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International Journal of Radiation Biology Volume 98, 2022 - Issue 5: ConRad 2021 - Conference on Radiation Topics/ Munich
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Original Articles

A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice

Vijay K. Singha Department of Pharmacology and Molecular Therapeutics, Division of Radioprotectants, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;b Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6631-3849View further author information
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Oluseyi O. Fatanmia Department of Pharmacology and Molecular Therapeutics, Division of Radioprotectants, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;b Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USAView further author information
,
Stephen Y. Wisea Department of Pharmacology and Molecular Therapeutics, Division of Radioprotectants, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;b Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USAView further author information
,
Alana Carpentera Department of Pharmacology and Molecular Therapeutics, Division of Radioprotectants, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;b Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USAView further author information
,
Sara Nakamura-Peeka Department of Pharmacology and Molecular Therapeutics, Division of Radioprotectants, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA;b Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USAView further author information
,
Artur A. Serebrenikc Humanetics Corporation, Edina, MN, USAView further author information
&
Michael D. Kaytorc Humanetics Corporation, Edina, MN, USAView further author information
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Pages 958-967 | Received 14 Jul 2021, Accepted 25 Aug 2021, Published online: 28 Sep 2021

Citations (8)

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Read on this site (1)

Vijay K. Singh, Meera Srivastava & Thomas M Seed. (2023) Protein biomarkers for radiation injury and testing of medical countermeasure efficacy: promises, pitfalls, and future directions. Expert Review of Proteomics 20:10, pages 221-246.
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Articles from other publishers (7)

Artur A. Serebrenik, Carin W. Verduyn & Michael D. Kaytor. (2022) Safety, Pharmacokinetics, and Biomarkers of an Amorphous Solid Dispersion of Genistein, a Radioprotectant, in Healthy Volunteers. Clinical Pharmacology in Drug Development 12:2, pages 190-201.
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Vijay K. Singh, Artur A. Serebrenik, Oluseyi O. Fatanmi, Stephen Y. Wise, Alana D. Carpenter, Brianna L. Janocha & Michael D. Kaytor. (2023) The Radioprotectant, BIO 300, Protects the Lungs from Total-Body Irradiation Injury in C57L/J Mice. Radiation Research 199:3.
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Evgeny Bazdyrev, Maria Panova, Valeria Zherebtsova, Alexandra Burdenkova, Ivan Grishagin, Fedor Novikov & Vladimir Nebolsin. (2022) The Hidden Pandemic of COVID-19-Induced Organizing Pneumonia. Pharmaceuticals 15:12, pages 1574.
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Tomas Perecko, Zuzana Hoferova, Michal Hofer, Jana Pereckova & Martin Falk. (2022) Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice. Life Sciences 310, pages 121106.
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Vijay K. Singh & Thomas M Seed. (2022) Armed Forces Radiobiology Research Institute/Uniformed Services University of the Health Sciences perspective on space radiation countermeasure discovery. Life Sciences in Space Research 35, pages 20-29.
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Yaoxiang Li, Michael Girgis, Meth Jayatilake, Artur A. Serebrenik, Amrita K. Cheema, Michael D. Kaytor & Vijay K. Singh. (2022) Pharmacokinetic and metabolomic studies with a BIO 300 Oral Powder formulation in nonhuman primates. Scientific Reports 12:1.
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Yuanyun Wei, Yaqi Gong, Shuang Wei, Yonglin Chen, Jian Cui, Xiang Lin, Yueqiu Yu, Hongxia Yan, Hui Qin & Lan Yi. (2022) Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments. Archives of Pharmacal Research 45:8, pages 558-571.
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