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Original Article

Biphasic Survival Curves for XRS Radiosensitive Cells: Subpopulations or Transient Expression of Repair Competence?

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Pages 605-617 | Received 16 May 1988, Accepted 26 Nov 1988, Published online: 03 Jul 2009

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Eric Weterings, Nicole S. Verkaik, Guido Keijzers, Bogdan I. Florea, Shih-Ya Wang, Laura G. Ortega, Naoya Uematsu, David J. Chen & Dik C. van Gent. (2009) The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends. Molecular and Cellular Biology 29:5, pages 1134-1142.
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B. K. Singleton, A. Priestley, H. Steingrimsdottir, D. Gell, T. Blunt, S. P. Jackson, A. R. Lehmann & P. A. Jeggo. (1997) Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80. Molecular and Cellular Biology 17:3, pages 1264-1273.
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J. Dahm-Daphi, E. Dikomey & C. Pyttlik. (1994) Relationship between Non-reparable DNA Strand Breaks and Cell Survival Studied in X-irradiated CHO, CHO K1, xrs1 and xrs5 Cells. International Journal of Radiation Biology 65:6, pages 657-663.
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G. P. Raaphorst, M. Thakar & C. E. Ng. (1993) Thermal radiosensitization in two pairs of CHO wild-type and radiation-sensitive mutant cell lines. International Journal of Hyperthermia 9:3, pages 383-391.
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G.P. Raaphorst, A. Bussey, M. Thakar, T. Bichay & C.E. Ng. (1993) Postirradiation Exposure to Hypotonic Saline Shows Normal Damage Processing in Radiation-sensitive Cell Lines. International Journal of Radiation Biology 64:5, pages 593-600.
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J. Dahm-Daphi, E. Dikomey, C. Pyttlik & P.A. Jeggo. (1993) Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutants xrs1 and xrs5. International Journal of Radiation Biology 64:1, pages 19-26.
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J.Y. Ostashevsky. (1990) Prediction of Cell Survival Curves from DNA Double-strand Break Repair Data for Low- and High-LET Radiation. International Journal of Radiation Biology 57:3, pages 523-536.
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G.F. Whitmore, A.J. Varghese & S. Gulyas. (1989) Cell Cycle Responses of Two X-ray Sensitive Mutants Defective in DNA Repair. International Journal of Radiation Biology 56:5, pages 657-665.
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C. Hennequin & V. Favaudon. (2002) Biological basis for chemo-radiotherapy interactions. European Journal of Cancer 38:2, pages 223-230.
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L. Manti, H. E. Davies, S. Venables, I. D. Bowen & J. B. Court. (2000) Correlation between the Clonogenic Initial Slope and the Response of Polykaryon-Forming Units: The Behavior of Strains Defective in XRCC5 and ATM and the Heritability of Small Variations in Radioresponse . Radiation Research 154:6, pages 650-658.
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Alexandru Daşu & Juliana Denekamp. (1999) Superfractionation as a potential hypoxic cell radiosensitizer: prediction of an optimum dose per fraction. International Journal of Radiation Oncology*Biology*Physics 43:5, pages 1083-1094.
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Larry H Thompson & David Schild. (1999) The contribution of homologous recombination in preserving genome integrity in mammalian cells. Biochimie 81:1-2, pages 87-105.
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P. A. Jeggo. 1998. DNA Damage and Repair. DNA Damage and Repair 317 334 .
J.A. Hanson, E.M. Parry, A.R. Gibbs, J.B. Court, M.A.H. Pour-Faizi, I.J. Kerby & E.A. Bean. (1997) Characterization of Highly Radiosensitive Cell Lines from a Human Ovarian Small-Cell Cancer. Gynecologic Oncology 67:2, pages 147-153.
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Peter J Johnston, Elizabeth Stoppard & Peter E Bryant. (1997) Induction and distribution of damage in CHO-K1 and the X-ray-sensitive hamster cell line xrs5, measured by the cytochalasin-B-cytokinesis block micronucleus assay. Mutation Research/DNA Repair 385:1, pages 1-12.
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Wei Zhu, Marina Kriajevskaia, Peter C. Keng & Wen-Gang Chou. (1993) A “trans-acting” factor for activation of transcription is defective in the xrs-5 mutant of the Chinese hamster ovary cell line. Mutation Research/DNA Repair 294:2, pages 101-108.
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Carmel Mothersill & C.B. Seymour. (1993) Recovery of the radiation survival-curve shoulder in CHO-KI, XRS-5 and revertant XRS-5 populations. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 285:2, pages 259-266.
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Wei Zhu, Peter C. Keng & Wen-Gang Chou. (1992) Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines. Mutation Research/DNA Repair 274:3, pages 237-245.
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Paul J. Meechan, Daniel J. Haraf, Alan M. Diamond & David J. Grdina. (1992) Reversion of radiosensitivity in azacytidine-treated xrs5 cells does not result in full radioprotection by WR-1065. International Journal of Radiation Oncology*Biology*Physics 23:5, pages 999-1002.
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Nina D. Costa & Peter E. Bryant. (1991) Elevated levels of DNA double-strand breaks (dsb) in restriction endonuclease-treated xrs5 cells correlate with the reduced capacity to repair dsb. Mutation Research/DNA Repair 255:3, pages 219-226.
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Penny A. Jeggo. (1990) Studies on mammalian mutants defective in rejoining double-strand breaks in DNA. Mutation Research/Reviews in Genetic Toxicology 239:1, pages 1-16.
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G. F. Whitmore, A. Dulhanty, A. J. Varghese & S. Gulyas. 1990. Selective Activation of Drugs by Redox Processes. Selective Activation of Drugs by Redox Processes 285 294 .

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