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International Journal of Radiation Biology Volume 64, 1993 - Issue 1
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Original Article

Reparable and Non-reparable DNA Strand Breaks Induced by X-irradiation in CHO K1 Cells and the Radiosensitive Mutants xrs1 and xrs5

J. Dahm-Daphi Institute of Biophysics and Radiobiology, University of Hamburg, Martinistraße 52, D-2000, Hamburg 20, Germany
,
E. Dikomey MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, BN1 9RR, UK
,
C. Pyttlik Institute of Biophysics and Radiobiology, University of Hamburg, Martinistraße 52, D-2000, Hamburg 20, Germany
&
P.A. Jeggo MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, BN1 9RR, UK
Pages 19-26 | Received 18 Dec 1992, Accepted 07 Mar 1993, Published online: 03 Jul 2009

Citations (23)

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B. K. Singleton, A. Priestley, H. Steingrimsdottir, D. Gell, T. Blunt, S. P. Jackson, A. R. Lehmann & P. A. Jeggo. (1997) Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80. Molecular and Cellular Biology 17:3, pages 1264-1273.
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N. FORAY, A. PRIESTLEY, G. ALSBEIH, C. BADIE, E. P. CAPULAS, C. F. ARLETT and E. P. MALAISE. (1997) Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks. International Journal of Radiation Biology 72:3, pages 271-283.
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K. BORGMANN and E. DIKOMEY. (1997) Relationship between PCC fragments and cell killing studied in X-irradiated CHO, CHO-K1 cells and two radiosensitive mutants xrs1 and xrs5. International Journal of Radiation Biology 72:6, pages 667-674.
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J. DAHM-DAPHI. (1996) Rejoining of DNA double-strand breaks in X-irradiated CHO cells studied by constant- and graded-field gel electrophoresis. International Journal of Radiation Biology 69:5, pages 615-621.
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R. GREINERT. (1996) Comparative study of the repair kinetics of chromosomal aberrations and DNA strand breaks in proliferating and quiescent. International Journal of Radiation Biology 70:1, pages 33-43.
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A. Chukhlovin, J. Dahm-Daphi, G. Gercken, A. Rolf Zander & E. Dikomey. (1995) Comparative Studies of Induction and Repair of DNA Double-strand Breaks in X-irradiated Alveolar Macrophages and Resting Peripheral Blood Lymphocytes Using Constant-field Gel Electrophoresis. International Journal of Radiation Biology 68:2, pages 163-168.
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J. Dahm-Daphi & E. Dikomey. (1994) Non-reparable DNA Strand Breaks and Cell Killing Studied in CHO Cells after X-irradiation at Different Passage Numbers. International Journal of Radiation Biology 66:5, pages 553-555.
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P.J. Johnston & P.E. Bryant. (1994) A Component of DNA Double-strand Break Repair Is Dependent on the Spatial Orientation of the Lesions within the Higher-order Structures of Chromatin. International Journal of Radiation Biology 66:5, pages 531-536.
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J. Dahm-Daphi, E. Dikomey & C. Pyttlik. (1994) Relationship between Non-reparable DNA Strand Breaks and Cell Survival Studied in X-irradiated CHO, CHO K1, xrs1 and xrs5 Cells. International Journal of Radiation Biology 65:6, pages 657-663.
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E. Dikomey & J. Lorenzen. (1993) Saturated and Unsaturated Repair of DNA Strand Breaks in CHO Cells after X-irradiation with Doses Ranging from 3 to 90 Gy. International Journal of Radiation Biology 64:6, pages 659-667.
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Articles from other publishers (13)

Jigar Lad, Andrej Rusin, Colin Seymour & Carmel Mothersill. (2019) An investigation into neutron-induced bystander effects: How low can you go?. Environmental Research 175, pages 84-99.
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Karin H. Karlsson, Irina Radulescu, Björn Rydberg & Bo Stenerlöw. (2008) Repair of Radiation-Induced Heat-Labile Sites is Independent of DNA-PKcs, XRCC1 and PARP. Radiation Research 169:5, pages 506-512.
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Ulla Kasten-Pisula, Svetlana Vronskaja, Jens Overgaard & Ekkehard Dikomey. (2008) In normal human fibroblasts variation in DSB repair capacity cannot be ascribed to radiation-induced changes in the localisation, expression or activity of major NHEJ proteins. Radiotherapy and Oncology 86:3, pages 321-328.
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Didier Boucher, Joëlle Hindo & Dietrich Averbeck. (2004) Increased repair of γ-induced DNA double-strand breaks at lower dose-rate in CHO cells. Canadian Journal of Physiology and Pharmacology 82:2, pages 125-132.
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Bo Stenerlöw, Karin H. Karlsson, Brian Cooper & Björn Rydberg. (2003) Measurement of Prompt DNA Double-Strand Breaks in Mammalian Cells without Including Heat-Labile Sites: Results for Cells Deficient in Nonhomologous End Joining. Radiation Research 159:4, pages 502-510.
Crossref
Björn Rydberg. (2000) Radiation-Induced Heat-Labile Sites that Convert into DNA Double-Strand Breaks. Radiation Research 153:6, pages 805-812.
Crossref
Kai Rothkamm & Markus Löbrich. (1999) Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutation Research/DNA Repair 433:3, pages 193-205.
Crossref
P. A. Jeggo. 1998. DNA Damage and Repair. DNA Damage and Repair 317 334 .
Scott R. Peterson, Murray Stackhouse, Mary Jo Waltman, Fanqing Chen, Koki Sato & David J. Chen. (1997) Characterization of Two DNA Double-stranded Break Repair-deficient Cell Lines That Express Inactive DNA-dependent Protein Kinase Catalytic Subunits. Journal of Biological Chemistry 272:15, pages 10227-10231.
Crossref
M.I. Núñez, T.J. McMillan, M.T. Valenzuela, J.M.Ruiz de Almodóvar & V. Pedraza. (1996) Relationship between DNA damage, rejoining and cell killing by radiation in mammalian cells. Radiotherapy and Oncology 39:2, pages 155-165.
Crossref
Elies C. Woudstra, Jeanette F. Brunsting, Judith M. Roesink, Antonius W.T. Konings & Harm H. Kampinga. (1996) Radiation induced DNA damage and damage repair in three human tumour cell lines. Mutation Research/DNA Repair 362:1, pages 51-59.
Crossref
Ulrich Hagen. (1994) Mechanisms of induction and repair of DNA double-strand breaks by ionizing radiation: Some contradictions. Radiation and Environmental Biophysics 33:1, pages 45-61.
Crossref
E. Dikomey. 1993. Current Topics in Clinical Radiobiology of Tumors. Current Topics in Clinical Radiobiology of Tumors 67 73 .

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