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International Journal of Radiation Biology Volume 57, 1990 - Issue 6
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Original Article

Production and Repair of Chromosome Damage in an X-ray Sensitive CHO Mutant Visualized and Analysed in Interphase Using the Technique of Premature Chromosome Condensation

G.E. Iliakis Department of Radiation Oncology and Nuclear Medicine, Laboratory of Experimental Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
&
G.E. Pantelias Department of Radiation Oncology and Nuclear Medicine, Laboratory of Experimental Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USA
Pages 1213-1223 | Received 15 Aug 1989, Accepted 23 Nov 1989, Published online: 03 Jul 2009

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E Gotoh, Y Tanno & K Takakura. (2005) Simple biodosimetry method for use in cases of high-dose radiation exposure that scores the chromosome number of Giemsa-stained drug-induced prematurely condensed chromosomes (PCC). International Journal of Radiation Biology 81:1, pages 33-40.
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D. LATZ, W. C. DEWEY, M. FLENTJE, F. LOHR, F. WENZ and K. J. WEBER. (1996) Migration patterns in pulsed-field electrophoresis of DNA restriction fragments from log-phase mammalian cells after irradiation and incubation for repair. International Journal of Radiation Biology 70:6, pages 637-646.
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L.S. Yasui, T.J. Fink & A.M. Enrique. (1994) Nuclear Scaffold Organization in the X-ray Sensitive Chinese Hamster Mutant Cell Line, xrs-5. International Journal of Radiation Biology 65:2, pages 185-192.
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M.C. Mühlmann-Díaz & J.S. Bedford. (1994) Breakage of Human Chromosomes 4, 19 and Y in G0 Cells Immediately after Exposure to γ-rays. International Journal of Radiation Biology 65:2, pages 165-173.
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J. Dahm-Daphi, E. Dikomey, C. Pyttlik & P.A. Jeggo. (1993) Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutants xrs1 and xrs5. International Journal of Radiation Biology 64:1, pages 19-26.
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B.P. Kysela, B.D. Michael & J.E. Arrand. (1993) Relative Contributions of Levels of Initial DNA Damage and Repair of Double Strand Breaks to the Ionizing Radiation-sensitive Phenotype of the Chinese Hamster Cell Mutant, XR-V15B. Part I. X-rays. International Journal of Radiation Biology 63:5, pages 609-616.
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G. Iliakis, R. Mehta & M. Jackson. (1992) Level of DNA Double-strand Break Rejoining in Chinese Hamster xrs-5 Cells is Dose-dependent: Implications for the Mechanism of Radiosensitivity. International Journal of Radiation Biology 61:3, pages 315-321.
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G. Iliakis, R. Seaner & R. Okayasu. (1990) Effects of hyperthermia on the repair of radiation-induced DNA single-and double-strand breaks in DNA double-strand break repair-deficient and repair-proficient cell lines. International Journal of Hyperthermia 6:4, pages 813-833.
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G. Iliakis & R. Seaner. (1990) A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth. International Journal of Hyperthermia 6:4, pages 801-812.
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G.E. Iliakis & R. Okayasu. (1990) Radiosensitivity Throughout the Cell Cycle and Repair of Potentially Lethal Damage and DNA Double-strand Breaks in an X-ray-sensitive CHO Mutant. International Journal of Radiation Biology 57:6, pages 1195-1211.
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Articles from other publishers (26)

Eisuke Gotoh. 2023. Chromosome Analysis. Chromosome Analysis 41 51 .
Eisuke Gotoh. 2019. Radiation Cytogenetics. Radiation Cytogenetics 47 60 .
Maddaly Ravi, Aswathy S. Lal & S. Kauser Begum. (2018) Prophasing interphase chromatin for assessing genetic damages—The evolution, applications and the future prospects. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 810, pages 19-32.
Crossref
Eisuke Gotoh. 2015. Chromatin Protocols. Chromatin Protocols 53 66 .
Nobuyuki HAMADA, Tatsuhiko IMAOKA, Shin-ichiro MASUNAGA, Toshiyuki OGATA, Ryuichi OKAYASU, Akihisa TAKAHASHI, Takamitsu A. KATO, Yasuhiko KOBAYASHI, Takeo OHNISHI, Koji ONO, Yoshiya SHIMADA & Teruki TESHIMA. (2010) Recent Advances in the Biology of Heavy-Ion Cancer Therapy. Journal of Radiation Research 51:4, pages 365-383.
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Paul F. Wilson & Joel S. Bedford. 2010. Leibel and Phillips Textbook of Radiation Oncology. Leibel and Phillips Textbook of Radiation Oncology 3 30 .
Z.Z. Wang, W.J. Li, D.J. Zhi, Q.X. Gao, Y. Qu & B.Q. Wang. (2009) Prematurely condensed chromosome fragments in human lymphocytes induced by high doses of high-linear-energy-transfer irradiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 679:1-2, pages 9-12.
Crossref
Eisuke Gotoh. 2009. Chromatin Protocols. Chromatin Protocols 83 92 .
Hatsumi Nagasawa & John B. Little. (2002) Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 508:1-2, pages 121-129.
Crossref
Joel S. Bedford & William C. Dewey. (2002) Historical and Current Highlights in Radiation Biology: Has Anything Important Been Learned by Irradiating Cells?. Radiation Research 158:3, pages 251-291.
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Nicole Rief & Markus Löbrich. (2002) Efficient Rejoining of Radiation-induced DNA Double-strand Breaks in Centromeric DNA of Human Cells. Journal of Biological Chemistry 277:23, pages 20572-20582.
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Rüdiger Greinert, Ellen Detzler & Dietrich Harder. (2000) The Kinetics of Postirradiation Chromatin Restitution as Revealed by Chromosome Aberrations Detected by Premature Chromosome Condensation and Fluorescence In Situ Hybridization . Radiation Research 154:1, pages 87-93.
Crossref
Santiago Mateos, G.Gordon Steel & Trevor J. McMillan. (1998) Differences between a human bladder carcinoma cell line and its radiosensitive clone in the formation of radiation-induced DNA double-strand breaks in different chromatin substrates. Mutation Research/DNA Repair 409:2, pages 73-80.
Crossref
. (2016) Genetic susceptibility to cancer: ICRP Publication 79. Annals of the ICRP 28:1-2, pages 1-157.
Crossref
M Suzuki, Y Kase, T Nakano, T Kanai & K Ando. (1998) Residual chromatin breaks as biodosimetry for cell killing by carbon ions. Advances in Space Research 22:12, pages 1663-1671.
Crossref
K Eguchi-Kasai, M Murakami, H Itsukaichi, K Fukutsu, F Yatagai, T Kanai, H Ohara & K Sato. (1998) Repair of DNA double-strand breaks and cell killing by charged particles. Advances in Space Research 22:4, pages 543-549.
Crossref
Michael N. Cornforth. 1998. DNA Damage and Repair. DNA Damage and Repair 559 585 .
K. Eguchi-Kasai, M. Murakami, H. Itsukaichi, K. Fukutsu, T. Kanai, Y. Furusawa, K. Sato, H. Ohara & F. Yatagai. (1996) The role of DNA repair on cell killing by charged particles. Advances in Space Research 18:1-2, pages 109-118.
Crossref
Jeffrey L. Schwartz, B.A. Sedita, Nicholas Laffely & David J. Grdina. (1994) Chromosome terminal deletion formation in Chinese hamster ovary cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 311:1, pages 125-131.
Crossref
Ryuichi Okayasu & George Iliakis. (1994) Mitotic metaphase cells from different cell lines cause different levels of expression of the α-form of interphase chromosome breaks irradiated CHO cels. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 310:1, pages 65-71.
Crossref
Ryuichi Okayasu, Gabriel E. Pantelias & George Iliakis. (1993) Increased frequency of formation of interphase ring-chromosomes in radiosensitive irs-1 cells exposed to X-rays. Mutation Research/DNA Repair 294:3, pages 199-206.
Crossref
Reinhard Kodym & Elfriede Hoerth. (1993) Determination of the radiation sensitivity of the stromal cells in the murine long-term bone marrow culture by measuring the induction and rejoining of interphase chromosome breaks. International Journal of Radiation Oncology*Biology*Physics 25:5, pages 829-833.
Crossref
M.N. Cornforth & J.S. Bedford. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 423 496 .
Jeffery L. Schwartz, Erich Moan, Reba Mustafi, Lisa Fink & Linda S. Yasui. (1992) Faster rates of DNA unwinding under alkaline conditions in xrs-5 cells may reflect chromatin structure alterations. Mutation Research Letters 282:1, pages 13-17.
Crossref
W.N. Hittelman, T. Pandita, R.V. Jayanth & D. Wlodek. 1992. Congress Proceedings. Congress Proceedings 195 200 .
George Iliakis, Lorenz Metzger, Ryuichi Okayasu, Gabriel Pantelias & Orlando Cicilioni. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 55 69 .

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