Citations (69)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (16)
Wei-Ren Luo, Fang-Hsin Chen, Ren-Jing Huang, Yu-Pin Chen & Ya-Yun Hsiao. (2020) Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB inductions and conversions induced by therapeutic proton beams. International Journal of Radiation Biology 96:2, pages 187-196.
Read now
Read now
K. M. PRISE, G. AHNSTRÖM, M. BELLI, J. CARLSSON, D. FRANKENBERG, J. KIEFER, M. LOÖBRICH, B. D. MICHAEL, J. NYGREN, G. SIMONE & B. STENERLÖW. (1998) A review of dsb induction data for varying quality radiations. International Journal of Radiation Biology 74:2, pages 173-184.
Read now
Read now
K. M. PRISE. (1998) Studies of bystander effects in human fibroblasts using a charged particle microbeam. International Journal of Radiation Biology 74:6, pages 793-798.
Read now
Read now
H. C. NEWMAN, K. M. PRISE, M. FOLKARD and B. D. MICHAEL. (1997) DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage. International Journal of Radiation Biology 71:4, pages 347-363.
Read now
Read now
M. FOLKARD. (1996) Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions. International Journal of Radiation Biology 69:6, pages 729-738.
Read now
Read now
J. Heilmann, G. Taucher-Scholz & G. Kraft. (1995) Induction of DNA Double-strand Breaks in CHO-K1 Cells by Carbon Ions. International Journal of Radiation Biology 68:2, pages 153-162.
Read now
Read now
K.H. Chadwick & H.P. Leenhouts. (1994) On the Linearity of the Dose—effect Relationship of DNA Double Strand Breaks. International Journal of Radiation Biology 66:5, pages 549-552.
Read now
Read now
K.M. Prise, M. Folkard, H.C. Newman & B.D. Michael. (1994) Effect of Radiation Quality on Lesion Complexity in Cellular DNA. International Journal of Radiation Biology 66:5, pages 537-542.
Read now
Read now
M. Belli, F. Cera, R. Cherubini, F. Ianzini, G. Moschini, O. Sapora, G. Simone, M.A. Tabocchini & P. Tiveron. (1994) DNA Double-strand Breaks Induced by Low Energy Protons in V79 Cells. International Journal of Radiation Biology 65:5, pages 529-536.
Read now
Read now
D. Murray, R. Simpson, E. Rosenberg, A. Carraway & R. Britten. (1994) Correlation between γ-ray-induced DNA Double-strand Breakage and Cell Killing after Biologically Relevant Doses: Analysis by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 65:4, pages 419-426.
Read now
Read now
K.M. Prise. (1994) Use of Radiation Quality as a Probe for DNA Lesion Complexity. International Journal of Radiation Biology 65:1, pages 43-48.
Read now
Read now
D.T. Goodhead. (1994) Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA. International Journal of Radiation Biology 65:1, pages 7-17.
Read now
Read now
B.P. Kysela, J.E. Arrand & B.D. Michael. (1993) Relative Contributions of Levels of Initial Damage and Repair of Double-strand Breaks to the Ionizing Radiation-sensitive Phenotype of the Chinese Hamster Cell Mutant, XR-V15B. Part II. Neutrons. International Journal of Radiation Biology 64:5, pages 531-538.
Read now
Read now
K.J. Weber & M. Flentje. (1993) Lethality of Heavy Ion-induced DNA Double-strand Breaks in Mammalian Cells. International Journal of Radiation Biology 64:2, pages 169-178.
Read now
Read now
B.P. Kysela, B.D. Michael & J.E. Arrand. (1993) Relative Contributions of Levels of Initial DNA Damage and Repair of Double Strand Breaks to the Ionizing Radiation-sensitive Phenotype of the Chinese Hamster Cell Mutant, XR-V15B. Part I. X-rays. International Journal of Radiation Biology 63:5, pages 609-616.
Read now
Read now
T.J. Jenner, M. Belli, D.T. Goodhead, F. Ianzini, G. Simone & M.A. Tabocchini. (1992) Direct Comparison of Biological Effectiveness of Protons and Alpha-particles of the Same LET. III. Initial Yield of DNA Double-strand Breaks in V79 Cells. International Journal of Radiation Biology 61:5, pages 631-637.
Read now
Read now
Articles from other publishers (53)
Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar, Giada Petringa, Roberto Catalano, Francesco P. Cammarata, Giuseppe A. P. Cirrone, Stephen J. McMahon, Kevin M. Prise & Marco Borghesi. (2022) Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications. Radiation Oncology 17:1.
Crossref
Crossref
Géraldine Gonon, Sonia M. de Toledo, Venkatachalam Perumal, Jean-Paul Jay-Gerin & Edouard I. Azzam. (2022) Impact of the redox environment on propagation of radiation bystander effects: The modulating effect of oxidative metabolism and oxygen partial pressure. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 883-884, pages 503559.
Crossref
Crossref
Anna Bianchi, Anna Selva, Massimo Rossignoli, Flavio Pasquato, Marta Missiaggia, Emanuele Scifoni, Chiara La Tessa, Francesco Tommasino & Valeria Conte. (2022) Microdosimetry with a mini-TEPC in the spread-out Bragg peak of 148 MeV protons. Radiation Physics and Chemistry, pages 110567.
Crossref
Crossref
Alessio Parisi, Chris J. Beltran & Keith M. Furutani. (2022) The Mayo Clinic Florida microdosimetric kinetic model of clonogenic survival: formalism and first benchmark against in vitro and in silico data. Physics in Medicine & Biology 67:18, pages 185013.
Crossref
Crossref
Hossein Taghipour & Payvand Taherparvar. (2022) Development of modified microdosimetric kinetic model for relative biological effectiveness in proton therapy. Radiation and Environmental Biophysics 61:3, pages 375-390.
Crossref
Crossref
M Loan & A Bhat. (2022) Effect of overdispersion of lethal lesions on cell survival curves. Biomedical Physics & Engineering Express 8:4, pages 045011.
Crossref
Crossref
Chun-Chieh Chan, Fang-Hsin Chen, Kuang-Lung Hsueh & Ya-Yun Hsiao. (2022) The Effect of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for Cells Irradiated with Grenz Rays. Cancers 14:5, pages 1262.
Crossref
Crossref
Eugene Surdutovich, Alexey V. Verkhovtsev & Andrey V. Solov’yov. 2022. Dynamics of Systems on the Nanoscale. Dynamics of Systems on the Nanoscale
389
457
.
Erik Almhagen, Erik Traneus & Anders Ahnesjö. (2021) Handling of beam spectra in training and application of proton RBE models. Physics in Medicine & Biology 66:18, pages 185015.
Crossref
Crossref
Hongyu Zhu, Junli Li, Xiaowu Deng, Rui Qiu, Zhen Wu & Hui Zhang. (2021) Development of a DNA damage model that accommodates different cellular oxygen concentrations and radiation qualities. Medical Physics 48:9, pages 5511-5521.
Crossref
Crossref
Frank Van den Heuvel, Anna Vella, Francesca Fiorini, Mark Brooke, Mark A Hill & Tim Maughan. (2021) Incorporating oxygenation levels in analytical DNA-damage models—quantifying the oxygen fixation mechanism. Physics in Medicine & Biology 66:14, pages 145005.
Crossref
Crossref
Chun-Chieh Chan, Fang-Hsin Chen & Ya-Yun Hsiao. (2021) Impact of Hypoxia on Relative Biological Effectiveness and Oxygen Enhancement Ratio for a 62-MeV Therapeutic Proton Beam. Cancers 13:12, pages 2997.
Crossref
Crossref
Alessio Parisi, Tatsuhiko Sato, Yusuke Matsuya, Yuki Kase, Giulio Magrin, Claudio Verona, Linh Tran, Anatoly Rosenfeld, Anna Bianchi, Pawel Olko, Lara Struelens & Filip Vanhavere. (2020)
Development of a new microdosimetric biological weighting function for the RBE
10
assessment in case of the V79 cell line exposed to ions from
1
H to
238
U
. Physics in Medicine & Biology 65:23, pages 235010.
Crossref
Crossref
Hong Qi Tan, Wei Yang Calvin Koh, Eugenia Li Ling Yeo, Khong Wei Ang, Dennis Jun Jie Poon, Chu Pek Lim, Saumitra K. Vajandar, Ce-Belle Chen, Minqin Ren, Thomas Osipowicz, Khee Chee Soo, Melvin Lee Kiang Chua & Sung Yong Park. (2020) Dosimetric uncertainties impact on cell survival curve with low energy proton. Physica Medica 76, pages 277-284.
Crossref
Crossref
Yoshitaka Matsumoto. 2020. Proton Beam Radiotherapy. Proton Beam Radiotherapy
209
222
.
George Iliakis, Emil Mladenov & Veronika Mladenova. (2019) Necessities in the Processing of DNA Double Strand Breaks and Their Effects on Genomic Instability and Cancer. Cancers 11:11, pages 1671.
Crossref
Crossref
Eivind Rørvik, Sara Thörnqvist & Kristian S Ytre-Hauge. (2019)
The experimental dose ranges influence the LET
d
dependency of the proton minimum RBE (RBE
min
)
. Physics in Medicine & Biology 64:19, pages 195001.
Crossref
Crossref
Hong Qi Tan, Wei Yang Calvin Koh, Lloyd Kuan Rui Tan, Jun Hao Phua, Khong Wei Ang, Sung Yong Park, Wen Siang Lew & James Cheow Lei Lee. (2019) Dependence of LET on material and its impact on current RBE model. Physics in Medicine & Biology 64:13, pages 135022.
Crossref
Crossref
Wenjing Wang, Chunyan Li, Rui Qiu, Yizheng Chen, Zhen Wu, Hui Zhang & Junli Li. (2018) Modelling of Cellular Survival Following Radiation-Induced DNA Double-Strand Breaks. Scientific Reports 8:1.
Crossref
Crossref
Robert D. Stewart, David J. Carlson, Michael P. Butkus, Roland Hawkins, Thomas Friedrich & Michael Scholz. (2018) A comparison of mechanism‐inspired models for particle relative biological effectiveness (RBE). Medical Physics 45:11.
Crossref
Crossref
Jake C. Forster, Michael J. J. Douglass, Wendy M. Phillips & Eva Bezak. (2018) Monte Carlo Simulation of the Oxygen Effect in DNA Damage Induction by Ionizing Radiation. Radiation Research 190:3, pages 248.
Crossref
Crossref
V. Conte, A. Selva, P. Colautti, G. Hilgers & H. Rabus. (2017) Track structure characterization and its link to radiobiology. Radiation Measurements 106, pages 506-511.
Crossref
Crossref
Eivind Rørvik, Sara Thörnqvist, Camilla H. Stokkevåg, Tordis J. Dahle, Lars Fredrik Fjaera & Kristian S. Ytre-Hauge. (2017) A phenomenological biological dose model for proton therapy based on linear energy transfer spectra. Medical Physics 44:6, pages 2586-2594.
Crossref
Crossref
M Cunha, C Monini, E Testa & M Beuve. (2017) NanOx, a new model to predict cell survival in the context of particle therapy. Physics in Medicine and Biology 62:4, pages 1248-1268.
Crossref
Crossref
Alexey Verkhovtsev, Eugene Surdutovich & Andrey V. Solov’yov. 2017. Nanoscale Insights into Ion-Beam Cancer Therapy. Nanoscale Insights into Ion-Beam Cancer Therapy
359
377
.
Alexey Verkhovtsev, Eugene Surdutovich & Andrey V. Solov’yov. (2016) Multiscale approach predictions for biological outcomes in ion-beam cancer therapy. Scientific Reports 6:1.
Crossref
Crossref
A Mairani, G Magro, I Dokic, S M Valle, T Tessonnier, R Galm, M Ciocca, K Parodi, A Ferrari, O Jäkel, T Haberer, P Pedroni & T T Böhlen. (2016) Data-driven RBE parameterization for helium ion beams. Physics in Medicine and Biology 61:2, pages 888-905.
Crossref
Crossref
Aimee L McNamara, Jan Schuemann & Harald Paganetti. (2015)
A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published
in vitro
cell survival data
. Physics in Medicine and Biology 60:21, pages 8399-8416.
Crossref
Crossref
Reza Taleei, Peter M. Girard & Hooshang Nikjoo. (2015) DSB repair model for mammalian cells in early S and G1 phases of the cell cycle: Application to damage induced by ionizing radiation of different quality. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 779, pages 5-14.
Crossref
Crossref
Harald Paganetti. (2014) Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Physics in Medicine and Biology 59:22, pages R419-R472.
Crossref
Crossref
T. Friedrich, U. Scholz, T. ElsaSser, M. Durante & M. Scholz. (2012) Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. Journal of Radiation Research 54:3, pages 494-514.
Crossref
Crossref
M. Langenbacher, R.J. Abdel-Jalil, W. Voelter, M. Weinmann & S.M. Huber. (2013) In vitro hypoxic cytotoxicity and hypoxic radiosensitizationHypoxische Zytotoxizität und Strahlensensibilisierung in vitro. Strahlentherapie und Onkologie 189:3, pages 246-255.
Crossref
Crossref
Hong Song, Srinivasan Senthamizhchelvan, Robert F. Hobbs & George Sgouros. (2012) Alpha Particle Emitter Radiolabeled Antibody for Metastatic Cancer: What Can We Learn from Heavy Ion Beam Radiobiology?. Antibodies 1:2, pages 124-148.
Crossref
Crossref
Harald PaganettiHarald Paganetti. 2011. Proton Therapy Physics. Proton Therapy Physics
593
626
.
Tatiana Wenzl & Jan J Wilkens. (2011) Theoretical analysis of the dose dependence of the oxygen enhancement ratio and its relevance for clinical applications. Radiation Oncology 6:1.
Crossref
Crossref
Robert D. Stewart, Victor K. Yu, Alexandros G. Georgakilas, Constantinos Koumenis, Joo Han Park & David J. Carlson. (2011) Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death. Radiation Research 176:5, pages 587-602.
Crossref
Crossref
Tatiana Wenzl & Jan J Wilkens. (2011) Modelling of the oxygen enhancement ratio for ion beam radiation therapy. Physics in Medicine and Biology 56:11, pages 3251-3268.
Crossref
Crossref
Veerle Vandersickel, Monica Mancini, Jacobus Slabbert, Emanuela Marras, Hubert Thierens, Gianpaolo Perletti & Anne Vral. (2010) The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons. Radiation Oncology 5:1.
Crossref
Crossref
Jie Li, Roashan Ayene, Kathleen M. Ward, Eswarkumar Dayanandam & Iraimoudi S. Ayene. (2009) Glucose deprivation increases nuclear DNA repair protein Ku and resistance to radiation induced oxidative stress in human cancer cells. Cell Biochemistry and Function 27:2, pages 93-101.
Crossref
Crossref
David J. Carlson, Robert D. Stewart & Vladimir A. Semenenko. (2006) Effects of oxygen on intrinsic radiation sensitivity: A test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parametersa). Medical Physics 33:9, pages 3105-3115.
Crossref
Crossref
Hooshang Nikjoo & Shuzo Uehara. 2003. Charged Particle and Photon Interactions with Matter. Charged Particle and Photon Interactions with Matter.
Werner Friedland, Peter Jacob, Philipp Bernhardt, Herwig G. Paretzke & Michael Dingfelder. (2003) Simulation of DNA Damage after Proton Irradiation. Radiation Research 159:3, pages 401-410.
Crossref
Crossref
Richard A. Britten, Lester J. Peters & David Murray. (2001) Biological Factors Influencing the RBE of Neutrons: Implications for Their Past, Present and Future Use in Radiotherapy. Radiation Research 156:2, pages 125-135.
Crossref
Crossref
D. Frankenberg, H.J. Brede, U.J. Schrewe, Ch. Steinmetz, M. Frankenberg-Schwager, G. Kasten & E. Pralle. (2000) Induction of DNA double-strand breaks in mammalian cells and yeast. Advances in Space Research 25:10, pages 2085-2094.
Crossref
Crossref
J. Besserer, J. de Boer, M. Dellert, C. Gahn, M. Moosburger, P. Pemler, P. Quicken, L. Distel & H. Schüßler. (1999) An irradiation facility with a vertical beam for radiobiological studies. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 430:1, pages 154-160.
Crossref
Crossref
G. Taucher-Scholz, J. Heilmann & G. Kraft. (1996) Induction of DNA strand breaks by heavy ions. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 107:1-4, pages 318-322.
Crossref
Crossref
G. Taucher-Scholz, J. Heilmann & G. Kraft. (1996) Induction and rejoining of DNA double-strand breaks in cho cells after heavy ion irradiation. Advances in Space Research 18:1-2, pages 83-92.
Crossref
Crossref
M. Belli, F. Ianzini, O. Sapora, M.A. Tabocchini, F. Cera, R. Cherubini, A.M.I. Haque, G. Moschini, P. Tiveron & G. Simone. (1996) DNA double strand break production and rejoining in V79 cells irradiated with light ions. Advances in Space Research 18:1-2, pages 73-82.
Crossref
Crossref
G. Taucher-Scholz, J. Heilmann, M. Schneider & G. Kraft. (1995) Detection of heavy-ion-induced DNA double-strand breaks using static-field gel electrophoresis. Radiation and Environmental Biophysics 34:2, pages 101-106.
Crossref
Crossref
S. Ikpeme, M. L�brich, T. Akpa, E. Schneider & J. Kiefer. (1995) Heavy ion-induced DNA double-strand breaks with yeast as a model system. Radiation and Environmental Biophysics 34:2, pages 95-99.
Crossref
Crossref
Flavia Barone, Mauro Belli & Filomena Mazzei. (1994) Influence of DNA conformation on radiation-induced single-strand breaks. Radiation and Environmental Biophysics 33:1, pages 23-33.
Crossref
Crossref
James B. Robertson, William C. Glisson, John O. Archambeau, George B. Coutrakan, Daniel W. Miller, Michael F. Moyers, Jeffrey F. Siebers, James M. Slater & John F. Dicello. 1993. Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B. Biological Effects and Physics of Solar and Galactic Cosmic Radiation Part B
853
858
.
Michael C. Elia, John G. DeLuca & Matthews O. Bradley. (1991) Significance and measurement of DNA double strand breaks in mammalian cells. Pharmacology & Therapeutics 51:3, pages 291-327.
Crossref
Crossref