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International Journal of Radiation Biology Volume 59, 1991 - Issue 5
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Original Article

Dependence of the Mutation Spectrum in a Shuttle Plasmid Replicated in Human Lymphoblasts on Dose of Gamma Radiation

M.O. Sikpi Division of Oral and Maxillofacial Radiology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA
,
M.L. Freedman Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA
,
E.R. Ziobron Department of Biostructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA
,
W.B. Upholt Division of Oral and Maxillofacial Radiology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA
&
A.G. Lurie Department of Oral Diagnosis, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 06032, USA
Pages 1115-1126 | Received 13 Aug 1990, Accepted 30 Nov 1990, Published online: 03 Jul 2009

Citations (19)

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Read on this site (3)

M.O. Sikpi, X. Liu, A.G. Lurie & M.L. Freedman. (1994) Alteration of Irradiated Shuttle Vector Processing by Exposure of Human Lymphoblast Host Cells to Single or Split γ-ray Doses. International Journal of Radiation Biology 65:2, pages 157-164.
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M.O. Sikpi, S.M. Dry, M.L. Freedman & A.G. Lurie. (1992) Mutations Caused by γ-radiation-induced Double-strand Breaks in a Shuttle Plasmid Replicated in Human Lymphoblasts. International Journal of Radiation Biology 62:5, pages 555-562.
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H. Bertram & U. Hagen. (1992) Radical Effects on Mutation Spectra in Lambda Phage. International Journal of Radiation Biology 62:1, pages 3-8.
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Articles from other publishers (16)

E. Liapis, K. I.E. McLuckie, P. D. Lewis, P. B. Farmer & K. Brown. (2008) Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots. Nucleic Acids Research 36:18, pages 5933-5945.
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Bin-Shan Shi, Zhu-Nan Cai, Jun Yang & Ying-Nian Yu. (2004) N-Methyl-N′-nitro-N-nitrosoguanidine sensitivity, mutator phenotype and sequence specificity of spontaneous mutagenesis in FEN-1-deficient cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 556:1-2, pages 1-9.
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Keith I. E. McLuckieMichael N. RoutledgeKaren BrownMargaret GaskellPeter B. FarmerGordon C. K. RobertsElizabeth A. Martin. (2002) DNA Adducts Formed from 4-Hydroxytamoxifen Are More Mutagenic than Those Formed by α-Acetoxytamoxifen in a Shuttle Vector Target Gene Replicated in Human Ad293 Cells. Biochemistry 41:28, pages 8899-8906.
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P.D. Lewis & J.M. Parry. (2002) An exploratory analysis of multiple mutation spectra. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 518:2, pages 163-180.
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Kathleen Dixon & Mario Medvedovic. 2002. Biomarkers of Environmentally Associated Disease. Biomarkers of Environmentally Associated Disease.
Gitta K Kuipers, Ben J Slotman & M.Vincent M Lafleur. (2001) The importance of using absolute mutant frequencies to compare mutation spectra. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 479:1-2, pages 95-99.
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Manu Kohli & Timothy J. Jorgensen. (1999) Lack of Dependence on p53 for DNA Double Strand Break Repair of Episomal Vectors in Human Lymphoblasts. Biochemical and Biophysical Research Communications 264:3, pages 702-708.
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Jeongmi K. Jeong, Marlene J. Juedes & Gerald N. Wogan. (1998) Mutations Induced in the supF Gene of pSP189 by Hydroxyl Radical and Singlet Oxygen:  Relevance to Peroxynitrite Mutagenesis . Chemical Research in Toxicology 11:5, pages 550-556.
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Christian Czerny, Erwin Eder & Thomas M Rünger. (1998) Genotoxicity and mutagenicity of the α,β-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector. Mutation Research/DNA Repair 407:2, pages 125-134.
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Marlene J. Juedes & Gerald N. Wogan. (1996) Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 349:1, pages 51-61.
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Shaojun Liu & Kathleen Dixon. (1996) Induction of mutagenic DNA damage by chromium(VI) and glutathione. Environmental and Molecular Mutagenesis 28:2, pages 71-79.
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Jörg Wehner & Gerda Horneck. (1995) Effects of vacuum UV and UVC radiation on dry Escherichia coli plasmid pUC19 II. Mutational specificity at the lacZ gene. Journal of Photochemistry and Photobiology B: Biology 30:2-3, pages 171-177.
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Steffen Emmert, Bernd Epe, Chantu R. Saha‐Möller, Waldemar Adam & Thomas M. Rünger. (2008) ASSESSMENT OF GENOTOXICITY AND MUTAGENICITY OF 1,2‐DIOXETANES IN HUMAN CELLS USING A PLASMID SHUTTLE VECTOR. Photochemistry and Photobiology 61:2, pages 136-141.
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Neil J. Sargentini & Kendric C. Smith. (1994) DNA sequence analysis of γ-radiation (anoxic)-induced and spontaneous lacId mutations in Escherichia coli K-12. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 309:2, pages 147-163.
Crossref
Jan Retèl, Barbara Hoebee, Jacqueline E.F. Braun, Jan T. Lutgerink, Eric van den Akker, A. Handayani Wanamarta, Hans Joenje & M.Vincent M. Lafleur. (1993) Mutational specificity of oxidative DNA damage. Mutation Research/Genetic Toxicology 299:3-4, pages 165-182.
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Franklin Hutchinson. (1992) Published data on mutagenesis by ionizing radiation of plasmids in solution probably reflect in part the specificity of adventitious transition metal ions complexed to the DNA. Mutation Research Letters 281:4, pages 261-266.
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