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Therapy

A dose-finding trial with a novel ingenol derivative (ingenol disoxate: LEO 43204) for field treatment of actinic keratosis on full face or 250 cm2 on the chest

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Pages 652-658 | Received 07 Dec 2016, Accepted 17 Feb 2017, Published online: 04 Apr 2017

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Elias A. T. Koch, Anja Wessely, Theresa Steeb, Carola Berking & Markus V. Heppt. (2021) Safety of topical interventions for the treatment of actinic keratosis. Expert Opinion on Drug Safety 20:7, pages 801-814.
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Si-Jia Xiao, Shan-Shan Li, Bin Xie, Wei Chen, Xi-Ke Xu, Xian-Peng Zu & Yun-Heng Shen. (2021) Systematic characterization of metabolic profiles of ingenol in rats by UPLC-Q/TOF-MS and NMR in combination with microbial biotransformation. RSC Advances 11:60, pages 37752-37759.
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Edward Lain, Torsten Skov & Anders Hall. (2017) Pharmacokinetics and Safety of Ingenol Disoxate Gel Administered Under Maximum-Use Conditions to Patients With Actinic Keratosis. Clinical Drug Investigation 38:3, pages 249-257.
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Eve Lebas, Charlotte Castronovo, Jorge E. Arrese, Florence Libon, Nazli Tassoudji, Laurence Seidel & Arjen F. Nikkels. (2017) Prospective Pilot Evaluation of the Efficacy and Safety of Topical Ingenol Mebutate Gel for Localized Patch/Plaque Stage Mycosis Fungoides. The Open Dermatology Journal 11:1, pages 98-107.
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P. Arenberger & M. Arenbergerova. (2017) New and current preventive treatment options in actinic keratosis. Journal of the European Academy of Dermatology and Venereology 31, pages 13-17.
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