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International Journal of Radiation Biology Volume 54, 1988 - Issue 6
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Original Article

The Doubling Time of Regenerating Clonogenic Cells in the Crypts of the Irradiated Mouse Small Intestine

C.S. Potten Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, U.K.
,
Y. Taylor Department of Radiobiology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, U.K.
&
J.H. Hendry Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Withington, Manchester, U.K.
Pages 1041-1051 | Received 29 Jan 1988, Accepted 07 Jul 1988, Published online: 03 Jul 2009

Citations (26)

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C. S. Potten & C. A. Chadwick. (1994) Small Intestinal Growth Regulatory Factors Extracted by Simple Diffusion from Intact Irradiated Intestine and Tested In Vivo. Growth Factors 10:1, pages 63-75.
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C. S. Potten, C. Booth, C. A. Chadwick & G. S Evans. (1994) A Potent Stimulator of Small Intestinal Cell Proliferation Extracted by Simple Diffusion from Intact Irradiated Intestine: In Vitro Studies. Growth Factors 10:1, pages 53-61.
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Kumari Veena & Pathirissery Uma Devi. (1992) Modification of Radioresponse of Sublethally Irradiated Mouse Jejunum by Misonidazole. Acta Oncologica 31:5, pages 585-589.
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C.S. Potten. (1990) A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine. International Journal of Radiation Biology 58:6, pages 925-973.
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C.S. Potten, G. Owen & S.A. Roberts. (1990) The Temporal and Spatial Changes in Cell Proliferation within the Irradiated Crypts of the Murine Small Intestine. International Journal of Radiation Biology 57:1, pages 185-199.
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Articles from other publishers (21)

Mumtaz Anwar, Shabeer Ahmad, Reyhan Akhtar, Akhtar Mahmood & Safrun Mahmood. (2017) Antioxidant Supplementation: A Linchpin in Radiation-Induced Enteritis. Technology in Cancer Research & Treatment 16:6, pages 676-691.
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Monica M. Olcina & Amato J. Giaccia. (2016) Reducing radiation-induced gastrointestinal toxicity — the role of the PHD/HIF axis. Journal of Clinical Investigation 126:10, pages 3708-3715.
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Randal May, Dongfeng Qu, Nathaniel Weygant, Parthasarathy Chandrakesan, Naushad Ali, Stanley A. Lightfoot, Linheng Li, Sripathi M. Sureban & Courtney W. Houchen. (2014) Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury. Stem Cells 32:3, pages 822-827.
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Rafael Bravo & David E Axelrod. (2013) A calibrated agent-based computer model of stochastic cell dynamics in normal human colon crypts useful for in silico experiments. Theoretical Biology and Medical Modelling 10:1.
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Guoqiang Hua, Tin Htwe Thin, Regina Feldman, Adriana Haimovitz–Friedman, Hans Clevers, Zvi Fuks & Richard Kolesnick. (2012) Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant. Gastroenterology 143:5, pages 1266-1276.
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Noor Al‐Dasooqi, Rachel J. Gibson, Joanne M. Bowen & Dorothy M. Keefe. 2012. Molecular and Cellular Therapeutics. Molecular and Cellular Therapeutics 69 102 .
F.A. Stewart, A.V. Akleyev, M. Hauer-Jensen, J.H. Hendry, N.J. Kleiman, T.J. MacVittie, B.M. Aleman, A.B. Edgar, K. Mabuchi, C.R. Muirhead, R.E. Shore & W.H. Wallace. (2012) ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context. Annals of the ICRP 41:1-2, pages 1-322.
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Konstantin Krepkin & José Costa. (2011) Defining the role of cooperation in early tumor progression. Journal of Theoretical Biology 285:1, pages 36-45.
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Randal May, Sripathi M. Sureban, Nguyet Hoang, Terrence E. Riehl, Stan A. Lightfoot, Rama Ramanujam, James H. Wyche, Shrikant Anant & Courtney W. Houchen. (2009) Doublecortin and CaM Kinase-like-1 and Leucine-Rich-Repeat-Containing G-Protein-Coupled Receptor Mark Quiescent and Cycling Intestinal Stem Cells, Respectively. Stem Cells 27:10, pages 2571-2579.
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Archana Jindal, Dhanraj Soyal, Abhilasha Sharma & P.K. Goyal. (2009) Protective Effect of an Extract of Emblica officinalis Against Radiation-Induced Damage in Mice. Integrative Cancer Therapies 8:1, pages 98-105.
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Christopher S. Potten. 2007. Ciba Foundation Symposium 160 - Regeneration of Vertebrate Sensory Receptor Cells. Ciba Foundation Symposium 160 - Regeneration of Vertebrate Sensory Receptor Cells 54 76 .
Christopher S. Potten, Catherine Booth, Gregory L. Tudor, Dawn Booth, Gerard Brady, Patricia Hurley, Gary Ashton, Robert Clarke, Shin-ichi Sakakibara & Hideyuki Okano. (2003) Identification of a putative intestinal stem cell and early lineage marker; musashi-1. Differentiation 71:1, pages 28-41.
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John Cairns. (2002) Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proceedings of the National Academy of Sciences 99:16, pages 10567-10570.
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Sabine Köst, Klaus Keinert & Felix-Herbert Glaser. (1998) D-Xylose-Resorptionstest als Methode zur Erfassung der Strahlenreaktion des DarmsD-Xylose test of resorption as a method to determine radiation side effects in small intestine. Coloproctology 20:6, pages 240-246.
Crossref
Sabine Köst, Klaus Keinert & Felix-Herbert Glaser. (1998) D-Xylose-Resorptionstest als Methode zur Erfassung der Strahlenreaktion des DarmsD-xylose test of resorption as a method to determine radiation side effects in small intestine. Strahlentherapie und Onkologie 174:9, pages 462-467.
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A.Yu. Yakovlev. (1996) Threshold models of tumor recurrence. Mathematical and Computer Modelling 23:6, pages 153-164.
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H. Rodney Withers, Kathy A. Mason & Jeremy M.G. Taylor. (1993) The number of clonogenic cells in a mouse jejunal crypt. Radiotherapy and Oncology 26:3, pages 238-243.
Crossref
Janusz A. Jankowski & Nicholas A. Wright. (1992) Epithelial stem cells in gastrointestinal morphogenesis, adaptation and carcinogenesis. Seminars in Cell Biology 3:6, pages 445-456.
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U. Paulus, C. S. Potten & M. Loeffler. (2008) A model of the control of cellular regeneration in the intestinal crypt after perturbation based solely on local stem cell regulation. Cell Proliferation 25:6, pages 559-578.
Crossref
Christopher S. Potten. (1992) The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer and Metastasis Review 11:2, pages 179-195.
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Jeremy M.G. Taylor, H.Rodney Withers, Kathy A. Mason & Cally A. Davis. (1991) Repopulation of mouse jejunal crypt cells. Radiotherapy and Oncology 20:3, pages 181-190.
Crossref

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