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Original Article

The Dose—response for Low-LET Radiation-induced DNA Double-strand Breakage: Methods of Measurement and Implications for Radiation Action Models

Pages 1-11 | Received 09 Oct 1987, Accepted 15 Feb 1988, Published online: 03 Jul 2009

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Read on this site (20)

M. Flentje, B. Asadpour, D. Latz & K.J. Weber. (1993) Sensitivity of Neutral Filter Elution but Not PFGE Can Be Modified by Non-dsb Chromatin Damage. International Journal of Radiation Biology 63:6, pages 715-724.
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M. Löbrich, S. Ikpeme, P. Haub, K.-J. Weber & J. Kiefer. (1993) DNA Double-strand Break Induction in Yeast by X-rays and α-particles Measured by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 64:5, pages 539-546.
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V. Michalik. (1992) Model of DNA Damage Induced by Radiations of Various Qualities. International Journal of Radiation Biology 62:1, pages 9-20.
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S. Saigusa, Y. Ejima, K. Kobayashi & M.S. Sasaki. (1992) Induction of Chromosome Aberrations by Monochromatic X-rays with Resonance Energy of Phosphorus K-shell Absorption Edge. International Journal of Radiation Biology 61:6, pages 785-790.
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D.J. Brenner & J.F. Ward. (1992) Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks. International Journal of Radiation Biology 61:6, pages 737-748.
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R. Okayasu & G. Iliakis. (1992) The Shape of DNA Elution Dose-response Curves Under Non-denaturing Conditions: The Contribution of the Degree of Chromatin Condensation. International Journal of Radiation Biology 61:4, pages 455-463.
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L. Hlatky, R. Sachs & P. Hahnfeldt. (1991) Reaction Kinetics for the Development of Radiation-induced Chromosome Aberrations. International Journal of Radiation Biology 59:5, pages 1147-1172.
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D. Blöcher & G. Iliakis. (1991) Size Distribution of DNA Molecules Recovered from Non-denaturing Filter Elution. International Journal of Radiation Biology 59:4, pages 919-926.
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S.Y. Ahn, B. Nevaldine & P.J. Hahn. (1991) Direct Measurement by Pulsed-field Gel Electrophoresis of Induction and Rejoining of X-ray-induced Double-strand Breaks in Cultured Mouse Cells. International Journal of Radiation Biology 59:3, pages 661-675.
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. (1990) Abstracts of the Association for Radiation Research Meeting, Bristol, U.K., 20–22 September 1989. International Journal of Radiation Biology 57:3, pages 593-608.
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I.R. Radford. (1990) Rapid Communication. International Journal of Radiation Biology 57:3, pages 479-483.
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M. Spotheim-Maurizot, M. Charlier & R. Sabattier. (1990) DNA Radiolysis by Fast Neutrons. International Journal of Radiation Biology 57:2, pages 301-313.
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T.J. McMillan, A.M. Cassoni, S. Edwards, A. Holmes & J.H. Peacock. (1990) The Relationship of DNA Double-strand Break Induction to Radiosensitivity in Human Tumour Cell Lines. International Journal of Radiation Biology 58:3, pages 427-438.
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K.M. Prise, M. Folkard, S. Davies & B.D. Michael. (1990) The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV. Part II. Measurement of Oxygen Enhancement Ratios and DNA Damage. International Journal of Radiation Biology 58:2, pages 261-277.
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D.E. Charlton, H. Nikjoo & J.L. Humm. (1989) Calculation of Initial Yields of Single- and Double-strand Breaks in Cell Nuclei from Electrons, Protons and Alpha Particles. International Journal of Radiation Biology 56:1, pages 1-19.
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Ryuichi Okayasu & George Iliakis. (1989) Linear DNA Elution Dose Response Curves Obtained in CHO Cells with Non-unwinding Filter Elution after Appropriate Selection of the Lysis Conditions. International Journal of Radiation Biology 55:4, pages 569-581.
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Kevin M. Prise, Susan Davies & Barry D. Michael. (1989) An Improved Method for the Treatment of Data from DNA Strand Break Measurements Using Filter Elution Techniques with an Internal Standard. International Journal of Radiation Biology 55:3, pages 323-330.
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Gunnar Ahnström. (1988) Techniques to Measure DNA Single-strand Breaks in Cells: A Review. International Journal of Radiation Biology 54:5, pages 695-707.
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Articles from other publishers (20)

Yanlei Cheng, Fanghua Li, Emil Mladenov & George Iliakis. (2015) The yield of DNA double strand breaks determined after exclusion of those forming from heat-labile lesions predicts tumor cell radiosensitivity to killing. Radiotherapy and Oncology 116:3, pages 366-373.
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C Shao, M Saito & Z Yu. (1999) Radiation induced DNA strand breaks measured by a modified method of gel scanning. Radiation Physics and Chemistry 56:5-6, pages 547-551.
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C. Baumstark-khan, E. Halbe & H. Rink. 1999. Ocular Radiation Risk Assessment in Populations Exposed to Environmental Radiation Contamination. Ocular Radiation Risk Assessment in Populations Exposed to Environmental Radiation Contamination 153 162 .
Michael V. Filatov, Rimma A. Pantina & Leonid A. Noskin. (1998) Methods for registration of spontaneous DNA instability in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 403:1-2, pages 95-101.
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Peggy L. Olive. 1998. DNA Damage and Repair. DNA Damage and Repair 539 557 .
N. Foray, C.F. Arlett & E.P. Malaise. (1997) Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look. Biochimie 79:9-10, pages 567-575.
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Björn Cedervall & Tomas Radivoyevitch. (2005) Methods for analysis of DNA fragment distributions on pulsed field gel electrophoretic gels. ELECTROPHORESIS 17:6, pages 1080-1086.
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Reinhard Wurm, Neil G. Burnet, Nisha Duggal, John R. Yarnold & John H. Peacock. (1994) Cellular radiosensitivity and dna damage in primary human fibroblasts. International Journal of Radiation Oncology*Biology*Physics 30:3, pages 625-633.
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U. Micke, G. Horneck & S. Kozubek. (1994) Double strand breaks in the DNA of Bacillus subtilis cells irradiated by heavy ions. Advances in Space Research 14:10, pages 207-211.
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Bj�rn Cedervall & Patric K�llman. (1994) Randomly distributed DNA double-strand breaks as measured by pulsed field gel electrophoresis: A series of explanatory calculations. Radiation and Environmental Biophysics 33:1, pages 9-21.
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Theodore S Lawrence, Daniel P Normolle, Mary A Davis & Jonathan Maybaum. (1993) The use of biphasic linear ramped pulsed field gel electrophoresis to quantify dna damage based on fragment size distribution. International Journal of Radiation Oncology*Biology*Physics 27:3, pages 659-663.
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M.N. Cornforth & J.S. Bedford. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 423 496 .
Christopher S. Lange, Arthur Cole & Joseph Y. Ostashevsky. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 261 421 .
P. Hahnfeldt, R. K. Sachse & L. R. Hlatky. (1992) Evolution of DNA damage in irradiated cells. Journal of Mathematical Biology 30:5, pages 493-511.
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George Lliakis. (2005) The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells. BioEssays 13:12, pages 641-648.
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Stephen J. Whitaker, Simon N. Powell & Trevor J. McMillan. (1991) Molecular assays of radiation-induced DNA damage. European Journal of Cancer and Clinical Oncology 27:7, pages 922-928.
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H. H. Evans. 1991. Advances in Mutagenesis Research. Advances in Mutagenesis Research 28 52 .
Nina D. Costa & Peter E. Bryant. (1990) Neutral filter elution detects only limited inhibition of double-strand break repair by 9-β-d-arabinofuranosyladenine. Mutation Research/DNA Repair 235:3, pages 217-223.
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Hassan K. AwwadHassan K. Awwad. 1990. Radiation Oncology: Radiobiological and Physiological Perspectives. Radiation Oncology: Radiobiological and Physiological Perspectives 53 83 .
Chun-Zhang Chen & John C. Sutherland. (1989) Gel electrophoresis method for quantitation of gamma ray induced single- and double-strand breaks in DNA irradiatedin vitro. Electrophoresis 10:5-6, pages 318-326.
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