2014, pages 1-10.
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Mohinder Bansal & Naveen KaushalMohinder Bansal & Naveen Kaushal. 2014. Oxidative Stress Mechanisms and their Modulation. Oxidative Stress Mechanisms and their Modulation 55 83 .
Javier Modrego, Luis Azcona, Naiara Martín-Palacios, José J. Zamorano-León, Antonio Segura, Pablo Rodríguez, Reddy Guerra, Juan Tamargo, Carlos Macaya & Antonio J. López-Farré. (2013) Platelet Content of Nitric Oxide Synthase 3 Phosphorylated At Serine1177 Is Associated with the Functional Response of Platelets to Aspirin. PLoS ONE 8:12, pages e82574.
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Pradipta Jana, Smarajit Maiti, Rajeshwary Ghosh, Tamal K. Ghosh & Asru K. Sinha. (2013) Estriol, a stimulator of nitric oxide synthesis in platelets, and its role as the powerful inhibitor of platelet aggregation. Cardiovascular Endocrinology 2:3, pages 50-54.
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Giovanni Davì, Francesca Santilli & Natale Vazzana. 2013. Platelets. Platelets 711 732 .
Isabella Russo, Michela Viretto, Cristina Barale, Luigi Mattiello, Gabriella Doronzo, Andrea Pagliarino, Franco Cavalot, Mariella Trovati & Giovanni Anfossi. (2012) High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets. Diabetes 61:11, pages 2913-2921.
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Udayan Ray, Gausal. A. Khan, Kushal Chakraborty, Shyamali Basuroy, Sharmistha Chakraborty Patra, Gannareddy Girish, G. Bhattacharya & Asru K. Sinha. (2012) Isolation and study of insulin activated nitric oxide synthase inhibitory protein in acute myocardial infarction subjects. Journal of Thrombosis and Thrombolysis 33:3, pages 218-229.
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Rajeshwary Ghosh, Uttam K. Maji, Rabindra Bhattacharya & Asru K. Sinha. (2012) The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It. Thrombosis 2012, pages 1-9.
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F. Santilli, N. Vazzana, R. Liani, M. T. Guagnano & G. Davì. (2012) Platelet activation in obesity and metabolic syndrome. Obesity Reviews 13:1, pages 27-42.
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Alba Fernández-Sánchez, Eduardo Madrigal-Santillán, Mirandeli Bautista, Jaime Esquivel-Soto, Ángel Morales-González, Cesar Esquivel-Chirino, Irene Durante-Montiel, Graciela Sánchez-Rivera, Carmen Valadez-Vega & José A. Morales-González. (2011) Inflammation, Oxidative Stress, and Obesity. International Journal of Molecular Sciences 12:5, pages 3117-3132.
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Rajeshwary Ghosh, Soumendra Krishna Karmohapatra, Mau Bhattacharyya, Rabindra Bhattacharya, Gorachand Bhattacharya & A. Kumar Sinha. (2010) The appearance of dermcidin isoform 2, a novel platelet aggregating agent in the circulation in acute myocardial infarction that inhibits insulin synthesis and the restoration by acetyl salicylic acid of its effects. Journal of Thrombosis and Thrombolysis 31:1, pages 13-21.
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Mau Bhattacharyya, Gannareddy V. Girish, Rajeshwary Ghosh, Somashree Chakraborty & Asru K. Sinha. (2010) Acetyl salicyclic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients. Cancer Science 101:10, pages 2105-2109.
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Mau Bhattacharyya, Soumendra K. Karmohapatra, Gorachand Bhattacharya, Rabindra Bhattacharya & A. Kumar Sinha. (2008) The role of leucocytes in the acetyl salicylic acid (aspirin) induced nitric oxide synthesis in the production of interferon-α, a potent inhibitor of platelet aggregation and a thrombolytic agent. Journal of Thrombosis and Thrombolysis 28:2, pages 173-184.
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P. O'Kane, L. Xie, Z. Liu, L. Queen, G. Jackson, Y. Ji & A. Ferro. (2009) Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity. Cardiovascular Research 83:1, pages 123-130.
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Somashree Chakraborty, Gausal A. Khan, Soumendra K. Karmohapatra, Rabindra Bhattacharya, Gorachand Bhattacharya & A. Kumar Sinha. (2009) Purification and mechanism of action of “cortexin,” a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men. Journal of the American Society of Hypertension 3:2, pages 119-132.
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Armen Yuri Gasparyan, Timothy Watson & Gregory Y.H. Lip. (2008) The Role of Aspirin in Cardiovascular Prevention. Journal of the American College of Cardiology 51:19, pages 1829-1843.
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Soumendra K. Karmohapatra, Kushal Chakraborty, Nighat N. Kahn & Asru K. Sinha. (2007) The role of nitric oxide in aspirin induced thrombolysis in vitro and the purification of aspirin activated nitric oxide synthase from human blood platelets. American Journal of Hematology 82:11, pages 986-995.
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Soumendra K. Karmohapatra, Nighat N. Kahn & Asru K. Sinha. (2007) The thrombolytic effect of aspirin in animal model. Journal of Thrombosis and Thrombolysis 24:2, pages 123-129.
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Eli I. Lev, Ramanujam S. Ramabadran, Sasidhar Guthikonda, Rajnikant Patel, Amanda Kleiman, Juan F. Granada, Timothy DeLao & Neal S. Kleiman. (2007) Effect of Ranitidine on the Antiplatelet Effects of Aspirin in Healthy Human Subjects. The American Journal of Cardiology 99:1, pages 124-128.
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G.V. Girish, G. Bhattacharya & A Kumar Sinha. (2006) The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer. Journal of Cancer Research and Clinical Oncology 132:6, pages 389-398.
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Byron Cryer, Roger G. Berlin, Stephen A. Cooper, Ching Hsu & Suman Wason. (2005) Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-tereated healthy adult volunteers. Clinical Therapeutics 27:2, pages 185-191.
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