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Original

Actions of delta-9-tetrahydrocannabinol in cannabis: Relation to use, abuse, dependence

& , PhD
Pages 104-112 | Published online: 11 Jul 2009

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Hye Bin Yoo, Jennifer DiMuzio & Francesca M. Filbey. (2020) Interaction of Cannabis Use and Aging: From Molecule to Mind. Journal of Dual Diagnosis 16:1, pages 140-176.
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Crossref
LV Panlilio, SR Goldberg & Z Justinova. (2015) Cannabinoid abuse and addiction: Clinical and preclinical findings. Clinical Pharmacology & Therapeutics 97:6, pages 616-627.
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Katherine A. Scott, Angus G. Dalgleish & Wai M. Liu. (2014) The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model. Molecular Cancer Therapeutics 13:12, pages 2955-2967.
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George Panagis, Brian Mackey & Styliani Vlachou. (2014) Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future. Frontiers in Psychiatry 5.
Crossref
Selcuk Ozyurt, Fatma Muderrisoglu, Murat Ermete & Fatma Afsar. (2014) Cannabis-induced erythema multiforme-like recurrent drug eruption. International Journal of Dermatology 53:1, pages e22-e23.
Crossref
Andrew J. Saxon & Kendall W. Browne. (2014) Marijuana not ready for prime time as an analgesic. General Hospital Psychiatry 36:1, pages 4-6.
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Muhammad T. AkhtarShaukat AliHassan RashidiFrank van der KooyRobert VerpoorteMichael K. Richardson. (2013) Developmental Effects of Cannabinoids on Zebrafish Larvae. Zebrafish 10:3, pages 283-293.
Crossref
Ziva D Cooper, Sandra D Comer & Margaret Haney. (2013) Comparison of the Analgesic Effects of Dronabinol and Smoked Marijuana in Daily Marijuana Smokers. Neuropsychopharmacology 38:10, pages 1984-1992.
Crossref
Joshua A. Lile, Thomas H. Kelly, Richard J. Charnigo, Audra L. Stinchcomb & Lon R. Hays. (2013) Pharmacokinetic and Pharmacodynamic Profile of Supratherapeutic Oral Doses of Δ 9 -THC in Cannabis Users . The Journal of Clinical Pharmacology 53:7, pages 680-690.
Crossref
Gillinder Bedi, Ziva D. Cooper & Margaret Haney. 2013. Interventions for Addiction. Interventions for Addiction 397 406 .
Ryan G. Vandrey & Alan J. Budney. 2010. Encyclopedia of Psychopharmacology. Encyclopedia of Psychopharmacology 1 6 .
Tomohisa Mori, Masahiro Shibasaki, Minako Abe, Yuya Udagawa & Tsutomu Suzuki. (2012) Effects of dronabinol on morphine-induced dopamine-related behavioral effects in animals. Synapse 66:11, pages 931-937.
Crossref
Michael E Ballard, Gillinder Bedi & Harriet de Wit. (2012) Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images. Journal of Psychopharmacology 26:10, pages 1289-1298.
Crossref
J Hirvonen, R S Goodwin, C-T Li, G E Terry, S S Zoghbi, C Morse, V W Pike, N D Volkow, M A Huestis & R B Innis. (2011) Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. Molecular Psychiatry 17:6, pages 642-649.
Crossref
J. Michael Bostwick. (2012) Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana. Mayo Clinic Proceedings 87:2, pages 172-186.
Crossref
Yehoshua Zarfin, Enav Yefet, Said Abozaid, Wael Nasser, Tamer Mor & Yoram Finkelstein. (2012) Infant with altered consciousness after cannabis passive inhalation. Child Abuse & Neglect 36:2, pages 81-83.
Crossref
Louis A. Pagliaro & Ann Marie Pagliaro. 2011. Handbook of Child and Adolescent Drug and Substance Abuse. Handbook of Child and Adolescent Drug and Substance Abuse 371 453 .
Leslie Iversen. 2011. Marijuana and Madness. Marijuana and Madness 1 16 .
O. Sagredo. (2011) Efectos farmacológicos y fisiológicos del consumo de cannabis. Trastornos Adictivos 13:3, pages 94-96.
Crossref
Adam Stewart, Keith Wong, Jonathan Cachat, Siddharth Gaikwad, Evan Kyzar, Nadine Wu, Peter Hart, Valerie Piet, Eli Utterback, Marco Elegante, David Tien & Allan V. Kalueff. (2011) Zebrafish models to study drug abuse-related phenotypes. revneuro 22:1, pages 95-105.
Crossref
José Luis G. Pinho Costa, Lucas O. Maia, P. Orlandi-Mattos, João C. Villares & Manuel A. Fernandez Esteves. (2011) Neurobiologia da Cannabis: do sistema endocanabinoide aos transtornos por uso de Cannabis. Jornal Brasileiro de Psiquiatria 60:2, pages 111-122.
Crossref
Joshua A. Lile, Thomas H. Kelly & Lon R. Hays. (2010) Substitution Profile of the Cannabinoid Agonist Nabilone in Human Subjects Discriminating Δ9-Tetrahydrocannabinol. Clinical Neuropharmacology 33:5, pages 235-242.
Crossref
Celia JA Morgan, Tom P Freeman, Gráinne L Schafer & H Valerie Curran. (2010) Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis. Neuropsychopharmacology 35:9, pages 1879-1885.
Crossref
Alan J. Budney, Ryan G. Vandrey & Catherine Stanger. (2010) Intervenções farmacológica e psicossocial para os distúrbios por uso da cannabis. Revista Brasileira de Psiquiatria 32:suppl 1, pages 546-555.
Crossref
Nikolai Zvonok, Wei Xu, John Williams, David R. Janero, Srinivasan C. Krishnan & Alexandros Makriyannis. (2010) Mass Spectrometry-Based GPCR Proteomics: Comprehensive Characterization of the Human Cannabinoid 1 Receptor. Journal of Proteome Research 9:4, pages 1746-1753.
Crossref
Jonathan Cachat, Peter Canavello, Marco Elegante, Brett Bartels, Peter Hart, Carisa Bergner, Rupert Egan, Ashley Duncan, David Tien, Amanda Chung, Keith Wong, Jason Goodspeed, Julia Tan, Chelsea Grimes, Salem Elkhayat, Christopher Suciu, Michael Rosenberg, Kyung Min Chung, Ferdous Kadri, Sudipta Roy, Siddharth Gaikwad, Adam Stewart, Ivan Zapolsky, Thomas Gilder, Sopan Mohnot, Esther Beeson, Hakima Amri, Zofia Zukowska, R. Denis Soignier & Allan V. Kalueff. (2010) Modeling withdrawal syndrome in zebrafish. Behavioural Brain Research 208:2, pages 371-376.
Crossref
Didier Jutras-AswadM.D. M. ScM.D. M. Sc, Julie BruneauM.D. M. ScM.D. M. Sc & Yasmin L. HurdPh. D.Ph. D.. (2010) Neurobiologie de la toxicomanie : avancées récentes et nouvelles stratégies d’intervention. Drogues, santé et société 8:2, pages 27-73.
Crossref

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