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Platelets Volume 32, 2021 - Issue 6
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Special review series

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Foteini-Nafsika Damaskinaki1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK;3 Biodiscovery Institute, University Park, University of Nottingham, Nottingham, UKView further author information
,
Luis A. Moran1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;4 Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela, and Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, SpainORCID Iconhttps://orcid.org/0000-0002-5232-3376View further author information
ORCID Icon,
Angel Garcia4 Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela, and Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, SpainView further author information
,
Barrie Kellam2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK;3 Biodiscovery Institute, University Park, University of Nottingham, Nottingham, UKORCID Iconhttps://orcid.org/0000-0003-0030-9908View further author information
ORCID Icon &
Steve P. Watson1 Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK;2 Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UKCorrespondence[email protected]
View further author information
Pages 744-752 | Received 12 Oct 2020, Accepted 30 Nov 2020, Published online: 07 Jan 2021

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Steve P. Watson. (2021) Editorial: structure–function relationships of tyrosine kinase- and tyrosine phosphatase-linked receptors in platelets and megakaryocytes. Platelets 32:6, pages 722-723.
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Eleyna M Martin, Malou Zuidscherwoude, Luis a Morán, Ying Di, Angel García & Steve P Watson. (2021) The structure of CLEC-2: mechanisms of dimerization and higher-order clustering. Platelets 32:6, pages 733-743.
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Articles from other publishers (7)

Fabio Giannone, Nevena Slovic, Patrick Pessaux, Catherine Schuster, Thomas F. Baumert & Joachim Lupberger. (2023) Inflammation-related prognostic markers in resected hepatocellular carcinoma. Frontiers in Oncology 13.
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Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai & Zhaohui Meng. (2023) Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. Frontiers in Pharmacology 14.
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Kadir Batçıoğlu, F. Zehra Küçükbay, Mehmet Abdullah Alagöz, Selami Günal & Yakup Yilmaztekin. (2023) Antioxidant and antithrombotic properties of fruit, leaf, and seed extracts of the Halhalı olive (Olea europaea L.) native to the Hatay region in Turkey. Foods and Raw Materials, pages 84-93.
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Foteini-Nafsika Damaskinaki, Natalie J. Jooss, Eleyna M. Martin, Joanne C. Clark, Mark R. Thomas, Natalie S. Poulter, Jonas Emsley, Barrie Kellam, Steve P. Watson & Alexandre Slater. (2023) Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. Journal of Thrombosis and Haemostasis 21:2, pages 317-328.
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Mehmet Abdullah ALAGÖZ, İnci Selin DOĞAN, Sıla SENER & Zeynep ÖZDEMİR. (2022) Synthesis, Molecular Docking and Molecular Dynamics Simulation Studies of Some Pyridazinone Derivatives as Lipase Inhibitors. Cumhuriyet Science Journal 43:3, pages 391-397.
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Luis A. Morán, Ying Di, Marcin A. Sowa, Lidia Hermida-Nogueira, María N. Barrachina, Eleyna Martin, Joanne C. Clark, Todd H. Mize, Johannes A. Eble, David Moreira, Alice Y. Pollitt, María I. Loza, Eduardo Domínguez, Steve P. Watson & Ángel García. (2022) Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist. Thrombosis and Haemostasis 122:08, pages 1361-1368.
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Holly Foster, Clare WilsonJulia S. GauerRui-Gang XuMark J. HowardIain W. ManfieldRobert AriënsKhalid NaseemLewis R. VidlerHelen PhilippouRichard Foster. (2022) A Comparative Assessment Study of Known Small-molecule GPVI Modulators. ACS Medicinal Chemistry Letters 13:2, pages 171-181.
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