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Review

The Radiolysis of Pyrimidines in Aqueous Solutions: An Updating Review

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Pages 1-34 | Received 21 Mar 1985, Accepted 17 Jun 1985, Published online: 03 Jul 2009

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C. Decarroz, J. R. Wagner & J. Cadet. (1987) Specific Deprotonation Reactions of the Pyrimidine Radical Cation Resulting from the Menadione Mediated Photosensitization of 2′-Deoxycytidine. Free Radical Research Communications 2:4-6, pages 295-301.
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Clemens Von Sonntag. (1987) New Aspects in the Free-Radical Chemistry of Pyrimidine Nucleobases. Free Radical Research Communications 2:4-6, pages 217-224.
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T. L. Luke, H. Mohan, T. A. Jacob, V. M. Manoj, P. Manoj, J. P. Mittal, H. Destaillats, M. R. Hoffmann & C. T. Aravindakumar. (2002) Kinetic and spectral investigation of the electron and hydrogen adducts of dihydroxy‐ and dimethyl‐substituted pyrimidines: a pulse radiolysis and product analysis study. Journal of Physical Organic Chemistry 15:5, pages 293-305.
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Horácio M. Novais, João P. Telo & Steen Steenken. (2002) Structure of radicals derived from hydroxypyrimidines in aqueous solution. Journal of the Chemical Society, Perkin Transactions 2:8, pages 1412.
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Evelyne Muller, Didier Gasparutto, Colette Lebrun & Jean Cadet. (2001) Site-Specific Insertion of the (5R*) and (5S*) Diastereoisomers of 1-[2-Deoxy-β-D-erythro-pentofuranosyl]-5-hydroxyhydantoin into Oligodeoxyribonucleotides. European Journal of Organic Chemistry 2001:11, pages 2091-2099.
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Stacey D. Wetmore, Leif A. Eriksson & Russell J. Boyd. 2001. Theoretical Biochemistry - Processes and Properties of Biological Systems. Theoretical Biochemistry - Processes and Properties of Biological Systems 409 466 .
C. von Sonntag & H.-P. Schuchmann. 2001. Radiation Chemistry - Present Status and Future Trends. Radiation Chemistry - Present Status and Future Trends 513 551 .
William B. Davis, Izabela Naydenova, Reinhard Haselsberger, Alexander Ogrodnik, Bernd Giese & Maria E. Michel-Beyerle. (2000) Dynamics of Hole Trapping by G, GG, and GGG in DNA. Angewandte Chemie 39:20, pages 3649-3652.
Crossref
William B. Davis, Izabela Naydenova, Reinhard Haselsberger, Alexander Ogrodnik, Bernd Giese & Maria E. Michel-Beyerle. (2000) Dynamics of Hole Trapping by G, GG, and GGG in DNA. Angewandte Chemie 112:20, pages 3795-3798.
Crossref
Chang-Yuan Lu, Wei-Zhen Lin, Wen-Feng Wang, Zhen-Hui Han, Zhi-De Zheng & Si-De Yao. (2000) Kinetic observation of rapid electron transfer between pyrimidine electron adducts and sensitizers of riboflavin, flavin adenine dinucleotide (FAD) and chloranil: a pulse radiolysis study. Radiation Physics and Chemistry 59:1, pages 61-66.
Crossref
Lu Chang-Yuan, Han Zhen-Hui, Tu Tie-Cheng, Mlvo Jin-Ling, Yao Si-De & Lin Nian-Yun. (2010) Pulse radiolysis study of rapid electron transfer from electron adduct and reducing OH adduct of dAMP to riboflavin and flavin adenine dinucleotide (FAD). Chinese Journal of Chemistry 18:4, pages 500-505.
Crossref
Koichi Takimoto, Keizo Tano, Mitsumasa Hashimoto, Manabu Hori, Susumu Akasaka & Hiroshi Utsumi. (1999) Delayed transfection of DNA after riboflavin mediated photosensitization increases G:C to C:G transversions of supF gene in Escherichia coli mutY strain. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 445:1, pages 93-98.
Crossref
R.M.B. Dias & A.J.S.C. Vieira. (1998) Substituent effect on superoxide elimination from peroxyl radicals of adenine and methylated derivatives. Journal of Photochemistry and Photobiology A: Chemistry 117:3, pages 217-222.
Crossref
Yue Jiang, Si-De Yao & Nian-Yun Lin. (1997) Fast repair of oxidizing oh radical adduct of dGMP by hydroxycinnamic acid derivatives. A pulse radiolytic study. Radiation Physics and Chemistry 49:4, pages 447-450.
Crossref
Chun-Lin Shao & Zeng-Liang Yu. (1997) Dose effects of N+ ion beam irradiation-induced damage to 5′-AMP and its components. Radiation Physics and Chemistry 49:3, pages 337-345.
Crossref
J. K. Dohrmann. 1997. Radicals Centered on Other Heteroatoms. Proton Transfer Equilibria. Radicals Centered on Other Heteroatoms. Proton Transfer Equilibria 465 478 .
J. K. Dohrmann. 1997. Radicals Centered on Other Heteroatoms. Proton Transfer Equilibria. Radicals Centered on Other Heteroatoms. Proton Transfer Equilibria 207 213 .
Lester Packer, Maret Traber & Wenjuan XinX Fang, J Wu & G Wei. 1996. Proceedings of the International Symposium on Natural Antioxidants. Proceedings of the International Symposium on Natural Antioxidants 286 293 .
F. G. Mosqueira, G. Albarrán & A. Negrón-Mendoza. (1996) A review of conditions affecting the radiolysis due to40K on nucleic acid bases and their derivatives adsorbed on clay minerals: Implications in prebiotic chemistry. Origins of Life and Evolution of the Biosphere 26:1, pages 75-94.
Crossref
Helmut Görner & Dietrich Schulte-Frohlinde. (1995) Ion-forming processes on 248 NM laser excitation of uracil and methyl-monosubstituted uracils: A time-resolved transient conductivity study in aqueous solution. Radiation Physics and Chemistry 45:4, pages 677-688.
Crossref
K. Chabita, P. C. Mandal & S. N. Bhattacharyya. (1994) Absorption and fluorescence behavior of cytosine irradiated at different pH and in the presence of Cu(II) ions at neutral pH. Journal of Radioanalytical and Nuclear Chemistry Letters 188:2, pages 133-148.
Crossref
Karol Miaskiewicz, John Miller & Roman Osman. (1994) Energetic basis for structural preferences in 5/6-hydroxy-5,6-dihydropyrimidines: Products of ionizing and ultraviolet radiation action on DNA bases. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1218:3, pages 283-291.
Crossref
S. Chakrabarti, P. C. Mandal & S. N. Bhattacharyya. (2004) Reactions of cobalt(III) complexes with free radicals derived from thymine. International Journal of Chemical Kinetics 26:7, pages 693-703.
Crossref
Gerardo D. Castro, John T. Simpson & JoséA. Castro. (1994) Interaction of trichloromethyl free radicals with thymine in a model system: a mass spectrometric study. Chemico-Biological Interactions 90:1, pages 13-22.
Crossref
J. Anastassopoulou & J. Brekoulakis. 1994. Properties and Chemistry of Biomolecular Systems. Properties and Chemistry of Biomolecular Systems 31 36 .
Mikinori Kuwabara, Hideki Ohshima, Fumiaki Sato, Akira Ono & Akira Matsuda. (2002) Spin-trapping detection of precursors of hydroxyl-radical-induced DNA damage: Identification of precursor radicals of DNA strand breaks in oligo(dC)10 and oligo(dT)10. Biochemistry 32:40, pages 10599-10606.
Crossref
Janet Evans, Margaret Maccabee, Zafer Hatahet, Justin Courcelle, Richard Bockrath, Hirioshi Ide & Susan Wallace. (1993) Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis. Mutation Research/Genetic Toxicology 299:3-4, pages 147-156.
Crossref
David Becker & Michael D. Sevilla. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 121 180 .
Irving H. Goldberg. 1993. Molecular Aspects of Anticancer Drug-DNA Interactions. Molecular Aspects of Anticancer Drug-DNA Interactions 243 271 .
Mikinori Kuwabara. (1991) Chemical processes induced by OH attack on nucleic acids. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 37:5-6, pages 691-704.
Crossref
S.N. Bhattacharyya, P.C. Mandal & S. Chakrabarti. (1991) Effect of Cu(II)-aminopolycarboxylates on the radiosensitivity of thymine. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 37:2, pages 347-352.
Crossref
Jürgen Hüttermann. 1991. Radical Ionic Systems. Radical Ionic Systems 435 462 .
Helen H. Evans. 1991. Photobiology. Photobiology 83 95 .
Zeev B. Alfassi. 1991. Amidines and Imidates (1991). Amidines and Imidates (1991) 707 748 .
Yoke W. Kow, Susan S. Wallace & Bennett Van Houten. (1990) UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage. Mutation Research/DNA Repair 235:2, pages 147-156.
Crossref
Stefan W. Ryter, Robert E. Pacifici & Kelvin J.A. Davies. 1990. Biological Oxidation Systems. Biological Oxidation Systems 929 952 .
Slobodan V. Jovanovic & Michael G. Simic. (1989) The DNA guanyl radical: kinetics and mechanisms of generation and repair. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1008:1, pages 39-44.
Crossref
Karen Hubbard, Hiroshi Ide, Bernard F. Erlanger & Susan S. Wallace. (2002) Characterization of antibodies to dihydrothymine, a radiolysis product of DNA. Biochemistry 28:10, pages 4382-4387.
Crossref
F. Busi, V. Concialini, O. Tubertini & M. D'Angelantonio. (1989) Study of electrochemical properties of radiation induced purine and pyrimidine radicals using a microsecond voltammetric technique. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 34:5, pages 857-862.
Crossref
U. Hagen. (1989) Biochemical aspects of radiation biology. Experientia 45:1, pages 7-12.
Crossref
D. Schulte-Frohlinde & K. Hildenbrand. 1989. Free Radicals in Synthesis and Biology. Free Radicals in Synthesis and Biology 335 359 .
S. A. Grachev, E. V. Kropachev & G. I. Litvyakova. (1988) Hydrogen atom transfer reactions from the SH group of thiols to OH adducts to uracil during radiolysis. Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 37:12, pages 2472-2477.
Crossref
E. Kohfeldt, H. Bertram & U. Hagen. (1988) Action of gamma endonuclease on clustered lesions in irradiated DNA. Radiation and Environmental Biophysics 27:2, pages 123-132.
Crossref
C. Herskind & J. Thacker. (1988) Inactivation of DNA-mediated transformation of hamster cells by γ-rays and deoxyribonuclease I. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 198:1, pages 169-178.
Crossref
J.F. Ward. 1988. 95 125 .
Daniel L. Comins & Sean O'Connor. 1988. Advances in Heterocyclic Chemistry Volume 44. Advances in Heterocyclic Chemistry Volume 44 199 267 .
Jean Bernadou, Pascale Gelas & Bernard Meunier. (1988) Hydroxylating activity of a water-soluble manganese porphyrin associated with potassium hydrogen persulfate: Formation of 8-hydroxyadenosine-5′-mono-phosphate from AMP.. Tetrahedron Letters 29:50, pages 6615-6617.
Crossref
J. Cadet, M. Berger, P. Demonchaux & J. Lhomme. (1988) Modifying effects of cysteine and aromatic sulfhydryl and disulfide agents on the radiation-induced decomposition of thymidine. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 32:2, pages 197-202.
Crossref
D. Jore, B. Champion, N. Kaouadji, J.-P. Jay-Gerin & C. Ferradini. (1988) Radiolysis of ethanol and ethanol-water solutions: A tool for studying bioradical reactions. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 32:3, pages 443-448.
Crossref
Susan S. Wallace. (2006) Ap endonucleases and dna glycosylases that recognize oxidative dna damage. Environmental Mutagenesis 12:4, pages 431-477.
Crossref
J.R. Wagner, J.E. van Lier, C. Decarroz & J. Cadet. (1987) Photo and radiation-induced formation of thymidine hydroperoxides. Bioelectrochemistry and Bioenergetics 18:1-3, pages 155-162.
Crossref
Clemens von Sonntag. (1987) Pulse radiolysis of nucleic acids and their base constituents: An updating review. International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry 30:5-6, pages 313-330.
Crossref
U. Hagen. (1986) Current aspects on the radiation induced base damage in DNA. Radiation and Environmental Biophysics 25:4, pages 261-271.
Crossref
Mikinori Kuwabara, Atsuko Minegishi, Atsushi Ito & Takashi Ito. (2008) A STUDY OF AQUEOUS SOLUTIONS OF NUCLEIC ACID CONSTITUENTS EXPOSED TO MONOCHROMATIC 160 nm VACUUM‐UV LIGHT BY SPIN‐TRAPPING METHOD. Photochemistry and Photobiology 44:3, pages 265-272.
Crossref
Clemens von Sonntag. 1986. Mechanisms of DNA Damage and Repair. Mechanisms of DNA Damage and Repair 51 59 .

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