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Comparing the efficacy of topical hydroquinone 2% versus intradermal tranexamic acid microinjections in treating melasma: a split-face controlled trial

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Pages 405-410 | Received 06 Jul 2017, Accepted 09 Sep 2017, Published online: 09 Nov 2017

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Nader Pazyar, Reza Yaghoobi, Maryam Zeynalie & Samin Vala. (2019) Comparison of the efficacy of intradermal injected tranexamic acid vs hydroquinone cream in the treatment of melasma. Clinical, Cosmetic and Investigational Dermatology 12, pages 115-122.
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Articles from other publishers (25)

Zou Jia, Kai Tian, Yuanyuan Zhong, Xiaoyun Wang, Suyue Gao, Wushuang Xu, Ke Li & Lijun Wu. (2023) Effectiveness of combination therapy of broadband light and intradermal injection of tranexamic acid in the treatment of chloasma. Journal of Cosmetic Dermatology 22:5, pages 1536-1544.
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Nazila Poostiyan, Maryam Alizadeh, Zabihollah Shahmoradi & Farahnaz Fatemi Naeini. (2023) Tranexamic acid microinjections versus tranexamic acid mesoneedling in the treatment of facial melasma: A randomized assessor‐blind split‐face controlled trial. Journal of Cosmetic Dermatology 22:4, pages 1238-1244.
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Rashmi Sarkar, Evangeline B. Handog, Anupam Das, Anuva Bansal, Ma. Juliet Macarayo, Vinay Keshavmurthy, Vignesh Narayan, Soumya Jagadeesan, Eugenio Pipo, Grace Monica Ibaviosa, Indrashis Podder & Shivani Bansal. (2023) Topical and Systemic Therapies in Melasma: A Systematic Review. Indian Dermatology Online Journal 14:6, pages 769-781.
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Zuzanna Piętowska, Danuta Nowicka & Jacek C. Szepietowski. (2022) Understanding Melasma-How Can Pharmacology and Cosmetology Procedures and Prevention Help to Achieve Optimal Treatment Results? A Narrative Review. International Journal of Environmental Research and Public Health 19:19, pages 12084.
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Shigref Mushtaq, Syeda Sibgha Naz, Muhammad Rizwan, Nudrat Jehangir Khan, Obed Ullah & Anjum Muhammad. (2022) Comparison of the Efficacy of Intralesional Tranexamic Acid Versus Topical 4% Hydroquinone in Treating Melasma. Cureus.
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O T B. Sarah, Abeer Attia Tawfik, Mona Soliman, Eman Shaarawy & Noha Abdallah. (2022) A Dermoscopic Evaluation of Melasma Treated with Tranexamic Acid. Open Access Macedonian Journal of Medical Sciences 10:B, pages 1686-1691.
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Shereen O. Tawfic, Rania M. Abdel Hay, Dina I. Abouelazm & Eman R. Said. (2022) Tranexamic Acid Microinjection Alone Versus Its Combination With Fractional Carbon Dioxide Laser in Melasma Treatment: A Dermoscopic Evaluation. Dermatologic Surgery 48:5, pages 556-561.
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Nader Pazyar, Seyedeh Nasrin Molavi, Parisa Hosseinpour, Maryam Hadibarhaghtalab, Seyedeh Yasamin Parvar & Motahareh Babazadeh Dezfuly. (2022) Efficacy of intradermal injection of tranexamic acid and ascorbic acid versus tranexamic acid and placebo in the treatment of melasma: A split‐face comparative trial. Health Science Reports 5:2.
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Pawan Gupta, Shital Poojary & Lily Dubey. (2022) A randomized comparative study of intralesional tranexemic acid and Kligman’s regimen in Indian patients with melasma. Journal of Cutaneous and Aesthetic Surgery 15:2, pages 135.
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Maryam Khalili, Rezvan Amiri, Behzad Iranmanesh, Hamed Zartab & Mahin Aflatoonian. (2021) Safety and efficacy of mesotherapy in the treatment of melasma: A review article. Journal of Cosmetic Dermatology 21:1, pages 118-129.
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Mohamed S. Zaky, Zakaria M. Obaid, Eman A. Khalil & Mohamed L. Elsaie. (2021) Microneedling‐assisted topical tranexamic acid solution versus 4% hydroquinone for treating melasma: A split‐face randomized study. Journal of Cosmetic Dermatology 20:12, pages 4011-4016.
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Xiaowei Feng, Hong Su & Jinwei Xie. (2021) Efficacy and safety of tranexamic acid in the treatment of adult melasma: An updated meta‐analysis of randomized controlled trials. Journal of Clinical Pharmacy and Therapeutics 46:5, pages 1263-1273.
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Yi Liu, Shanshan Wu, Haixuan Wu, Xuelei Liang, Dechao Guo & Fenglin Zhuo. (2021) Comparison of the Efficacy of Melasma Treatments: A Network Meta-Analysis of Randomized Controlled Trials. Frontiers in Medicine 8.
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Jennifer Nguyen, Harini Rajgopal Bala, Angelique Ross, Celestine C Wong, Eldho Paul & Michelle Rodrigues. (2020) Effect of oral tranexamic acid on erythema index in patients with melasma. Australasian Journal of Dermatology 62:2, pages 206-209.
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Yan Qu, Fengjuan Wang, Junru Liu & Xiujuan Xia. (2021) Clinical observation and dermoscopy evaluation of fractional CO 2 laser combined with topical tranexamic acid in melasma treatments . Journal of Cosmetic Dermatology 20:4, pages 1110-1116.
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Khadiga S. Sayed, Samar Tuqan & Rana F. Hilal. (2020) Q‐Switched Nd:YAG (532 nm) Laser Versus Intra‐Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial. Lasers in Surgery and Medicine 53:3, pages 324-332.
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Yu.I. Vashkevich & V.V. Krumkachou. (2021) Analysis of the use of tranexamic acid for the treatment of melasma. Klinicheskaya dermatologiya i venerologiya 20:1, pages 157.
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Abeba T. Giorgis, Amer F. Alsoudi, Abiye M. Alemu, Tesfaye Tadesse, Jibat Gemida, Kalekirstos Taye, Mhretab Zeru, Caitlin A. Moe, Robert L. Stamper & Jeremy D. Keenan. (2020) The Relationship Between Melanin and Glaucoma: A Case-control Study. Journal of Glaucoma 29:12, pages 1143-1146.
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Simin Shamsi Meymandi, Amirhossein Mozayyeni, Manzumeh Shamsi Meymandi & Mahin Aflatoonian. (2020) Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single‐blind randomized clinical trial. Journal of Cosmetic Dermatology 19:11, pages 2906-2911.
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Rania El‐Husseiny, Noha Rakha & Mohamad Sallam. (2020) Efficacy and safety of tranexamic acid 5% cream vs hydroquinone 4% cream in treating melasma: A split‐face comparative clinical, histopathological, and antera 3D camera study. Dermatologic Therapy 33:6.
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E. Forbat, F. Al‐Niaimi & F.R. Ali. (2019) The emerging importance of tranexamic acid in dermatology. Clinical and Experimental Dermatology 45:4, pages 445-449.
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Jacqueline McKesey, Andrea Tovar-Garza & Amit G. Pandya. (2019) Melasma Treatment: An Evidence-Based Review. American Journal of Clinical Dermatology 21:2, pages 173-225.
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Jian-Wei Zhu, Ya-Jie Ni, Xiao-Yun Tong, Xia Guo & Xiao-Ping Wu. (2020) Activation of VEGF receptors in response to UVB promotes cell proliferation and melanogenesis of normal human melanocytes. Experimental Cell Research 387:2, pages 111798.
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Huijuan Zhao, Mengna Li, Xiaofeng Zhang, Li Li, Yan Yan & Baoxi Wang. (2019) Comparing the efficacy of Myjet‐assisted tranexamic acid and vitamin C in treating melasma: A split‐face controlled trial. Journal of Cosmetic Dermatology 19:1, pages 47-54.
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Soon‐Hyo Kwon, Jung‐Im Na, Ji‐Young Choi & Kyoung‐Chan Park. (2018) Melasma: Updates and perspectives. Experimental Dermatology 28:6, pages 704-708.
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