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International Journal of Radiation Biology Volume 60, 1991 - Issue 1-2
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Original Article

Induction of Tumour Hypoxia by FAA and TNF: Interaction with Bioreductive Drugs

H.S. Edwards MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
,
J.C.M. Bremner MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
&
I.J. Stratford MRC Radiobiology Unit, Chilton, Didcot, OX11 0RD, UK
Pages 373-377 | Published online: 03 Jul 2009

Citations (14)

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Read on this site (3)

Pauline J. Wood, Michael R. Horsman, Azza A. Khalil, Fritz Steinberg, Christian Streffer, Jens Overgaard, Ian J. Stratford & Gerald E. Adams. (1996) A Comparison of the Physiological Effects of RSU1069 and RB6145 in the SCCVII Murine Tumour. Acta Oncologica 35:8, pages 989-994.
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I.J. Stratford, G.E. Adams, J.C.M. Bremner, S. Cole, H.S. Edwards, N. Robertson & P.J. Wood. (1994) Manipulation and Exploitation of the Tumour Environment for Therapeutic Benefit. International Journal of Radiation Biology 65:1, pages 85-94.
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J.C.M. Bremner, C.J.R. Counsell, H.S. Edwards, I.J. Stratford, G.E. Adams, A.B.W. Nethersell & P. Bedford. (1991) Monitoring Metabolic Responses after Induction of Hypoxia in the KHT Tumour Using 31P NMR Spectroscopy. International Journal of Radiation Biology 60:1-2, pages 363-367.
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Articles from other publishers (11)

Michael R. Horsman & Dietmar W. Siemann. (2006) Pathophysiologic Effects of Vascular-Targeting Agents and the Implications for Combination with Conventional Therapies. Cancer Research 66:24, pages 11520-11539.
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Roger M Phillips. (1999) Inhibition of DT-diaphorase (NAD(P)H:Quinone oxidoreductase, ec 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochemical Pharmacology 58:2, pages 303-310.
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William R. Wilson & Frederik B. Pruijn. (2007) Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 1994: HYPOXIA‐ACTIVATED PRODRUGS AS ANTITUMOUR AGENTS: STRATEGIES FOR MAXIMIZING TUMOUR CELL KILLING. Clinical and Experimental Pharmacology and Physiology 22:11, pages 881-885.
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Charles S. Parkins, Sally A. Hill, Sarah J. Lonergan, Michael R. Horsman, Jennifer A. Chadwick & David J. Chaplin. (1994) Ischaemia induced cell death in tumors: Importance of temperature and pH. International Journal of Radiation Oncology*Biology*Physics 29:3, pages 499-503.
Crossref
Stephen Cliffe, Maryann L. Taylor, Michael Rutland, Bruce C. Baguley, Richard P. Hill & William R. Wilson. (1994) Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid. International Journal of Radiation Oncology*Biology*Physics 29:2, pages 373-377.
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Radhika Kalra, Jane C.M. Bremner, Pauline J. Wood, Janet Sansom, Christopher J.R. Counsell, Ian J. Stratford & Gerald E. Adams. (1994) 31P MRS to monitor the induction of tumor hypoxia by the modification of the oxygen affinity of hemoglobin using BW 589C. International Journal of Radiation Oncology*Biology*Physics 29:2, pages 285-288.
Crossref
Gerald E. Adams & Ian J. Stratford. (1994) Bioreductive drugs for cancer therapy: The search for tumor specificity. International Journal of Radiation Oncology*Biology*Physics 29:2, pages 231-238.
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Paul Baas, Hugo Oppelaar, Mireile Stavenuiter, Nico Van Zandwijk & Fiona A Stewart. (1993) Interaction of the bioreductive drug sr 4233 and photodynamic therapy using photofrin in a mouse tumor model. International Journal of Radiation Oncology*Biology*Physics 27:3, pages 665-670.
Crossref
Jane C. M. Bremner. (1993) Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference toin vivo methods of evaluation. Cancer and Metastasis Reviews 12:2, pages 177-193.
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William A. Denny & William R. Wilson. (1993) Bioreducible mustards: a paradigm for hypoxia-selective prodrugs of diffusible cytotoxins (HPDCs). Cancer and Metastasis Reviews 12:2, pages 135-151.
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Christopher M. Riley, Bhasker V. Shetty, Nik C. Chetwyn, Virginia T. Kasper, Carl G. Kindberg & C.Michael Dicken. (1993) A stability-indicating assay and the preformulation characteristics of the radiosensitizer, 1,2,4-benzotriazin-3-amine 1,4-dioxide. Journal of Pharmaceutical and Biomedical Analysis 11:2, pages 131-138.
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