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Original Article

Bleomycin, in Contrast to Gamma Irradiation, Induces Extreme Variation of DNA Strand Breakage from Cell to Cell

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Pages 683-691 | Received 19 Dec 1986, Accepted 17 Aug 1987, Published online: 03 Jul 2009

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W.-U. Müller, T. Bauch, C. Streffer, F. Niedereichholz & W. Böcker. (1994) Comet Assay Studies of Radiation-induced DNA Damage and Repair in Various Tumour Cell Lines. International Journal of Radiation Biology 65:3, pages 315-319.
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Yiwei Li, Xiaojun Feng, Wei Du, Ying Li & Bi-Feng Liu. (2013) Ultrahigh-Throughput Approach for Analyzing Single-Cell Genomic Damage with an Agarose-Based Microfluidic Comet Array. Analytical Chemistry 85:8, pages 4066-4073.
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Amaya Azqueta & Andrew R. Collins. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Atef M.M. Attia, Ghada M. Nabil, Dieter Frankenberg & M. Frankenberg-Schwager. (2011) Measurement of X-ray-induced DNA double-strand breaks at various stages of the cell cycle using the total fluorescence as a comet assay parameter. Radiation Physics and Chemistry 80:11, pages 1178-1185.
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Omar García, Ivonne Romero, Jorge Ernesto González, Damaris L. Moreno, Elizabeth Cuétara, Yesenia Rivero, Ariadne Gutiérrez, Carlos L. Pérez, Aimée Álvarez, Deyanira Carnesolta & Irania Guevara. (2011) Visual estimation of the percentage of DNA in the tail in the comet assay: Evaluation of different approaches in an intercomparison exercise. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 720:1-2, pages 14-21.
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Gary Peter Watters, Daniel James Smart, James Stephen Harvey & Caroline Ann Austin. (2009) H2AX phosphorylation as a genotoxicity endpoint. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 679:1-2, pages 50-58.
Crossref
Piero Sestili, Chiara Martinelli & Vilberto Stocchi. (2006) The fast halo assay: An improved method to quantify genomic DNA strand breakage at the single-cell level. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 607:2, pages 205-214.
Crossref
Peggy L Olive & Judit P Banáth. (2006) The comet assay: a method to measure DNA damage in individual cells. Nature Protocols 1:1, pages 23-29.
Crossref
Peggy L. Olive & Ralph E. Durand. (2005) Heterogeneity in DNA damage using the comet assay. Cytometry Part A 66A:1, pages 1-8.
Crossref
Shaolong Feng, Zhiming Kong, Xinming Wang, Pingan Peng & Eddy Y. Zeng. (2005) Assessing the genotoxicity of imidacloprid and RH-5849 in human peripheral blood lymphocytes in vitro with comet assay and cytogenetic tests. Ecotoxicology and Environmental Safety 61:2, pages 239-246.
Crossref
Åsa Holgersson, Thomas Heiden, Juan Castro, Margareta R. Edgren, Rolf Lewensohn & Annelie E. Meijer. (2005) Different G2/M accumulation in M059J and M059K cells after exposure to DNA double-strand break–inducing agents. International Journal of Radiation Oncology*Biology*Physics 61:3, pages 915-921.
Crossref
Sudhir Chandna. (2004) Single‐cell gel electrophoresis assay monitors precise kinetics of DNA fragmentation induced during programmed cell death. Cytometry Part A 61A:2, pages 127-133.
Crossref
Shaolong Feng, Zhiming Kong, Xinming Wang, Lirong Zhao & Pingan Peng. (2004) Acute toxicity and genotoxicity of two novel pesticides on amphibian, Rana N. Hallowell. Chemosphere 56:5, pages 457-463.
Crossref
Richard D Bowden, Matthew R Buckwalter, Jeremy F McBride, David A Johnson, Byron K Murray & Kim L O’Neill. (2003) Tail profile: a more accurate system for analyzing DNA damage using the Comet assay. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 537:1, pages 1-9.
Crossref
Kum-Ju Park, Hai-Hong Jin & Chang-Kee Hyun. (2002) Antigenotoxicity of peptides produced from silk fibroin. Process Biochemistry 38:3, pages 411-418.
Crossref
Maria Wojewódzka, Iwona Buraczewska & Marcin Kruszewski. (2002) A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 518:1, pages 9-20.
Crossref
Kum-Ju Park & Chang-Kee Hyun. (2002) Antigenotoxic effects of the peptides derived from bovine blood plasma proteins. Enzyme and Microbial Technology 30:5, pages 633-638.
Crossref
Yaming Wei, Xiaozhe Cao, Yinxian Ou, Jihong Lu, Chuanping Xing & Rongliang Zheng. (2001) SeO2 induces apoptosis with down-regulation of Bcl-2 and up-regulation of P53 expression in both immortal human hepatic cell line and hepatoma cell line. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 490:2, pages 113-121.
Crossref
Peggy L. Olive, Ralph E. Durand, Judit P. Banath & Peter J. Johnston. 2001. Cytometry: Part B. Cytometry: Part B 235 249 .
Jong‐Heum Park, Chang‐Kee Hyun, Seok‐Kyu Jeong, Mi‐Ae Yi, Seung‐Taek Ji & Heuyn‐Kil Shin. (2008) Use of the single cell gel electrophoresis assay (Comet assay) as a technique for monitoring low‐temperature treated and 
irradiated muscle tissues. International Journal of Food Science & Technology 35:6, pages 555-561.
Crossref
Bogdan Smolka, Konrad Wojciechowski, Andrzej Swierniak, Marek Szczepanski, Damian Bereska, Marek Karasek, Maria Widel & Bozena Lubecka. (2000) A New Method of the Analysis of Comet Assay Images 1. IFAC Proceedings Volumes 33:3, pages 239-244.
Crossref
I Testard & L Sabatier. (2000) Assessment of DNA damage induced by high-LET ions in human lymphocytes using the comet assay. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 448:1, pages 105-115.
Crossref
Piero Sestili & Orazio Cantoni. (1999) Osmotically driven radial diffusion of single-stranded DNA fragments on an agarose bed as a convenient measure of DNA strand scission. Free Radical Biology and Medicine 26:7-8, pages 1019-1026.
Crossref
Stylianos M. Piperakis, Evangelos-E. Visvardis & Aspasia M. Tassiou. 1999. Oxidants and Antioxidants Part B. Oxidants and Antioxidants Part B 184 194 .
Paweł Jałoszyński, Maciej Kujawski, Maria Czub-Świerczek, Janina Markowska & Krzysztof Szyfter. (1997) Bleomycin-induced DNA damage and its removal in lymphocytes of breast cancer patients studied by comet assay. Mutation Research/DNA Repair 385:3, pages 223-233.
Crossref
G.R. Aravindan, J. Bjordahl, L.K. Jost & D.P. Evenson. (1997) Susceptibility of Human Sperm toin SituDNA Denaturation Is Strongly Correlated with DNA Strand Breaks Identified by Single-Cell Electrophoresis. Experimental Cell Research 236:1, pages 231-237.
Crossref
Roderick A.F. MacLeod, Torsten Buchheim, Maren Kaufmann & Hans G. Drexler. (1996) Chromosomal breakage correlates with delayed lethality in normal and ataxia telangiectasia cell lines treated with bleomycin. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 372:1, pages 33-42.
Crossref
Suzanne M. Morris, Olen E. Domon, Lynda J. McGarrity, James J. Chen, M.G. Manjanatha, Annette M. Andrews, Anane Aidoo & Daniel A. Casciano. (1996) A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk+− human lymphoblastoid cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 357:1-2, pages 143-165.
Crossref
Maria Klaude, Stefan Eriksson, Jonas Nygren & Gunnar Ahnström. (1996) The comet assay: mechanisms and technical considerations. Mutation Research/DNA Repair 363:2, pages 89-96.
Crossref
Daryl W. Fairbairn, Peggy L. Olive & Kim L. O'Neill. (1995) The comet assay: a comprehensive review. Mutation Research/Reviews in Genetic Toxicology 339:1, pages 37-59.
Crossref
Sian Ellard, Elizabeth M. Parry & James M. Parry. (2006) Use of multicolour chromosome painting to identify chromosomal rearrangements in human lymphocytes exposed to bleomycin: A comparison with conventional cytogenetic analysis of giemsa‐stained chromosomes. Environmental and Molecular Mutagenesis 26:1, pages 44-54.
Crossref
Christoph Schöber, John F. Gibbs, Ming-Biao Yin, Harry K. Slocum & Youcef M. Rustum. (1994) Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays. Biochemical Pharmacology 48:5, pages 997-1002.
Crossref
P. L. Olive, J. P. Banáth & C. D. Fjell. (2005) DNA strand breakage and DNA structure influence staining with propidium iodide using the alkaline comet assay. Cytometry 16:4, pages 305-312.
Crossref
W.D. Wrigh & J.L. Roti Roti. 1994. Organelles in Vivo. Organelles in Vivo 43 61 .
Kim L. O'Neill, Daryl W. Fairbairn & Michael D. Standing. (1993) Analysis of single-cell gel electrophoresis using laser-scanning microscopy. Mutation Research/Genetic Toxicology 319:2, pages 129-134.
Crossref
V.J. McKelvey-Martin, M.H.L. Green, P. Schmezer, B.L. Pool-Zobel, M.P. De Méo & A. Collins. (1993) The single cell gel electrophoresis assay (comet assay): A European review. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 288:1, pages 47-63.
Crossref
P.J. Johnston & P.E. Bryant. (1993) Chromosome damage induced by nanomolar concentrations of bleomycin in porated mammalian cells. Biochemical Pharmacology 45:3, pages 569-572.
Crossref
Joseph L. Roti Roti, William D. Wright & Yvonne C. Taylor. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 227 259 .
George R. Hoffmann, Shirley P. Colyer & L. Gayle Littlefield. (2006) Induction of micronuclei by bleomycin in G 0 human lymphocytes: I. Dose‐response and distribution . Environmental and Molecular Mutagenesis 21:2, pages 130-135.
Crossref
Alejandro D. Bolzán, Néstor O. Bianchi, Marcelo L. Larramendy & Martha S. Bianchi. (1992) Chromosomal sensitivity of human lymphocytes to bleomycin. Cancer Genetics and Cytogenetics 64:2, pages 133-138.
Crossref
P.L. Olive, D. Wlodek, R.E. Durand & J.P. Banáth. (1992) Factors influencing DNA migration from individual cells subjected to gel electrophoresis. Experimental Cell Research 198:2, pages 259-267.
Crossref
Andrew D. Kligerman, Miriam F. Bryant, Carolyn L. Doerr, Edward C. Halperin, Puntipa Kwanyuen, Marc R. Sontag & Gregory L. Erexson. (2006) Interspecies cytogenetic comparisons: Studies with x‐radiation and bleomycin sulfate. Environmental and Molecular Mutagenesis 19:3, pages 235-243.
Crossref
Lawrence F. Povirk & M.J. Finley Austin. (1991) Genotoxicity of bleomycin. Mutation Research/Reviews in Genetic Toxicology 257:2, pages 127-143.
Crossref
De-Yan Hou & And Yosh Maruyama. (1990) Enhanced killing of human small cell lung cancer by hyperthermia and lndium-111- bleomycin complex. Journal of Surgical Oncology 44:1, pages 5-9.
Crossref

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