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Original Article

Steepness of the Clinical Dose–control Curve and Variation in the in Vitro Radiosensitivity of Head and Neck Squamous Cell Carcinoma

Pages 417-423 | Received 20 Jun 1991, Accepted 13 Oct 1991, Published online: 03 Jul 2009

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Wolfgang A. Tomé, John D. Fenwick & Søren M. Bentzen. (2006) Does a local bystander effect necessitate a revision of TCP models that are based on observed clinical data?. Acta Oncologica 45:4, pages 406-411.
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S. L. TUCKER and J. M. G. TAYLOR. (1996) Improved models of tumour cure. International Journal of Radiation Biology 70:5, pages 539-553.
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SØRen M. Bentzen. (1993) Quantitative Clinical Radiobiology. Acta Oncologica 32:3, pages 259-275.
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Clemens Grassberger, David McClatchyIIIIII, Changran Geng, Sophia C. Kamran, Florian Fintelmann, Yosef E. Maruvka, Zofia Piotrowska, Henning Willers, Lecia V. Sequist, Aaron N. Hata & Harald Paganetti. (2019) Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Research 79:14, pages 3776-3788.
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Zhaodong Fei, Chuanben Chen, Yingying Huang, Xiufang Qiu, Yi Li, Li Li & Taojun Chen. (2019) Metabolic tumor volume and conformal radiotherapy based on prognostic PET/CT for treatment of nasopharyngeal carcinoma. Medicine 98:28, pages e16327.
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Angus G. Dalgleish & Peter L. Stern. (2018) The failure of radical treatments to cure cancer: can less deliver more?. Therapeutic Advances in Vaccines and Immunotherapy 6:5-6, pages 69-76.
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Søren M. Bentzen. 2018. Basic Clinical Radiobiology. Basic Clinical Radiobiology 44 53 .
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Brian A. Hrycushko, Shihong Li, Beth Goins, Randal A. Otto & Ande Bao. (2011) Direct intratumoral infusion of liposome encapsulated rhenium radionuclides for cancer therapy: Effects of nonuniform intratumoral dose distribution. Medical Physics 38:3, pages 1339-1347.
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Francesca M. Buffa. 2009. Radiotherapy and Brachytherapy. Radiotherapy and Brachytherapy 3 9 .
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Robert D. Stewart & X. Allen Li. (2007) BGRT: Biologically guided radiation therapy-The future is fast approaching!. Medical Physics 34:10, pages 3739-3751.
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P J Keall & S Webb. (2007) Optimum parameters in a model for tumour control probability, including interpatient heterogeneity: evaluation of the log-normal distribution. Physics in Medicine and Biology 52:1, pages 291-302.
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Stephen A Roberts & Jolyon H Hendry. 2007. Radiobiological Modelling in Radiation Oncology. Radiobiological Modelling in Radiation Oncology 169 195 .
M Zhang, V Moiseenko, M Liu & T Craig. (2006) Internal fiducial markers can assist dose escalation in treatment of prostate cancer: result of organ motion simulations. Physics in Medicine and Biology 51:2, pages 269-285.
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B Warkentin, P Stavrev, N A Stavreva & B G Fallone. (2005) Limitations of a TCP model incorporating population heterogeneity. Physics in Medicine and Biology 50:15, pages 3571-3588.
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V Moiseenko, M Mulligan & T Kron. (2004) RADIATION QUALITY OF A TOMOTHERAPY PHOTON FAN BEAM. Health Physics 87:2, pages 166-170.
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David Murray, Razmik Mirzayans, April L. Scott & M. Joan Allalunis-Turner. (2003) Influence of Oxygen on the Radiosensitivity of Human Glioma Cell Lines. American Journal of Clinical Oncology 26:5, pages e169-e177.
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Alan E Nahum, Benjamin Movsas, Eric M Horwitz, Corinne C Stobbe & J.Donald Chapman. (2003) Incorporating clinical measurements of hypoxia into tumor local control modeling of prostate cancer: Implications for the α/β ratio. International Journal of Radiation Oncology*Biology*Physics 57:2, pages 391-401.
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Wolfgang A Tom & Jack F Fowler. (2003) On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours. Physics in Medicine and Biology 48:18, pages N261-N268.
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R M Wyatt, A H Beddoe & R G Dale. (2003) The effects of delays in radiotherapy treatment on tumour control. Physics in Medicine and Biology 48:2, pages 139-155.
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N Stavreva, P Stavrev, B Warkentin & B G Fallone. (2002) Derivation of the expressions for   50 and D 50 for different individual TCP and NTCP models . Physics in Medicine and Biology 47:20, pages 3591-3604.
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Wolfgang A. Tomé & Jack F. Fowler. (2002) On cold spots in tumor subvolumes. Medical Physics 29:7, pages 1590-1598.
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Søren M Bentzen, Michele I Saunders, Stanley Dische & Simon J Bond. (2001) Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial. Radiotherapy and Oncology 60:2, pages 123-135.
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Francesca M. Buffa, John D. Fenwick & Alan E. Nahum. (2000) An analysis of the relationship between radiosensitivity and volume effects in tumor control probability modeling. Medical Physics 27:6, pages 1258-1265.
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Gereon Kåver, Bengt K Lind, Johan Löf, Anders Liander & Anders Brahme. (1999) Stochastic optimization of intensity modulated radiotherapy to account for uncertainties in patient sensitivity. Physics in Medicine and Biology 44:12, pages 2955-2969.
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Stephen A. Roberts & Jolyon H. Hendry D.Sc. (1999) Time factors in larynx tumor radiotherapy: lag times and intertumor heterogeneity in clinical datasets from four centers. International Journal of Radiation Oncology*Biology*Physics 45:5, pages 1247-1257.
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R.I. Mackay & J.H. Hendry. (1999) The modelled benefits of individualizing radiotherapy patients’ dose using cellular radiosensitivity assays with inherent variability. Radiotherapy and Oncology 50:1, pages 67-75.
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J D Fenwick. (1998) Predicting the radiation control probability of heterogeneous tumour ensembles: data analysis and parameter estimation using a closed-form expression. Physics in Medicine and Biology 43:8, pages 2159-2178.
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Stephen A. Roberts & Jolyon H. Hendry. (1998) A realistic closed-form radiobiological model of clinical tumor-control data incorporating intertumor heterogeneity. International Journal of Radiation Oncology*Biology*Physics 41:3, pages 689-699.
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Steffen Appold, Michael Baumann, Cordula Petersen, Kirsten Horn & Frauke Eichhorn. (1998) Comparison of the Response of human FaDu squamous cell carcinoma in nude mice after hypofractionated-accelerated regimens and “curative” fractionation schedulesVergleich hypofraktioniert-akzelerierter mit „kurativen” Fraktionierungsschemata bei der Strahlentherapie humaner FaDu-Plattenepithelkarzinome in Nacktmäusen. Strahlentherapie und Onkologie 174:6, pages 315-319.
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Hans-Hermann Dubben, Howard D Thames & Hans-Peter Beck-Bornholdt. (1998) Tumor volume: a basic and specific response predictor in radiotherapy. Radiotherapy and Oncology 47:2, pages 167-174.
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J.H. Hendry, S.M. Bentzen, R.G. Dale, J.F. Fowler, T.E. Wheldon, B. Jones, A.J. Munro, N.J. Slevin & A.G. Robertson. (1996) A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy. Clinical Oncology 8:5, pages 297-307.
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Christopher R. Johnson, Howard D. Thames, David T. Huang & Rupert K. Schmidt-Ullrich. (1995) The tumor voluem and clonogen number relationship: Tumor control predictions based upon tumor volume estimates derived from computed tomography. International Journal of Radiation Oncology*Biology*Physics 33:2, pages 281-287.
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Søren M. Bentzen. (1995) Dose escalation, treatment protraction, and the steepness of the dose-response curve for squamous cell carcinoma of the head and neck. Radiotherapy and Oncology 34:1, pages 82-83.
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Søren M. Bentzen. (1994) Radiobiological considerations in the design of clinical trials. Radiotherapy and Oncology 32:1, pages 1-11.
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S.M. Bentzen. (1994) Prediction of radiotherapy response using SF2: Why it may work after all. Radiotherapy and Oncology 31:1, pages 85-86.
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