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Original Article

The Induction of Chromosome Aberrations in Human Lymphocytes by in Vitro Irradiation with α-particles from Plutonium-239

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Pages 277-284 | Received 11 Oct 1979, Accepted 20 Feb 1980, Published online: 03 Jul 2009

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Robert Stainforth, Jan Schuemann, Aimee L. McNamara, Ruth C. Wilkins & Vinita Chauhan. (2021) Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer. International Journal of Radiation Biology 97:1, pages 85-101.
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K. Karthik, Vasumathy Rajan, Badri N. Pandey, K. Sivasubramanian, Solomon F.D. Paul & P. Venkatachalam. (2019) Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay. International Journal of Radiation Biology 95:6, pages 725-736.
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Roser Puig, Mònica Pujol, Leonardo Barrios, María Rosa Caballín & Joan-Francesc Barquinero. (2016) Analysis of α-particle-induced chromosomal aberrations by chemically-induced PCC. Elaboration of dose-effect curves. International Journal of Radiation Biology 92:9, pages 493-501.
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C. Meenakshi & Mary N. Mohankumar. (2015) Relative biological effectiveness of radon: An in vitro study using chromosome aberrations as a biomarker. International Journal of Radiation Biology 91:8, pages 681-685.
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M. S. Sasaki. (2009) Advances in the biophysical and molecular bases of radiation cytogenetics. International Journal of Radiation Biology 85:1, pages 26-47.
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J. F. Barquinero, G. Stephan & E. Schmid. (2004) Effect of americium‐241 α‐particles on the dose–response of chromosome aberrations in human lymphocytes analysed by fluorescence in situ hybridization. International Journal of Radiation Biology 80:2, pages 155-164.
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C.S. Griffin, A.N. Harvey & J.R.K. Savage. (1994) Chromatid Damage Induced by 238Pu α-particles in G2 and S Phase Chinese Hamster V79 Cells. International Journal of Radiation Biology 66:1, pages 85-98.
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M. A. Kotb, A. M. El-Khatib, A. A. Morsey, M. I. A. Ramadan & E. A. El-Bassiouni. (1990) Changes in Mineral Elements in Some Tissues of Mice Following Neutron Irradiation. Isotopenpraxis Isotopes in Environmental and Health Studies 26:7, pages 297-300.
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M. Frankenberg-Schwager, D. Frankenberg, R. Harbich & C. Adamczyk. (1990) A Comparative Study of Rejoining of DNA Double-strand Breaks in Yeast Irradiated with 3·5 MeV α-particles or with 30 MeV Electrons. International Journal of Radiation Biology 57:6, pages 1151-1168.
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H. Nagasawa, J. Robertson & J.B. Little. (1990) Induction of Chromosomal Aberrations and Sister Chromatid Exchanges by Alpha Particles in Density-inhibited Cultures of Mouse 10T½ and 3T3 Cells. International Journal of Radiation Biology 57:1, pages 35-44.
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A. Bilbao, J.S. Prosser, A.A. Edwards, J.C. Moody & D.C. Lloyd. (1989) The Induction of Micronuclei in Human Lymphocytes by in Vitro Irradiation with Alpha Particles from Plutonium-239. International Journal of Radiation Biology 56:3, pages 287-292.
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V. Svoboda, A. Sedlák, H. Kypěnová & D. Bubeníková. (1987) Long-term Effects of Low-level 239Pu Contamination on Murine Bone-marrow Stem Cells and Their Progeny. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:4, pages 517-526.
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A.A. Edwards, D.C. Lloyd, J.S. Prosser, P. Finnon & J.E. Moquet. (1986) Chromosome Aberrations Induced in Human Lymphocytes by 8·7 MeV Protons and 23·5 MeV Helium-3 Ions. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:1, pages 137-145.
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Christine Lücke-Huhle, Ludwig Hieber & Rolf-Dieter Wegner. (1983) Caffeine-mediated Release of Alpha-radiation-induced G2 Arrest Increases the Yield of Chromosome Aberrations. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 43:2, pages 123-132.
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Darrell R. Fisher & Rebekah Harty. (1982) The Microdosimetry of Lymphocytes Irradiated by Alpha-particles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 41:3, pages 315-324.
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W. Merkle. (1981) Poisson Goodness-of-fit Tests for Radiation-induced Chromosome Aberrations. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 40:6, pages 685-692.
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Articles from other publishers (22)

Andreas Maier, Tarryn Bailey, Annika Hinrichs, Sylvie Lerchl, Richard T. Newman, Claudia Fournier & Charlot Vandevoorde. (2023) Experimental Setups for In Vitro Studies on Radon Exposure in Mammalian Cells—A Critical Overview. International Journal of Environmental Research and Public Health 20:9, pages 5670.
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Lukas Göring, Sarah Schumann, Jessica Müller, Andreas K. Buck, Matthias Port, Michael Lassmann, Harry Scherthan & Uta Eberlein. (2022) Repair of α-particle-induced DNA damage in peripheral blood mononuclear cells after internal ex vivo irradiation with 223Ra. European Journal of Nuclear Medicine and Molecular Imaging 49:12, pages 3981-3988.
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S. Schumann, U. Eberlein, C. Lapa, J. Müller, S. Serfling, M. Lassmann & H. Scherthan. (2021) α-Particle-induced DNA damage tracks in peripheral blood mononuclear cells of [223Ra]RaCl2-treated prostate cancer patients. European Journal of Nuclear Medicine and Molecular Imaging 48:9, pages 2761-2770.
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Sarah Schumann, Uta Eberlein, Razan Muhtadi, Michael Lassmann & Harry Scherthan. (2018) DNA damage in leukocytes after internal ex-vivo irradiation of blood with the α-emitter Ra-223. Scientific Reports 8:1.
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E. A. Ainsbury, J. Moquet, K. Rothkamm, F. Darroudi, A. Vozilova, M. Degteva, T. V. Azizova, D. C. Lloyd & J. Harrison. (2014) What radiation dose does the FISH translocation assay measure in cases of incorporated radionuclides for the Southern Urals populations?. Radiation Protection Dosimetry 159:1-4, pages 26-33.
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Gillian B. Curwen, E. Janet Tawn, Kevin K. Cadwell, Laura Guyatt, James Thompson & Mark A. Hill. (2012) mFISH Analysis of Chromosome Aberrations Induced In Vitro by α-Particle Radiation: Examination of Dose-Response Relationships . Radiation Research 178:5, pages 414-424.
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Yasuo Ukai & Atsushi Yamashita. (2010) Relative biological effectiveness of alpha particles and protons varies with biological criteria, and values are mutually correlated in thermal neutron exposure. Breeding Science 60:2, pages 121-129.
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E. Janet Tawn, Caroline A. Whitehouse, Kim De Ruyck, Leanne Hodgson, Katia Vandenbulcke & Hubert Thierens. (2007) The Characterization and Transmissibility of Chromosome Aberrations Induced in Peripheral Blood Lymphocytes by In Vitro α-Particle Radiation . Radiation Research 168:6, pages 666-674.
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Douglas B. Chambers, Richard V. Osborne & Amy L. Garva. (2006) Choosing an alpha radiation weighting factor for doses to non-human biota. Journal of Environmental Radioactivity 87:1, pages 1-14.
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N. D. Okladnikova, B. R. Scott, Z. B. Tokarskaya, G. V. Zhuntova, V. F. Khokhryakov, V. A. Syrchikov & E. S. Grigoryeva. (2005) Chromosomal aberrations in lymphocytes of peripheral blood among Mayak facility workers who inhaled insoluble forms of 239PU. Radiation Protection Dosimetry 113:1, pages 3-13.
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J. Valentin. (2016) Relative biological effectiveness (RBE), quality factor ( Q ), and radiation weighting factor ( w R ) . Annals of the ICRP 33:4, pages 1-121.
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F Ballarini & A Ottolenghi. (2003) Chromosome aberrations as biomarkers of radiation exposure: Modelling basic mechanisms. Advances in Space Research 31:6, pages 1557-1568.
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Simon D. Bouffler, Jackie W. Haines, Alan A. Edwards, John D. Harrison & Roger Cox. (2001) Lack of Detectable Transmissible Chromosomal Instability after In Vivo or In Vitro Exposure of Mouse Bone Marrow Cells to 224 Ra Alpha Particles . Radiation Research 155:2, pages 345-352.
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D. Frankenberg. (1994) Repair of DNA double-strand breaks and its effect on RBE. Advances in Space Research 14:10, pages 235-248.
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Rainer K. Sachs, Pei-Li Chen, Philip J. Hahnfeldt & Lynn R. Hlatky. (1992) DNA damage caused by ionizing radiation. Mathematical Biosciences 112:2, pages 271-303.
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A.A. Edwards. (1992) Chromosomal data relevant for Q values. Advances in Space Research 12:2-3, pages 421-430.
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A. A. Edwards & D. C. Lloyd. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 385 396 .
D. Frankenberg. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 287 305 .
J. Pohl-Rüling & E. Pohl. (1990) Method for α-irradiation of blood cultures with short-lived radon-222 decay products. Mutation Research/Environmental Mutagenesis and Related Subjects 234:1, pages 43-45.
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Michael A Bender, Akio A. Awa, Antone L. Brooks, H.John Evans, Peter G. Groer, L.Gayle Littlefield, Carlos Pereira, R.Julian Preston & Bruce W. Wachholz. (1988) Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Research/Reviews in Genetic Toxicology 196:2, pages 103-159.
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K. H. Chadwick & H. P. Leenhouts. 1986. Radiation Carcinogenesis and DNA Alterations. Radiation Carcinogenesis and DNA Alterations 277 291 .
G Scarpa, N Vulpis, M E De Santis & G Vulpis. (1981) The dose absorbed by lymphocytes irradiated in vitro with tritiated water. Physics in Medicine and Biology 26:6, pages 1137-1144.
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