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Original Article

Radiosensitivity Throughout the Cell Cycle and Repair of Potentially Lethal Damage and DNA Double-strand Breaks in an X-ray-sensitive CHO Mutant

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Pages 1195-1211 | Received 15 Aug 1989, Accepted 23 Nov 1989, Published online: 03 Jul 2009

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Mireia Borràs, Gemma Armengol, Martí De Cabo, Joan-Francesc Barquinero & Leonardo Barrios. (2015) Comparison of methods to quantify histone H2AX phosphorylation and its usefulness for prediction of radiosensitivity. International Journal of Radiation Biology 91:12, pages 915-924.
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Penny Jeggo & Martin F. Lavin. (2009) Cellular radiosensitivity: How much better do we understand it?. International Journal of Radiation Biology 85:12, pages 1061-1081.
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J. Dahm-Daphi, E. Dikomey & C. Pyttlik. (1994) Relationship between Non-reparable DNA Strand Breaks and Cell Survival Studied in X-irradiated CHO, CHO K1, xrs1 and xrs5 Cells. International Journal of Radiation Biology 65:6, pages 657-663.
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M.F.M.A. Smeets, E.H.M. Mooren & A.C. Begg. (1993) Radiation-induced DNA Damage and Repair in Radiosensitive and Radioresistant Human Tumour Cells Measured by Field Inversion Gel Electrophoresis. International Journal of Radiation Biology 63:6, pages 703-713.
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J. Dahm-Daphi, E. Dikomey, C. Pyttlik & P.A. Jeggo. (1993) Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutants xrs1 and xrs5. International Journal of Radiation Biology 64:1, pages 19-26.
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G. Iliakis, R. Mehta & M. Jackson. (1992) Level of DNA Double-strand Break Rejoining in Chinese Hamster xrs-5 Cells is Dose-dependent: Implications for the Mechanism of Radiosensitivity. International Journal of Radiation Biology 61:3, pages 315-321.
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L. Metzger & G. Iliakis. (1991) Kinetics of DNA Double-strand Break Repair Throughout the Cell Cycle as Assayed by Pulsed Field Gel Electrophoresis in CHO Cells. International Journal of Radiation Biology 59:6, pages 1325-1339.
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Articles from other publishers (32)

Annelie Lindström, Kristine Midtbö, Lars-Gunnar Arnesson, Stina Garvin & Ivan Shabo. (2017) Fusion between M2-macrophages and cancer cells results in a subpopulation of radioresistant cells with enhanced DNA-repair capacity. Oncotarget 8:31, pages 51370-51386.
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Emil Mladenov, Simon Magin, Aashish Soni & George Iliakis. (2016) DNA double-strand-break repair in higher eukaryotes and its role in genomic instability and cancer: Cell cycle and proliferation-dependent regulation. Seminars in Cancer Biology 37-38, pages 51-64.
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Dayton D. McMillan, Junko Maeda, Justin J. Bell, Matthew D. Genet, Garrett Phoonswadi, Kelly A. Mann, Susan L. Kraft, Hisashi Kitamura, Akira Fujimori, Yukie Yoshii, Takako Furukawa, Yasuhisa Fujibayashi & Takamitsu A. Kato. (2015) Validation of 64 Cu-ATSM damaging DNA via high-LET Auger electron emission . Journal of Radiation Research 56:5, pages 784-791.
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Satyendra K. Singh, Wenqi Wu, Lihua Zhang, Holger Klammer, Minli Wang & George Iliakis. (2011) Widespread Dependence of Backup NHEJ on Growth State: Ramifications for the Use of DNA-PK Inhibitors. International Journal of Radiation Oncology*Biology*Physics 79:2, pages 540-548.
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Hatsumi Nagasawa, John B. Little, Yu-Fen Lin, Sairei So, Akihiro Kurimasa, Yuanlin Peng, John R. Brogan, David J. Chen, Joel S. Bedford & Benjamin P. C. Chen. (2011) Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability. Radiation Research 175:1, pages 83-89.
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Lori J. Chappell, Mary K. Whalen, Sheena Gurai, Artem Ponomarev, Francis A. Cucinotta & Janice M. Pluth. (2010) Analysis of Flow Cytometry DNA Damage Response Protein Activation Kinetics after Exposure to X Rays and High-Energy Iron Nuclei. Radiation Research 174:6a, pages 691-702.
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Mary K. Whalen, Sukhleen K. Gurai, Hengameh Zahed-Kargaran & Janice M. Pluth. (2008) Specific ATM-Mediated Phosphorylation Dependent on Radiation Quality. Radiation Research 170:3, pages 353-364.
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Steve Braunstein, Silvia C. Formenti & Robert J. Schneider. (2008) Acquisition of Stable Inducible Up-Regulation of Nuclear Factor-κB by Tumor Necrosis Factor Exposure Confers Increased Radiation Resistance without Increased Transformation in Breast Cancer Cells. Molecular Cancer Research 6:1, pages 78-88.
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Takamitsu A. Kato, Paul F. Wilson, Hatsumi Nagasawa, Markus M. Fitzek, Michael M. Weil, John B. Little & Joel S. Bedford. (2007) A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans. DNA Repair 6:6, pages 818-829.
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Peter Tamulevicius, Minli Wang & George Iliakis. (2007) Homology-Directed Repair is Required for the Development of Radioresistance during S Phase: Interplay between Double-Strand Break Repair and Checkpoint Response. Radiation Research 167:1, pages 1-11.
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Andrea Krempler & Markus Löbrich. 2007. Genome Integrity. Genome Integrity 399 421 .
M. Scholz. 2006. Microdosimetric Response of Physical and Biological Systems to Low- and High-LET Radiations. Microdosimetric Response of Physical and Biological Systems to Low- and High-LET Radiations 1 73 .
Timothy M. Pawlik & Khandan Keyomarsi. (2004) Role of cell cycle in mediating sensitivity to radiotherapy. International Journal of Radiation Oncology*Biology*Physics 59:4, pages 928-942.
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N. CASTRO KREDER, R. ten CATE, H. M. RODERMOND, C. van BREE, N. A. P. FRANKEN, M. Z. ZDZIENICKA & J. HAVEMAN. (2004) Cellular Response to Pulsed Low-dose Rate Irradiation in X-ray Sensitive Hamster Mutant Cell Lines. Journal of Radiation Research 45:3, pages 385-391.
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Charles L. Limoli & Erich Giedzinski. (2003) Induction of Chromosomal Instability by Chronic Oxidative Stress. Neoplasia 5:4, pages 339-346.
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P.A. Jeggo. 1998. 185 218 .
P. A. Jeggo. 1998. DNA Damage and Repair. DNA Damage and Repair 317 334 .
Yoshihisa Matsumoto, Norio Suzuki, Kazuo Sakai, Akeshi Morimatsu, Kazuya Hirano & Hiromu Murofushi. (1997) A Possible Mechanism for Hyperthermic Radiosensitization Mediated through Hyperthermic Lability of Ku Subunits in DNA-Dependent Protein Kinase. Biochemical and Biophysical Research Communications 234:3, pages 568-572.
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P. Mlejnek & S. Kozubek. (1996) Complex repair kinetics of DNA strand breaks induced by γ-rays or UV radiation in Ehrlich ascites tumour cells. Radiation and Environmental Biophysics 35:3, pages 171-177.
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M.I. Núñez, T.J. McMillan, M.T. Valenzuela, J.M.Ruiz de Almodóvar & V. Pedraza. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology 39:2, pages 155-165.
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Mary Heenan, Kevin Kavanagh, Alice Redmond, Michael Maher, Elanie Dolan, Pauline O'Neill, Michael Moriarty & Martin Clynes. (1996) Absence of correlation between chemo- and radioresistance in a range of human tumour cell lines. Cytotechnology 19:3, pages 237-242.
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Penny A. Jeggo, Guillermo E. Taccioli & Stephen P. Jackson. (2005) Menage á trois: Double strand break repair, V(D)J recombination and DNA‐PK. BioEssays 17:11, pages 949-957.
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Fréderic Dhermain, Michèle Dardalhon, Eric Queinnec & Dietrich Averbeck. (1995) Induction of double-strand breaks in Chinese hamster ovary cells at two different dose rates of γ-irradiation. Mutation Research/DNA Repair 336:2, pages 161-167.
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Jeffrey L. Schwartz. 1996. Chemical Induction of Cancer. Chemical Induction of Cancer 473 508 .
Jeffrey L. Schwartz, B.A. Sedita, Nicholas Laffely & David J. Grdina. (1994) Chromosome terminal deletion formation in Chinese hamster ovary cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 311:1, pages 125-131.
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Santiago Mateos, Pedrag Slijepcevic, Roderick A.F. MacLeod & Peter E. Bryant. (1994) DNA double-strand break rejoining in xrs5 cells is more rapid in the G2 than in the G1 phase of the cell cycle. Mutation Research/DNA Repair 315:2, pages 181-187.
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L.R. Hlatky, P. Hahnfeldt & R.K. Sachs. (1994) Influence of time-dependent stochastic heterogeneity on the radiation response of a cell population. Mathematical Biosciences 122:2, pages 201-220.
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Nge Cheong, Xiaoming Wang, Ya Wang & George Iliakis. (1994) Loss of S-phase-dependent radioresistance in irs-1 cells exposed to X-rays. Mutation Research/DNA Repair 314:1, pages 77-85.
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Ryuichi Okayasu, Gabriel E. Pantelias & George Iliakis. (1993) Increased frequency of formation of interphase ring-chromosomes in radiosensitive irs-1 cells exposed to X-rays. Mutation Research/DNA Repair 294:3, pages 199-206.
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Lorie L. Hughes, Jorge Luengas, Tyvin A. Rich & David Murray. (1992) Radiosensitization of cultured human colon adenocarcinoma cells by 5-fluorouracil: Effects on cell survival, DNA repair, and cell recovery. International Journal of Radiation Oncology*Biology*Physics 23:5, pages 983-991.
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George Iliakis, Lorenz Metzger, Ryuichi Okayasu, Gabriel Pantelias & Orlando Cicilioni. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 55 69 .
John F. Ward. 1992. Physical and Chemical Mechanisms in Molecular Radiation Biology. Physical and Chemical Mechanisms in Molecular Radiation Biology 403 421 .

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