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The influence of ketogenic therapy on the 5 R’s of radiobiology

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Pages 394-407 | Received 16 Aug 2017, Accepted 05 Sep 2017, Published online: 09 Oct 2017

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Alireza Amanollahi, Maryam Khazdouz, Mahsa Malekahmadi, Rainer J. Klement, Derek Lee & Adeleh Khodabakhshi. (2023) Effect of Ketogenic Diets on Cardio-Metabolic Outcomes in Cancer Patients: A Systematic Review and Meta-Analysis of Controlled Clinical Trials. Nutrition and Cancer 75:1, pages 95-111.
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Luigi Barrea, Massimiliano Caprio, Dario Tuccinardi, Eleonora Moriconi, Laura Di Renzo, Giovanna Muscogiuri, Annamaria Colao & Silvia Savastano. (2022) Could ketogenic diet “starve” cancer? Emerging evidence. Critical Reviews in Food Science and Nutrition 62:7, pages 1800-1821.
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Igor Koturbash & Robert J Griffin. (2019) Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy. International Journal of Radiation Biology 95:4, pages 379-381.
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Articles from other publishers (24)

Peng Zou & Lin Wang. (2023) Dietary pattern and hepatic lipid metabolism. Liver Research.
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Rainer J. Klement & Reinhart A. Sweeney. (2023) Metabolic factors associated with the prognosis of oligometastatic patients treated with stereotactic body radiotherapy. Cancer and Metastasis Reviews 42:3, pages 927-940.
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Rihab Hami, Sena Apeke, Pascal Redou, Laurent Gaubert, Ludwig J. Dubois, Philippe Lambin, Dimitris Visvikis & Nicolas Boussion. (2023) Predicting the Tumour Response to Radiation by Modelling the Five Rs of Radiotherapy Using PET Images. Journal of Imaging 9:6, pages 124.
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Zhiru Gao, Qian Zhao, Yiyue Xu & Linlin Wang. (2023) Improving the efficacy of combined radiotherapy and immunotherapy: focusing on the effects of radiosensitivity. Radiation Oncology 18:1.
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Rainer J. Klement. (2023) Anti-tumor effects of ketogenic diets and their synergism with other treatments in mice: Bayesian evidence synthesis of 1755 individual mouse survival data. Biomedical Journal, pages 100609.
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Rainer J. Klement & Reinhart A. Sweeney. (2022) Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients. Strahlentherapie und Onkologie 198:11, pages 981-993.
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Sture Hobro, Anders Nilsson, Jan Sternby, Carl Öberg, Kristian Pietras, Håkan Axelson, Ana Carneiro, Sara Kinhult, Anders Christensson, Jonas Fors, Steven Maciejewski, Jason Knox, Innas Forsal, Linda Källquist & Viktoria Roos. (2022) Dialysis as a Novel Adjuvant Treatment for Malignant Cancers. Cancers 14:20, pages 5054.
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Haobin Zhao, Han Jin, Junfang Xian, Zhifu Zhang, Junling Shi & Xiaosu Bai. (2022) Effect of Ketogenic Diets on Body Composition and Metabolic Parameters of Cancer Patients: A Systematic Review and Meta-Analysis. Nutrients 14:19, pages 4192.
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Martine Extermann, Indrin J. Chetty, Stephen L. Brown, Mohammed Al-Jumayli & Benjamin Movsas. (2022) Predictors of Toxicity Among Older Adults with Cancer. Seminars in Radiation Oncology 32:2, pages 179-185.
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Martin Voss, Katharina J. Wenger, Nina von Mettenheim, Jörg Bojunga, Manuela Vetter, Bianca Diehl, Kea Franz, Ruediger Gerlach, Michael W. Ronellenfitsch, Patrick N. Harter, Elke Hattingen, Joachim P. Steinbach, Claus Rödel & Johannes Rieger. (2021) Short-term fasting in glioma patients: analysis of diet diaries and metabolic parameters of the ERGO2 trial. European Journal of Nutrition 61:1, pages 477-487.
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Rainer J. Klement, Detlef Meyer, Stefan Kanzler & Reinhart A. Sweeney. (2021) Ketogenic diets consumed during radio-chemotherapy have beneficial effects on quality of life and metabolic health in patients with rectal cancer. European Journal of Nutrition 61:1, pages 69-84.
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Nicolas Nelson, Joseph Lombardo, Lauren Matlack, Alexandria Smith, Kamryn Hines, Wenyin Shi & Nicole L. Simone. (2022) Chronoradiobiology of Breast Cancer: The Time Is Now to Link Circadian Rhythm and Radiation Biology. International Journal of Molecular Sciences 23:3, pages 1331.
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Jose M. Pimiento & William J. Kraemer. (2021) Dudrick Research Symposium: Expanding the boundaries of cancer care through nutrition support. Journal of Parenteral and Enteral Nutrition 45:8, pages 1683-1689.
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Carlos Sosa-Marrero, Renaud de Crevoisier, Alfredo Hernandez, Pierre Fontaine, Nathalie Rioux-Leclercq, Romain Mathieu, Alain Fautrel, Francois Paris & Oscar Acosta. (2021) Towards a Reduced In Silico Model Predicting Biochemical Recurrence After Radiotherapy in Prostate Cancer . IEEE Transactions on Biomedical Engineering 68:9, pages 2718-2729.
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Keren Porper, Yael Shpatz, Luba Plotkin, Ronit Goldman Pechthold, Alisa Talianski, Colin E. Champ, Orit Furman, Ariel Shimoni-Sebag, Zvi Symon, Uri Amit, Rina Hemi, Hannah Kanety, Yael Mardor, Zvi R. Cohen, Elisheva Jan, Hili Genssin, Yair Anikster, Leor Zach & Yaacov R. Lawrence. (2021) A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma. Journal of Neuro-Oncology 153:3, pages 487-496.
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Rainer J. Klement, Colin E. Champ, Ulrike Kämmerer, Petra S. Koebrunner, Kelley Krage, Gabriele Schäfer, M. Weigel & Reinhart A. Sweeney. (2020) Impact of a ketogenic diet intervention during radiotherapy on body composition: III—final results of the KETOCOMP study for breast cancer patients. Breast Cancer Research 22:1.
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Yuan-Hsi Wang, Fat-Moon Suk & Yi-Jen Liao. (2020) Loss of HMGCS2 Enhances Lipogenesis and Attenuates the Protective Effect of the Ketogenic Diet in Liver Cancer. Cancers 12:7, pages 1797.
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Daniela D. Weber, Sepideh Aminzadeh-Gohari, Julia Tulipan, Luca Catalano, René G. Feichtinger & Barbara Kofler. (2020) Ketogenic diet in the treatment of cancer – Where do we stand?. Molecular Metabolism 33, pages 102-121.
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Rainer J. Klement, Nanina Brehm & Reinhart A. Sweeney. (2020) Ketogenic diets in medical oncology: a systematic review with focus on clinical outcomes. Medical Oncology 37:2.
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Silvia Vidali, Sepideh Aminzadeh-Gohari, Renaud Vatrinet, Luisa Iommarini, Anna Maria Porcelli, Barbara Kofler & René Günther Feichtinger. (2019) Lithium and Not Acetoacetate Influences the Growth of Cells Treated with Lithium Acetoacetate. International Journal of Molecular Sciences 20:12, pages 3104.
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Catharina Bartmann, Sudha R. Janaki Raman, Jessica Flöter, Almut Schulze, Katrin Bahlke, Jana Willingstorfer, Maria Strunz, Achim Wöckel, Rainer J. Klement, Michaela Kapp, Cholpon S. Djuzenova, Christoph Otto & Ulrike Kämmerer. (2018) Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation. Cancer & Metabolism 6:1.
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Rainer J. Klement, Prasanta S. Bandyopadhyay, Colin E. Champ & Harald Walach. (2018) Application of Bayesian evidence synthesis to modelling the effect of ketogenic therapy on survival of high grade glioma patients. Theoretical Biology and Medical Modelling 15:1.
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Xueru Zhu, Yiting Wang, Li Tan & Xiaolong Fu. (2018) The pivotal role of DNA methylation in the radio-sensitivity of tumor radiotherapy. Cancer Medicine 7:8, pages 3812-3819.
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Rainer Johannes Klement. (2018) Fasting, Fats, and Physics: Combining Ketogenic and Radiation Therapy against Cancer. Complementary Medicine Research 25:2, pages 102-113.
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