83
Views
105
CrossRef citations to date
0
Altmetric
Original Article

Measurement of DNA Double-strand Breaks in CHO Cells at Various Stages of the Cell Cycle Using Pulsed Field Gel Electrophoresis: Calibration by Means of 125I Decay

, &
Pages 343-357 | Received 03 May 1990, Accepted 29 Jul 1990, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (34)

Fanghua Li, Yanlei Cheng & George Iliakis. (2015) The contribution of thermally labile sugar lesions to DNA double-strand break formation in cells grown in the presence of BrdU. International Journal of Radiation Biology 91:4, pages 312-320.
Read now
Kristina Claesson, Karin Magnander, Helena Kahu, Sture Lindegren, Ragnar Hultborn & Kecke Elmroth. (2011) RBE of α-particles from 211At for complex DNA damage and cell survival in relation to cell cycle position. International Journal of Radiation Biology 87:4, pages 372-384.
Read now
Penny Jeggo & Martin F. Lavin. (2009) Cellular radiosensitivity: How much better do we understand it?. International Journal of Radiation Biology 85:12, pages 1061-1081.
Read now
Alexandra Jensen, Jürgen Debus & Klaus-Josef Weber. (2008) S-phase cell-specific modification by gemcitabine of PFGE-analyzed radiation-induced DNA fragmentation and rejoining. International Journal of Radiation Biology 84:9, pages 770-777.
Read now
Cecilia Lundin, Klaus Erixon, Catherine Arnaudeau, Niklas Schultz, Dag Jenssen, Mark Meuth & Thomas Helleday. (2002) Different Roles for Nonhomologous End Joining and Homologous Recombination following Replication Arrest in Mammalian Cells. Molecular and Cellular Biology 22:16, pages 5869-5878.
Read now
Spiros Vamvakas, Esther H. Vock & Werner K. Lutz. (1997) On the Role of DNA Double-Strand Breaks in Toxicity and Carcinogenesis. Critical Reviews in Toxicology 27:2, pages 155-174.
Read now
N. FORAY. (1996) Dose-rate effect on radiation-induced DNA double-strand breaks in the human fibroblast HF19 cell line. International Journal of Radiation Biology 69:2, pages 241-249.
Read now
S. MATEOS. (1996) Cell-cycle variation in DNA migration in pulsed-field gel electrophoresis. International Journal of Radiation Biology 69:6, pages 687-693.
Read now
N. CHEONG. (1996) In vitro rejoining of double-strand breaks in cellular DNA by factors present in extracts of HeLa cells. International Journal of Radiation Biology 69:6, pages 665-677.
Read now
T. Ganguly & G. Iliakis. (1995) A Cell-free Assay Using Cytoplasmic Cell Extracts to Study Rejoining of Radiation-induced DNA Double-strand Breaks in Human Cell Nuclei. International Journal of Radiation Biology 68:4, pages 447-457.
Read now
J. Heilmann, G. Taucher-Scholz & G. Kraft. (1995) Induction of DNA Double-strand Breaks in CHO-K1 Cells by Carbon Ions. International Journal of Radiation Biology 68:2, pages 153-162.
Read now
R.S.L. Wong, J.R. Dynlacht, B. Cedervall & W.C. Dewey. (1995) Analysis by Pulsed-field Gel Electrophoresis of DNA Double-strand Breaks Induced by Heat and/or X-irradiation in Bulk and Replicating DNA of CHO Cells. International Journal of Radiation Biology 68:2, pages 141-152.
Read now
M.A. Davis, H.Y. Tang, J. Maybaum & T.S. Lawrence. (1995) Dependence of Fluorodeoxyuridine-mediated Radiosensitization on S Phase Progression. International Journal of Radiation Biology 67:5, pages 509-517.
Read now
J. Dahm-Daphi & E. Dikomey. (1995) Separation of DNA Fragments Induced by Ionizing Irradiation Using a Graded-field Gel Electrophoresis. International Journal of Radiation Biology 67:2, pages 161-168.
Read now
S.J. Whitaker, Y.C. Ung & T.J. McMillan. (1995) DNA Double-strand Break Induction and Rejoining as Determinants of Human Tumour Cell Radiosensitivity. A Pulsed-field Gel Electrophoresis Study. International Journal of Radiation Biology 67:1, pages 7-18.
Read now
K.H. Chadwick & H.P. Leenhouts. (1994) On the Linearity of the Dose—effect Relationship of DNA Double Strand Breaks. International Journal of Radiation Biology 66:5, pages 549-552.
Read now
J.M. Ruiz de Almodóvar, G.G. Steel, S.J. Whitaker & T.J. McMillan. (1994) A Comparison of Methods for Calculating DNA Double-strand Break Induction Frequency in Mammalian Cells by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 65:6, pages 641-649.
Read now
M. Löbrich, S. Ikpeme & J. Kiefer. (1994) DNA Double-strand Break Measurement in Mammalian Cells by Pulsed-field Gel Electrophoresis: An Approach Using Restriction Enzymes and Gene Probing. International Journal of Radiation Biology 65:6, pages 623-630.
Read now
D. Murray, R. Simpson, E. Rosenberg, A. Carraway & R. Britten. (1994) Correlation between γ-ray-induced DNA Double-strand Breakage and Cell Killing after Biologically Relevant Doses: Analysis by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 65:4, pages 419-426.
Read now
M. Dardalhon, A. Nohturfft, V. Meniel & D. Averbeck. (1994) Repair of DNA Double-strand Breaks Induced in Saccharomyces Cerevisiae Using Different γ-ray Dose-rates: A Pulsed-field Gel Electrophoresis Analysis. International Journal of Radiation Biology 65:3, pages 307-314.
Read now
M.C. Mühlmann-Díaz & J.S. Bedford. (1994) Breakage of Human Chromosomes 4, 19 and Y in G0 Cells Immediately after Exposure to γ-rays. International Journal of Radiation Biology 65:2, pages 165-173.
Read now
M. Flentje, B. Asadpour, D. Latz & K.J. Weber. (1993) Sensitivity of Neutral Filter Elution but Not PFGE Can Be Modified by Non-dsb Chromatin Damage. International Journal of Radiation Biology 63:6, pages 715-724.
Read now
P.L. Olive & J.P. Banáth. (1993) Detection of DNA Double-strand Breaks through the Cell Cycle after Exposure to X-rays, Bleomycin, Etoposide and 125IdUrd. International Journal of Radiation Biology 64:4, pages 349-358.
Read now
M.D. Story, K.C. Garrett, P.J. Tofilon & R.E. Meyn. (1993) Influence of Irradiation Conditions on the Measurement of DNA Double-strand Breaks by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 63:3, pages 297-304.
Read now
A.A. Friedl, W. Beisker, K. Hahn, F. Eckardt-Schupp & A.M. Kellerer. (1993) Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules. International Journal of Radiation Biology 63:2, pages 173-181.
Read now
R. Okayasu & G. Iliakis. (1992) The Shape of DNA Elution Dose-response Curves Under Non-denaturing Conditions: The Contribution of the Degree of Chromatin Condensation. International Journal of Radiation Biology 61:4, pages 455-463.
Read now
G. Iliakis, R. Mehta & M. Jackson. (1992) Level of DNA Double-strand Break Rejoining in Chinese Hamster xrs-5 Cells is Dose-dependent: Implications for the Mechanism of Radiosensitivity. International Journal of Radiation Biology 61:3, pages 315-321.
Read now
S.J. Whitaker & T.J. McMillan. (1992) Oxygen Effect for DNA Double-strand Break Induction Determined by Pulsed-field Gel Electrophoresis. International Journal of Radiation Biology 61:1, pages 29-41.
Read now
L. Metzger & G. Iliakis. (1991) Kinetics of DNA Double-strand Break Repair Throughout the Cell Cycle as Assayed by Pulsed Field Gel Electrophoresis in CHO Cells. International Journal of Radiation Biology 59:6, pages 1325-1339.
Read now
G.E. Iliakis, L. Metzger, N. Denko & T.D. Stamato. (1991) Detection of DNA Double-strand Breaks in Synchronous Cultures of CHO Cells by Means of Asymmetric Field Inversion Gel Electrophoresis. International Journal of Radiation Biology 59:2, pages 321-341.
Read now

Articles from other publishers (71)

Benjamin Frey, Kerstin Borgmann, Tina Jost, Burkhard Greve, Michael Oertel, Oliver Micke & Franziska Eckert. (2023) DNA as the main target in radiotherapy—a historical overview from first isolation to anti-tumour immune response. Strahlentherapie und Onkologie 199:12, pages 1080-1090.
Crossref
Satzhan Sitmukhambetov, Bryan Dinh, Youfang Lai, Edward J Banigan, Zui Pan, Xun Jia & Yujie Chi. (2022) Development and implementation of a metaphase DNA model for ionizing radiation induced DNA damage calculation. Physics in Medicine & Biology 68:1, pages 014001.
Crossref
Dousatsu Sakata, Ryoichi Hirayama, Wook-Geun Shin, Mauro Belli, Maria A. Tabocchini, Robert D. Stewart, Oleg Belov, Mario A. Bernal, Marie-Claude Bordage, Jeremy M.C. Brown, Milos Dordevic, Dimitris Emfietzoglou, Ziad Francis, Susanna Guatelli, Taku Inaniwa, Vladimir Ivanchenko, Mathieu Karamitros, Ioanna Kyriakou, Nathanael Lampe, Zhuxin Li, Sylvain Meylan, Claire Michelet, Petteri Nieminen, Yann Perrot, Ivan Petrovic, Jose Ramos-Mendez, Aleksandra Ristic-Fira, Giovanni Santin, Jan Schuemann, Hoang N. Tran, Carmen Villagrasa & Sebastien Incerti. (2023) Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA. Physica Medica 105, pages 102508.
Crossref
Dousatsu Sakata, Masao Suzuki, Ryoichi Hirayama, Yasushi Abe, Masayuki Muramatsu, Shinji Sato, Oleg Belov, Ioanna Kyriakou, Dimitris Emfietzoglou, Susanna Guatelli, Sebastien Incerti & Taku Inaniwa. (2021) Performance Evaluation for Repair of HSGc-C5 Carcinoma Cell Using Geant4-DNA. Cancers 13:23, pages 6046.
Crossref
Wook-Geun Shin, Dousatsu Sakata, Nathanael Lampe, Oleg Belov, Ngoc Hoang Tran, Ivan Petrovic, Aleksandra Ristic-Fira, Milos Dordevic, Mario A. Bernal, Marie-Claude Bordage, Ziad Francis, Ioanna Kyriakou, Yann Perrot, Takashi Sasaki, Carmen Villagrasa, Susanna Guatelli, Vincent Breton, Dimitris Emfietzoglou & Sebastien Incerti. (2021) A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. Cancers 13:19, pages 4940.
Crossref
Tamara Murmann-Konda, Aashish Soni, Martin Stuschke & George Iliakis. (2021) Analysis of chromatid-break-repair detects a homologous recombination to non-homologous end-joining switch with increasing load of DNA double-strand breaks. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 867, pages 503372.
Crossref
Dousatsu Sakata, Oleg Belov, Marie-Claude Bordage, Dimitris Emfietzoglou, Susanna Guatelli, Taku Inaniwa, Vladimir Ivanchenko, Mathieu Karamitros, Ioanna Kyriakou, Nathanael Lampe, Ivan Petrovic, Aleksandra Ristic-Fira, Wook-Geun Shin & Sebastien Incerti. (2020) Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA. Scientific Reports 10:1.
Crossref
Fanghua Li, Emil Mladenov, Sharif Mortoga & George Iliakis. (2020) SCFSKP2 regulates APC/CCDH1-mediated degradation of CTIP to adjust DNA-end resection in G2-phase. Cell Death & Disease 11:7.
Crossref
Aashish Soni, Tamara Murmann-Konda, Maria Siemann-Loekes, Gabriel E. Pantelias & George Iliakis. (2020) Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion. DNA Repair 89, pages 102828.
Crossref
Emil Mladenov, Christian Staudt, Aashish Soni, Tamara Murmann-Konda, Maria Siemann-Loekes & George Iliakis. (2020) Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52. Nucleic Acids Research 48:4, pages 1905-1924.
Crossref
Anthony Ku, Valerie J. Facca, Zhongli Cai & Raymond M. Reilly. (2019) Auger electrons for cancer therapy – a review. EJNMMI Radiopharmacy and Chemistry 4:1.
Crossref
Dousatsu Sakata, Nathanael Lampe, Mathieu Karamitros, Ioanna Kyriakou, Oleg Belov, Mario A. Bernal, David Bolst, Marie-Claude Bordage, Vincent Breton, Jeremy M.C. Brown, Ziad Francis, Vladimir Ivanchenko, Sylvain Meylan, Koichi Murakami, Shogo Okada, Ivan Petrovic, Aleksandra Ristic-Fira, Giovanni Santin, David Sarramia, Takashi Sasaki, Wook-Geun Shin, Nicolas Tang, Hoang N. Tran, Carmen Villagrasa, Dimitris Emfietzoglou, Petteri Nieminen, Susanna Guatelli & Sebastien Incerti. (2019) Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA. Physica Medica 62, pages 152-157.
Crossref
Teresa Anglada, Joan Repullés, Anna Espinal, Mark A LaBarge, Martha R Stampfer, Anna Genescà & Marta Martín. (2019) Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect. Aging 11:5, pages 1510-1523.
Crossref
Karolin Klement & Aaron A. Goodarzi. 2017. ATM Kinase. ATM Kinase 303 315 .
Janapriya Saha & Anthony J. Davis. (2016) Unsolved mystery: the role of BRCA1 in DNA end-joining. Journal of Radiation Research 57:S1, pages i18-i24.
Crossref
Mario Moscariello, Radi Wieloch, Aya Kurosawa, Fanghua Li, Noritaka Adachi, Emil Mladenov & George Iliakis. (2015) Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining. DNA Repair 31, pages 29-40.
Crossref
Megan McKerlie, John R. Walker, Taylor R. H. Mitchell, Florence R. Wilson & Xu-Dong Zhu. (2013) Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation. Nucleic Acids Research 41:22, pages 10268-10282.
Crossref
Reza Taleei & Hooshang Nikjoo. (2013) Biochemical DSB-repair model for mammalian cells in G1 and early S phases of the cell cycle. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 756:1-2, pages 206-212.
Crossref
K. Karanam, A. Loewer & G. Lahav. (2013) Dynamics of the DNA damage response: insights from live-cell imaging. Briefings in Functional Genomics 12:2, pages 109-117.
Crossref
E. M. SALEH, R. A. EL-AWADY & N. ANIS. (2013) Predictive markers for the response to 5-fluorouracil therapy in cancer cells: Constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy. Oncology Letters 5:1, pages 321-327.
Crossref
Ekram M. Saleh, Raafat A. El-awady, Noha Anis & Nahla El-sharkawy. (2012) Induction and repair of DNA double-strand breaks using constant-field gel electrophoresis and apoptosis as predictive markers for sensitivity of cancer cells to cisplatin. Biomedicine & Pharmacotherapy 66:7, pages 554-562.
Crossref
Wenjian Ma, Christopher J. Halweg, Daniel Menendez & Michael A. Resnick. (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein–Barr virus. Proceedings of the National Academy of Sciences 109:17, pages 6590-6595.
Crossref
Vasilissa Manova, Satyendra K Singh & George Iliakis. (2012) Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome Integrity 3:1, pages 4.
Crossref
Satyendra K. Singh, Minli Wang, Christian Staudt & George Iliakis. (2011) Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Research 39:19, pages 8416-8429.
Crossref
Penny A. Jeggo, Verena Geuting & Markus Löbrich. (2011) The role of homologous recombination in radiation-induced double-strand break repair. Radiotherapy and Oncology 101:1, pages 7-12.
Crossref
Aaron A. Goodarzi, Penny Jeggo & Markus Lobrich. (2010) The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA Repair 9:12, pages 1273-1282.
Crossref
Zhen Cao, Wendy W. Kuhne, Jennifer Steeb, Mark A. Merkley, Yunfeng Zhou, Jiri Janata & William S. Dynan. (2010) Use of a microscope stage-mounted Nickel-63 microirradiator for real-time observation of the DNA double-strand break response. Nucleic Acids Research 38:14, pages e144-e144.
Crossref
Shuyi Li, Wendy W. Kuhne, Anita Kulharya, Farlyn Z. Hudson, Kyungsoo Ha, Zhen Cao & William S. Dynan. (2009) Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. Nucleic Acids Research 37:20, pages 6746-6753.
Crossref
Takamitsu A. Kato, Ryuichi Okayasu & Joel S. Bedford. (2008) Comparison of the induction and disappearance of DNA double strand breaks and γ-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 639:1-2, pages 108-112.
Crossref
William DynanYoshihiko TakedaDavid RothGang Bao. (2008) Understanding and re-engineering nucleoprotein machines to cure human disease. Nanomedicine 3:1, pages 93-105.
Crossref
Frank Windhofer, Wenqi Wu & George Iliakis. (2007) Low levels of DNA ligases III and IV sufficient for effective NHEJ. Journal of Cellular Physiology 213:2, pages 475-483.
Crossref
Catherine L. Bladen, Melody A. Flowers, Katsuya Miyake, Robert H. Podolsky, John T. Barrett, David J. Kozlowski & William S. Dynan. (2007) Quantification of Ionizing Radiation-Induced Cell Death In Situ in a Vertebrate Embryo . Radiation Research 168:2, pages 149-157.
Crossref
Kecke Elmroth & Bo Stenerlöw. (2007) Influence of Chromatin Structure on Induction of Double-Strand Breaks in Mammalian Cells Irradiated with DNA-Incorporated 125 I . Radiation Research 168:2, pages 175-182.
Crossref
Yuichiro Yokota, Shinya Yamada, Yoshihiro Hase, Naoya Shikazono, Issay Narumi, Atsushi Tanaka & Masayoshi Inoue. (2007) Initial Yields of DNA Double-Strand Breaks and DNA Fragmentation Patterns Depend on Linear Energy Transfer in Tobacco BY-2 Protoplasts Irradiated with Helium, Carbon and Neon Ions. Radiation Research 167:1, pages 94-101.
Crossref
Iwona Grądzka & Teresa Iwaneńko. (2005) A non-radioactive, PFGE-based assay for low levels of DNA double-strand breaks in mammalian cells. DNA Repair 4:10, pages 1129-1139.
Crossref
Kecke Elmroth & Bo Stenerlöw. (2005) DNA-Incorporated 125 I Induces more than one Double-Strand Break per Decay in Mammalian Cells . Radiation Research 163:4, pages 369-373.
Crossref
Nicole Chavaudra, Jean Bourhis & Nicolas Foray. (2004) Quantified relationship between cellular radiosensitivity, DNA repair defects and chromatin relaxation: a study of 19 human tumour cell lines from different origin. Radiotherapy and Oncology 73:3, pages 373-382.
Crossref
Didier Boucher, Joëlle Hindo & Dietrich Averbeck. (2004) Increased repair of γ-induced DNA double-strand breaks at lower dose-rate in CHO cells. Canadian Journal of Physiology and Pharmacology 82:2, pages 125-132.
Crossref
George Iliakis. 2004. Life Sciences and Radiation. Life Sciences and Radiation 9 27 .
R A El-Awady, E Dikomey & J Dahm-Daphi. (2003) Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. British Journal of Cancer 89:3, pages 593-601.
Crossref
Leslie E. Smith, Shruti Nagar, Grace J. Kim & William F. Morgan. (2003) RADIATION-INDUCED GENOMIC INSTABILITY: RADIATION QUALITY AND DOSE RESPONSE. Health Physics 85:1, pages 23-29.
Crossref
Cecilia Lundin, Niklas Schultz, Catherine Arnaudeau, Atul Mohindra, Lasse Tengbjerg Hansen & Thomas Helleday. (2003) RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells. Journal of Molecular Biology 328:3, pages 521-535.
Crossref
Sentaro Takahashi, Hiroshi Sato, Yoshihisa Kubota, Hiroshi Utsumi, Joel S Bedford & Ryuichi Okayasu. (2002) Inhibition of DNA-double strand break repair by antimony compounds. Toxicology 180:3, pages 249-256.
Crossref
Björn E. Cedervall & Trevor J. McMillan. (2002) The Fraction of DNA Released on Pulsed-Field Gel Electrophoresis Gels may Differ Significantly between Genomes at Low Levels of Double-Strand Breaks. Radiation Research 158:2, pages 247-249.
Crossref
Huichen Wang, Zhao-Chong Zeng, Tu-Anh Bui, Eiichiro Sonoda, Minoru Takata, Shunichi Takeda & George Iliakis. (2001) Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group. Oncogene 20:18, pages 2212-2224.
Crossref
Sentaro Takahashi, Eriko Takeda, Yoshihisa Kubota & Ryuichi Okayasu. (2000) Inhibition of Repair of Radiation-Induced DNA Double-Strand Breaks by Nickel and Arsenite. Radiation Research 154:6, pages 686-691.
Crossref
Nesrin A Asaad, Zhao-Chong Zeng, Jun Guan, John Thacker & George Iliakis. (2000) Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants. Oncogene 19:50, pages 5788-5800.
Crossref
Maria-Antonella Tabocchini, Kai Rothkamm, Claudia Signoretti, Jana Risse, Orazio Sapora & Markus Löbrich. (2000) Formation and repair of DNA double-strand breaks in γ-irradiated K562 cells undergoing erythroid differentiation. Mutation Research/DNA Repair 461:1, pages 71-82.
Crossref
Bijan Fouladi, Charles A. Waldren, Björn Rydberg & Priscilla K. Cooper. (2000) Comparison of Repair of DNA Double-Strand Breaks in Identical Sequences in Primary Human Fibroblast and Immortal Hamster–Human Hybrid Cells Harboring a Single Copy of Human Chromosome 11. Radiation Research 153:6, pages 795-804.
Crossref
Michael V. Filatov, Rimma A. Pantina & Leonid A. Noskin. (1998) Methods for registration of spontaneous DNA instability in mammalian cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 403:1-2, pages 95-101.
Crossref
E.H Vock, W.K Lutz, P Hormes, H.D Hoffmann & S Vamvakasa. (1998) Discrimination between genotoxicity and cytotoxicity in the induction of DNA double-strand breaks in cells treated with etoposide, melphalan, cisplatin, potassium cyanide, Triton X-100, and γ-irradiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 413:1, pages 83-94.
Crossref
Peggy L. Olive. 1998. DNA Damage and Repair. DNA Damage and Repair 539 557 .
N. Foray, C.F. Arlett & E.P. Malaise. (1997) Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look. Biochimie 79:9-10, pages 567-575.
Crossref
G. Taucher-Scholz, J. Heilmann & G. Kraft. (1996) Induction and rejoining of DNA double-strand breaks in cho cells after heavy ion irradiation. Advances in Space Research 18:1-2, pages 83-92.
Crossref
Björn Cedervall & Tomas Radivoyevitch. (2005) Methods for analysis of DNA fragment distributions on pulsed field gel electrophoretic gels. ELECTROPHORESIS 17:6, pages 1080-1086.
Crossref
Anna A. Friedl, Alfred Kraxenberger & Friederike Eckardt‐Schupp. (2005) An electrophoretic approach to the assessment of the spatial distribution of DNA double‐strand breaks in mammalian cells. ELECTROPHORESIS 16:1, pages 1865-1874.
Crossref
M. Schneider, G. Taucher-Scholz, J. Heilmann & G. Kraft. (1994) Combination of static-field gel electrophoresis and densitometric scanning for the determination of radiation-induced DNA double-strand breaks in CHO cells. Radiation and Environmental Biophysics 33:2, pages 111-124.
Crossref
Bj�rn Cedervall & Patric K�llman. (1994) Randomly distributed DNA double-strand breaks as measured by pulsed field gel electrophoresis: A series of explanatory calculations. Radiation and Environmental Biophysics 33:1, pages 9-21.
Crossref
. 1993. Pulsed Field Gel Electrophoresis. Pulsed Field Gel Electrophoresis 193 244 .
M.N. Cornforth & J.S. Bedford. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 423 496 .
Christopher S. Lange, Arthur Cole & Joseph Y. Ostashevsky. 1993. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation. Advances in Radiation Biology - DNA and Chromatin Damage Caused by Radiation 261 421 .
Raymond L. Warters, Bradley W. Lyons, David J. Chen & Koki Sato. (1993) DNA-damage processing in a radiation-sensitive mouse cell line. Mutation Research/DNA Repair 293:2, pages 91-98.
Crossref
M. Frankenberg-Schwager. 1993. Biological Effects and Physics of Solar and Galactic Cosmic Radiation. Biological Effects and Physics of Solar and Galactic Cosmic Radiation 1 31 .
Rosemary S. L. Wong & William C. Dewey. (2006) Molecular mechanisms for the induction of chromosomal aberrations in CHO cells heated in S phase. Environmental and Molecular Mutagenesis 22:4, pages 257-263.
Crossref
William G. DeGraff, Murali C. Krishna, Dwight Kaufman & James B. Mitchell. (1992) Nitroxide-mediated protection against X-ray-and neocarzinostatin-induced DNA damage. Free Radical Biology and Medicine 13:5, pages 479-487.
Crossref
Nge Cheong, Ya Wang, Mary Jackson & George Iliakis. (1992) Radiation-sensitive irs mutants rejoin DNA double-strand breaks with efficiency similar to that of parental V79 cells but show altered response to radiation-induced G2 delay. Mutation Research/DNA Repair 274:2, pages 111-122.
Crossref
Ya Wang & George Iliakis. (1992) Effects of 5′-iododeoxyuridine on the repair of radiation induced potentially lethal damage interphase chromatin breaks and DNA double strand breaks in chinese hamster ovary cells. International Journal of Radiation Oncology*Biology*Physics 23:2, pages 353-360.
Crossref
Shoshana Squires, Anderson J. Ryan, Helen L. Strutt, Paul J. Smith & Robert T. Johnson. (1991) Deoxyguanosine enhances the cytotoxicity of the topoisomerase i inhibitor camptothecin by reducing the repair of double-strand breaks induced in replicating dna. Journal of Cell Science 100:4, pages 883-893.
Crossref
George Lliakis. (2005) The role of DNA double strand breaks in lonizing radiation‐induced killing of eukaryotic cells. BioEssays 13:12, pages 641-648.
Crossref
Joel S. Bedford. (1991) Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations. International Journal of Radiation Oncology*Biology*Physics 21:6, pages 1457-1469.
Crossref
George Iliakis, Lorenz Metzger, Ryuichi Okayasu, Gabriel Pantelias & Orlando Cicilioni. 1991. The Early Effects of Radiation on DNA. The Early Effects of Radiation on DNA 55 69 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.