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International Journal of Radiation Biology Volume 63, 1993 - Issue 1
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Original Article

Application of Programmable, Autonomously Controlled Electrode (PACE) Technology to the Development of an Improved Pulsed Field Gel Electrophoresis Assay for DNA Double-strand Breaks in Mammalian Cells

M.C. Elia Department of Genetic and Cellular Toxicology, Merck Research Laboratories, West Point, PA, 19486, USA
&
W.W. Nichols Laboratory of Genetic Toxicology, Department of Toxicology, Rohm & Haas Research Laboratories, Spring House, PA, 19477, USA
Pages 7-11 | Received 10 Mar 1992, Accepted 23 Jul 1992, Published online: 03 Jul 2009

Citations (10)

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Read on this site (2)

H. C. NEWMAN, K. M. PRISE, M. FOLKARD and B. D. MICHAEL. (1997) DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage. International Journal of Radiation Biology 71:4, pages 347-363.
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J. Dahm-Daphi & E. Dikomey. (1995) Separation of DNA Fragments Induced by Ionizing Irradiation Using a Graded-field Gel Electrophoresis. International Journal of Radiation Biology 67:2, pages 161-168.
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Articles from other publishers (8)

D. Grygoryev, O. Moskalenko, T. G. Hinton & J. D. Zimbrick. (2013) DNA Damage Caused by Chronic Transgenerational Exposure to Low Dose Gamma Radiation in Medaka Fish ( Oryzias latipes ) . Radiation Research 180:3, pages 235-246.
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Dmytro Grygoryev, Oleksandr Moskalenko & John D. Zimbrick. (2007) Non-Linear Effects in the Formation of DNA Damage in Medaka Fish Fibroblast Cells Caused by Combined Action of Cadmium and Ionizing Radiation. Dose-Response 6:3, pages dose-response.0.
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Piero Sestili, Flaminio Cattabeni & Orazio Cantoni. (1996) Direct excision of 50 kb pair DNA fragments from megabase-sized fragments produced during apoptotic cleavage of genomic DNA. FEBS Letters 396:2-3, pages 337-342.
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Richard D. Storer, Troy W. McKelvey, Andrew R. Kraynak, Michael C. Elia, John E. Barnum, Lori S. Harmon, Warren W. Nichols & John G. DeLuca. (1996) Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds. Mutation Research/Genetic Toxicology 368:2, pages 59-101.
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Piero Sestili, Flaminio Cattabeni & Orazio Cantoni. (1995) The L-histidine-mediated enhancement of hydrogen peroxide-induced DNA double strand breakage and cytotoxicity does not involve metabolic processes. Biochemical Pharmacology 50:11, pages 1823-1830.
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M. Schneider, G. Taucher-Scholz, J. Heilmann & G. Kraft. (1994) Combination of static-field gel electrophoresis and densitometric scanning for the determination of radiation-induced DNA double-strand breaks in CHO cells. Radiation and Environmental Biophysics 33:2, pages 111-124.
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Michael C. Elia, Richard D. Storer, Troy W. McKelvey, Andrew R. Kraynak, John E. Barnum, Lori S. Harmon, John G. Deluca & Warren W. Nichols. (2006) Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: Analysis by pulsed field gel electrophoresis and implications for alkaline elution assays. Environmental and Molecular Mutagenesis 24:3, pages 181-191.
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Michael C. Elia, Richard D. Storer, Lori S. Harmon, Andrew R. Kraynak, Troy W. McKelvey, Phillip R. Hertzog, Kevin P. Keenan, John G. DeLuca & Warren W. Nichols. (1993) Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay. Mutation Research/Environmental Mutagenesis and Related Subjects 291:3, pages 193-205.
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