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Original Article

Study of Dose-rate and Split-dose Effects on the in Vitro Micronucleus Yield in Human Lymphocytes Exposed to X-rays

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Pages 777-784 | Received 06 Aug 1991, Accepted 13 Nov 1991, Published online: 03 Jul 2009

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Mariana E. Mendes, Julyanne C. G. Mendonça, Joan F. Barquinero, Manuel Higueras, Jorge E. Gonzalez, Aida M. G. Andrade, Laís M. Silva, Alyne M. S. Nascimento, Julianne C. F. Lima, Júlio C. G. Silva, Suy Hwang, Ana M. M. A. Melo, Neide Santos & Fabiana F. Lima. (2019) Comparative study of micronucleus assays and dicentric plus ring chromosomes for dose assessment in particular cases of partial-body exposure. International Journal of Radiation Biology 95:8, pages 1058-1071.
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Ans Baeyens, Jacobus P. Slabbert, Pascale Willem, Sibusiso Jozela, Debby Van Der Merwe & Anne Vral. (2010) Chromosomal radiosensitivity of HIV positive individuals. International Journal of Radiation Biology 86:7, pages 584-592.
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A. VRAL, H. THIERENS and L. DE RIDDER. (1997) In vitro micronucleus-centromere assay to detect radiation-damage induced by low doses in human lymphocytes. International Journal of Radiation Biology 71:1, pages 61-68.
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A. VRAL. (1996) Micronucleus induction by 60Co gamma-rays and fast neutrons in ataxia telangiectasia lymphocytes. International Journal of Radiation Biology 70:2, pages 171-176.
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H. Thierens, A. Vral, M. Van Eijkeren, F. Speleman & L. De Ridder. (1995) Micronucleus Induction in Peripheral Blood Lymphocytes of Patients under Radiotherapy Treatment for Cervical Cancer or Hodgkin's Disease. International Journal of Radiation Biology 67:5, pages 529-539.
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A. Vral, F. Verhaegen, H. Thierens & L. de Ridder. (1994) Micronuclei Induced by Fast Neutrons Versus 60Co γ-rays in Human Peripheral Blood Lymphocytes. International Journal of Radiation Biology 65:3, pages 321-328.
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Articles from other publishers (23)

Dante Olofsson, Lei Cheng, Rubén Barrios Fernández, Magdalena Płódowska, Milagrosa López Riego, Pamela Akuwudike, Halina Lisowska, Lovisa Lundholm & Andrzej Wojcik. (2020) Biological effectiveness of very high gamma dose rate and its implication for radiological protection. Radiation and Environmental Biophysics 59:3, pages 451-460.
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Shin Koyama, Eijiro Narita, Naoki Shinohara & Junji Miyakoshi. (2018) Recovery kinetics of micronucleus formation by fractionated X-ray irradiation in various types of human cells. Journal of Radiation Research 59:5, pages 547-554.
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D. Bazyka, S. C. Finch, I. M. Ilienko, O. Lyaskivska, I. Dyagil, N. Trotsiuk, N. Gudzenko, V. V. Chumak, K. M. Walsh, J. Wiemels, M. P. Little & L.B. Zablotska. (2017) Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures. Environmental Health 16:1.
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Hiroo Nakajima, Chiharu Furukawa, Young-Chae Chang, Hiromitsu Ogata & Junji Magae. (2017) Delayed Growth Suppression and Radioresistance Induced by Long-Term Continuous Gamma Irradiation. Radiation Research 188:2, pages 181-190.
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Justyna Miszczyk, Kamila Rawojć, Agnieszka Panek, Jan Swakoń, Pataje G. Prasanna & Marzena Rydygier. (2015) Response of human lymphocytes to proton radiation of 60MeV compared to 250kV X-rays by the cytokinesis-block micronucleus assay. Radiotherapy and Oncology 115:1, pages 128-134.
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H. C. Turner, I. Shuryak, M. Taveras, A. Bertucci, J. R. Perrier, C. Chen, C. D. Elliston, G. W. Johnson, L. B. Smilenov, S. A. Amundson & D. J. Brenner. (2015) Effect of Dose Rate on Residual γ-H2AX Levels and Frequency of Micronuclei in X-Irradiated Mouse Lymphocytes. Radiation Research 183:3, pages 315-324.
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Junji Magae, Chiharu Furukawa & Hiromitsu Ogata. (2011) Dose-Rate Effect on Proliferation Suppression in Human Cell Lines Continuously Exposed to γ Rays. Radiation Research 176:4, pages 447.
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G J Heyes, A J Mill & M W Charles. (2009) Mammography—oncogenecity at low doses. Journal of Radiological Protection 29:2A, pages A123-A132.
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E.G. Góes, M.A. Ottoboni, P.V.B. Palma, F.R. Morais, C.A. Pelá, J.C. Borges & D.T. Covas. (2007) Quality control of blood irradiation with a teletherapy unit: damage to stored red blood cells after cobalt-60 gamma irradiation. Transfusion 0:0, pages 071121030748002-???.
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Anita Krokosz, Renata Koziczak, Marta Gonciarz & Zofia Szweda-Lewandowska. (2006) Study of the effect of dose-rate on radiation-induced damage to human erythrocytes. Radiation Physics and Chemistry 75:1, pages 98-105.
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Nao Kagawa, Masahiko Shimura, Akinori Takai, Satoru Endo & Kazuo Fujikawa. (2004) Relative biological effectiveness of fission neutrons for induction of micronucleus formation in mouse reticulocytes in vivo. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 556:1-2, pages 93-99.
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Akinori Takai, Nao Kagawa & Kazuo Fujikawa. (2004) Dose‐ and time‐dependent responses for micronucleus induction by X‐rays and fast neutrons in gill cells of medaka ( Oryzias latipes ) . Environmental and Molecular Mutagenesis 44:2, pages 108-112.
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Nathalie Gault & Jean-Louis Lefaix. (2003) Infrared Microspectroscopic Characteristics of Radiation-Induced Apoptosis in Human Lymphocytes. Radiation Research 160:2, pages 238-250.
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K. George, V. Willingham, H. Wu, D. Gridley, G. Nelson & F.A. Cucinotta. (2002) Chromosome aberrations in human lymphocytes induced by 250 MeV protons: effects of dose, dose rate and shielding. Advances in Space Research 30:4, pages 891-899.
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D. R. Boreham, J-A. Dolling, S. R. Maves, N. Siwarungsun & R. E. J. Mitchel. (2000) Dose-Rate Effects for Apoptosis and Micronucleus Formation in Gamma-Irradiated Human Lymphocytes. Radiation Research 153:5, pages 579-586.
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Hossein Mozdarani & Ali R Khoshbin-Khoshnazar. (1998) In vivo protection by cimetidine against fast neutron-induced micronuclei in mouse bone marrow cells. Cancer Letters 124:1, pages 65-71.
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Sung Ho Kim, Dong Un Han, Jeong Taek Lim, Sung Kee Jo & Tae Hwan Kim. (1997) Induction of micronuclei in human, goat, rabbit peripheral blood lymphocytes and mouse splenic lymphocytes irradiated in vitro with gamma radiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 393:3, pages 207-214.
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J.K Brown, A Williams, H.R Withers, K.T Ow, C Gramacho, R Grey & C Amies. (1997) Sources of variability in the determination of micronuclei in irradiated peripheral blood lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 389:2-3, pages 123-128.
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Wolfgang-Ulrich Müller, Michael Nüsse, Beate M. Miller, Anne Slavotinek, Silvia Viaggi & Christian Streffer. (1996) Micronuclei: a biological indicator of radiation damage. Mutation Research/Reviews in Genetic Toxicology 366:2, pages 163-169.
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Adel Courdi, Danielle Mari, Serge Marcié, Jeannine Gioanni & Pierre Chauvel. (1995) Micronucleus induction in 10 human tumour cells after high- and low-dose radiation. Radiotherapy and Oncology 37:2, pages 117-123.
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Adel Courdi, Danielle Mari, Jo�l H�rault & Pierre Chauvel. (1995) Micronucleus induction and reproductive death in a human cell line exposed to low-energy argon beam. Radiation and Environmental Biophysics 34:2, pages 85-89.
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M.J. Silva, A. Carothers, A. Dias, J.H. Luis, J. Piper & M.G. Boavida. (1994) Dose dependence of radiation-induced micronuclei in cytokinesis-blocked human lymphocytes. Mutation Research/Genetic Toxicology 322:2, pages 117-128.
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C.L. Greenstock & A. Trivedi. (1994) Biological and biophysical techniques to assess radiation exposure: A perspective. Progress in Biophysics and Molecular Biology 61:2, pages 81-130.
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