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Platelets Volume 31, 2020 - Issue 2
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Original Article

Comparison of the GPVI inhibitors losartan and honokiol

Marie-Blanche OnselaerInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKCorrespondence[email protected]
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Magdolna NagyDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, MD, The NetherlandsView further author information
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Chiara PalliniInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKView further author information
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Jeremy A PikeCentre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, The MidlandsView further author information
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Gina PerrellaInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, MD, The NetherlandsView further author information
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Lourdes Garcia QuintanillaInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKView further author information
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Johannes A EbleInstitute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, GermanyView further author information
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Natalie S. PoulterInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, The MidlandsORCID Iconhttps://orcid.org/0000-0002-3187-2130View further author information
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Johan W.M. HeemskerkDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, MD, The NetherlandsView further author information
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Steve P WatsonInstitute of Cardiovascular Sciences, IBR Building, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, The MidlandsORCID Iconhttps://orcid.org/0000-0002-7846-7423View further author information
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Pages 187-197 | Received 03 Oct 2018, Accepted 17 Feb 2019, Published online: 08 Mar 2019

Citations (19)

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Fatima Khatoon, Sabeeha Ali, Vijay Kumar, Abdelbaset Mohamed Elasbali, Hassan H. Alhassan, Salem Hussain Alharethi, Asimul Islam & Md. Imtaiyaz Hassan. (2023) Pharmacological features, health benefits and clinical implications of honokiol. Journal of Biomolecular Structure and Dynamics 41:15, pages 7511-7533.
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Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam & Steve P. Watson. (2021) Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2. Platelets 32:6, pages 744-752.
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Fawaz O. Alenazy & Mark R. Thomas. (2021) Novel antiplatelet targets in the treatment of acute coronary syndromes. Platelets 32:1, pages 15-28.
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Articles from other publishers (16)

Natalia Sławińska, Agata Rolnik, Anna Stochmal & Beata Olas. (2023) Response of human blood platelets to preparations from leaves of Paulownia Clon in Vitro 112. Biomedicine & Pharmacotherapy 165, pages 115220.
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Natalie J. Jooss, Christopher W. Smith, Jeremy A. Pike, Richard W. Farndale, Yvonne M.C. Henskens, Steve P. Watson, Johan W.M. Heemskerk & Natalie S. Poulter. (2023) Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear. Journal of Thrombosis and Haemostasis 21:8, pages 2260-2267.
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Foteini-Nafsika Damaskinaki, Natalie J. Jooss, Eleyna M. Martin, Joanne C. Clark, Mark R. Thomas, Natalie S. Poulter, Jonas Emsley, Barrie Kellam, Steve P. Watson & Alexandre Slater. (2023) Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. Journal of Thrombosis and Haemostasis 21:2, pages 317-328.
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Gabrielle J. Pennings, Caroline J. Reddel, Vivien M. Chen, Sonali R. Gnanenthiran & Leonard Kritharides. (2023) Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Frontiers in Cardiovascular Medicine 9.
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Kakarla Ramakrishna, Sushil Kumar Singh & Sairam Krishnamurthy. (2022) Diindolylmethane Ameliorates Ischemic Stroke-Induced Brain Injury by Peripheral and Central Mechanisms. Current Neurovascular Research 19:5, pages 462-475.
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Funda Tamer, Bibian M. E. Tullemans, Marijke J. E. Kuijpers, Theodora A.M. Claushuis & Johan W. M. Heemskerk. (2021) Nutrition Phytochemicals Affecting Platelet Signaling and Responsiveness: Implications for Thrombosis and Hemostasis. Thrombosis and Haemostasis 122:06, pages 879-894.
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Simla Olğaç, Abdurrahman Olğaç, İdil Yenicesu & Yesim Ozkan. (2022) Identification of novel antiplatelet agents by targeting Glycoprotein VI: A combined virtual screening study. Bioorganic Chemistry 121, pages 105661.
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Kakarla Ramakrishna, Neha Singh & Sairam Krishnamurthy. (2022) Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies. European Journal of Pharmacology 919, pages 174812.
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Holly Foster, Clare WilsonJulia S. GauerRui-Gang XuMark J. HowardIain W. ManfieldRobert AriënsKhalid NaseemLewis R. VidlerHelen PhilippouRichard Foster. (2022) A Comparative Assessment Study of Known Small-molecule GPVI Modulators. ACS Medicinal Chemistry Letters 13:2, pages 171-181.
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Gina Perrella, Samantha J. Montague, Helena C. Brown, Lourdes Garcia Quintanilla, Alexandre Slater, David Stegner, Mark Thomas, Johan W. M. Heemskerk & Steve P. Watson. (2022) Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. International Journal of Molecular Sciences 23:1, pages 493.
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Linhua Li, Chong Chen, Chunle Zhang, Rifang Luo, Xiaorong Lan, Fan Guo, Liang Ma, Ping Fu & Yunbing Wang. (2021) A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties. Journal of Materials Chemistry B 9:47, pages 9770-9783.
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Alexey Martyanov & Mikhail Panteleev. (2021) Platelet functional responses and signalling: the molecular relationship. Part 2: receptors.. Systems Biology and Physiology Reports 1:3, pages 13-30.
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Adam BelcherAbu Hasanat Md Zulfiker, Oliver Qiyue LiHong YueAnirban Sen GuptaWei Li. (2021) Targeting Thymidine Phosphorylase With Tipiracil Hydrochloride Attenuates Thrombosis Without Increasing Risk of Bleeding in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology 41:2, pages 668-682.
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Holly FosterClare WilsonHelen PhilippouRichard Foster. (2020) Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. Journal of Medicinal Chemistry 63:21, pages 12213-12242.
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Caterina Visconte, Jessica Canino, Mauro Vismara, Gianni Francesco Guidetti, Sara Raimondi, Giordano Pula, Mauro Torti & Ilaria Canobbio. (2020) Fibrillar amyloid peptides promote platelet aggregation through the coordinated action of ITAM‐ and ROS‐dependent pathways. Journal of Thrombosis and Haemostasis 18:11, pages 3029-3042.
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Lili Donner, Laura Mara Toska, Irena KrügerSandra Gröniger, Ruben Barroso, Alice Burleigh, Diego MezzanoSusanne Pfeiler, Malte Kelm, Norbert Gerdes, Steve P. Watson, Yi Sun & Margitta Elvers. (2020) The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid. Science Signaling 13:643.
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