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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 26, 1974 - Issue 1
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Original Article

Oxygen Depletion in Cells Irradiated at Ultra-high Dose-rates and at Conventional Dose-rates

H. Weiss Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, U.S.A.
,
E.R. Epp Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, U.S.A.
,
J.M. Heslin Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, U.S.A.
,
C.C. Ling Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, U.S.A.
&
A. Santomasso Memorial Sloan-Kettering Cancer Center, New York, N.Y., 10021, U.S.A.
Pages 17-29 | Received 31 Dec 1973, Accepted 15 Feb 1974, Published online: 03 Jul 2009

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Ankang Hu, Rui Qiu, Wei Bo Li, Wanyi Zhou, Zhen Wu, Hui Zhang & Junli Li. (2023) Radical recombination and antioxidants: a hypothesis on the FLASH effect mechanism. International Journal of Radiation Biology 99:4, pages 620-628.
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Eui Jung Moon, Kristoffer Petersson & Monica M. Olcina. (2022) The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT. International Journal of Radiation Biology 98:3, pages 439-451.
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David Ewing. (1987) Radiation Sensitization of E. Coli B/r by Mixtures of Oxygen and Nitrous Oxide. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:6, pages 921-933.
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David Ewing. (1980) Breaking Survival Curves and Oxygen Removal Times in Irradiated Bacterial Spores. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 37:3, pages 321-329.
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Nancy L. Oleinick, John E. Biaglow & Ronald C. Rustad. (1979) Radiation-induced Fluctuations of the Polysome Content in Adequately Oxygenated Tetrahymena Pyriformis. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 36:6, pages 555-564.
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I.J. Stratford, R.L. Maughan, B.D. Michael & A. Tallentire. (1977) The Decay of Potentially Lethal Oxygen-dependent Damage in Fully Hydrated Bacillus Megaterium Spores Exposed to Pulsed Electron Irradiation. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 32:5, pages 447-455.
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Pelagia Tsoutsou, Pierre Montay-Gruel & Marie-Catherine Vozenin. 2019. Radiation Oncology. Radiation Oncology 1 15 .
Anne-Sophie Charlotte Hieke & Suresh D. Pillai. (2018) Escherichia coli Cells Exposed to Lethal Doses of Electron Beam Irradiation Retain Their Ability to Propagate Bacteriophages and Are Metabolically Active. Frontiers in Microbiology 9.
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Lloyd M. L. Smyth, Jacqueline F. Donoghue, Jessica A. Ventura, Jayde Livingstone, Tracy Bailey, Liam R. J. Day, Jeffrey C. Crosbie & Peter A. W. Rogers. (2018) Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model. Scientific Reports 8:1.
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Pierre Montay-Gruel, Lydia Meziani, Chakradhar Yakkala & Marie-Catherine Vozenin. (2018) Expanding the therapeutic index of radiation therapy by normal tissue protection. The British Journal of Radiology, pages 20180008.
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Howard B. Michaels. (1986) Oxygen depletion in irradiated aqueous solutions containing electron affinic hypoxic cell radiosensitizers. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1055-1058.
Crossref
Cameron J. Koch. 1979. Advances in Radiation Biology - Volume 8. Advances in Radiation Biology - Volume 8 273 315 .

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