19
Views
40
CrossRef citations to date
0
Altmetric
Original Article

Manipulation and Exploitation of the Tumour Environment for Therapeutic Benefit

, , , , , & show all
Pages 85-94 | Received 11 Nov 1993, Accepted 22 Nov 1993, Published online: 03 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Ralph E. Durand & Nancy E. Lepard. (1995) Contribution of Transient Blood Flow to Tumour Hypoxia in Mice. Acta Oncologica 34:3, pages 317-323.
Read now

Articles from other publishers (38)

Ayano Enomoto & Kazuhiro Ichikawa. (2022) Research and Development of Preclinical Overhauser-Enhanced Magnetic Resonance Imaging. Antioxidants & Redox Signaling 37:13-15, pages 1094-1110.
Crossref
Aida López Ruiz, Ann Ramirez & Kathleen McEnnis. (2022) Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery. Pharmaceutics 14:2, pages 421.
Crossref
Huan Wang, Tingtao Chen, Linxi Wan, Jiachen Lu, Hong Wei, Ke-Yu Deng, Jing Wei & Hong-Bo Xin. (2020) Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo. Applied Microbiology and Biotechnology 104:8, pages 3517-3528.
Crossref
Manuela Curcio, Paola Avena, Giuseppe Cirillo, Ivan Casaburi, Umile Gianfranco Spizzirri, Fiore Pasquale Nicoletta, Francesca Iemma & Vincenzo Pezzi. (2020) Functional Albumin Nanoformulations to Fight Adrenocortical Carcinoma: a Redox-Responsive Approach. Pharmaceutical Research 37:3.
Crossref
Qiuhui Qian, Lijuan Zhu, Xinyuan Zhu, Mo Sun & Deyue Yan. (2019) Drug-Polymer Hybrid Macromolecular Engineering: Degradable PEG Integrated by Platinum(IV) for Cancer Therapy. Matter 1:6, pages 1618-1630.
Crossref
Shun KishimotoKen-Ichiro MatsumotoKeita SaitoAyano EnomotoShingo MatsumotoJames B. MitchellNallathamby DevasahayamMurali C. Krishna. (2018) Pulsed Electron Paramagnetic Resonance Imaging: Applications in the Studies of Tumor Physiology. Antioxidants & Redox Signaling 28:15, pages 1378-1393.
Crossref
Shun KishimotoMurali C. KrishnaValery V. KhramtsovHideo UtsumiDavid J. Lurie. (2018) In Vivo Application of Proton-Electron Double-Resonance Imaging . Antioxidants & Redox Signaling 28:15, pages 1345-1364.
Crossref
Masayuki Matsuo, Tatsuya Kawai, Shun Kishimoto, Keita Saito, Jeeva Munasinghe, Nallathamby Devasahayam, James B. Mitchell & Murali C. Krishna. (2018) Co-imaging of the tumor oxygenation and metabolism using electron paramagnetic resonance imaging and 13-C hyperpolarized magnetic resonance imaging before and after irradiation. Oncotarget 9:38, pages 25089-25100.
Crossref
Jing Ma, Xiande Yang, Wenpei Hao, Zhonglv Huang, Xin Wang & Peng George Wang. (2017) Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo. European Journal of Medicinal Chemistry 128, pages 45-55.
Crossref
Hongdong ShiQinqin ChengSiming YuanXin DingYangzhong Liu. (2015) Human Serum Albumin Conjugated Nanoparticles for pH and Redox‐Responsive Delivery of a Prodrug of Cisplatin. Chemistry – A European Journal 21:46, pages 16547-16554.
Crossref
John R. Eisenbrey, Daniel A. Merton, Andrew Marshall, Ji-Bin Liu, Traci B. Fox, Anush Sridharan & Flemming Forsberg. (2014) Comparison of Photoacoustically Derived Hemoglobin and Oxygenation Measurements with Contrast-Enhanced Ultrasound Estimated Vascularity and Immunohistochemical Staining in a Breast Cancer Model. Ultrasonic Imaging 37:1, pages 42-52.
Crossref
Masayuki Matsuo, Shingo Matsumoto, James B. Mitchell, Murali C. Krishna & Kevin Camphausen. (2014) Magnetic Resonance Imaging of the Tumor Microenvironment in Radiotherapy: Perfusion, Hypoxia, and Metabolism. Seminars in Radiation Oncology 24:3, pages 210-217.
Crossref
Phulwinder K. Grover, Jennifer E. Hardingham & Adrian G. Cummins. (2010) Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis. Cancer and Metastasis Reviews 29:4, pages 761-775.
Crossref
Fuminori Hyodo, Benjamin P Soule, Ken-ichiro Matsumoto, Shingo Matusmoto, John A Cook, Emi Hyodo, Anastasia L Sowers, Murali C Krishna & James B Mitchell. (2008) Assessment of tissue redox status using metabolic responsive contrast agents and magnetic resonance imaging. Journal of Pharmacy and Pharmacology 60:8, pages 1049-1060.
Crossref
D L Roberts, K J Williams, R L Cowen, M Barathova, A J Eustace, S Brittain-Dissont, M J Tilby, D G Pearson, C J Ottley, I J Stratford & C Dive. (2009) Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells. British Journal of Cancer 101:8, pages 1290-1297.
Crossref
GuoPing Yan, Lei Peng, ShuangQuan Jian, Liang Li & Steven Eric Bottle. (2008) Spin probes for electron paramagnetic resonance imaging. Science Bulletin 53:24, pages 3777-3789.
Crossref
Luke H. Stockwin, Josip Blonder, Maja A. Bumke, David A. Lucas, King C. Chan, Thomas P. Conrads, Haleem J. Issaq, Timothy D. Veenstra, Dianne L. Newton & Susanna M. Rybak. (2006) Proteomic Analysis of Plasma Membrane from Hypoxia-Adapted Malignant Melanoma. Journal of Proteome Research 5:11, pages 2996-3007.
Crossref
Sarah Jane Lunt & Richard P. Hill. 2006. Cancer Drug Resistance. Cancer Drug Resistance 43 66 .
Sarah Jane Lunt, Brian A. Telfer, Richard J. Fitzmaurice, Ian J. Stratford & Kaye J. Williams. (2005) Tirapazamine Administered as a Neoadjuvant to Radiotherapy Reduces Metastatic Dissemination. Clinical Cancer Research 11:11, pages 4212-4216.
Crossref
Franklyn A. Howe, James P. Connelly, Simon P. Robinson, Roger Springett & John R. Griffiths. 2005. Oxygen Transport to Tissue XXVI. Oxygen Transport to Tissue XXVI 75 81 .
Xiuwu Zhang, Takashi Kon, He Wang, Fang Li, Qian Huang, Zahid N. Rabbani, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst & Chuan-Yuan Li. (2004) Enhancement of Hypoxia-Induced Tumor Cell Death In vitro and Radiation Therapy In vivo by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1α . Cancer Research 64:22, pages 8139-8142.
Crossref
Xiuwu Zhang, Qian Huang, Zhonghui Yang, Yongping Li & Chuan-Yuan Li. (2004) GW112, A Novel Antiapoptotic Protein That Promotes Tumor Growth. Cancer Research 64:7, pages 2474-2481.
Crossref
Govindasamy Ilangovan, Haiquan Li, Jay L. Zweier & Periannan Kuppusamy. 2003. Oxygen Transport To Tissue XXIII. Oxygen Transport To Tissue XXIII 13 17 .
Yulin Song, Kate L. Worden, Xin Jiang, Dawen Zhao, Anca Constantinescu, Hanli Liu & Ralph P. Mason. 2003. Oxygen Transport to Tissue XXIV. Oxygen Transport to Tissue XXIV 225 236 .
Wolfgang Wrasidlo, Andreas Niethammer, Serdar Deger, Jalid Sehouli, Andreas Kulozik, Wilhelm Geilen, Günter Henze, Gerhard Gaedicke & Holger N. Lode. (2002) Pilot study of hydrolytically activated paclitaxel prodrug therapy in patients with progressive malignancies. Current Therapeutic Research 63:4, pages 247-262.
Crossref
Murali C. Krishna, Sean English, Kenichi Yamada, John Yoo, Ramachandran Murugesan, Nallathamby Devasahayam, John A. Cook, Klaes Golman, Jan Henrik Ardenkjaer-Larsen, Sankaran Subramanian & James B. Mitchell. (2002) Overhauser enhanced magnetic resonance imaging for tumor oximetry: Coregistration of tumor anatomy and tissue oxygen concentration. Proceedings of the National Academy of Sciences 99:4, pages 2216-2221.
Crossref
Govindasamy Ilangovan, Haiquan Li, Jay L. Zweier & Periannan Kuppusamy. 2002. Oxygen/Nitrogen Radicals: Cell Injury and Disease. Oxygen/Nitrogen Radicals: Cell Injury and Disease 393 398 .
Andreas Niethammer, Gerhard Gaedicke, Holger N. Lode & Wolfgang Wrasidlo. (2001) Synthesis and Preclinical Characterization of a Paclitaxel Prodrug with Improved Antitumor Activity and Water Solubility. Bioconjugate Chemistry 12:3, pages 414-420.
Crossref
Sandeep Hunjan, Dawen Zhao, Anca Constantinescu, Eric W Hahn, Peter P Antich & Ralph P Mason. (2001) Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. International Journal of Radiation Oncology*Biology*Physics 49:4, pages 1097-1108.
Crossref
A.P van den Berg, Cornelis A.J.F van Geel, Christel M.C van Hooije, Ad J van der Kleij & Andries G Visser. (2000) Tumor hypoxia—a confounding or exploitable factor in interstitial brachytherapy? Effects of tissue trauma in an experimental rat tumor model. International Journal of Radiation Oncology*Biology*Physics 48:1, pages 233-240.
Crossref
Simon P. Robinson, Loreta M. Rodrigues, John R. Griffiths & Marion Stubbs. (1999) Response of Hepatoma 9618a and Normal Liver to Host Carbogen and Carbon Monoxide Breathing. Neoplasia 1:6, pages 537-543.
Crossref
Simon P. Robinson, Franklyn A. Howe, Loreta M. Rodrigues, Marion Stubbs & John R. Griffiths. (1998) Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow. Seminars in Radiation Oncology 8:3, pages 197-207.
Crossref
S P Robinson, S J Barton, P M J McSheehy & J R Griffiths. (1997) Nuclear Magnetic Resonance Spectroscopy of Cancer. The British Journal of Radiology 70:Special-Issue-1, pages S60-S69.
Crossref
John R. Griffiths, N.Jane Taylor, Franklyn A. Howe, Michele I. Saunders, Simon P. Robinson, Peter J. Hoskin, Melanie E.B. Powell, Michelle Thoumine, Linda A. Caine & Hiram Baddeley. (1997) The response of human tumors to carbogen breathing, monitored by gradient-recalled echo magnetic resonance imaging. International Journal of Radiation Oncology*Biology*Physics 39:3, pages 697-701.
Crossref
Ralph E Durand & Nancy E LePard. (1997) Tumour blood flow influences combined radiation and doxorubicin treatments. Radiotherapy and Oncology 42:2, pages 171-179.
Crossref
Dennis Le, Ralph P. Mason, Sandeep Hunjan, Anca Constantinescu, Bruce R. Barker & Peter P. Antich. (1997) Regional tumor oxygen dynamics: 19F PBSR EPI of hexafluorobenzene. Magnetic Resonance Imaging 15:8, pages 971-981.
Crossref
Ralph P. Mason, Watchara Rodbumrung & Peter P. Antich. (1996) Hexafluorobenzene: a Sensitive19F NMR Indicator of Tumor Oxygenation. NMR in Biomedicine 9:3, pages 125-134.
Crossref
Adrian L. Harris, Huatang Zhang, Amir Moghaddam, Steve Fox, Prudence Scott, Adam Pattison, Kevin Gatter, Ian Stratford & Roy Bicknell. (1996) Breast cancer angiogenesis — new approaches to therapy via antiangiogenesis, hypoxic activated drugs, and vascular targeting. Breast Cancer Research and Treatment 38:1, pages 97-108.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.