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Original Article

Evaluation of Various Types of New Hypoxic Cell Sensitizers Using the EMT6 Single Cell—Spheroid—Solid Tumour System

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Pages 347-357 | Received 09 Feb 1987, Accepted 15 May 1987, Published online: 03 Jul 2009

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Kento Nomura, Hiromitsu Iwata, Toshiyuki Toshito, Chihiro Omachi, Junpei Nagayoshi, Koichiro Nakajima, Hiroyuki Ogino & Yuta Shibamoto. (2021) Biological effects of passive scattering and spot scanning proton beams at the distal end of the spread-out Bragg peak in single cells and multicell spheroids. International Journal of Radiation Biology 97:5, pages 695-703.
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John E. Moulder. (2019) Chemical radiosensitizers: the Journal history. International Journal of Radiation Biology 95:7, pages 940-944.
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Robert J. Myerson, Anurag K. Singh, Heather M. Bigott, Bibiana Cha, John A. Engelbach, Joonyoung Kim, Wayne T. Lamoreaux, Eduardo Moros, Petr Novak, Terry L. Sharp, William Straube, Michael J. Welch & Mai Xu. (2006) Monitoring the effect of mild hyperthermia on tumour hypoxia by Cu-ATSM PET scanning. International Journal of Hyperthermia 22:2, pages 93-115.
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Y. Shibamoto, Y. Mimasu, Y. Tachi, H. Hatta & S. Nishimoto. (2002) Comparison of 5-Fluorouracil and 5-Fluoro-2'-Deoxyuridine as an Effector in Radiation-Activated Prodrugs. Journal of Chemotherapy 14:4, pages 390-396.
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Y. Shibamoto, C. Streffer, K. Sasai, N. Oya & M. Abe. (1992) Radiosensitization Efficacy of KU-2285, RP-170 and Etanidazole at Low Radiation Doses: Assessment by in Vitro Cytokinesis-block Micronucleus Assay. International Journal of Radiation Biology 61:4, pages 473-478.
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Y. Shibamoto, K. Sasai, M. Sakaguchi, P. Tamulevicius, Y. Kitakabu, C. Streffer & M. Abe. (1991) Evaluation of a New 2-nitroimidazole Nucleoside Analogue, RK-28 as a Radiosensitizer for Clinical Use. International Journal of Radiation Biology 59:1, pages 105-115.
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K. Sasai, Y. Shibamoto, M. Takahashi, T. Ito, S. Nishimoto & M. Abe. (1990) Pharmacokinetics of 2-nitroimidazole Hypoxic Cell Radiosensitizers in Rodent Peripheral Nervous Tissue. International Journal of Radiation Biology 57:5, pages 971-980.
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Articles from other publishers (25)

Muhammad Saqib, Farhad Izadi, Leon U. Isierhienrhien, Milan Ončák & Stephan Denifl. (2023) Decomposition of triazole and 3-nitrotriazole upon low-energy electron attachment. Physical Chemistry Chemical Physics 25:20, pages 13892-13901.
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S. Sreeja & C.K. Krishnan Nair. (2018) Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle – Berberine complexes in a mouse model. Life Sciences 195, pages 71-80.
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Taro Murai, Shin-Etsu KamataKengo Sato, Kouki MiuraMitsuhiro Inoue, Naoki YokotaSeiji Ohta, Michio Iwabuchi, Hiromitsu IwataYuta Shibamoto. (2016) Hypofractionated Stereotactic Radiotherapy for Auditory Canal or Middle Ear Cancer. Cancer Control 23:3, pages 311-316.
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Karim Asadpour‐Zeynali, Mir Reza Majidi, Parvaneh Najafi‐Marandi & Zinalabedin Norysaray. (2013) Electrocatalytic Reduction of Metronidazole on Bismuth Modified Pencil‐lead Electrode. Journal of the Chinese Chemical Society 60:10, pages 1253-1259.
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Sharmila Banerjee, Tapas Das, S. Chakraborty & Meera Venkatesh. (2012) Emergence and present status of Lu-177 in targeted radiotherapy: the Indian scenario. ract 100:2, pages 115-126.
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Romain Bejot, Laurence Carroll, Kishore Bhakoo, Jérôme Declerck & Veronique Gouverneur. (2012) A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers. Bioorganic & Medicinal Chemistry 20:1, pages 324-329.
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Tapas Das, Sudipta Chakraborty, Sharmila Banerjee, Archana Mukherjee, Grace Samuel, H.D. Sarma, C.K.K. Nair, V.T. Kagiya & Meera Venkatesh. (2004) Preparation and preliminary biological evaluation of a 177Lu labeled sanazole derivative for possible use in targeting tumor hypoxia. Bioorganic & Medicinal Chemistry 12:23, pages 6077-6084.
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P.C Mandal. (2004) Reactions of the nitro radical anion of metronidazole in aqueous and mixed solvent: a cyclic voltammetric study. Journal of Electroanalytical Chemistry 570:1, pages 55-61.
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Yuta Shibamoto, Ling Zhou, Hiroshi Hatta, Mayuko Mori & Sei‐ichi Nishimoto. (2005) A Novel Class of Antitumor Prodrug, 1‐(2′‐Oxopropyl)‐5‐fluorouracil (OFU001), That Releases 5‐Fluorouracil upon Hypoxic Irradiation. Japanese Journal of Cancer Research 91:4, pages 433-438.
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R. Mathew, S. Kapoor, C.K.K. Nair, M.S. Sastry, N.G. Huilgol, C. Gopinathan, B.B. Singh & V.T. Kagiya. (1997) Pulse and gamma radiolytic studies of the radiosensitizer sanazole (AK-2123) in presence of uracil. Radiation Physics and Chemistry 49:2, pages 233-235.
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Kazuyu Ebe, Hiroki Suda, Tatsuya Kuramitsu, Yutaka Honma, Takashi Nakanishi, Yoshiyuki Miyata, Masakazu Sakaguchi & Naofumi Matsunaga. (1996) Evaluation of the radiosensitizing effects of RK28 intravenous, intraarterial, and intratumoral injections on the rabbit VX2 tumor system. International Journal of Radiation Oncology*Biology*Physics 36:5, pages 1107-1116.
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Yuta Shibamoto, Masaji Takahashi & Mitsuyuki Abe. (1996) A Phase I study of a hypoxic cell sensitizer KU-2285 in combination with conventional radiotherapy. Radiotherapy and Oncology 40:1, pages 55-58.
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Toru Shibata, Yuta Shibamoto, Natsuo Oya, Keisuke Sasai, Rumi Murata, Takashi Ishigaki & Mitsuyuki Abe. (1994) Comparison of radiosensitizing effect of KU-2285 and SR-2508 at low drug concentrations and doses. International Journal of Radiation Oncology*Biology*Physics 29:3, pages 587-590.
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Sei-ichi Nishimoto & Ling Zhou. (1994) Cellular non-protein thiol depletion and radiosensitization of hypoxic cells by a novel 2-nitroimidazole derivative possessing an NPSH-reactive side chain. Bioorganic & Medicinal Chemistry Letters 4:3, pages 439-442.
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V Tsutomu Kagiya, Sei-Ichi Nishimoto, Takashi Ito, Jun Wang, Mitsuyuki Abe & Keisuke Sasai. (1992) Fluorine modification of nitroazole radiosensitizers for the enhancement of sensitizing activity with lowering toxicity: A pharmacokinetic characterization. International Journal of Radiation Oncology*Biology*Physics 22:3, pages 601-605.
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V. Tsutomu Kagiya, Toshio Sugita, Sei-Ichi Nishimoto, Masamichi Masuoka, Lin Zhou, Mitsuyuki Abe, Yuta Shibamoto & Keisuke Sasai. (1992) Metabolic rate modification of nitrotriazole radiosensitizers by sulfur substitution of side chain. International Journal of Radiation Oncology*Biology*Physics 22:3, pages 597-600.
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Keisuke Sasai, Yuta Shibamoto, Tadao Manabe, Nobuo Baba, Masaji Takahashi, Masakazu Sakaguchi & Mitsuyuki Abe. (1992) Pharmacokinetics of intratumoral RK-28, a new hypoxic radiosensitizer. International Journal of Radiation Oncology*Biology*Physics 24:5, pages 959-963.
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Keisuke Sasai, Sei-Ichi Nishimoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Yoshizumi Kitakabu, Yuta Shibamoto, Lin Zhou, Jun Wang, Masaji Takahashi, Tsutomu Kagiya & Mitsuyuki Abe. (1991) A fluorinated 2-nitroimidazole, ku-2285, as a new hypoxic cell radiosensitizer. International Journal of Radiation Oncology*Biology*Physics 20:6, pages 1249-1254.
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Harukazu Mashiba, Keiko Matsunaga & Kazuo Hata. (1991) Enhancement of radiosensitizing effect of the nitroimidazole derivative RK28 on the proliferation of MethA tumor cells in combined use with diethyldithiocarbamate. Life Sciences 49:19, pages 1419-1425.
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Yoshimitsu Nagao, Shigeki Sano, Masahito Ochiai & Eiichi Fujita. (1990) Biomimetic chemical, and spectroscopic evaluations for the radiosensitizing potential of N1- and N2-substituted derivatives of 3-Nitro-1,2,4-Triazole toward hypoxic cells in the radiotherapy: Remarkably different substitution effect. Tetrahedron 46:9, pages 3211-3232.
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Keisuke Sasai, Yuta Shibamoto, Masaji Takahashi, Mitsuyuki Abe, Jun Wang, Lin Zhou, Sei-ichi Nishimoto & Tsutomu Kagiya. (1989) A New, Potent 2-Nitroimidazole Nucleoside Hypoxic Cell Radiosensitizer, RP170. Japanese Journal of Cancer Research 80:11, pages 1113-1118.
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Chieko Murayama, Akira Suzuki, Toshimitsu Suzuki, Yoshiyuki Miyata, Masakazu Sakaguchi, Yoshitaka Tanabe, Norimoto Tanaka & Tomoyuki Mori. (1989) Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170). International Journal of Radiation Oncology*Biology*Physics 17:3, pages 575-581.
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Keisuke Sasai, Koji Ono, Takehiro Nishidai, Kazushige Tsutsui, Yuta Shibamoto, Masaji Takahashi & Mitsuyuki Abe. (1989) Variation in tumor response to fluosol-DA (20%). International Journal of Radiation Oncology*Biology*Physics 16:5, pages 1149-1152.
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Yuta Shibamoto, Sei-Ichi Nishimoto, Kazuhiro Shimokawa, Yorisato Hisanaga, Lin Zhou, Jun Wang, Keisuke Sasai, Masaji Takaihashi, Mitsuyuki Abe & Tsutomu Kagiya. (1989) Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. International Journal of Radiation Oncology*Biology*Physics 16:4, pages 1045-1048.
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Hitoshi Hori, Chieko Murayama, Tomoyuki Mori, Yuta Shibamoto, Mitsuyuki Abe, Yasuto Onoyama & Seiichi Inayama. (1989) KIH-802: 2-nitroimidazole-1-acetohydroxamate as a hypoxic cell radiosensitizer. International Journal of Radiation Oncology*Biology*Physics 16:4, pages 1029-1032.
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