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Original Article

Effect of 2-deoxy-d-glucose on DNA Double Strand Break Repair, Cell Survival and Energy Metabolism in Euoxic Ehrlich Ascites Tumour Cells

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Pages 409-415 | Received 12 Feb 1992, Accepted 20 Apr 1992, Published online: 03 Jul 2009

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Rainer J. Klement. (2019) The influence of ketogenic therapy on the 5 R’s of radiobiology. International Journal of Radiation Biology 95:4, pages 394-407.
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R Varshney, BS Dwarakanath & V Jain. (2005) Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells. International Journal of Radiation Biology 81:5, pages 397-408.
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W. SONTAG. (1997) A discrete cell survival model including repair after high dose-rate of ionizing radiation. International Journal of Radiation Biology 71:2, pages 129-144.
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B. Jha & W. Pohlit. (1993) Reversibility of Inhibition of DNA Double Strand Break Repair by 2-Deoxy-d-Glucose in Ehrlich Ascites Tumour Cells. International Journal of Radiation Biology 63:4, pages 459-467.
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Articles from other publishers (11)

Felix Christian Hasse, Stefan Alexander Koerber, Elena Sophie Prigge, Jakob Liermann, Magnus von Knebel Doeberitz, Juergen Debus & Florian Sterzing. (2019) Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation. Clinical and Translational Radiation Oncology 19, pages 52-58.
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Fakeng Liu, Yuan Liu, Xiuju Liu, Kaisheng Mao, Diansheng Zhong, Adam I. Marcus, Fadlo R. Khuri, Shi-Yong Sun, Yulong He & Wei Zhou. (2018) Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer. Lung Cancer 123, pages 36-43.
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Mayumi Kawata, Kazuhiro Ogi, Koyo Nishiyama, Sho Miyamoto, Takafumi Nakagaki, Makoto Shimanishi, Akihiro Miyazaki & Hiroyoshi Hiratsuka. (2017) Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma. Journal of Oral Pathology & Medicine.
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Gaurav Chauhan, Vianni Chopra, Amit Tyagi, Goutam Rath, Rakesh K Sharma & Amit K. Goyal. (2017) “Gold nanoparticles composite-folic acid conjugated graphene oxide nanohybrids” for targeted chemo-thermal cancer ablation: In vitro screening and in vivo studies. European Journal of Pharmaceutical Sciences 96, pages 351-361.
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Abdullah Farooque, Farhat Afrin, Jawahar Singh Adhikari & Bilikere Srinivasa Rao Dwarakanath. (2016) Polarization of macrophages towards M1 phenotype by a combination of 2-deoxy- d -glucose and radiation: Implications for tumor therapy. Immunobiology 221:2, pages 269-281.
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Harleen Khurana, Virendra Kumar Meena, Surbhi Prakash, Krishna Chuttani, Nidhi Chadha, Ambika Jaswal, Devinder Kumar Dhawan, Anil Kumar Mishra & Puja Panwar Hazari. (2015) Preclinical Evaluation of a Potential GSH Ester Based PET/SPECT Imaging Probe DT(GSHMe)2 to Detect Gamma Glutamyl Transferase Over Expressing Tumors. PLOS ONE 10:7, pages e0134281.
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Saurabh Singh, Sanjay Pandey, Anant Narayan Bhatt, Richa Chaudhary, Vikas Bhuria, Namita Kalra, Ravi Soni, Bal Gangadhar Roy, Daman Saluja & Bilikere S. Dwarakanath. (2015) Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich’s Ascites Tumor in Mice. PLOS ONE 10:7, pages e0132089.
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Abdullah Farooque, Niharika Singh, Jawahar Singh Adhikari, Farhat Afrin & Bilikere Srinivasa Rao Dwarakanath. (2014) Enhanced Antitumor Immunity Contributes to the Radio-Sensitization of Ehrlich Ascites Tumor by the Glycolytic Inhibitor 2-Deoxy-D-Glucose in Mice. PLoS ONE 9:9, pages e108131.
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Diansheng Zhong, Xiuju Liu, Katherine Schafer-Hales, Adam I. Marcus, Fadlo R. Khuri, Shi-Yong Sun & Wei Zhou. (2008) 2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition. Molecular Cancer Therapeutics 7:4, pages 809-817.
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Seema Gupta, A.K. Mishra, K. Muralidhar & Viney Jain. (2016) Improved Targeting of Photosensitizers by Intratumoral Administration of Immunoconjugates. Technology in Cancer Research & Treatment 3:3, pages 295-301.
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B.S Dwarakanath, J.S Adhikari & Viney Jain. (1999) Hematoporphyrin derivatives potentiate the radiosensitizing effects of 2-deoxy-D-glucose in cancer cells. International Journal of Radiation Oncology*Biology*Physics 43:5, pages 1125-1133.
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