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Article

A pilot study evaluating anxiety and depressive scores in acne patients treated with isotretinoin

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Pages 153-157 | Received 18 Mar 2003, Accepted 02 Feb 2004, Published online: 12 Jul 2009

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Tânia Fernandes & Sofia Magina. (2023) Oral isotretinoin in the treatment of juvenile acne and psychiatric adverse effects – a systematic review. Cutaneous and Ocular Toxicology 42:3, pages 83-90.
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Haady Fallah & Marius Rademaker. (2022) Isotretinoin for acne vulgaris – an update on adverse effects and laboratory monitoring. Journal of Dermatological Treatment 33:5, pages 2414-2424.
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M Le Moigne, S Bulteau, Marie Grall-Bronnec, M Gerardin, Jean-Pascal Fournier, AP Jonville-Bera, Pascale Jolliet, Brigitte Dreno & C Victorri-Vigneau. (2017) Psychiatric disorders, acne and systemic retinoids: comparison of risks. Expert Opinion on Drug Safety 16:9, pages 989-995.
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Yavuz YesIlova, Yasin Bez, Mustafa ArI, Mehmet Cemal Kaya & Gokay Alpak. (2012) Effects of isotretinoin on obsessive compulsive symptoms, depression, and anxiety in patients with acne vulgaris. Journal of Dermatological Treatment 23:4, pages 268-271.
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Brigitte Dreno & Olivier Chosidow. (2008) Isotretinoin and psychiatric side effects: facts and hypothesis. Expert Review of Dermatology 3:6, pages 711-720.
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Articles from other publishers (39)

Nicole Kye Wen Tan, Adelina Tang, Neil Chen Yi Lun MacAlevey, Benjamin Kye Jyn Tan & Hazel H. Oon. (2023) Risk of Suicide and Psychiatric Disorders Among Isotretinoin Users. JAMA Dermatology.
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Jan Kapała, Julia Lewandowska, Waldemar Placek & Agnieszka Owczarczyk-Saczonek. (2022) Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis. International Journal of Environmental Research and Public Health 19:11, pages 6463.
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J. Douglas Bremner. (2021) Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed. Journal of Affective Disorders Reports 6, pages 100230.
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Selami Aykut Temiz, Koray Durmaz, Recep Dursun, Arzu Ataseven, Begüm Işık, Onur Karaağaç, İlkay Özer & Munise Daye. (2020) Effect of the COVID‐19 pandemic on the anxiety and depression levels in patients who applied to the cosmetology unit. Dermatologic Therapy 34:1.
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Asude Kara Polat, Asli Akin Belli, Ecem Zeliha Ergun, Vildan Manav Bas, Duygu Erdil, Ayse Esra Koku Aksu & Mehmet Salih Gurel. (2020) Knowledge levels and concerns about oral isotretinoin treatment in the parents of adolescent acne patients. Dermatologic Therapy 33:4.
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Pu Hu, Anne-Marie van Dam, Yu Wang, Paul J. Lucassen & Jiang-Ning Zhou. (2020) Retinoic acid and depressive disorders: Evidence and possible neurobiological mechanisms. Neuroscience & Biobehavioral Reviews 112, pages 376-391.
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Changqiang Li, Jianmei Chen, Wo Wang, Ming Ai, Qi Zhang & Li Kuang. (2019) Use of isotretinoin and risk of depression in patients with acne: a systematic review and meta-analysis. BMJ Open 9:1, pages e021549.
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Alessandra Suuberg. (2019) Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris. Current Therapeutic Research 90, pages 27-31.
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Caroline S Costa, Ediléia Bagatin, Ana Luiza C Martimbianco, Edina MK da Silva, Marília M Lúcio, Parker Magin & Rachel Riera. (2018) Oral isotretinoin for acne. Cochrane Database of Systematic Reviews 2019:2.
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Mohammed Al Alawi, Hamed Al Sinawi, Al Mutasim Al Qasabi, Al Moatasem Al Mamari, Sathiya Murthi Panchatcharam & Samir Al-Adawi. (2018) Prevalence and predictors of depressive symptoms among attendees of a tertiary care dermatology clinic in Muscat, Oman. International Journal of Dermatology 57:3, pages 284-290.
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Mio Nakamura, Sahil Sekhon, Amanda Raymond & John Koo. 2018. Biologic and Systemic Agents in Dermatology. Biologic and Systemic Agents in Dermatology 221 231 .
Yu-Chen Huang & Ying-Chih Cheng. (2017) Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis. Journal of the American Academy of Dermatology 76:6, pages 1068-1076.e9.
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Bella Suarez, Ana Serrano, Yves Cova & Trino Baptista. (2016) Isotretinoin was not associated with depression or anxiety: A twelve-week study. World Journal of Psychiatry 6:1, pages 136.
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Michael Romano & Robert P. Dellavalle. 2014. Evidence-Based Dermatology. Evidence-Based Dermatology 85 105 .
. (2013) Isotretinoin therapy for acne is associated with controversial issues regarding specific adverse effects. Drugs & Therapy Perspectives 29:10, pages 321-323.
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Alena Borovaya, Olga Olisova, Thomas Ruzicka & Miklós Sárdy. (2013) Does isotretinoin therapy of acne cure or cause depression?. International Journal of Dermatology 52:9, pages 1040-1052.
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Stephen E. Wolverton & Julie C. Harper. (2013) Important Controversies Associated with Isotretinoin Therapy for Acne. American Journal of Clinical Dermatology 14:2, pages 71-76.
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Zuzana Nevoralová & Dagmar Dvořáková. (2013) Mood changes, depression and suicide risk during isotretinoin treatment: a prospective study. International Journal of Dermatology 52:2, pages 163-168.
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Caroline S Costa, Ediléia Bagatin, Edina MK da Silva, Marília M Lúcio, Parker Magin & Rachel Riera. (2011) Oral isotretinoin for acne. Cochrane Database of Systematic Reviews.
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Chelsea J. Hodgkiss-Harlow, Lawrence F. Eichenfield & Magdalene A. Dohil. (2011) Effective monitoring of isotretinoin safety in a pediatric dermatology population: A novel “patient symptom survey” approach. Journal of the American Academy of Dermatology 65:3, pages 517-524.
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. 2011. British Association of Dermatologists' Management Guidelines. British Association of Dermatologists' Management Guidelines 205 317 .
P. Wolkenstein. (2010) Isotretinoin, Depression, and the Media. Annales de Dermatologie et de Vénéréologie 137:12, pages 22-24.
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Jennifer N. Griffin, Daniel Pinali, Kaylan Olds, Na Lu, Lindsay Appleby, Louis Doan & Michelle A. Lane. (2010) 13-Cis-retinoic acid decreases hypothalamic cell number in vitro. Neuroscience Research 68:3, pages 185-190.
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P. Wolkenstein. (2010) Isotrétinoïne et dépression : un sujet médiatisé. Annales de Dermatologie et de Vénéréologie 137, pages S69-S71.
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M.J.D. Goodfield, N.H. Cox, A. Bowser, J.C. McMillan, L.G. Millard, N.B. Simpson & A.D. Ormerod. (2010) Advice on the safe introduction and continued use of isotretinoin in acne in the U.K. 2010. British Journal of Dermatology 162:6, pages 1172-1179.
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PJ Magin, CD Pond, WT Smith & SM Goode. (2009) Acne's relationship with psychiatric and psychological morbidity: results of a school‐based cohort study of adolescents. Journal of the European Academy of Dermatology and Venereology 24:1, pages 58-64.
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LMH Rehn, E Meririnne, J Höök-Nikanne, E Isometsä & M Henriksson. (2009) Depressive symptoms and suicidal ideation during isotretinoin treatment: a 12-week follow-up study of male Finnish military conscripts. Journal of the European Academy of Dermatology and Venereology 23:11, pages 1294-1297.
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Yesim Kaymak, Ender Taner & Yasemen Taner. (2009) Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents. International Journal of Dermatology 48:1, pages 41-46.
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Sabien van Neerven, Eric Kampmann & Jörg Mey. (2008) RAR/RXR and PPAR/RXR signaling in neurological and psychiatric diseases. Progress in Neurobiology 85:4, pages 433-451.
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J. Douglas Bremner & Peter McCaffery. (2008) The neurobiology of retinoic acid in affective disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry 32:2, pages 315-331.
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. (2008) Argumentaire. Annales de Dermatologie et de Vénéréologie 135, pages 75-136.
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Ann L. Marqueling & Lee T. Zane. (2007) Depression and Suicidal Behavior in Acne Patients Treated With Isotretinoin: A Systematic Review. Seminars in Cutaneous Medicine and Surgery 26:4, pages 210-220.
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Sherry A. Ferguson, F. Javier Cisneros, Joseph P. Hanig & Kimberly J. Berry. (2007) Oral treatment with ACCUTANE® does not increase measures of anhedonia or depression in rats. Neurotoxicology and Teratology 29:6, pages 642-651.
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Kally C O'Reilly, Jason Shumake, F Gonzalez-Lima, Michelle A Lane & Sarah J Bailey. (2006) Chronic Administration of 13-Cis-Retinoic Acid Increases Depression-Related Behavior in Mice. Neuropsychopharmacology 31:9, pages 1919-1927.
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Sherry A. Ferguson, F. Javier Cisneros, B. Gough, Joseph P. Hanig & Kimberly J. Berry. (2005) Chronic Oral Treatment with 13-cis-Retinoic Acid (Isotretinoin) or all-trans-Retinoic Acid Does Not Alter Depression-Like Behaviors in Rats. Toxicological Sciences 87:2, pages 451-459.
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Ann L. Marqueling & Lee T. Zane. (2005) Depression and Suicidal Behavior in Acne Patients Treated With Isotretinoin: A Systematic Review. Seminars in Cutaneous Medicine and Surgery 24:2, pages 92-102.
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A. Tirado Sánchez & G. León Dorantes. (2005) Disfunción eréctil durante el tratamiento con isotretinoína. Actas Urológicas Españolas 29:10, pages 974-976.
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Gerd Plewig. 2005. Fortschritte der praktischen Dermatologie und Venerologie. Fortschritte der praktischen Dermatologie und Venerologie 245 258 .
Alessandra Suuberg. (2018) Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris. SSRN Electronic Journal.
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