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International Journal of Radiation Biology Volume 58, 1990 - Issue 2
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Original Article

Use of the Micronucleus Assay for the Selective Detection of Radiosensitivity in BUdR-unincorporated Cells after Pulse-labelling of Exponentially Growing Tumour Cells

S. Masunaga Department of Radiology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606, Japan
,
K. Ono University Clinic for Radiotherapy and Radiobiology, Alser Strasse 4, 1090, Vienna, Austria
,
E.O. Wandl Department of Radiology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606, Japan
,
M. Fushiki University Clinic for Radiotherapy and Radiobiology, Alser Strasse 4, 1090, Vienna, Austria
&
M. Abe Department of Radiology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, 606, Japan
Pages 303-311 | Received 09 Nov 1989, Accepted 21 Feb 1990, Published online: 03 Jul 2009

Citations (22)

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Read on this site (5)

S. Masunaga, K. Ono, M. Suzuki, Y. Kinashi, M. Takagaki & M. Akaboshi. (1997) Alteration in the hypoxic fraction of quiescent cell populations by hyperthermia at mild temperatures. International Journal of Hyperthermia 13:4, pages 401-411.
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M. ABEND. (1996) Evaluation of a modified micronucleus assay. International Journal of Radiation Biology 69:6, pages 717-727.
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M. Abend, A. Rhein, K.-P. Gilbertz, W.F. Blakely & D. Van Beuningen. (1995) Correlation of Micronucleus and Apoptosis Assays with Reproductive Cell Death. International Journal of Radiation Biology 67:3, pages 315-326.
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A. Vral, H. Thierens & L. de Ridder. (1992) Study of Dose-rate and Split-dose Effects on the in Vitro Micronucleus Yield in Human Lymphocytes Exposed to X-rays. International Journal of Radiation Biology 61:6, pages 777-784.
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Y. Shibamoto, C. Streffer, K. Sasai, N. Oya & M. Abe. (1992) Radiosensitization Efficacy of KU-2285, RP-170 and Etanidazole at Low Radiation Doses: Assessment by in Vitro Cytokinesis-block Micronucleus Assay. International Journal of Radiation Biology 61:4, pages 473-478.
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Articles from other publishers (17)

Hiroaki Shimono, Atsushi Kaida, Hisao Homma, Hitomi Nojima, Yusuke Onozato, Hiroyuki Harada & Masahiko Miura. (2020) Fluctuation in radioresponse of HeLa cells during the cell cycle evaluated based on micronucleus frequency. Scientific Reports 10:1.
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Yun Huang, Heli Hou, Qiyi Yi, Yingyin Zhang, Dawei Chen, Erkang Jiang, Yunfei Xia, Michael Fenech & Qinghua Shi. (2011) The fate of micronucleated cells post X-irradiation detected by live cell imaging. DNA Repair 10:6, pages 629-638.
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Nobuyuki HAMADA, Tatsuhiko IMAOKA, Shin-ichiro MASUNAGA, Toshiyuki OGATA, Ryuichi OKAYASU, Akihisa TAKAHASHI, Takamitsu A. KATO, Yasuhiko KOBAYASHI, Takeo OHNISHI, Koji ONO, Yoshiya SHIMADA & Teruki TESHIMA. (2010) Recent Advances in the Biology of Heavy-Ion Cancer Therapy. Journal of Radiation Research 51:4, pages 365-383.
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SHIN-ICHIRO MASUNAGA & KOJI ONO. (2002) Significance of the Response of Quiescent Cell Populations within Solid Tumors in Cancer Therapy. Journal of Radiation Research 43:1, pages 11-11.
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J. M. Akudugu, J. P. Slabbert, A. Serafin & L. Bohm. (2000) Frequency of Radiation-Induced Micronuclei in Neuronal Cells Does Not Correlate with Clonogenic Survival. Radiation Research 153:1, pages 62-67.
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Shin-ichiro Masunaga, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Tooru Kobayashi, Masao Takagaki, Yuko Kinashi & Mitsuhiko Akaboshi. (1999) Reoxygenation in quiescent and total intratumor cells following thermal neutron irradiation with or without 10B-compound—compared with that after γ-ray irradiation. International Journal of Radiation Oncology*Biology*Physics 44:2, pages 391-398.
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P. Morales-Ramírez, T. Vallarino-Kelly & R. Rodríguez-Reyes. (1996) Effect of chlorophyllin on gamma ray induced micronuclei in polychromatic erythrocytes of murine peripheral blood determined by the ABC strategy. Mutation Research/Genetic Toxicology 367:2, pages 51-56.
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Adel Courdi, Danielle Mari, Jo�l H�rault & Pierre Chauvel. (1995) Micronucleus induction and reproductive death in a human cell line exposed to low-energy argon beam. Radiation and Environmental Biophysics 34:2, pages 85-89.
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P. Morales-Ramírez, T. Vallarino-Kelly, J. Mercader-Martínez & R. Rodríguez-Reyes. (1994) Induction of micronuclei by acute and chronic exposure in vivo to gamma rays in murine polychromatic erythrocytes. Mutation Research/Genetic Toxicology 341:1, pages 47-55.
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M.J. McKay, G.J. Mann, D.A. McDonald, S. Jones & R.F. Kefford. (1994) Isolation and preliminary characterisation of an X-ray-sensitive mamamalian mutant cell line (WMXRS-1). Mutation Research/DNA Repair 314:3, pages 261-271.
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Natsuo Oya, Yuta Shibamoto, Keisuke Sasai, Taketoshi Sugiyama & Mitsuyuki Abe. (1993) In vivo radiosensitization efficacy of KU-2285 and etanidazole at clinically relevant low radiation doses. International Journal of Radiation Oncology*Biology*Physics 27:5, pages 1113-1119.
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M Fenech. (1993) The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations.. Environmental Health Perspectives 101:suppl 3, pages 101-107.
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S Masunaga, K Ono & M Abe. (1993) The detection and modification of the hypoxic fraction in quiescent cell populations in murine solid tumours. The British Journal of Radiology 66:790, pages 918-926.
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K. Ono, S. Masunaga, K. Akuta, M. Akaboshi & M. Abe. (1993) Radiosensitization of SCCVII tumours and normal tissues by nicotinamide and carbogen: analysis by micronucleus assay. Radiotherapy and Oncology 28:2, pages 162-167.
Crossref
Michael Fenech. (1993) The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 285:1, pages 35-44.
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Shin-Ichiro Masunaga, Koji Ono & Mitsuyuki Abe. (1992) Potentially lethal damage repair by quiescent cells in murine solid tumors. International Journal of Radiation Oncology*Biology*Physics 22:5, pages 973-978.
Crossref
Georg A. Schreiber, Wolfgang Beisker, Manfred Bauchinger & Michael Nüsse. (2005) Multiparametric flow cytometric analysis of radiation‐induced micronuclei in mammalian cell cultures. Cytometry 13:1, pages 90-102.
Crossref

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