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Original Article

Biological Effectiveness of Low Energy Protons. I. Survival of Chinese Hamster Cells

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Pages 1093-1101 | Received 09 May 1986, Accepted 16 Jun 1986, Published online: 03 Jul 2009

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A. Gutierrez, V. Rompokos, K. Li, C. Gillies, D. D’Souza, F. Solda, N. Fersht, Y.-C. Chang, G. Royle, R. A. Amos & T. Underwood. (2019) The impact of proton LET/RBE modeling and robustness analysis on base-of-skull and pediatric craniopharyngioma proton plans relative to VMAT. Acta Oncologica 58:12, pages 1765-1774.
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M. FOLKARD. (1996) Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions. International Journal of Radiation Biology 69:6, pages 729-738.
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M. Belli, F. Cera, R. Cherubini, A.M.I. Haque, F. Ianzini, G. Moschini, O. Sapora, G. Simone, M.A. Tabocchini & P. Tiveron. (1993) Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility. International Journal of Radiation Biology 63:3, pages 331-337.
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T.J. Jenner, M. Belli, D.T. Goodhead, F. Ianzini, G. Simone & M.A. Tabocchini. (1992) Direct Comparison of Biological Effectiveness of Protons and Alpha-particles of the Same LET. III. Initial Yield of DNA Double-strand Breaks in V79 Cells. International Journal of Radiation Biology 61:5, pages 631-637.
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M. Belli, F. Cera, R. Cherubini, F. Ianzini, G. Moschini, O. Sapora, G. Simone, M.A. Tabocchini & P. Tiveron. (1991) Mutation Induction and RBE-LET Relationship of Low-energy Protons in V79 Cells. International Journal of Radiation Biology 59:2, pages 459-465.
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M. Spotheim-Maurizot, M. Charlier & R. Sabattier. (1990) DNA Radiolysis by Fast Neutrons. International Journal of Radiation Biology 57:2, pages 301-313.
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K.M. Prise, M. Folkard, S. Davies & B.D. Michael. (1990) The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV. Part II. Measurement of Oxygen Enhancement Ratios and DNA Damage. International Journal of Radiation Biology 58:2, pages 261-277.
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M. Folkard, K.M. Prise, B. Vojnovic, S. Davies, M.J. Roper & B.D. Michael. (1989) The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV. International Journal of Radiation Biology 56:3, pages 221-237.
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M. Belli, R. Cherubini, S. Finotto, G. Moschini, O. Sapora, G. Simone & M.A. Tabocchini. (1989) RBE-LET Relationship for the Survival of V79 Cells Irradiated with Low Energy Protons. International Journal of Radiation Biology 55:1, pages 93-104.
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A.M. Fuhrman Conti, G. Francone, M. Volonte & R.E. Gallini. (1988) Induction of 8-azaguanine Resistant Mutants in Human Cultured Cells Exposed to 31 MeV Protons. International Journal of Radiation Biology 53:3, pages 467-476.
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Articles from other publishers (33)

Fredrik Kalholm, Leszek Grzanka, Erik Traneus & Niels Bassler. (2021) A systematic review on the usage of averaged LET in radiation biology for particle therapy. Radiotherapy and Oncology 161, pages 211-221.
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Lydia J Wilson, Fakhriddin Pirlepesov, Vadim Moskvin, Zuofeng Li, Yian Guo, Yimei Li, Thomas E Merchant & Austin M Faught. (2021) Proton therapy delivery method affects dose-averaged linear energy transfer in patients. Physics in Medicine & Biology 66:7, pages 074003.
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Alessio Parisi, Tatsuhiko Sato, Yusuke Matsuya, Yuki Kase, Giulio Magrin, Claudio Verona, Linh Tran, Anatoly Rosenfeld, Anna Bianchi, Pawel Olko, Lara Struelens & Filip Vanhavere. (2020) Development of a new microdosimetric biological weighting function for the RBE 10 assessment in case of the V79 cell line exposed to ions from 1 H to 238 U . Physics in Medicine & Biology 65:23, pages 235010.
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Bleddyn Jones & Mark A Hill. (2019) Physical characteristics at the turnover-points of relative biological effect (RBE) with linear energy transfer (LET). Physics in Medicine & Biology 64:22, pages 225010.
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Mehrdad Shahmohammadi Beni, Dragana Krstic, Dragoslav Nikezic & Kwan Ngok Yu. (2019) Medium-thickness-dependent proton dosimetry for radiobiological experiments. Scientific Reports 9:1.
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Hong Qi Tan, Wei Yang Calvin Koh, Lloyd Kuan Rui Tan, Jun Hao Phua, Khong Wei Ang, Sung Yong Park, Wen Siang Lew & James Cheow Lei Lee. (2019) Dependence of LET on material and its impact on current RBE model. Physics in Medicine & Biology 64:13, pages 135022.
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Harald Paganetti. (2018) Proton Relative Biological Effectiveness – Uncertainties and Opportunities. International Journal of Particle Therapy 5:1, pages 2-14.
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M Cunha, C Monini, E Testa & M Beuve. (2017) NanOx, a new model to predict cell survival in the context of particle therapy. Physics in Medicine and Biology 62:4, pages 1248-1268.
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Aimee L McNamara, Jan Schuemann & Harald Paganetti. (2015) A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data . Physics in Medicine and Biology 60:21, pages 8399-8416.
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Harald Paganetti. (2014) Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Physics in Medicine and Biology 59:22, pages R419-R472.
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K. Ando, Y. Kase & N. Matsufuji. 2014. Comprehensive Biomedical Physics. Comprehensive Biomedical Physics 195 210 .
T. Friedrich, U. Scholz, T. ElsaSser, M. Durante & M. Scholz. (2012) Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. Journal of Radiation Research 54:3, pages 494-514.
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Alejandro Carabe, Samuel España, Clemens Grassberger & Harald Paganetti. (2013) Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Physics in Medicine and Biology 58:7, pages 2103-2117.
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Maria Antonella Tabocchini, Alessandro Campa & Valentina Dini. (2012) DNA and Cellular Effects of Charged Particles. Health Physics 103:5, pages 547-555.
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Alejandro Carabe, Maryam Moteabbed, Nicolas Depauw, Jan Schuemann & Harald Paganetti. (2012) Range uncertainty in proton therapy due to variable biological effectiveness. Physics in Medicine and Biology 57:5, pages 1159-1172.
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John W. Hopewell, Gerard M. Morris, Amanda E. Schwint & Jeffrey A. Coderre. 2012. Neutron Capture Therapy. Neutron Capture Therapy 329 358 .
Harald PaganettiHarald Paganetti. 2011. Proton Therapy Physics. Proton Therapy Physics 593 626 .
I. K. Khvostunov, H. Nikjoo, S. Uehara & M. Hoshi. (2011) The consideration of biological effectiveness of low energy protons using biophysical modeling of the effects induced by exposure of V79 cells. Biophysics 55:6, pages 1067-1075.
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Pavel Kundrát. (2009) Detailed probabilistic modelling of cell inactivation by ionizing radiations of different qualities: The model and its applications. Applied Radiation and Isotopes 67:3, pages 399-401.
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Pavel Kundrát. (2006) Detailed analysis of the cell-inactivation mechanism by accelerated protons and light ions. Physics in Medicine and Biology 51:5, pages 1185-1199.
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J J Wilkens & U Oelfke. (2004) A phenomenological model for the relative biological effectiveness in therapeutic proton beams. Physics in Medicine and Biology 49:13, pages 2811-2825.
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Maddalena Mognato, Elisabetta Bortoletto, Paola Ferraro, Laura Baggio, Roberto Cherubini, Sabrina Canova, Antonella Russo & Lucia Celotti. (2003) Genetic Damage Induced by In Vitro Irradiation of Human G 0 Lymphocytes with Low-Energy Protons (28 keV/μm): HPRT Mutations and Chromosome Aberrations . Radiation Research 160:1, pages 52-60.
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H Paganetti. (2002) Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Physics in Medicine and Biology 47:5, pages 747-764.
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I Gudowska, A Brahme, P Andreo, W Gudowski & J Kierkegaard. (1999) Calculation of absorbed dose and biological effectiveness from photonuclear reactions in a bremsstrahlung beam of end point 50 MeV. Physics in Medicine and Biology 44:9, pages 2099-2125.
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H Paganetti. (1998) Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Physics in Medicine and Biology 43:8, pages 2147-2157.
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M. Belli, F. Ianzini, O. Sapora, M.A. Tabocchini, F. Cera, R. Cherubini, A.M.I. Haque, G. Moschini, P. Tiveron & G. Simone. (1996) DNA double strand break production and rejoining in V79 cells irradiated with light ions. Advances in Space Research 18:1-2, pages 73-82.
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David E. Watt & Ali S. Alkharam. (1994) Charged particle track structure parameters for application in radiation biology and radiation chemistry. International Journal of Quantum Chemistry 52:S21, pages 195-207.
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James B. Robertson, William C. Glisson, John O. Archambeau, George B. Coutrakan, Daniel W. Miller, Michael F. Moyers, Jeffrey F. Siebers, James M. Slater & John F. Dicello. 1993. Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B. Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B 853 858 .
J A Simmons. (1992) Absorbed dose-an irrelevant concept for irradiation with heavy charged particles?. Journal of Radiological Protection 12:3, pages 173-179.
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Eleanor A. Blakely. (1992) Cell inactivation by heavy charged particles. Radiation and Environmental Biophysics 31:3, pages 181-196.
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V. Valković & G. Moschini. (1991) Some advances in medical applications of low energy accelerators. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 56-57, pages 1274-1278.
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D E Watt. (1989) On absolute biological effectiveness and unified dosimetry. Journal of Radiological Protection 9:1, pages 33-49.
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P. D. Holt. (1988) Biophysical interpretation of the response of Chinese hamster cells to 24 keV neutrons. The British Journal of Radiology 61:732, pages 1142-1146.
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