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International Journal of Radiation Biology Volume 58, 1990 - Issue 5
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Original Article

The Combined Effects of α-particles and X-rays on Cell Killing and Micronuclei Induction in Lung Epithelial Cells

A.L. Brooks Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, PO Box 5890, Albuquerque, NM, 87185, USA
,
G.J. Newton Battelle, Pacific Northwest Laboratories, PO Box 999, P7-50, Richland, WA, 99352, USA
,
L.-J. Shyr Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, PO Box 5890, Albuquerque, NM, 87185, USA
,
F.A. Seiler Battelle, Pacific Northwest Laboratories, PO Box 999, P7-50, Richland, WA, 99352, USA
&
B.R. Scott Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, PO Box 5890, Albuquerque, NM, 87185, USA
Pages 799-811 | Received 19 Feb 1990, Accepted 08 May 1990, Published online: 03 Jul 2009

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Bobby E. Leonard. (2008) A composite microdose Adaptive Response (AR) and Bystander Effect (BE) model–application to low LET and high LET AR and BE data. International Journal of Radiation Biology 84:8, pages 681-701.
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Bobby E. Leonard. (2007) Adaptive response and human benefit: Part I. A microdosimetry dose-dependent model. International Journal of Radiation Biology 83:2, pages 115-131.
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AntoneL. Brooks, KeithE. McDonald, Charlotte Mitchell, DianeS. Culp, Aaron Lloyd, NeilF. Johnson, RobertM. Kitchin & RobertM. Kitchin. (1996) The Combined Genotoxic Effects of Radiation and Occupational Pollutants. Applied Occupational and Environmental Hygiene 11:4, pages 410-416.
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Articles from other publishers (34)

Francisco D. C. Guerra Liberal, Shannon J. Thompson, Kevin M. Prise & Stephen J. McMahon. (2023) High-LET radiation induces large amounts of rapidly-repaired sublethal damage. Scientific Reports 13:1.
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Alejandro Bertolet & Alejandro Carabe. (2020) Modelling Dose Effects from Space Irradiations: Combination of High-LET and Low-LET Radiations with a Modified Microdosimetric Kinetic Model. Life 10:9, pages 161.
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Tabea Pfuhl, Thomas Friedrich & Michael Scholz. (2019) Prediction of Cell Survival after Exposure to Mixed Radiation Fields with the Local Effect Model. Radiation Research 193:2, pages 130.
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Maria Moreno-Villanueva & Honglu Wu. (2019) Radiation and microgravity – Associated stress factors and carcinogensis. REACH 13, pages 100027.
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Lei Cheng, Beata Brzozowska, Alice Sollazzo, Lovisa Lundholm, Halina Lisowska, Siamak Haghdoost & Andrzej Wojcik. (2018) Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes. PLOS ONE 13:10, pages e0204068.
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Jay H. Solanki, Thomas Tritt, Jordan B. Pasternack, Julia J. Kim, Calvin N. Leung, Jason D. Domogauer, Nicholas W. Colangelo, Venkat R. Narra & Roger W. Howell. (2017) Cellular Response to Exponentially Increasing and Decreasing Dose Rates: Implications for Treatment Planning in Targeted Radionuclide Therapy. Radiation Research 188:2, pages 221.
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Candy Ng, Shuk Cheng & Kwan Yu. (2017) Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish Embryos. International Journal of Molecular Sciences 18:2, pages 385.
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Ruiping Ren, Mingyuan He, Chen Dong, Yuexia Xie, Shuang Ye, Dexiao Yuan & Chunlin Shao. (2013) Dose response of micronuclei induced by combination radiation of α-particles and γ-rays in human lymphoblast cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 741-742, pages 51-56.
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E. Staaf, K. Brehwens, S. Haghdoost, K. Pachnerova-Brabcova, J. Czub, J. Braziewicz, S. Nievaart & A. Wojcik. (2012) Characterisation of a setup for mixed beam exposures of cells to 241Am alpha particles and X-rays. Radiation Protection Dosimetry 151:3, pages 570-579.
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A Wojcik, G Obe, H Lisowska, J Czub, V Nievaart, R Moss, R Huiskamp & W Sauerwein. (2012) Chromosomal aberrations in peripheral blood lymphocytes exposed to a mixed beam of low energy neutrons and gamma radiation. Journal of Radiological Protection 32:3, pages 261-274.
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Elina Staaf, Karl Brehwens, Siamak Haghdoost, Sander Nievaart, Katerina Pachnerova-Brabcova, Joanna Czub, Janusz Braziewicz & Andrzej Wojcik. (2012) Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles. Radiation and Environmental Biophysics 51:3, pages 283-293.
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Elina Staaf, Karl Brehwens, Siamak Haghdoost, Joanna Czub & Andrzej Wojcik. (2012) Gamma-H2AX foci in cells exposed to a mixed beam of X-rays and alpha particles. Genome Integrity 3:1, pages 8.
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Magnus G. Olsson, E. J. Charlotta Nilsson, Sigurbjörg Rutardóttir, Jan Paczesny, Jan Pallon & Bo Åkerström. (2010) Bystander Cell Death and Stress Response is Inhibited by the Radical Scavenger α 1 -Microglobulin in Irradiated Cell Cultures . Radiation Research 174:5, pages 590-600.
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V. Zareena Hamza & Mary N. Mohankumar. (2009) Cytogenetic damage in human blood lymphocytes exposed in vitro to radon. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 661:1-2, pages 1-9.
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Bobby E. Leonard. (2008) A Review: Development of a Microdose Model for Analysis of Adaptive Response and Bystander Dose Response Behavior. Dose-Response 6:2, pages dose-response.0.
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R. Pathak, A. R. Khuda Bukhsh, S. K. Dey, U. Ghosh, B. Sen Gupta, M. Semwal & N. P. Bhattacharyya. (2007) Resistance to induction of micronuclei, chromosomal aberrations and apoptosis by 60Co gamma-ray in a cell strain M5, derived from Chinese hamster V79 cells. Journal of Radioanalytical and Nuclear Chemistry 274:2, pages 441-447.
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Rupak Pathak, Subrata Kumar Dey, Asiti Sarma & Anisur Rahman Khuda-Bukhsh. (2007) Cell killing, nuclear damage and apoptosis in Chinese hamster V79 cells after irradiation with heavy-ion beams of 16O, 12C and 7Li. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 632:1-2, pages 58-68.
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Rupak Pathak, Subrata Kumar Dey, Asiti Sarma & Anisur Rahman Khuda-Bukhsh. (2007) Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET=60keV/μm) and correlation of their survival dynamics to nuclear damages and cell death. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 628:1, pages 56-66.
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Milan Beno, Marta Hurbankova, Maria Dusinska, Sylvia Cerna, Katarina Volkovova, Marta Staruchova, Magda Barancokova, Alena Kazimirova, Zuzana Kovacikova, Miroslav Mikulecky & Soterios Andreou Kyrtopoulos. (2005) Multinucleate cells (MNC) as sensitive semiquantitative biomarkers of the toxic effect after experimental fibrous dust and cigarette smoke inhalation by rats. Experimental and Toxicologic Pathology 57:1, pages 77-87.
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Natalia Medvedeva, John Ford & Leslie Braby. (2004) Changes in Micronucleus Frequency Resulting from Preirradiation of Cell Culture Surfaces. Radiation Research 162:6, pages 660-666.
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Michael CR Alavanja. (2002) Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions. Oncogene 21:48, pages 7365-7375.
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M. Durante. (2002) Radiation protection in space. La Rivista del Nuovo Cimento 25:8, pages 1-70.
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Y. Furusawa, M. Aoki & M. Durante. (2002) Simultaneous exposure of mammalian cells to heavy ions and X-rays. Advances in Space Research 30:4, pages 877-884.
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Hongning Zhou, Gerhard Randers-Pehrson, Charles A. Waldren, Diane Vannais, Eric J. Hall & Tom K. Hei. (2000) Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proceedings of the National Academy of Sciences 97:5, pages 2099-2104.
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Kerstin Wuttke, Wolfgang-Ulrich Müller & Christian Streffer. (1998) The sensitivity of the in vitro cytokinesis-blocked micronucleus assay in lymphocytes for different and combined radiation qualitiesDie Sensitivität des In-vitro-Zytokinesis-Block-Mikronukleus-Assays für verschiedene Strahlenqualitäten und deren Kombination. Strahlentherapie und Onkologie 174:5, pages 262-268.
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B E Lehnert & E H Goodwin. (1997) A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny.. Environmental Health Perspectives 105:suppl 5, pages 1095-1101.
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R.F. Jostes. (1996) Genetic, cytogenetic, and carcinogenic effects of radon: A review. Mutation Research/Reviews in Genetic Toxicology 340:2-3, pages 125-139.
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P. Morales-Ramírez, T. Vallarino-Kelly & R. Rodríguez-Reyes. (1996) Effect of chlorophyllin on gamma ray induced micronuclei in polychromatic erythrocytes of murine peripheral blood determined by the ABC strategy. Mutation Research/Genetic Toxicology 367:2, pages 51-56.
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Jürgen Kiefer, Karin Schenk-Meuser & Michael Kost. 1996. Biological and Medical Research in Space. Biological and Medical Research in Space 300 367 .
Adel Courdi, Danielle Mari, Jo�l H�rault & Pierre Chauvel. (1995) Micronucleus induction and reproductive death in a human cell line exposed to low-energy argon beam. Radiation and Environmental Biophysics 34:2, pages 85-89.
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P. Morales-Ramírez, T. Vallarino-Kelly, J. Mercader-Martínez & R. Rodríguez-Reyes. (1994) Induction of micronuclei by acute and chronic exposure in vivo to gamma rays in murine polychromatic erythrocytes. Mutation Research/Genetic Toxicology 341:1, pages 47-55.
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W.-U. Müller & C. Streffer. 1994. Advances in Mutagenesis Research. Advances in Mutagenesis Research 1 134 .
Tung‐Kwang Lee, Albert L. WileyJr.Jr., James D. Esinhart & Lisa D. Blackburn. (2005) Radiation dose‐dependent variations of micronuclei production in cytochalasin B‐blocked human lymphocytes. Teratogenesis, Carcinogenesis, and Mutagenesis 14:1, pages 1-12.
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James M. Parry, Elizabeth M. Parry, Sian Ellard, T. Warr, Joye O’Donovan & Anna Lafi. 1993. Chromosome Segregation and Aneuploidy. Chromosome Segregation and Aneuploidy 391 415 .

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