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Original Article

In CHEF Electrophoresis a Linear Induction of Dsb Corresponds to a Nonlinear Fraction of Extracted DNA with Dose

Pages 7-12 | Received 12 May 1989, Accepted 14 Aug 1989, Published online: 03 Jul 2009

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Read on this site (38)

Ann-Sofie Gustafsson, Torbjörn Hartman & Bo Stenerlöw. (2015) Formation and repair of clustered damaged DNA sites in high LET irradiated cells. International Journal of Radiation Biology 91:10, pages 820-826.
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Kristina Claesson, Karin Magnander, Helena Kahu, Sture Lindegren, Ragnar Hultborn & Kecke Elmroth. (2011) RBE of α-particles from 211At for complex DNA damage and cell survival in relation to cell cycle position. International Journal of Radiation Biology 87:4, pages 372-384.
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AE Meijer, AR-M Jernberg, T Heiden, B Stenerlöw, LM Persson, N Tilly, BK Lind & MR Edgren. (2005) Dose and time dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET. International Journal of Radiation Biology 81:4, pages 261-272.
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K. Elmroth, J. Nygren, B. Stenerlöw & R. Hultborn. (2003) Chromatin‐ and temperature‐dependent modulation of radiation‐induced double‐strand breaks. International Journal of Radiation Biology 79:10, pages 809-816.
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V. Rudat, N. Bachmann, J.-H. Küpper & K.-J. Weber. (2001) Overexpression of the DNA-binding domain of poly(ADP-ribose) polymerase inhibits rejoining of ionizing radiation-induced DNA double-strand breaks. International Journal of Radiation Biology 77:3, pages 303-307.
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RAINER K.SACHS, DAVID J.BRENNER, PHILIP J.HAHNFELDT & LYNN R. HLATKYS. (1998) A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes. International Journal of Radiation Biology 74:2, pages 185-206.
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K. M. PRISE, G. AHNSTRÖM, M. BELLI, J. CARLSSON, D. FRANKENBERG, J. KIEFER, M. LOÖBRICH, B. D. MICHAEL, J. NYGREN, G. SIMONE & B. STENERLÖW. (1998) A review of dsb induction data for varying quality radiations. International Journal of Radiation Biology 74:2, pages 173-184.
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H. C. NEWMAN, K. M. PRISE, M. FOLKARD and B. D. MICHAEL. (1997) DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage. International Journal of Radiation Biology 71:4, pages 347-363.
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H. SCHUESSLER, L. DISTEL and R. SIEBER. (1997) Radiolysis of DNA in the presence of a protein studied by HPL-gel chromatography. International Journal of Radiation Biology 71:5, pages 543-553.
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J. DAHM-DAPHI, I. BRAMMER and E. DIKOMEY. (1997) Heat effects on the repair of DNA double-strand breaks in CHO cells. International Journal of Radiation Biology 72:2, pages 171-179.
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N. FORAY, A. PRIESTLEY, G. ALSBEIH, C. BADIE, E. P. CAPULAS, C. F. ARLETT and E. P. MALAISE. (1997) Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. International Journal of Radiation Biology 72:3, pages 271-283.
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N. FORAY. (1996) Dose-rate effect on radiation-induced DNA double-strand breaks in the human fibroblast HF19 cell line. International Journal of Radiation Biology 69:2, pages 241-249.
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S. MATEOS. (1996) Cell-cycle variation in DNA migration in pulsed-field gel electrophoresis. International Journal of Radiation Biology 69:6, pages 687-693.
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M. LOBRICH, P. K. COOPER and B. RYDBERG. (1996) Non-random distribution of DNA double-strand breaks induced by particle irradiation. International Journal of Radiation Biology 70:5, pages 493-503.
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D. LATZ, W. C. DEWEY, M. FLENTJE, F. LOHR, F. WENZ and K. J. WEBER. (1996) Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair. International Journal of Radiation Biology 70:6, pages 637-646.
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A. Chukhlovin, J. Dahm-Daphi, G. Gercken, A. Rolf Zander & E. Dikomey. (1995) Comparative Studies of Induction and Repair of DNA Double-strand Breaks in X-irradiated Alveolar Macrophages and Resting Peripheral Blood Lymphocytes Using Constant-field Gel Electrophoresis. International Journal of Radiation Biology 68:2, pages 163-168.
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J. Heilmann, G. Taucher-Scholz & G. Kraft. (1995) Induction of DNA Double-strand Breaks in CHO-K1 Cells by Carbon Ions. International Journal of Radiation Biology 68:2, pages 153-162.
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J. Dahm-Daphi & E. Dikomey. (1995) Separation of DNA Fragments Induced by Ionizing Irradiation Using a Graded-field Gel Electrophoresis. International Journal of Radiation Biology 67:2, pages 161-168.
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S.J. Whitaker, Y.C. Ung & T.J. McMillan. (1995) DNA Double-strand Break Induction and Rejoining as Determinants of Human Tumour Cell Radiosensitivity. A Pulsed-field Gel Electrophoresis Study. International Journal of Radiation Biology 67:1, pages 7-18.
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J.M. Ruiz de Almodóvar, G.G. Steel, S.J. Whitaker & T.J. McMillan. (1994) A Comparison of Methods for Calculating DNA Double-strand Break Induction Frequency in Mammalian Cells by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 65:6, pages 641-649.
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B. Stenerlöw, J. Carlsson, E. Blomquist & K. Erixon. (1994) Clonogenic Cell Survival and Rejoining of DNA Double-strand Breaks: Comparisons between Three Cell Lines after Photon or He Ion Irradiation. International Journal of Radiation Biology 65:6, pages 631-639.
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M. Löbrich, S. Ikpeme & J. Kiefer. (1994) DNA Double-strand Break Measurement in Mammalian Cells by Pulsed-field Gel Electrophoresis: An Approach Using Restriction Enzymes and Gene Probing. International Journal of Radiation Biology 65:6, pages 623-630.
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M. Flentje, B. Asadpour, D. Latz & K.J. Weber. (1993) Sensitivity of Neutral Filter Elution but Not PFGE Can Be Modified by Non-dsb Chromatin Damage. International Journal of Radiation Biology 63:6, pages 715-724.
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M. Rosemann, B. Kanon, A.W.T. Konings & H.H. Kampinga. (1993) An Image Analysis Technique for Detection of Radiation-induced DNA Fragmentation after CHEF Electrophoresis. International Journal of Radiation Biology 64:2, pages 245-249.
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K.J. Weber & M. Flentje. (1993) Lethality of Heavy Ion-induced DNA Double-strand Breaks in Mammalian Cells. International Journal of Radiation Biology 64:2, pages 169-178.
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M.D. Story, K.C. Garrett, P.J. Tofilon & R.E. Meyn. (1993) Influence of Irradiation Conditions on the Measurement of DNA Double-strand Breaks by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 63:3, pages 297-304.
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A.A. Friedl, W. Beisker, K. Hahn, F. Eckardt-Schupp & A.M. Kellerer. (1993) Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules. International Journal of Radiation Biology 63:2, pages 173-181.
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D.J. Brenner & J.F. Ward. (1992) Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks. International Journal of Radiation Biology 61:6, pages 737-748.
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S.J. Whitaker & T.J. McMillan. (1992) Oxygen Effect for DNA Double-strand Break Induction Determined by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 61:1, pages 29-41.
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G.E. Iliakis, L. Metzger, N. Denko & T.D. Stamato. (1991) Detection of DNA Double-strand Breaks in Synchronous Cultures of CHO Cells by Means of Asymmetric Field Inversion Gel Electrophoresis. International Journal of Radiation Biology 59:2, pages 321-341.
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D. Blöcher & M. Kunhi. (1990) DNA Double-strand Break Analysis by CHEF Electrophoresis. International Journal of Radiation Biology 58:1, pages 23-34.
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