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Original Article

Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: Injury and recovery

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Pages 487-497 | Received 31 Aug 2007, Accepted 05 Mar 2008, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Brian L. Fish, Thomas J. MacVittie, Aniko Szabo, John E. Moulder & Meetha Medhora. (2020) WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP). International Journal of Radiation Biology 96:1, pages 81-92.
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Tyler A. Beach, Angela M. Groves, Jacqueline P. Williams & Jacob N. Finkelstein. (2020) Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation. International Journal of Radiation Biology 96:1, pages 129-144.
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Feng Gao, Brian L. Fish, Aniko Szabo, Ashley Schock, Jayashree Narayanan, Elizabeth R. Jacobs, John E. Moulder, Zelmira Lazarova & Meetha Medhora. (2014) Enhanced survival from radiation pneumonitis by combined irradiation to the skin. International Journal of Radiation Biology 90:9, pages 753-761.
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Michael G. Haase, Knut Liepe, Diana Faulhaber, Gerd Wunderlich, Michael Andreeff, Roland Jung, Gustavo B. Baretton, Guido Fitze & Jörg Kotzerke. (2013) Dose-dependent histological alterations in the rat lung following intravenous application of Re-188-labeled microspheres. International Journal of Radiation Biology 89:10, pages 863-869.
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Articles from other publishers (39)

Jie-Fu Fan, Yang-Kai Wang, Min Liu, Guang-Sheng Liu, Tian-Jiao Min, Rui-Yong Chen & Ying He. (2023) Effect of angiotensin II on irradiation exacerbated decompression sickness. Scientific Reports 13:1.
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Meetha Medhora, Feng Gao, Tracy Gasperetti, Jayashree Narayanan, Heather Himburg, Elizabeth R. Jacobs, Anne V. Clough, Brian L. Fish & Aniko Szabo. (2023) Biomarkers to Predict Lethal Radiation Injury to the Rat Lung. International Journal of Molecular Sciences 24:6, pages 5627.
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Soudeh Mostaghimi, Shima Mehrvar, Farnaz H. Foomani, Jayashree Narayanan, Brian Fish, Amadou K. S. Camara, Meetha Medhora & Mahsa Ranji. (2022) Vascular regression in the kidney: changes in 3D vessel structure with time post-irradiation. Biomedical Optics Express 13:8, pages 4338.
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Brian L. Fish, Thomas J. MacVittieFeng Gao, Jayashree Narayanan, Tracy Gasperetti, Dana Scholler, Yuri Sheinin, Heather A. Himburg, Barry Hart & Meetha Medhora. (2021) Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation. Health Physics 121:4, pages 419-433.
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Shachi Mehta, Vincent Aranzana-Climent, Blandine Rammaert, Nicolas Grégoire, Sandrine Marchand, William Couet & Julien M. Buyck. (2019) Preclinical Pharmacokinetic and Pharmacodynamic Data To Support Cefoxitin Nebulization for the Treatment of Mycobacterium abscessus. Antimicrobial Agents and Chemotherapy 63:7.
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Marek Lenarczyk, Amy Kronenberg, Marylou Mäder, Paula E. North, Richard Komorowski, Qunli Cheng, Mark P. Little, I-Hung Chiang, Chiara LaTessa, James Jardine & John E. Baker. (2019) Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats. Radiation Research 192:1, pages 63.
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Meetha Medhora, Feng GaoTracy GasperettiJayashree NarayananAbdul Hye KhanElizabeth R. Jacobs & Brian L. Fish. (2019) Delayed Effects of Acute Radiation Exposure (Deare) in Juvenile and Old Rats: Mitigation by Lisinopril. Health Physics 116:4, pages 529-545.
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Elizabeth R. Jacobs, Jayashree NarayananBrian L. FishFeng GaoLeanne M. Harmann, Carmen BergomTracy GasperettiJennifer L. Strande & Meetha Medhora. (2019) Cardiac Remodeling and Reversible Pulmonary Hypertension During Pneumonitis in Rats after 13-Gy Partial-Body Irradiation with Minimal Bone Marrow Sparing: Effect of Lisinopril. Health Physics 116:4, pages 558-565.
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N L Ford, S Tan & P Deman. (2019) An investigation of radiation damage in rat lungs following dual-energy micro-CT imaging. Biomedical Physics & Engineering Express 5:2, pages 025005.
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Barbara Lamy, Frederic Tewes, Dolores Remedios Serrano, Isabelle Lamarche, Patrice Gobin, William Couet, Anne Marie Healy & Sandrine Marchand. (2018) New aerosol formulation to control ciprofloxacin pulmonary concentration. Journal of Controlled Release 271, pages 118-126.
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. (2018) Optical metabolic imaging of irradiated rat heart exposed to ischemia–reperfusion injury. Journal of Biomedical Optics 23:01, pages 1.
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Bu-Yeo Kim, Hee Jin, Yoon-Jin Lee, Ga-Young Kang, Jaeho Cho & Yun-Sil Lee. (2016) Focal exposure of limited lung volumes to high-dose irradiation down-regulated organ development-related functions and up-regulated the immune response in mouse pulmonary tissues. BMC Genetics 17:1.
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Meetha Medhora, Steven Haworth, Yu Liu, Jayashree Narayanan, Feng Gao, Ming Zhao, Said Audi, Elizabeth R. Jacobs, Brian L. Fish & Anne V. Clough. (2016) Biomarkers for Radiation Pneumonitis Using Noninvasive Molecular Imaging. Journal of Nuclear Medicine 57:8, pages 1296-1301.
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Jong-Geol Lee, Sunhoo Park, Chang-Hwan Bae, Won-Suk Jang, Sun-Joo Lee, Dal Nim Lee, Jae Kyung Myung, Cheol Hyeon Kim, Young-Woo Jin, Seung-Sook Lee & Sehwan Shim. (2016) Development of a minipig model for lung injury induced by a single high-dose radiation exposure and evaluation with thoracic computed tomography. Journal of Radiation Research 57:3, pages 201-209.
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Eric P. Cohen, Brian L. Fish & John E. Moulder. (2016) Clinically Relevant Doses of Enalapril Mitigate Multiple Organ Radiation Injury. Radiation Research 185:3, pages 313-318.
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Meetha Medhora, Feng Gao, Chad Glisch, Jayashree Narayanan, Ashish Sharma, Leanne M. Harmann, Michael W. Lawlor, Laura A. Snyder, Brian L. Fish, Julian D. Down, John E. Moulder, Jennifer L. Strande & Elizabeth R. Jacobs. (2015) Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling. Journal of Radiation Research 56:2, pages 248-260.
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Meetha Medhora, Feng Gao, Qingping Wu, Robert C. Molthen, Elizabeth R. Jacobs, John E. Moulder & Brian L. Fish. (2014) Model Development and Use of ACE Inhibitors for Preclinical Mitigation of Radiation-Induced Injury to Multiple Organs. Radiation Research 182:5, pages 545-555.
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Feng Gao, Brian L. Fish, John E. Moulder, Elizabeth R. Jacobs & Meetha Medhora. (2013) Enalapril Mitigates Radiation-Induced Pneumonitis and Pulmonary Fibrosis if Started 35 Days after Whole-Thorax Irradiation. Radiation Research 180:5, pages 546-552.
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Richard E. Jacob, Mark K. Murphy, Jeffrey A. Creim & James P. Carson. (2013) Detecting Radiation-Induced Injury Using Rapid 3D Variogram Analysis of CT Images of Rat Lungs. Academic Radiology 20:10, pages 1264-1271.
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Julian D. Down, Meetha Medhora, Isabel L. Jackson, J. Mark Cline & Zeljko Vujaskovic. (2013) Do Variations in Mast Cell Hyperplasia Account for Differences in Radiation-Induced Lung Injury among Different Mouse Strains, Rats and Nonhuman Primates?. Radiation Research 180:2, pages 216-221.
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Feng Gao, Jayashree Narayanan, Cortney Joneikis, Brian L. Fish, Aniko Szabo, John E. Moulder, Robert C. Molthen, Elizabeth R. Jacobs, R. Nagarjun Rao & Meetha Medhora. (2013) Enalapril Mitigates Focal Alveolar Lesions, A Histological Marker of Late Pulmonary Injury by Radiation to the Lung. Radiation Research 179:4, pages 465-474.
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Rong Zhang, Huifang Niu, Ning Wang, Lihua Sun, Yi Xu, Ruibo Zhao, Xiang Ban, Yao Yu, Baofeng Yang & Jing Ai. (2012) Daming capsule restores endothelial dysfunction induced by high-fat diet. BMC Complementary and Alternative Medicine 12:1.
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Feng Gao, Brian L. Fish, Aniko Szabo, Susan R. Doctrow, Lakhan Kma, Robert C. Molthen, John E. Moulder, Elizabeth R. Jacobs & Meetha Medhora. (2012) Short-Term Treatment with a SOD/Catalase Mimetic, EUK-207, Mitigates Pneumonitis and Fibrosis after Single-Dose Total-Body or Whole-Thoracic Irradiation. Radiation Research 178:5, pages 468-480.
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Feng Gao, Brian L. Fish, Aniko Szabo, Susan R. Doctrow, Lakhan Kma, Robert C. Molthen, John E. Moulder, Elizabeth R. Jacobs & Meetha Medhora. (2012) Short-Term Treatment with a SOD/Catalase Mimetic, EUK-207, Mitigates Pneumonitis and Fibrosis after Single-Dose Total-Body or Whole-Thoracic Irradiation. Radiation Research 178:5, pages 468-480.
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ROBERT C. MOLTHEN, QINGPING WU, BRIAN L. FISH, JOHN E. MOULDER, ELIZABETH R. JACOBS & MEETHA M. MEDHORA. (2012) Mitigation of radiation induced pulmonary vascular injury by delayed treatment with captopril. Respirology 17:8, pages 1261-1268.
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M. Medhora, F. Gao, B. L. Fish, E. R. Jacobs, J. E. Moulder & A. Szabo. (2012) Dose-modifying factor for captopril for mitigation of radiation injury to normal lung. Journal of Radiation Research 53:4, pages 633-640.
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Jacqueline P. Williams, Isabel L. Jackson, Jui R. Shah, Christine W. Czarniecki, Bert W. Maidment & Andrea L. DiCarlo. (2012) Animal Models and Medical Countermeasures Development for Radiation-Induced Lung Damage: Report from an NIAID Workshop. Radiation Research 177:5, pages e0025-e0039.
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Magda A. Mansour & Hanan S. Seleem. (2012) Evaluation of the beneficial efficacy of curcumin on experimental lung fibrosis of adult male albino rats. The Egyptian Journal of Histology 35:1, pages 95-105.
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Lakhan KMA, Feng GAO, Brian L. FISH, John E. MOULDER, Elizabeth R. JACOBS & Meetha MEDHORA. (2012) Angiotensin Converting Enzyme Inhibitors Mitigate Collagen Synthesis Induced by a Single Dose of Radiation to the Whole Thorax. Journal of Radiation Research 53:1, pages 10-17.
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MEETHA MEDHORA, FENG GAO, ELIZABETH R. JACOBS & JOHN E. MOULDER. (2012) Radiation damage to the lung: Mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology 17:1, pages 66-71.
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Melpo Christofidou-Solomidou, Sonia Tyagi, Kay-See Tan, Sarah Hagan, Ralph Pietrofesa, Floyd Dukes, Evguenia Arguiri, Daniel F Heitjan, Charalambos C Solomides & Keith A Cengel. (2011) Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice. BMC Cancer 11:1.
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William J Janssen, Lea Barthel, Alaina Muldrow, Rebecca E Oberley-Deegan, Mark T Kearns, Claudia Jakubzick & Peter M Henson. (2011) Fas Determines Differential Fates of Resident and Recruited Macrophages during Resolution of Acute Lung Injury. American Journal of Respiratory and Critical Care Medicine 184:5, pages 547-560.
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Robert P. Coppes, Christina T. Muijs, Hette Faber, Sascha Gross, Jacobus M. Schippers, Sytze Brandenburg, Johannes A. Langendijk & Peter van Luijk. (2011) Volume-Dependent Expression of In-Field and Out-of-Field Effects in the Proton-Irradiated Rat Lung. International Journal of Radiation Oncology*Biology*Physics 81:1, pages 262-269.
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William J. Janssen, Alaina Muldrow, Mark T. Kearns, Lea Barthel & Peter M. Henson. (2010) Development and characterization of a lung-protective method of bone marrow transplantation in the mouse. Journal of Immunological Methods 357:1-2, pages 1-9.
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Jacqueline P. Williams, Stephen L. Brown, George E. Georges, Martin Hauer-Jensen, Richard P. Hill, Amy K. Huser, David G. Kirsch, Thomas J. MacVittie, Kathy A. Mason, Meetha M. Medhora, John E. Moulder, Paul Okunieff, Mary F. Otterson, Michael E. Robbins, James B. Smathers & William H. McBride. (2010) Animal Models for Medical Countermeasures to Radiation Exposure. Radiation Research 173:4, pages 557-578.
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Sara Szabo, Swarajit N. Ghosh, Brian L. Fish, Sreedhar Bodiga, Rade Tomic, Gagan Kumar, Natalya V. Morrow, John E. Moulder, Elizabeth R. Jacobs & Meetha Medhora. (2010) Cellular Inflammatory Infiltrate in Pneumonitis Induced by a Single Moderate Dose of Thoracic X Radiation in Rats. Radiation Research 173:4, pages 545-556.
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Swarajit N. Ghosh, Rong Zhang, Brian L. Fish, Vladimir A. Semenenko, X. Allen Li, John E. Moulder, Elizabeth R. Jacobs & Meetha Medhora. (2009) Renin-Angiotensin System Suppression Mitigates Experimental Radiation Pneumonitis. International Journal of Radiation Oncology*Biology*Physics 75:5, pages 1528-1536.
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Kishore K. Wary, Stephen M. Vogel, Sean Garrean, Yidan D. Zhao & Asrar B. Malik. (2009) Requirement of α4β1 and α5β1 Integrin Expression in Bone-Marrow-Derived Progenitor Cells in Preventing Endotoxin-Induced Lung Vascular Injury and Edema in Mice. Stem Cells 27:12, pages 3112-3120.
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S.N. Ghosh, Q. Wu, M. Mäder, B.L. Fish, J.E. Moulder, E.R. Jacobs, M. Medhora & R.C. Molthen. (2009) Vascular Injury After Whole Thoracic X-Ray Irradiation in the Rat. International Journal of Radiation Oncology*Biology*Physics 74:1, pages 192-199.
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