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Research Article

Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines

Pages 633-639 | Published online: 03 Jul 2009

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Stephanie E. Combs, Jessica Bohl, Thilo Elsässer, Klaus-Josef Weber, Daniela Schulz-Ertner, Jürgen Debus & Wilma K. Weyrather. (2009) Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines. International Journal of Radiation Biology 85:2, pages 126-137.
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Linda S. Yasui, Christine Andorf, Linda Schneider, Thomas Kroc, Arlene Lennox & K. R. Saroja. (2008) Gadolinium neutron capture in glioblastoma multiforme cells. International Journal of Radiation Biology 84:12, pages 1130-1139.
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Meric A. Altinoz, Yasemin Ucal, Muazzez C. Yilmaz, İrem Kiris, Ozan Ozisik, Ugur Sezerman, Aysel Ozpinar & İlhan Elmaci. (2020) Progesterone at high doses reduces the growth of U87 and A172 glioblastoma cells: Proteomic changes regarding metabolism and immunity. Cancer Medicine 9:16, pages 5767-5780.
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Zhongyou Que, Ping Wang, Yi Hu, Yixue Xue, Xiaobai Liu, Chengbin Qu, Jun Ma & Yunhui Liu. (2017) Dihydroartemisin inhibits glioma invasiveness via a ROS to P53 to β-catenin signaling. Pharmacological Research 119, pages 72-88.
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Jiann-Gwu Lee, Yan-Shiu Wang & Chin-Cheng Chou. (2014) Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines. Toxicology in Vitro 28:4, pages 562-570.
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Xiao-Yue Zhang, Xiao-Qi Wu, Rong Deng, Ting Sun, Gong-Kan Feng & Xiao-Feng Zhu. (2013) Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells. Cellular Signalling 25:1, pages 150-158.
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Driffa Moussata, Souheila Amara, Bénazir Siddeek, Myriam Decaussin, Stephanie Hehlgans, Rachel Paul-Bellon, Françoise Mornex, Jean-Pierre Gerard, Pascale Romestaing, Franz Rödel, Bernard Flourie, Mohamed Benahmed & Claire Mauduit. (2012) XIAP as a Radioresistance Factor and Prognostic Marker for Radiotherapy in Human Rectal Adenocarcinoma. The American Journal of Pathology 181:4, pages 1271-1278.
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Navrinder Kaur, Atul Ranjan, Vinod Tiwari, Ritu Aneja & Vibha Tandon. (2012) DMA, a Bisbenzimidazole, Offers Radioprotection by Promoting NFκB Transactivation through NIK/IKK in Human Glioma Cells. PLoS ONE 7:6, pages e39426.
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Diana Grochová & Jana Šmardová. (2007) The antimutagenic and cytoprotective effects of amifostine: the role of p53. Journal of Applied Biomedicine 5:4, pages 171-178.
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Minghua Wu, Chen Huang, Kai Gan, He Huang, Qiong Chen, Jue Ouyang, Yunlian Tang, Xiaoling Li, Yixin Yang, Houde Zhou, Yanhong Zhou, Zhaoyang Zeng, Lan Xiao, Dan Li, Ke Tang, Shourong Shen & Guiyuan Li. (2006) LRRC4 , a Putative Tumor Suppressor Gene, Requires a Functional Leucine-rich Repeat Cassette Domain to Inhibit Proliferation of Glioma Cells In Vitro by Modulating the Extracellular Signal-regulated Kinase/Protein Kinase B/Nuclear Factor-κB Pathway . Molecular Biology of the Cell 17:8, pages 3534-3542.
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A Pataer, M A Fanale, J A Roth, S G Swisher & K K Hunt. (2006) Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Therapy 13:8, pages 806-814.
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Victoria Findlay, Danyelle Townsend & Kenneth Tew. 2006. Toxicology of Glutathione Transferases. Toxicology of Glutathione Transferases 155 178 .
Olivier Pluquet, Sophie North, Anindita Bhoumik, Konstantinos Dimas, Ze'ev Ronai & Pierre Hainaut. (2003) The Cytoprotective Aminothiol WR1065 Activates p53 through a Non-genotoxic Signaling Pathway Involving c-Jun N-terminal Kinase. Journal of Biological Chemistry 278:14, pages 11879-11887.
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Andrei V Budanov, Tzipora Shoshani, Alexander Faerman, Elena Zelin, Iris Kamer, Hagar Kalinski, Svetlana Gorodin, Alla Fishman, Ayelet Chajut, Paz Einat, Rami Skaliter, Andrei V Gudkov, Peter M Chrumakov & Elena Feinstein. (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 21:39, pages 6017-6031.
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Jeffrey S. Murley, Yasushi Kataoka, Christine J. Weydert, Larry W. Oberley & David J. Grdina. (2002) Delayed Cytoprotection after Enhancement of Sod2 ( MnSOD ) Gene Expression in SA-NH Mouse Sarcoma Cells Exposed to WR-1065, the Active Metabolite of Amifostine . Radiation Research 158:1, pages 101-109.
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Yasushi Kataoka, Jeffrey S Murley, Nikolai N Khodarev, Ralph R Weichselbaum & David J Grdina. (2002) Activation of the nuclear transcription factor κB (NFκB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. International Journal of Radiation Oncology*Biology*Physics 53:1, pages 180-189.
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MI Koukourakis. (2002) Amifostine in clinical oncology: current use and future applications. Anti-Cancer Drugs 13:3, pages 181-209.
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David J. Grdina, Jeffrey S. Murley, Yasushi Kataoka & Douglas P. Calvin. (2002) Differential activation of nuclear transcription factor κB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells. Seminars in Radiation Oncology 12:1, pages 103-111.
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Nikolai N. Khodarev, James O. Park, Jianqing Yu, Nalin Gupta, Edwardine Nodzenski, Bernard Roizman & Ralph R. Weichselbaum. (2001) Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts. Proceedings of the National Academy of Sciences 98:22, pages 12665-12670.
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D.J. Grdina, Y. Kataoka & J.S. Murley. (2000) Amifostine: Mechanisms of Action Underlying Cytoprotection and Chemoprevention. Drug Metabolism and Drug Interactions 16:4.
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