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International Journal of Radiation Biology Volume 59, 1991 - Issue 1
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Original Article

Evaluation of a New 2-nitroimidazole Nucleoside Analogue, RK-28 as a Radiosensitizer for Clinical Use

Y. Shibamoto Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
,
K. Sasai Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, 4300, Essen 1, FRG
,
M. Sakaguchi Pola Corporation, Yokohama, 244, Japan
,
P. Tamulevicius Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
,
Y. Kitakabu Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, 4300, Essen 1, FRG
,
C. Streffer Pola Corporation, Yokohama, 244, Japan
&
M. Abe Department of Radiology, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan
 show all
Pages 105-115 | Received 21 Mar 1990, Accepted 19 Jun 1990, Published online: 03 Jul 2009

Citations (11)

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Junko Takahashi, Masaki Misawa & Hitoshi Iwahashi. (2016) Combined treatment with X-ray irradiation and 5-aminolevulinic acid elicits better transcriptomic response of cell cycle-related factors than X-ray irradiation alone. International Journal of Radiation Biology 92:12, pages 774-789.
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Y. Shibamoto, Y. Mimasu, Y. Tachi, H. Hatta & S. Nishimoto. (2002) Comparison of 5-Fluorouracil and 5-Fluoro-2'-Deoxyuridine as an Effector in Radiation-Activated Prodrugs. Journal of Chemotherapy 14:4, pages 390-396.
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Y. Shibamoto, C. Streffer, K. Sasai, N. Oya & M. Abe. (1992) Radiosensitization Efficacy of KU-2285, RP-170 and Etanidazole at Low Radiation Doses: Assessment by in Vitro Cytokinesis-block Micronucleus Assay. International Journal of Radiation Biology 61:4, pages 473-478.
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Articles from other publishers (8)

Tomoaki YAHIRO, Shigeki MASUI, Nobuo KUBOTA, Koji YAMADA, Ataru KOBAYASHI & Kenichi KISHII. (2005) Effects of Hypoxic Cell Radiosensitizer Doranidazole (PR-350) on the Radioresponse of Murine and Human Tumor Cells in vitro and in vivo. Journal of Radiation Research 46:3, pages 363-372.
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Kenji Nemoto, Yuta Shibamoto, Jun-ichi Ohmagari, Yuji Baba, Kazuyu Ebe, Hisanori Ariga, Yoshihiro Takai, Atsushi Ouchi, Keisuke Sasai, Misao Shinozaki, Michihiko Tsujitani, Masakazu Sakaguchi, Shogo Yamada & Kiyohiko Sakamoto. (2001) Phase Ia study of a hypoxic cell sensitizer doranidazole (PR-350) in combination with conventional radiotherapy. Anti-Cancer Drugs 12:1, pages 1-6.
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Christa E. Müller. 1999. Imaging of Hypoxia. Imaging of Hypoxia 47 59 .
Natsuo Oya, Yuta Shibamoto, Keisuke Sasai, Toru Shibata, Rumi Murata, Takehisa Takagi, Hiroyuki Iwai, Toshimitsu Suzuki & Mitsuyuki Abe. (1995) Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): Radiosensitization efficiency and toxicity. International Journal of Radiation Oncology*Biology*Physics 33:1, pages 119-127.
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Jef Rozenski, Camiel J. De Ranter & Hilda Verplanken. (2006) Quantitative Structure‐Activity Relationships for Antimicrobial Nitroheterocyclic Drugs. Quantitative Structure-Activity Relationships 14:2, pages 134-141.
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Natsuo Oya, Yuta Shibamoto, Toru Shibata, Keisuke Sasai, Taketoshi Sugiyama & Mitsuyuki Abe. (1994) Combined cytokinesis-block micronucleus and chromosomal aberration assay for the evaluation of radiosensitizers at low radiation doses. International Journal of Radiation Oncology*Biology*Physics 30:5, pages 1153-1159.
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Christian Streffer & Peter Tamulevicius. (1994) Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers. International Journal of Radiation Oncology*Biology*Physics 29:3, pages 571-575.
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Keisuke Sasai, Yuta Shibamoto, Tadao Manabe, Nobuo Baba, Masaji Takahashi, Masakazu Sakaguchi & Mitsuyuki Abe. (1992) Pharmacokinetics of intratumoral RK-28, a new hypoxic radiosensitizer. International Journal of Radiation Oncology*Biology*Physics 24:5, pages 959-963.
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