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Original Article

Mechanism of Action of Nitroimidazole Antimicrobial and Antitumour Radiosensitizing Drugs

Effects of Reduced Misonidazole on DNA

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Pages 367-377 | Received 11 Sep 1978, Accepted 11 Dec 1978, Published online: 03 Jul 2009

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Read on this site (4)

E. Gattavecchia, D. Tonelli & P.G. Fuochi. (1984) Electrochemical and Pulse Radiolysis Study of Misonidazole and Its Azo and Azoxy Derivatives. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 45:5, pages 469-477.
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Kathryn E. McLane, Jed Fisher & K. Ramakrishnan. (1983) Reductive Drug Metabolism. Drug Metabolism Reviews 14:4, pages 741-799.
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R.J. Knox, R.C. Knight & D.I. Edwards. (1982) The Effect of Temperature on the Release of Thymidine from DNA during Exposure to Electrolytically Reduced Misonidazole. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 41:4, pages 465-469.
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Articles from other publishers (25)

Mansi K. Aparnathi, Sami Ul Haq, Zishan Allibhai, Benjamin H. Lok & Anthony M. Brade. 2023. Advances in Radiation Oncology in Lung Cancer. Advances in Radiation Oncology in Lung Cancer 285 302 .
Bradley T. Endres, Eugénie Bassères, Ali Memariani, Long Chang, M. Jahangir Alam, Richard J. Vickers, Ioannis A. Kakadiaris & Kevin W. Garey. (2016) A novel method for imaging the pharmacological effects of antibiotic treatment on Clostridium difficile. Anaerobe 40, pages 10-14.
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Lyudmila Larina & Valentin LopyrevL. Larina & V. Lopyrev. 2009. Nitroazoles: Synthesis, Structure and Applications. Nitroazoles: Synthesis, Structure and Applications 407 432 .
Chieko Murayama, Akira Suzuki, Chihiro Sato, Yoshitaka Tanabe, Takahiro Shoji, Yoshiyuki Miyata, Azuma Nishio, Toshimitsu Suzuki, Masakazu Sakaguchi & Tomoyuki Mori. (1993) Radiosensitization by a new potent nucleoside analog: 1-(1′,3′,4′-trihydroxy-2′-butoxy)methyl-2-nitroimidazole(RP-343). International Journal of Radiation Oncology*Biology*Physics 26:3, pages 433-443.
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Joanne H. Tocher, Narinder S. Virk & David I. Edwards. (1990) DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide, SR4233, as a function of pH. Biochemical Pharmacology 40:6, pages 1405-1410.
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D. I. Edwards, J. H. Tocher, L. D. Dale, D. Widdick & N. Virk. 1990. Selective Activation of Drugs by Redox Processes. Selective Activation of Drugs by Redox Processes 275 283 .
Chieko Murayama, Akira Suzuki, Toshimitsu Suzuki, Yoshiyuki Miyata, Masakazu Sakaguchi, Yoshitaka Tanabe, Norimoto Tanaka & Tomoyuki Mori. (1989) Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170). International Journal of Radiation Oncology*Biology*Physics 17:3, pages 575-581.
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L.D. Dale, D.A. Widdick, G.I. Biol & D.I. Edwards. (1989) Comparative dna damage and repair induced by misonidazole, CB 1954 and RSU 1069. International Journal of Radiation Oncology*Biology*Physics 16:4, pages 995-999.
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A. Zahoor, M.V.M. Lafleur, R.C. Knight, H. Loman & D.I. Edwards. (1987) DNA damage induced by reduced nitroimidazole drugs. Biochemical Pharmacology 36:19, pages 3299-3304.
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Peter Wardman. (1987) The mechanism of radiosensitization by electron-affinic compounds. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 30:5-6, pages 423-432.
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D.I. Edwards, R.C. Knight & A. Zahoor. (1986) DNA damage induced by reductively activated nitroimidazoles—pH effects. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1207-1209.
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DAVID I. EDWARDS. 1986. Bioreduction in the Activation of Drugs. Bioreduction in the Activation of Drugs 53 58 .
D.I. Edwards, R.J. Knox, I.M. Skolimowski, A. Zahoor & R.C. Knight. (1984) Photosensitive interaction of RSU 1069 with DNA. International Journal of Radiation Oncology*Biology*Physics 10:8, pages 1319-1322.
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R.J Knox, D.I Edwards & R.C Knight. (1984) The mechanism of nitroimidazole damage to DNA: Coulometric evidence. International Journal of Radiation Oncology*Biology*Physics 10:8, pages 1315-1318.
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D. I. Edwards. 1984. IUPHAR 9th International Congress of Pharmacology. IUPHAR 9th International Congress of Pharmacology 391 397 .
Robert M. Sutherland, Dietmar W. Siemann & Peter J. Conroy. 1984. Adrenal and Endocrine Tumors in Children. Adrenal and Endocrine Tumors in Children 19 44 .
D.I. Edwards, R.J. Knox & R.C. Knight. (1982) Structure-cytotoxicity relationships of nitroimidazoles in an in vitro system. International Journal of Radiation Oncology*Biology*Physics 8:3-4, pages 791-793.
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Peggy L. Olive. (1982) Evidence suggesting that the mechanism for aerobic and hypoxic cytotoxicity of nitroheterocycles is the same. International Journal of Radiation Oncology*Biology*Physics 8:3-4, pages 687-691.
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C. E. Smithen & C. R. Hardy. 1982. Advanced Topics on Radiosensitizers of Hypoxic Cells. Advanced Topics on Radiosensitizers of Hypoxic Cells 1 47 .
D. I. Edwards, R. J. Knox, D. A. Rowley, I. M. Skolimowski & R. C. Knight. 1982. Nitroimidazoles. Nitroimidazoles 105 114 .
Francis P. Tally & C. Edmond Sullivan. (1981) Metronidazole: In Vitro Activity, Pharmacology and Efficacy in Anaerobic Bacterial Infections. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 1:1, pages 28-38.
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R.J. Knox, R.C. Knight & D.I. Edwards. (1981) Misonidazole-induced thymidine release from DNA. Biochemical Pharmacology 30:14, pages 1925-1929.
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T. Sugahara & S. Nakatsugawa. (1981) Radiation sensitization studies in Japan. Cancer Treatment Reviews 8:1, pages 51-61.
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David I. Edwards. 1981. 87 116 .
David A. Rowley, Richard C. Knight, Irena M. Skolimowski & David I. Edwards. (1980) The relationship between misonidazole cytotoxicity and base composition of DNA. Biochemical Pharmacology 29:15, pages 2095-2098.
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