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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 46, 1984 - Issue 6
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Original Article

Thiol Reactive Nitroimidazoles: Radiosensitization Studies in Vitro and in Vivo

I.J. Stratford M. R. C. Radiobiology Unit, Harwell, Didcot, Oxfordshire, OX11 ORD, U.K.
,
G.E. Adams Department of Organic Chemistry, University of Leeds, Leeds, U.K.
,
C. Hardy Nuffield Laboratory of Ophthalmology, Walton Street, Oxford, OX2 6AW, U.K.
,
S. Hoe M. R. C. Radiobiology Unit, Harwell, Didcot, Oxfordshire, OX11 ORD, U.K.
,
P. O'Neill Department of Organic Chemistry, University of Leeds, Leeds, U.K.
&
P.W. Sheldon Nuffield Laboratory of Ophthalmology, Walton Street, Oxford, OX2 6AW, U.K.
Pages 731-745 | Received 15 May 1984, Accepted 16 Jul 1984, Published online: 03 Jul 2009

Citations (23)

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M. Rybczynska, C. Feo, M. Marden & C. Poyart. (1993) Abnormal rheological response of erythrocytes caused by nitroimidazoles and hyperthermia. International Journal of Hyperthermia 9:2, pages 313-323.
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Y. Shibamoto, C. Streffer, K. Sasai, N. Oya & M. Abe. (1992) Radiosensitization Efficacy of KU-2285, RP-170 and Etanidazole at Low Radiation Doses: Assessment by in Vitro Cytokinesis-block Micronucleus Assay. International Journal of Radiation Biology 61:4, pages 473-478.
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R.S.L. Wong, R.A. Basas & C.C. Ling. (1991) Enhancement of SR 2508 (Etanidazole) Radiosensitization by Buthionine Sulphoximine at Low-dose-rate Irradiation. International Journal of Radiation Biology 59:1, pages 133-143.
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M. Rybczynska. (1990) The Evaluation of Erythrocyte Membrane Response to Combined Treatment of Radiation and Nitroimidazoles. International Journal of Radiation Biology 58:2, pages 313-323.
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K.A. Skov & N.P. Farrell. (1990) Radiosensitization by Metal Complexes of 4(5)-nitroimidazole. International Journal of Radiation Biology 57:5, pages 947-958.
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P.K.L. Chan, K.A. Skov & B.R. James. (1987) Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:1, pages 49-55.
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J.M. Walling, I.J. Stratford & G.E. Adams. (1987) Radiosensitization by the 2,4-dinitro-5-aziridinyl Benzamide CB 1954: A Structure/Activity Study. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:1, pages 31-41.
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R. Chibber, I.J. Stratford, P. O'Neill, P.W. Sheldon, I. Ahmed & B. Lee. (1985) The Interaction Between Radiation and Complexes of Cis-Pt(II) and Rh(II): Studies at the Molecular and Cellular Level. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 48:4, pages 513-524.
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Articles from other publishers (15)

Peng-Bao Lian, Yuan Yuan, Jian Chen, Li-Zhen Chen & Jian-Long Wang. (2020) Study of the methylation reaction of 2,4-dinitroimidazole and potassium 2,4,5-trinitroimidazol-1-ide with dimethyl sulfate. Chemistry of Heterocyclic Compounds 56:8, pages 1010-1014.
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Peter Wardman. (2018) Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes. The British Journal of Radiology, pages 20170915.
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Andrew M. Thompson, Muriel Bonnet, Ho H. Lee, Scott G. Franzblau, Baojie Wan, George S. Wong, Christopher B. Cooper & William A. Denny. (2017) Antitubercular Nitroimidazoles Revisited: Synthesis and Activity of the Authentic 3-Nitro Isomer of Pretomanid. ACS Medicinal Chemistry Letters 8:12, pages 1275-1280.
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Robert F. Anderson, Sujata S. Shinde, Andrej Maroz, Maruta Boyd, Brian D. Palmer & William A. Denny. (2008) Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution. Organic & Biomolecular Chemistry 6:11, pages 1973.
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Roger A. Egolf & Ned D. Heindel. (2009) The synthesis of aryl 4‐nitro‐5‐imidazolyl sulfone radiation sensitizers sterically protected against glutathione reaction. Journal of Heterocyclic Chemistry 28:3, pages 577-582.
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D.Lynn Kirkpatrick & Karen M. King. (1990) Inhibitory effects of cytotoxic disulfides on membrane Na+,K+-ATPase. Biochemical Pharmacology 39:9, pages 1484-1487.
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J. Martin Brown. (1989) Keynote address: Hypoxic cell radiosensitizers: Where next?. International Journal of Radiation Oncology*Biology*Physics 16:4, pages 987-993.
Crossref
D.Lynn Kirkpatrick. (1989) Kinetic study of the interaction of glutathione with four antitumor disulfides: Possible mechanism for cellular glutathione depletion. Chemico-Biological Interactions 69:2-3, pages 225-234.
Crossref
David M.L. Goodgame, Ann S. Lawrence, Alexandra M.Z. Slawin, David J. Williams & Ian J. Stratford. (1986) Synthesis, characterisation and radiosensitizing properties of some nitroimidazole adducts of rhodium(II) carboxylates; X-ray structure of {Rh(CH3CO2)2-[1-(2-hydroxy-3-methoxypropyl)-2-methyl-5-nitroimidazole])2}. Inorganica Chimica Acta 125:3, pages 143-149.
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Theodore L. Phillips, James B. Mitchell, William de Graff, Anthony Russo & Eli Glatstein. (1986) Variation in sensitizing efficiency for SR 2508 in human cells dependent on glutathione content. International Journal of Radiation Oncology*Biology*Physics 12:9, pages 1627-1635.
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James B. Mitchell, Theodore L. Phillips, William Degraff, James Carmichael, Rajesh K. Rajpal & Angelo Russo. (1986) The relationship of SR-2508 sensitizer enhancement ratio to cellular glutathione levels in human tumor cell lines. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1143-1146.
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M.E. Watts, M.F. Dennis, M.R.L. Stratford & P. Wardman. (1986) Glutathione-reactive nitro compounds as radiosensitizers: Mechanistic and therapeutic implications. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1135-1138.
Crossref
Timothy J. Kinsella, Patricia P. Dobson, Angelo Russo, James B. Mitchell & Albert J. FornaceJr.Jr.. (1986) Modulation of X ray dna damage by SR-2508 ± buthionine sulfoximine. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1127-1130.
Crossref
Ned D. Heindel, C. Jeffrey Lacey, Roger Egolf, Belle N. Mease & Keith J. Schray. (2009) A controlled‐oxidation synthesis of substituted aryl 1‐methyl‐4‐nitro‐5‐imidazolyl sulfones. Journal of Heterocyclic Chemistry 23:4, pages 1087-1090.
Crossref
IAN J. STRATFORD, PETER O'NEILL, PETER W. SHELDON, ANDREW R.J. SILVER, JACQUELINE M. WALLING & GERALD E. ADAMS. 1986. Bioreduction in the Activation of Drugs. Bioreduction in the Activation of Drugs 105 109 .

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