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Original Article

Mechanisms of Radiosensitization in Bromodeoxyuridine-substituted Cells

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Pages 695-705 | Received 04 Mar 1993, Accepted 21 Jul 1993, Published online: 03 Jul 2009

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Fanghua Li, Yanlei Cheng & George Iliakis. (2015) The contribution of thermally labile sugar lesions to DNA double-strand break formation in cells grown in the presence of BrdU. International Journal of Radiation Biology 91:4, pages 312-320.
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G. L. Newton, A. Ly, N. Q. Tran, J. F. Ward & J. R. Milligan. (2004) Radioprotection of plasmid DNA by oligolysines. International Journal of Radiation Biology 80:9, pages 643-651.
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N.A.P. FRANKEN *, C. VAN BREE, J.B.A. KIPP and G.W. BARENDSEN. (1997) Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines. International Journal of Radiation Biology 72:1, pages 101-109.
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Ann-Charlotte Jonsson, Bo-Anders Jönsson, Sven-Erik Strand, Gustav Grafström & Per Spanne. (1996) Cell Survival After Auger Electron Emission from Stable Intracellular Indium Exposed to Monochromatic Synchrotron Radiation. Acta Oncologica 35:7, pages 947-952.
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G.D.D. Jones, J.F. Ward, C.L. Limoli, D.J. Moyer & J.A. Aguilera. (1995) Mechanisms of Radiosensitization in Iododeoxyuridine-Substituted Cells. International Journal of Radiation Biology 67:6, pages 647-653.
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A.F. Fuciarelli, E.C. Sisk, J.H. Miller & J.D. Zimbrick. (1994) Radiation-induced Electron Migration in Nucleic Acids. International Journal of Radiation Biology 66:5, pages 505-509.
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Magdalena Zdrowowicz, Magdalena Datta, Michał Rychłowski & Janusz Rak. (2022) Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2′-deoxyuridine. Cancers 14:8, pages 2035.
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Jun Ma, Teseer Bahry, Sergey A. Denisov, Amitava Adhikary & Mehran Mostafavi. (2021) Quasi-Free Electron-Mediated Radiation Sensitization by C5-Halopyrimidines. The Journal of Physical Chemistry A 125:36, pages 7967-7975.
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Virginia Cruz‐Vallejo, Rocío Ortíz‐Muñiz, Teresita Vallarino‐Kelly, Elsa Cervantes‐Ríos & Pedro Morales‐Ramírez. (2019) In vivo Characterization of the Radiosensitizing Effect of a Very Low Dose of BrdU in Murine Cells Exposed to Low‐Dose Radiation . Environmental and Molecular Mutagenesis.
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Rebecca Meißner, Samanta Makurat, Witold Kozak, Paulo Limão-Vieira, Janusz Rak & Stephan Denifl. (2019) Electron-Induced Dissociation of the Potential Radiosensitizer 5-Selenocyanato-2′-deoxyuridine. The Journal of Physical Chemistry B 123:6, pages 1274-1282.
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Daiva Tauraitė, Jevgenija Jakubovska, Julija Dabužinskaitė, Maksim Bratchikov & Rolandas Meškys. (2017) Modified Nucleotides as Substrates of Terminal Deoxynucleotidyl Transferase. Molecules 22:4, pages 672.
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Anil Kumar & Michael D. Sevilla. 2017. Handbook of Computational Chemistry. Handbook of Computational Chemistry 1741 1802 .
Arnab Rudra, Dianjie Hou, Yonggang Zhang, Jonathan Coulter, Haoming Zhou, Theodore L. DeWeese & Marc M. Greenberg. (2015) Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases. The Journal of Organic Chemistry 80:21, pages 10675-10685.
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Anil Kumar & Michael D. Sevilla. 2016. Handbook of Computational Chemistry. Handbook of Computational Chemistry 1 63 .
Dianjie Hou & Marc M. Greenberg. (2014) DNA Interstrand Cross-Linking upon Irradiation of Aryl Halide C-Nucleotides. The Journal of Organic Chemistry 79:5, pages 1877-1884.
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YOSHIHIRO FUJII, MATTHEW D. GENET, ERICA J. ROYBAL, NOBUO KUBOTA, RYUICHI OKAYASU, KIYOSHI MIYAGAWA, AKIRA FUJIMORI & TAKAMITSU A. KATO. (2013) Comparison of the bromodeoxyuridine-mediated sensitization effects between low-LET and high-LET ionizing radiation on DNA double-strand breaks. Oncology Reports 29:6, pages 2133-2139.
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NICOLAAS A.P. FRANKEN, ARLENE L. OEI, H. PETRA KOK, HANS M. RODERMOND, PETER SMINIA, JOHANNES CREZEE, LUKAS J.A. STALPERS & GERRIT W. BARENDSEN. (2013) Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model. International Journal of Oncology 42:5, pages 1501-1515.
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Yeunsoo Park, Katarzyna Polska, Janusz Rak, J. Richard Wagner & Léon Sanche. (2012) Fundamental Mechanisms of DNA Radiosensitization: Damage Induced by Low-Energy Electrons in Brominated Oligonucleotide Trimers. The Journal of Physical Chemistry B 116:32, pages 9676-9682.
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Mandi Tsoi, Trinh T. Do, Vicky Tang, Joseph A. Aguilera, Christopher C. Perry & Jamie R. Milligan. (2010) Characterization of condensed plasmid DNA models for studying the direct effect of ionizing radiation. Biophysical Chemistry 147:3, pages 104-110.
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M. Zainol, J. Stoute, G. M. Almeida, A. Rapp, K. J. Bowman & G. D. D. Jones. (2009) Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair. Nucleic Acids Research 37:22, pages e150-e150.
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Emran Heshmati, Parviz Abdolmaleki, Hossein Mozdarani & Amir Sabet Sarvestani. (2009) Effects of halogen substitution on Watson–Crick base pairing: A possible mechanism for radiosensitivity. Bioorganic & Medicinal Chemistry Letters 19:17, pages 5256-5260.
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Yu Zeng & Yinsheng Wang. (2006) Sequence-dependent formation of intrastrand crosslink products from the UVB irradiation of duplex DNA containing a 5-bromo-2′-deoxyuridine or 5-bromo-2′-deoxycytidine. Nucleic Acids Research 34:22, pages 6521-6529.
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S. Cecchini, S. Girouard, M. A. Huels, L. Sanche & D. J. Hunting. (2004) Single-Strand-Specific Radiosensitization of DNA by Bromodeoxyuridine. Radiation Research 162:6, pages 604-615.
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Jean-Philippe Pignol, Eileen Rakovitch, David Beachey & Claude Le Sech. (2003) Clinical significance of atomic inner shell ionization (ISI) and Auger cascade for radiosensitization using IUdR, BUdR, platinum salts, or gadolinium porphyrin compounds. International Journal of Radiation Oncology*Biology*Physics 55:4, pages 1082-1091.
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John F Ward. (2002) The radiation-induced lesions which trigger the bystander effect. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 499:2, pages 151-154.
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Roland B. Hawkins. (2001) A Microdosimetric-Kinetic Model for the Sensitization of V79 Cells to Radiation by Incorporation of Bromodeoxyuridine. Radiation Research 155:5, pages 698-702.
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NICOLAAS A. P. FRANKEN, CHRIS VAN BREE, MARTIJN A. T. VELTMAAT, HANS M. RODERMOND, JAAP HAVEMAN & GERRIT W. BARENDSEN. (2001) Radiosensitization by Bromodeoxyuridine and Hyperthermia: Analysis of Linear and Quadratic Parameters of Radiation Survival Curves of Two Human Tumor Cell Lines. Journal of Radiation Research 42:2, pages 179-190.
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H.J. Hammers, H. Kirchner & P. Schlenke. (2000) Ultraviolet-induced detection of halogenated pyrimidines: Simultaneous analysis of DNA replication and cellular markers. Cytometry 40:4, pages 327-335.
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Manuel Rieber & Mary Strasberg‐Rieber. (1998) Induction of p53 and melanoma cell death is reciprocal with down‐regulation of E2F, cyclin D1 and pRB. International Journal of Cancer 76:5, pages 757-760.
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Chris Van Bree, Nicolaas A.P. Franken, Piet J.M. Bakker, Liana J. Klomp-Tukker, Gerrit W. Barendsen & J.Bart A. Kipp. (1997) Hyperthermia and incorporation of halogenated pyrimidines: Radiosensitization in cultured rodent and human tumor cells. International Journal of Radiation Oncology*Biology*Physics 39:2, pages 489-496.
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R. Dover & K. Patel. (1994) Improved methodology for detecting bromodeoxyuridine in cultured cells and tissue sections by immunocytochemistry. Histochemistry 102:5, pages 383-387.
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