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Original Article

The Effect of Extracellular pH on Radiosensitization by Misonidazole and Acidic or Basic Analogues

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Pages 645-653 | Received 05 Oct 1984, Accepted 21 Dec 1984, Published online: 03 Jul 2009

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Read on this site (5)

R. El Gamoussi, I.J. Stratford & M. Guichard. (1993) Relationship between Intracellular Concentration and Radiosensitizing Effect of Pimonidazole and Etanidazole on Two Human Melanoma Cell Lines. International Journal of Radiation Biology 63:1, pages 27-36.
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M.E. Watts, M.F. Dennis & I.J. Roberts. (1990) Radiosensitization by Misonidazole, Pimonidazole and Azomycin and Intracellular Uptake in Human Tumour Cell Lines. International Journal of Radiation Biology 57:2, pages 361-372.
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J. Walling, I.J. Stratford, G.E. Adams & M.A. Stephens. (1988) Dual-function Radiation Sensitizers and Bioreductive Drugs: Factors Affecting Cellular Uptake and Sensitizing Efficiency in Analogues of RSU 1069. International Journal of Radiation Biology 53:4, pages 641-649.
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M.E. Watts, M.F. Dennis, N.R. Jones & M.R.L. Stratford. (1987) A Comparison of the Intracellular Uptake and Radiosensitization Efficiency in Different Media of Uncharged 2-nitroimidazoles of Varying Lipophilicity. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52:3, pages 359-370.
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M.F. Dennis, M.R.L. Stratford, P. Wardman & M.E. Watts. (1985) Cellular Uptake of Misonidazole and Analogues with Acidic or Basic Functions. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 47:6, pages 629-643.
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Articles from other publishers (19)

Xudong Li, Jun Wang, Ranran Cui, Dekang Xu, Lisheng Zhu, Ziying Li, Haijun Chen, Yu Gao & Lee Jia. (2020) Hypoxia/pH dual-responsive nitroimidazole-modified chitosan/rose bengal derivative nanoparticles for enhanced photodynamic anticancer therapy. Dyes and Pigments 179, pages 108395.
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Brita Singers Sørensen, Morten Busk, Nadine Olthof, Ernst-Jan Speel, Michael R. Horsman, Jan Alsner & Jens Overgaard. (2013) Radiosensitivity and effect of hypoxia in HPV positive head and neck cancer cells. Radiotherapy and Oncology 108:3, pages 500-505.
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Shinae Kizaka-Kondoh & Hideko Konse-Nagasawa. (2009) Significance of nitroimidazole compounds and hypoxia-inducible factor-1 for imaging tumor hypoxia. Cancer Science 100:8, pages 1366-1373.
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Lyudmila Larina & Valentin LopyrevL. Larina & V. Lopyrev. 2009. Nitroazoles: Synthesis, Structure and Applications. Nitroazoles: Synthesis, Structure and Applications 407 432 .
Donald J. AbrahamEdward A. Bump, Stephen J. Hoffman & William O. Foye. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 151 214 .
David M.L. Goodgame, Christopher J. Page, David J. Williams & Ian J. Stratford. (1992) Metal complexes as radiosensitizers: Cobalt(II), copper(II), rhodium(II) and platinum(II) complexes of 3-(1-imidazoyl)propionic acid and some nitro-substituted derivatives, and the crystal structure and radiosensitizer activity of [CuL2(H2O)]2 · 2H2O, where LH = 3-[1-(4-nitroimidazoyl)]propionic acid. Polyhedron 11:19, pages 2507-2515.
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Peter Wardman, Madeleine F. Dennis, Michael R.L. Stratford & John White. (1992) Extracellular: Intracellular and subcellular concentration gradients of thiols. International Journal of Radiation Oncology*Biology*Physics 22:4, pages 751-754.
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Pierre-Antoine Bonnet, Vincent Roman, Marc Fatome & François Berleur. (1990) Carboxylic acid or primary amine titration at the lipid-water interface: on the role of electric charges and phospholipid acyl chain composition. A spin labeling experiment. Chemistry and Physics of Lipids 55:2, pages 133-143.
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Yoshimitsu Nagao, Shigeki Sano, Masahito Ochiai & Eiichi Fujita. (1990) Biomimetic chemical, and spectroscopic evaluations for the radiosensitizing potential of N1- and N2-substituted derivatives of 3-Nitro-1,2,4-Triazole toward hypoxic cells in the radiotherapy: Remarkably different substitution effect. Tetrahedron 46:9, pages 3211-3232.
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T. C. Jenkins. 1990. The Chemistry of Antitumour Agents. The Chemistry of Antitumour Agents 342 369 .
Marcelle Guichard, Alphonse Taghian, Francoise Lespinasse & Edmond Philippe Malaise. 1990. Selective Activation of Drugs by Redox Processes. Selective Activation of Drugs by Redox Processes 165 172 .
J. Martin Brown. (1989) Keynote address: Hypoxic cell radiosensitizers: Where next?. International Journal of Radiation Oncology*Biology*Physics 16:4, pages 987-993.
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P. Siem-Jørgensen. (1988) Text slides. The British Journal of Radiology 61:729, pages 861-862.
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Nicholas Chalmers & Jonathan Best. (1988) A method of weighing an obese, trolley-bound patient. The British Journal of Radiology 61:729, pages 861-861.
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M. R. L. Stratford, M. F. Dennis, M. E. Watts & R. R. Watfa. (1988) Radiosensitizer–DNA interactions. The British Journal of Radiology 61:729, pages 860-861.
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N. M. Bleehen, M. I. Walton & P. Workman. 1988. Preclinical Hyperthermia. Preclinical Hyperthermia 136 148 .
G. Adams & I. J. Stratford. 1988. Radiobiology in Radiotherapy. Radiobiology in Radiotherapy 153 164 .
Peter Wardman. (1987) The mechanism of radiosensitization by electron-affinic compounds. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 30:5-6, pages 423-432.
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J.M. Walling, I.J. Stratford, G.E. Adams, A.R.J. Silver, I. Ahmed, T.C. Jenkins & E.M. Fielden. (1986) Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1083-1086.
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