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International Journal of Radiation Biology Volume 59, 1991 - Issue 1
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Original Article

Aerobic Radiosensitization by SR 4233 in Rodent and Human Cells: Mechanistic and Therapeutic Implications

E.M. Zeman Department of Radiation Oncology, Division of Radiation Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA
&
J.M. Brown Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC, 27599-7512, USA
Pages 117-131 | Received 29 Jan 1990, Accepted 23 May 1990, Published online: 03 Jul 2009

Citations (10)

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E. Lartigau & M. Guichard. (1995) Does Tirapazamine (SR-4233) Have Any Cytotoxic or Sensitizing Effect on Three Human Tumour Cell Lines at Clinically Relevant Partial Oxygen Pressure?. International Journal of Radiation Biology 67:2, pages 211-216.
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Articles from other publishers (9)

Ashleigh Pulkoski-Gross, Nikki A. Evensen & Jian Cao. 2014. Tumor Metabolome Targeting and Drug Development. Tumor Metabolome Targeting and Drug Development 75 108 .
H.O. SMITH, C.S. JIANG, G.R. WEISS, A.V. HALLUM, P.Y. LIU, W.R. ROBINSON, P.C. CHENG, S.A. SCUDDER, M. MARKMAN & D.S. ALBERTS. (2006) Tirapazamine plus cisplatin in advanced or recurrent carcinoma of the uterine cervix: a Southwest Oncology Group study. International Journal of Gynecological Cancer 16:1, pages 298-305.
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Seyed K. Imam. (2001) Status of Radioimmunotherapy in the New Millennium. Cancer Biotherapy and Radiopharmaceuticals 16:3, pages 237-256.
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Toru Shibata, Yuta Shibamoto, Keisuke Sasai, Natsuo Oya, Rumi Murata, Takehisa Takagi, Masahiro Hiraoka & Mitsuyuki Abe. (2005) Comparison of in vivo Efficacy of Hypoxic Cytotoxin Tirapazamine and Hypoxic Cell Radiosensitizer KU‐2285 in Combination with Single and Fractionated Irradiation . Japanese Journal of Cancer Research 87:1, pages 98-104.
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Toru Shibata, Yuta Shibamoto, Keisuke Sasai, Natsuo Oya, Takehisa Takagi, Rumi Murata & Mitsuyuki Abe. (1995) Assessment of micronucleus induction in SCCVII cells treated with bioreductive agents, WIN 59075 (SR 4233) and mitomycin C, under aerobic and hypoxic conditions. Mutation Research/Genetic Toxicology 342:3-4, pages 171-177.
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Laurie L. Herscher, Murali C. Krishna, John A. Cook, C. Norman Coleman, John E. Biaglow, Stephen W. Tuttle, Frank J. Gonzalez & James B. Mitchell. (1994) Protection against sr 4233 (tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron. International Journal of Radiation Oncology*Biology*Physics 30:4, pages 879-885.
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Richard B. Wilder, Judeth K. McGann, William R. Sutherland, Edmund K. Waller, Andrew I. Minchinton, Michael L. Goris & Susan J. Knox. (1994) The hypoxic cytotoxin sr 4233 increases the effectiveness of radioimmunotherapy in mice with human non-Hodgkin's lymphoma xenografts. International Journal of Radiation Oncology*Biology*Physics 28:1, pages 119-126.
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Paul Baas, Hugo Oppelaar, Mireile Stavenuiter, Nico Van Zandwijk & Fiona A Stewart. (1993) Interaction of the bioreductive drug sr 4233 and photodynamic therapy using photofrin in a mouse tumor model. International Journal of Radiation Oncology*Biology*Physics 27:3, pages 665-670.
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P. Lambin, M. Guichard, N. Chavaudra & E.P. Malaise. (1992) The effect of the hypoxic cell drug SR-4233 alone or combined with the ionizing radiations on two human tumor cell lines having different radiosensitivity. Radiotherapy and Oncology 24:3, pages 201-204.
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