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Research Article

Effects of low dose irradiation on TK6 and U937 cells: induction of p53 and its role in cell-cycle delay and the adaptive response

Pages 11-21 | Published online: 03 Jul 2009

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Jeffrey L. Schwartz, Robert Jordan, Jana Slovic, Audrey M. Moruzzi, Robert R. Kimmel & Howard L. Liber. (2007) Induction and loss of a TP53-dependent radioadaptive response in the human lymphoblastoid cell model TK6 and its abrogation by BCL2 over-expression. International Journal of Radiation Biology 83:3, pages 153-159.
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I Szumiel. (2005) Adaptive response: stimulated DNA repair or decreased damage fixation?. International Journal of Radiation Biology 81:3, pages 233-241.
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Krzysztof W. Fornalski, Łukasz Adamowski, Ludwik Dobrzyński, Rafał Jarmakiewicz, Aleksandra Powojska & Joanna Reszczyńska. (2022) The radiation adaptive response and priming dose influence: the quantification of the Raper–Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations. Radiation and Environmental Biophysics 61:2, pages 221-239.
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Md Gulam Musawwir Khan & Yi Wang. (2022) Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle. Cells 11:3, pages 356.
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Guozi Yang, Wei Li, Hongyu Jiang, Xinyue Liang, Yuguang Zhao, Dehai Yu, Lei Zhou, Guanjun Wang, Huimin Tian, Fujun Han, Lu Cai & Jiuwei Cui. (2016) Low‐dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics. International Journal of Cancer 139:10, pages 2157-2168.
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YONG XIN, HAI-BIN ZHANG, TIAN-YOU TANG, GUI-HONG LIU, JIAN-SHE WANG, GUAN JIANG & LONG-ZHEN ZHANG. (2014) Low-dose radiation-induced apoptosis in human leukemia K562 cells through mitochondrial pathways. Molecular Medicine Reports 10:3, pages 1569-1575.
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Valerii E. Orel, Anatoliy D. Shevchenko, Nikolay A. Nikolov, Andriy V. Romanov, Alexander Y. Rykhalskyi, Anatoliy P. Burlaka, Sergey N. Lukin, Natalya N. Dzyatkovskaya & Igor B. Shchepotin. (2014) Comparative Study of Magnetic Properties and Antitumor Effect of Nanocomplexes from Oxides Iron Nanoparticles and Doxorubicin During Radio-Frequency Hyperthermia of the Walker-256 Carcinosarcoma. Nano LIFE 04:02, pages 1450003.
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Jing Yang, Takayuki Ikezoe, Chie Nishioka & Akihito Yokoyama. (2013) A novel treatment strategy targeting shugoshin 1 in hematological malignancies. Leukemia Research 37:1, pages 76-82.
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G. D. Zasukhina. (2011) Mechanisms of human cell resistance to mutagens. Biology Bulletin Reviews 1:6, pages 496-508.
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Guillaume Varès, Bing Wang, Kaoru Tanaka, Ayana Kakimoto, Kyomi Eguchi-Kasai & Mitsuru Nenoi. (2011) Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to low doses of heavy-ion radiation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 712:1-2, pages 49-54.
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Guillaume Varès, Bing Wang, Kaoru Tanaka, Ayana Kakimoto, Kyomi Eguchi-Kasai & Mitsuru Nenoi. (2011) Mutagenic adaptive response to high-LET radiation in human lymphoblastoid cells exposed to X-rays. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 706:1-2, pages 46-52.
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Akihisa Takahashi, Xiaoming Su, Hiromi Suzuki, Katsunori Omori, Masaya Seki, Toko Hashizume, Toru Shimazu, Noriaki Ishioka, Toshiyasu Iwasaki & Takeo Ohnishi. (2010) 53-Dependent Adaptive Responses in Human Cells Exposed to Space Radiations. International Journal of Radiation Oncology*Biology*Physics 78:4, pages 1171-1176.
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Dexiao Yuan, Yan Pan, Jianghong Zhang & Chunlin Shao. (2010) Role of nuclear factor-κB and P53 in radioadaptive response in Chang live cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 688:1-2, pages 66-71.
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Ki Moon Seong, Cha Soon Kim, Ha Yeon Jeon, Sin-Hye Oh, Seon Young Nam, Kwang Hee Yang, Ji-Young Kim & Young-Woo Jin. (2010) Intrinsic radiosensitivity correlated with radiation-induced ROS and cell cycle regulation. Molecular & Cellular Toxicology 6:1, pages 1-7.
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Akihisa Takahashi, Aiko Nagamatsu, Xiaoming Su, Masao Suzuki, Chizuru Tsuruoka, Katsunori Omori, Hiromi Suzuki, Toru Shimazu, Masaya Seki, Toko Hashizume, Toshiyasu Iwasaki, Noriaki Ishioka & Takeo Ohnishi. (2010) The First Life Science Experiments in ISS: Reports of "Rad Gene"-Space Radiation Effects on Human Cultured Cells-. Biological Sciences in Space 24:1, pages 17-41.
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Min Zhang, RuiPeng Wang, YanYi Wang, FeiCi Diao, Fei Lu, Dong Gao, DanYing Chen, ZhongHe Zhai & HongBing Shu. (2009) The CXXC finger 5 protein is required for DNA damage-induced p53 activation. Science in China Series C: Life Sciences 52:6, pages 528-538.
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Sheng-Yow Ho, Wei-Chih Chen, Hui-Wen Chiu, Ching-Shu Lai, How-Ran Guo & Ying-Jan Wang. (2009) Combination treatment with arsenic trioxide and irradiation enhances apoptotic effects in U937 cells through increased mitotic arrest and ROS generation. Chemico-Biological Interactions 179:2-3, pages 304-313.
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A. Takahashi & T. Ohnishi. (2009) A low dose pre-irradiation induces radio- and heat-resistance via HDM2 and NO radicals, and is associated with p53 functioning. Advances in Space Research 43:8, pages 1185-1192.
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Gaëtan Gruel, Pascale Voisin, Aurélie Vaurijoux, Sandrine Roch-Lefevre, Eric Grégoire, Peggy Maltere, Cyrille Petat, Xavier Gidrol, Philippe Voisin & Laurence Roy. (2008) Broad Modulation of Gene Expression in CD4 + Lymphocyte Subpopulations in Response to Low Doses of Ionizing Radiation . Radiation Research 170:3, pages 335-344.
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Akihisa Takahashi, Hideki Matsumoto & Takeo Ohnishi. (2008) Hdm2 and Nitric Oxide Radicals Contribute to the P53-Dependent Radioadaptive Response. International Journal of Radiation Oncology*Biology*Physics 71:2, pages 550-558.
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Hongyu JIANG, Wei LI, Xiuyi LI, Lu CAI & Guanjun WANG. (2008) Low-Dose Radiation Induces Adaptive Response in Normal Cells, but not in Tumor Cells: In vitro and in vivo Studies. Journal of Radiation Research 49:3, pages 219-230.
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Janice M. Pluth, Vikky Yamazaki, Brian A. Cooper, Bjorn E. Rydberg, Cordula U. Kirchgessner & Priscilla K. Cooper. (2008) DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells. DNA Repair 7:1, pages 108-118.
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Kurt Hafer, Keisuke K. Iwamoto, Zorica Scuric & Robert H. Schiestl. (2007) Adaptive Response to Gamma Radiation in Mammalian Cells Proficient and Deficient in Components of Nucleotide Excision Repair. Radiation Research 168:2, pages 168-174.
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Soile Tapio & Vesna Jacob. (2006) Radioadaptive response revisited. Radiation and Environmental Biophysics 46:1, pages 1-12.
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Sheng-Yow Ho, Po-Chang Huang, How-Ran Guo, Wen-Huei Chang, Rong-Jane Chen, Bai-Lu Wei, Wei-Jr Wu, Chein Tai & Ying-Jan Wang. (2006) Mechanisms of Apoptosis Induction and Cell Cycle Regulation in Irradiated Leukemia U937 Cells and Enhancement by Arsenic Trioxide. Radiation Research 165:4, pages 390-399.
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G. D. Zasukhina. (2005) Mechanisms of human cell protection associated with genetic polymorphism. Russian Journal of Genetics 41:4, pages 412-424.
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Louise Enns, Kenneth T. Bogen, Juanita Wizniak, Albert D. Murtha & Michael Weinfeld. (2004) Low-Dose Radiation Hypersensitivity Is Associated With p53-Dependent Apoptosis. Molecular Cancer Research 2:10, pages 557-566.
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Yann Schneider, Barbara Fischer, David Coelho, Stamatiki Roussi, Francine Gosse, Pierre Bischoff & Francis Raul. (2004) (Z)-3,5,4′-Tri-O-methyl-resveratrol, induces apoptosis in human lymphoblastoid cells independently of their p53 status. Cancer Letters 211:2, pages 155-161.
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Timothy M. Pawlik & Khandan Keyomarsi. (2004) Role of cell cycle in mediating sensitivity to radiotherapy. International Journal of Radiation Oncology*Biology*Physics 59:4, pages 928-942.
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C. Fournier, C. Wiese & G. Taucher-Scholz. (2004) Accumulation of the Cell Cycle Regulators TP53 and CDKN1A (p21) in Human Fibroblasts after Exposure to Low- and High-LET Radiation. Radiation Research 161:6, pages 675-684.
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M. Inoue, G-P. Shen, M. A. Chaudhry, H. Galick, J. O. Blaisdell & S. S. Wallace. (2004) Expression of the Oxidative Base Excision Repair Enzymes is not Induced in TK6 Human Lymphoblastoid Cells after Low Doses of Ionizing Radiation. Radiation Research 161:4, pages 409-417.
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Yuri MIURA. (2004) Oxidative Stress, Radiation-Adaptive Responses, and Aging. Journal of Radiation Research 45:3, pages 357-372.
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E Mata-Greenwood, M Cuendet, D Sher, D Gustin, W Stock & JM Pezzuto. (2002) Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc. Leukemia 16:11, pages 2275-2284.
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Sudhir Chandna, B. S. Dwarakanath, Divya Khaitan, T. Lazar Mathew & Viney Jain. (2002) Low-Dose Radiation Hypersensitivity in Human Tumor Cell Lines: Effects of Cell–Cell Contact and Nutritional Deprivation. Radiation Research 157:5, pages 516-525.
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Detlef Bartkowiak, Stephanie Högner, Wilhelm Nothdurft & Erwin M Röttinger. (2001) Cell cycle and growth response of CHO cells to X-irradiation: Threshold-free repair at low doses. International Journal of Radiation Oncology*Biology*Physics 50:1, pages 221-227.
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S. Morimoto, A. Gordon, N. Fukunishi & F. Yatagai. (2001) Cellular responses by exposure to heavy-ions. Advances in Space Research 27:2, pages 401-409.
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A. Hendrikse, A. Hunter & G. Blekkenhorst. (2000) TP53 AS A BIOMARKER OF CYTOGENETIC DAMAGE. Health Physics 78:6, pages 753.
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