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AIDS Care
Psychological and Socio-medical Aspects of AIDS/HIV
Volume 27, 2015 - Issue 3
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Original Articles

Assessment of HIV antiretroviral therapy adherence by measuring drug concentrations in hair among children in rural Uganda

Peter K. OldsDepartment of Medicine, Harvard Medical School, Boston, MA, USAView further author information
,
Julius P. KiwanukaDepartment of Paediatrics, Mbarara University of Science and Technology, Mbarara, UgandaView further author information
,
Denis NanseraDepartment of Paediatrics, Mbarara University of Science and Technology, Mbarara, UgandaView further author information
,
Yong HuangDepartment of Medicine, University of California, San Francisco, CA, USAView further author information
,
Peter BacchettiDepartment of Medicine, University of California, San Francisco, CA, USAView further author information
,
Chengshi JinDepartment of Medicine, University of California, San Francisco, CA, USAView further author information
,
Monica GandhiDepartment of Medicine, University of California, San Francisco, CA, USAView further author information
&
Jessica E. HabererDepartment of Medicine, Harvard Medical School, Boston, MA, USA;Department of Medicine and Center for Global Health, Massachusetts General Hospital, Boston, MA, USACorrespondence[email protected]
View further author information
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Pages 327-332 | Received 09 Jul 2014, Accepted 14 Oct 2014, Published online: 06 Dec 2014

Citations (34)

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Parya Saberi, Kristin Ming, Dominique Legnitto, Torsten B Neilands, Monica Gandhi & Mallory O Johnson. (2018) Novel methods to estimate antiretroviral adherence: protocol for a longitudinal study. Patient Preference and Adherence 12, pages 1033-1042.
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C.T. Kekwaletswe, S. Nkosi, N.B. Kitleli, B. Myers, P. Shuper, C.D.H. Parry & N.K. Morojele. (2018) Acceptability of obtaining hair samples for assessing antiretroviral therapy (ART) exposure amongst alcohol drinking ART recipients in Tshwane, South Africa. AIDS Care 30:12, pages 1498-1501.
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Articles from other publishers (32)

Amanda Poliseno, Ella Ferguson, Rose Perry, Alexandra Munson, Alexandra Davis, Lauren Hill, Jessica Keys, Nicole White, Claire Farel, Cynthia Gay, Carol Golin, Elias Rosen & Angela Kashuba. (2023) Establishing Novel Antiretroviral Imaging for Hair to Elucidate Nonadherence: Protocol for a Single-Arm Cross-sectional Study. JMIR Research Protocols 12, pages e41188.
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Michael A. Rapoff, Christina Duncan & Cynthia KarlsonMichael A. Rapoff, Christina Duncan & Cynthia Karlson. 2023. Adherence to Pediatric Medical Regimens. Adherence to Pediatric Medical Regimens 115 159 .
Honghu Liu, Yan Wang, Yilan Huang, Di Xiong, Jie Shen, Lisa Siqueiros, Veenu Bala, George M. Savage, Mario Guerrero, Katya Corado, Marc I. Rosen, Courtney V. Fletcher & Eric S. Daar. (2022) Ingestible sensor system for measuring, monitoring and enhancing adherence to antiretroviral therapy: An open-label, usual care-controlled, randomised trial. eBioMedicine 86, pages 104330.
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Godfrey Zari Rukundo, Jonathan Levin, Richard Stephen Mpango, Vikram Patel & Eugene Kinyanda. (2021) Effect of suicidality on clinical and behavioural outcomes in HIV positive adults in Uganda. PLOS ONE 16:8, pages e0254830.
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Jillian Pintye, Yanling Huo, Deborah Kacanek, Kevin Zhang, Karen Kuncze, Hideaki Okochi & Monica Gandhi. (2021) Detectable HIV RNA in late pregnancy associated with low tenofovir hair levels at time of delivery among women living with HIV in the United States. AIDS 35:2, pages 267-274.
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Haoran Yang, Liuxi Chu, Yan Wu, Wei Wang, Jin Yang, Quan Zhang, Shan Qiao, Xiaoming Li, Zhiyong Shen, Yuejiao Zhou, Shuaifeng Liu & Huihua Deng. (2020) LC-MS/MS Quantification of Nevirapine and Its Metabolites in Hair for Assessing Long-Term Adherence. Molecules 25:23, pages 5692.
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Quan Zhang, Xiaoming Li, Shan Qiao, Zhiyong Shen & Yuejiao Zhou. (2020) Comparing self-reported medication adherence measures with hair antiretroviral concentration among people living with HIV in Guangxi, China. AIDS Research and Therapy 17:1.
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Matthew A. Spinelli, Jessica E. Haberer, Peter R. Chai, Jose Castillo-Mancilla, Peter L. Anderson & Monica Gandhi. (2020) Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions. Current HIV/AIDS Reports 17:4, pages 301-314.
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Sangeeta Tanna, John Ogwu & Graham Lawson. (2020) Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives. Clinical Chemistry and Laboratory Medicine (CCLM) 58:5, pages 643-663.
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Quan Zhang, Shan Qiao, Xueying Yang & Xiaoming Li. (2019) Antiretroviral Concentration in Hair as a Measure for Antiretroviral Medication Adherence: A Systematic Review of Global Literature. AIDS and Behavior 24:1, pages 311-330.
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Jacinta N. NwoguChinedum P. BabalolaSamuel O. NgeneBabafemi O. TaiwoBaiba BerzinsMonica Gandhi. (2019) Willingness to Donate Hair Samples for Research Among People Living with HIV/AIDS Attending a Tertiary Health Facility in Ibadan, Nigeria. AIDS Research and Human Retroviruses 35:7, pages 642-648.
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Monica Gandhi, Sarita Devi, Peter Bacchetti, Sara Chandy, Elsa Heylen, Nhi Phung, Karen Kuncze, Hideaki Okochi, Ravi Kumar, Anura V. Kurpad & Maria L. Ekstrand. (2019) Measuring Adherence to Antiretroviral Therapy via Hair Concentrations in India. JAIDS Journal of Acquired Immune Deficiency Syndromes 81:2, pages 202-206.
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Jenna Johnston, Lubbe Wiesner, Peter Smith, Gary Maartens & Catherine Orrell. (2019) Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans. Southern African Journal of HIV Medicine 20:1.
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Giulia Martelli, Rosa Antonucci, Alphonsina Mukurasi, Henry Zepherine & Christiana Nöstlinger. (2019) Adherence to antiretroviral treatment among children and adolescents in Tanzania: Comparison between pill count and viral load outcomes in a rural context of Mwanza region. PLOS ONE 14:3, pages e0214014.
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Linda Hartman, Willem F. Lems & Maarten Boers. (2019) Outcome measures for adherence data from a medication event monitoring system: A literature review. Journal of Clinical Pharmacy and Therapeutics 44:1, pages 1-5.
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Henry Ademola Adeola, Jennifer Cathryn Van Wyk, Afolake Temitope Arowolo & Nonhlanhla Patience Khumalo. 2018. Keratin. Keratin.
Zachary J. Tabb, Blandina T. Mmbaga, Monica Gandhi, Alexander Louie, Karen Kuncze, Hideaki Okochi, Aisa M. Shayo, Elizabeth L. Turner, Coleen K. Cunningham & Dorothy E. Dow. (2018) Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania. AIDS 32:9, pages 1115-1123.
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Nhi Phung, Karen Kuncze, Hideaki Okochi, Alexander Louie, Leslie Z. Benet, Igho Ofokotun, David W. Haas, Judith S. Currier, Tariro D. Chawana, Anandi N. Sheth, Peter Bacchetti, Monica Gandhi & Howard Horng. (2018) Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 32:5, pages 431-441.
Crossref
Jose R. Castillo-Mancilla & Jessica E. Haberer. (2018) Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring. Current HIV/AIDS Reports 15:1, pages 49-59.
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Gwamaka E. Mwasakifwa, Cecilia Moore, Dianne Carey, Janaki Amin, Paul Penteado, Marcelo Losso, Poh-Lian Lim, Lerato Mohapi, Jean-Michel Molina, Brian Gazzard, David A. Cooper & Mark Boyd. (2018) Relationship between untimed plasma lopinavir concentrations and virological outcome on second-line antiretroviral therapy. AIDS 32:3, pages 357-361.
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S Erb, E Letang, TR Glass, A Natamatungiro, D Mnzava, H Mapesi, M Haschke, U Duthaler, B Berger, L Muri, J Bader, C Marzolini, L Elzi, T Klimkait, W Langewitz & M Battegay. (2017) Health care provider communication training in rural Tanzania empowers HIV-infected patients on antiretroviral therapy to discuss adherence problems. HIV Medicine 18:9, pages 623-634.
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Lindsey E. Garrison & Jessica E. Haberer. (2017) Technological methods to measure adherence to antiretroviral therapy and preexposure prophylaxis. Current Opinion in HIV and AIDS 12:5, pages 467-474.
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Randy M. Stalter, Jenae Tharaldson, Derek H. Owen, Eunice Okumu, Thomas Moench, Natasha Mack, Elizabeth E. Tolley & Kathleen M. MacQueen. (2017) Attitudes and perceptions towards novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey. PLOS ONE 12:7, pages e0180963.
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HC Koenig, K Mounzer, GW Daughtridge, CE Sloan, L Lalley‐Chareczko, GS Moorthy, SC Conyngham, AF Zuppa, LJ Montaner & P Tebas. (2017) Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre‐exposure prophylaxis. HIV Medicine 18:6, pages 412-418.
Crossref
Irene N. Mukui, Lucy Ng’ang’a, John Williamson, Joyce N. Wamicwe, Shobha Vakil, Abraham Katana & Andrea A. Kim. (2016) Rates and Predictors of Non-Adherence to Antiretroviral Therapy among HIV-Positive Individuals in Kenya: Results from the Second Kenya AIDS Indicator Survey, 2012. PLOS ONE 11:12, pages e0167465.
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Mohamed El Alili, Bernard Vrijens, Jenny Demonceau, Silvia M. Evers & Mickael Hiligsmann. (2016) A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence. British Journal of Clinical Pharmacology 82:1, pages 268-279.
Crossref
Jessica E. Haberer. (2016) Current concepts for PrEP adherence in the PrEP revolution. Current Opinion in HIV and AIDS 11:1, pages 10-17.
Crossref
Sangeeta Tanna & Graham Lawson. 2016. Analytical Chemistry for Assessing Medication Adherence. Analytical Chemistry for Assessing Medication Adherence 87 127 .
Sangeeta Tanna & Graham Lawson. 2016. Analytical Chemistry for Assessing Medication Adherence. Analytical Chemistry for Assessing Medication Adherence 1 21 .
Sara Capiau, Jan-Willem Alffenaar & Christophe P. Stove. 2016. Clinical Challenges in Therapeutic Drug Monitoring. Clinical Challenges in Therapeutic Drug Monitoring 279 336 .
Mark A. Marzinke. 2016. Clinical Challenges in Therapeutic Drug Monitoring. Clinical Challenges in Therapeutic Drug Monitoring 135 163 .
Wasana PrasitsuebsaiStephen J. KerrKhanh Huu TruongJintanat AnanworanichViet Chau DoLam Van NguyenNia KurniatiPope KosalaraksaTavitiya SudjaritrukKulkanya ChokephaibulkitNarukjaporn ThammajarukThida SingtorojSirinya TeeraananchaiHoward HorngPeter BacchettiMonica GandhiAnnette H. Sohn. (2015) Using Lopinavir Concentrations in Hair Samples to Assess Treatment Outcomes on Second-Line Regimens Among Asian Children. AIDS Research and Human Retroviruses 31:10, pages 1009-1014.
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