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International Journal of Radiation Biology Volume 57, 1990 - Issue 2
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Original Article

A Generalized State-vector Model for Radiation-induced Cellular Transformation

D.J. Crawford-Brown Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, 27516-7400, U.S.A.
&
W. Hofmann Center for Extrapolation Modeling, Duke University Medical Center, Duke University, Durham, NC, 27710, U.S.A.; Abteilung fü Biophysik, University Salzburg, Hellbrunnerstrasse 34, A-5020, Salzburg, Austria
Pages 407-423 | Received 03 Jan 1989, Accepted 01 Sep 1989, Published online: 03 Jul 2009

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Lucia A. Truta-Popa, Werner Hofmann, Hatim Fakir & Constantin Cosma. (2011) The effect of non-targeted cellular mechanisms on lung cancer risk for chronic, low level radon exposures. International Journal of Radiation Biology 87:9, pages 944-953.
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Harry Friedmann. (1997) Radon—the Fleeting Daughter of Radium. Nuclear Physics News 7:4, pages 14-20.
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G.E.R. Schoeters, F. Vander Plaetse & R.L. van den Heuvel. (1994) Effects of in Vitro α-particle Irradiation on Osteogenic Bone Marrow Cultures. International Journal of Radiation Biology 66:2, pages 207-214.
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D.J. Brenner. (1992) Radon: Current Challenges in Cellular Radiobiology. International Journal of Radiation Biology 61:1, pages 3-13.
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Articles from other publishers (25)

Werner Hofmann, Wei Bo Li, Werner Friedland, Brian W. Miller, Balázs Madas, Manuel Bardiès & Imre Balásházy. (2019) Internal microdosimetry of alpha-emitting radionuclides. Radiation and Environmental Biophysics 59:1, pages 29-62.
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George Sgouros, John C. Roeske, Michael R. McDevitt, Stig Palm, Barry J. Allen, Darrell R. Fisher, A. Bertrand Brill, Hong Song, Roger W. Howell & Gamal Akabani. (2010) MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy. Journal of Nuclear Medicine 51:2, pages 311-328.
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L. Fleishman, D. Crawford-Brown & W. Hofmann. (2008) A computational model for radiation-induced cellular transformation to in vitro irradiation of cells by acute doses of X-rays. Mathematical Biosciences 215:2, pages 186-192.
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Rainer K. Sachs, Igor Shuryak, David Brenner, Hatim Fakir, Lynn Hlatky & Philip Hahnfeldt. (2007) Second cancers after fractionated radiotherapy: Stochastic population dynamics effects. Journal of Theoretical Biology 249:3, pages 518-531.
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Helmut Schöllnberger & Peter M. Eckl. (2007) Protective Bystander Effects Simulated with the State-Vector Model. Dose-Response 5:3, pages dose-response.0.
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W. Hofmann, D. J. Crawford-Brown, H. Fakir & G. Monchaux. (2006) Modeling lung cancer incidence in rats following exposure to radon progeny. Radiation Protection Dosimetry 122:1-4, pages 345-348.
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H. Fakir & W. Hofmann. (2006) Incorporation of microdosimetric concepts into a biologically-based model of radiation carcinogenesis. Radiation Protection Dosimetry 122:1-4, pages 330-334.
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H. Schöllnberger, R. E. J. Mitchel, D. J. Crawford-Brown & W. Hofmann. (2006) A model for the induction of chromosome aberrations through direct and bystander mechanisms. Radiation Protection Dosimetry 122:1-4, pages 275-281.
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H. Schöllnberger, M. Manuguerra, H. Bijwaard, H. Boshuizen, H.P. Altenburg, S.M. Rispens, M.J.P. Brugmans & P. Vineis. (2006) Analysis of epidemiological cohort data on smoking effects and lung cancer with a multi-stage cancer model. Carcinogenesis 27:7, pages 1432-1444.
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D.J. Crawford-Brown & W. Hofmann. 2005. The Natural Radiation Environment VII: VIIth Int. Symp. On the NRE. The Natural Radiation Environment VII: VIIth Int. Symp. On the NRE 632 639 .
H. Schöllnberger, R. D. Stewart, R. E. J. Mitchel & W. Hofmann. (2004) An Examination of Radiation Hormesis Mechanisms Using a Multistage Carcinogenesis Model. Nonlinearity in Biology, Toxicology, Medicine 2:4, pages 154014204909002.
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Bobby R. Scott, Dale M. Walker, Yohannes Tesfaigzi, Helmut Schöllnberger & Vernon Walker. (2003) Mechanistic Basis for Nonlinear Dose-Response Relationships for Low-Dose Radiation-Induced Stochastic Effects. Nonlinearity in Biology, Toxicology, Medicine 1:1, pages 154014203908444.
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Douglas J Crawford-Brown & Werner Hofmann. (2002) Analysis of radon-induced lung cancer risk by a stochastic state-vector model of radiation carcinogenesis. Journal of Radiological Protection 22:3A, pages A61-A65.
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Helmut Sch llnberger, Ron E Mitchel, Douglas J Crawford-Brown & Werner Hofmann. (2002) Nonlinear dose response relationships and inducible cellular defence mechanisms. Journal of Radiological Protection 22:3A, pages A21-A25.
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Alexandra C. Miller, Michael Stewart, Kia Brooks, Lin Shi & Natalie Page. (2002) Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha particle decay. Journal of Inorganic Biochemistry 91:1, pages 246-252.
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M. Mebust, D. Crawford-Brown, W. Hofmann & H. Schöllnberger. (2002) Testing Extrapolation of a Biologically Based Exposure–Response Model from in Vitro to in Vivo Conditions. Regulatory Toxicology and Pharmacology 35:1, pages 72-79.
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Werner Hofmann, Margaret G. Ménache, Douglas J. Crawford-Brown, Randall S. Caswell & Lisa R. Karam. (2000) MODELING ENERGY DEPOSITION AND CELLULAR RADIATION EFFECTS IN HUMAN BRONCHIAL EPITHELIUM BY RADON PROGENY ALPHA PARTICLES. Health Physics 78:4, pages 377-393.
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Carl M. Fleck, Helmut Schöllnberger, Markus M. Kottbauer, Thomas Dockal & Ulrike Prüfert. (1999) Modeling radioprotective mechanisms in the dose effect relation at low doses and low dose rates of ionizing radiation. Mathematical Biosciences 155:1, pages 13-44.
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D.J. Crawford-Brown & W. Hofmann. (1996) The testing of radiobiological models of radon carcinogenesis needed for in vitro to in vivo extrapolations. Environment International 22, pages 985-994.
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W. Hofmann, T. Heistracher, R.S. Caswell & L.R. Karam. (1996) Track structure predictions of radon-induced biological effects in human bronchial epithelium. Environment International 22, pages 949-957.
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J�rg Schmidt, Kathrin Heermeier, Utz Linzner, Arne Luz, Michael Silbermann, Erella Livne & Volker Erfle. (1994) Osteosarcomagenic doses of radium (224Ra) and infectious endogenous retroviruses enhance proliferation and osteogenic differentiation of skeletal tissue differentiating in vitro. Radiation and Environmental Biophysics 33:1, pages 69-79.
Crossref
Douglas J. Crawford-Brown & Werner Hofmann. (1993) Extension of a generalized state-vector model of radiation carcinogenesis to consideration of dose rate. Mathematical Biosciences 115:2, pages 123-144.
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Steve Wing, Carl M. Shy, Joy L. Wood, Susanne Wolf, Donna L. Cragle, William Tankersley & E. L. Frome. (2007) Job factors, radiation and cancer mortality at OAK ridge national Laboratory: Follow‐up through 1984. American Journal of Industrial Medicine 23:2, pages 265-279.
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John W. Wilson, F. A. Cucinotta & J. L. Shinn. 1993. Biological Effects and Physics of Solar and Galactic Cosmic Radiation. Biological Effects and Physics of Solar and Galactic Cosmic Radiation 295 338 .
J. Pohl-Rüling. 1990. Advances in Mutagenesis Research. Advances in Mutagenesis Research 155 190 .

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