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Original Article

Early Chelation Therapy for Injected Pu-238 and Am-241 in the Rat: Comparison of 3,4,3-LIHOPO, DFO-HOPO, DTPA-DX, DTPA and DFOA

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Pages 785-793 | Received 10 Dec 1992, Accepted 11 Feb 1993, Published online: 03 Jul 2009

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Read on this site (6)

Badri N. Pandey, Amit Kumar, Prabha Tiwari & Kaushala P. Mishra. (2010) Radiobiological basis in management of accidental radiation exposure. International Journal of Radiation Biology 86:8, pages 613-635.
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HH Chen, MC Luo, MZ Sun, YX Hu, YH Wang, MY Jin & WY Cheng. (2005) Decorporating efficacy of catecholaminocarboxylate chelating agents for thorium-234 and protective effects on associated radiation injury. International Journal of Radiation Biology 81:4, pages 309-318.
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V. VOLF. (1996) Treatment with 3,4,3-LIHOPO of simulated wounds contaminated with plutonium and americium in rat. International Journal of Radiation Biology 70:1, pages 109-114.
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F. Paquet, JL. Poncy, H. Metivier, G. Grillon, P. Fritsch, R. Burgada, T. Bailly, K.N. Raymond & P.W. Durbin. (1995) Efficacy of 3,4,3-LIHOPO for Enhancing the Excretion of Plutonium from Rat after Simulated Wound Contamination as a Tributyl-n-phosphate Complex. International Journal of Radiation Biology 68:6, pages 663-668.
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G.N. Stradling, S.A. Gray, J.C. Moody, M.J. Pearce, I. Wilson, R. Burgada, T. Bailly, Y. Leroux, K.N. Raymond & P.W. Durbin. (1993) Comparative Efficacies of 3,4,3-LIHOPO and DTPA for Enhancing the Excretion of Plutonium and Americium from the Rat After Simulated Wound Contamination as Nitrates. International Journal of Radiation Biology 64:1, pages 133-140.
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Articles from other publishers (17)

Olivier Grémy, Karine Devilliers & Laurent Miccoli. (2023) Chelation therapy with 3,4,3-Li(1,2-HOPO) after pulmonary exposure to plutonium in rats. Chemico-Biological Interactions 378, pages 110488.
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Qiwen Sun, Xiaomei Wang, Cen Shi, Jingwen Guan, Lanhua Chen, Yumin Wang, Shuao Wang & Juan Diwu. (2022) Effective mitigation of gadolinium deposition using the bidentate hydroxypyridinone ligand Me-3,2-HOPO. Dalton Transactions 51:34, pages 13055-13060.
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Anne Van der Meeren, Jaime F. Angulo, Sandra Bohand & Nina M. Griffiths. (2019) A quick and simple in vitro assay to predict bioavailability of actinides following accidental exposure. Toxicology in Vitro 58, pages 142-149.
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A. Kirstin Sockwell & Modi Wetzler. (2018) Beyond Biological Chelation: Coordination of f‐Block Elements by Polyhydroxamate Ligands. Chemistry – A European Journal 25:10, pages 2380-2388.
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Rebecca J. Abergel. 2016. Metal Chelation in Medicine. Metal Chelation in Medicine 183 212 .
Ole Andersen. 2016. Chelation Therapy in the Treatment of Metal Intoxication. Chelation Therapy in the Treatment of Metal Intoxication 253 284 .
Moses Q. Wilks, Marc D. Normandin, Hushan Yuan, Hoonsung Cho, Yanyan Guo, Fanny Herisson, Cenk Ayata, Dustin W. Wooten, Georges El Fakhri & Lee Josephson. (2015) Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjugate Chemistry 26:6, pages 1061-1069.
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Thomas E. Albrecht-Schmitt, Peter C. Burns & Sergey V. Krivovichev. 2011. The Chemistry of the Actinide and Transactinide Elements. The Chemistry of the Actinide and Transactinide Elements 3339 3440 .
Patricia W. Durbin. (2008) LAURISTON S. TAYLOR LECTURE: THE QUEST FOR THERAPEUTIC ACTINIDE CHELATORS. Health Physics 95:5, pages 465-492.
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David R. Cassatt, Joseph M. Kaminski, Richard J. Hatchett, Andrea L. DiCarlo, Jessica M. Benjamin & Bert W. Maidment. (2008) Medical Countermeasures against Nuclear Threats: Radionuclide Decorporation Agents. Radiation Research 170:4, pages 540-548.
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Anne E. V. Gorden, Jide Xu, Kenneth N. Raymond & Patricia Durbin. (2003) Rational Design of Sequestering Agents for Plutonium and Other Actinides. Chemical Reviews 103:11, pages 4207-4282.
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Jide Xu, Donald W. Whisenhunt, Alan C. Veeck, Linda C. Uhlir & Kenneth N. Raymond. (2003) Thorium(IV) Complexes of Bidentate Hydroxypyridinonates 1 . Inorganic Chemistry 42:8, pages 2665-2674.
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Jide Xu, Emil Radkov, Marco Ziegler & Kenneth N. Raymond. (2000) Plutonium(IV) Sequestration: Structural and Thermodynamic Evaluation of the Extraordinarily Stable Cerium(IV) Hydroxypyridinonate Complexes 1 . Inorganic Chemistry 39:18, pages 4156-4164.
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Jide Xu & Kenneth N. Raymond. (1999) Uranyl Sequestering Agents:  Correlation of Properties and Efficacy with Structure for UO 2 2+ Complexes of Linear Tetradentate 1-Methyl-3-hydroxy-2(1 H )-pyridinone Ligands 1 . Inorganic Chemistry 38:2, pages 308-315.
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B Ramounet, S Matton, G Grillon & P Fritsch. (1998) Early biokinetics of actinides after intravenous administration of soluble forms of Pu(IV), Np(IV) and Np(V). Journal of Alloys and Compounds 271-273, pages 103-105.
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G.N Stradling. (1998) Decorporation of actinides: a review of recent research. Journal of Alloys and Compounds 271-273, pages 72-77.
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N.C. O'Boyle, G.P. Nicholson, T.J. Piper, D.M. Taylor, D.R. Williams & G. Williams. (1997) A review of plutonium(IV) selective ligands. Applied Radiation and Isotopes 48:2, pages 183-200.
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